Posted by admin on Sep 1, 2012 in |
Transdermal drug delivery system has been accepted as potential non-invasive route of drug administration, with advantages of prolonged therapeutic effect, reduced side effects, improved bioavailability, better patient compliance and easy termination of drug therapy. Non-steroidal anti-inflammatory drugs (NSAIDs) represents the most commonly used medications for the treatment of pain and inflammation, but numerous well-described side effects can limit their use. Therefore transdermal delivery of NSAIDs has advantages of avoiding hepatic first pass effect, gastric irritation and delivering the drug for extended period of time at a sustained level. The present article gives the brief view on the work been done on various NSAIDs by formulated and delivered as transdermal patches to decrease the side effects associated with the oral delivery. The various NSAIDs included in this article include Ketoprofen, Ibuprofen, Naproxen, Fluribrofen, Diclofenac, Aceclofenac, Ketorolac, Indomethacin, Meloxicam, Nimesulide, Celecoxib,...
Read More
Posted by admin on Sep 1, 2012 in |
This investigation describes a new precise, sensitive and accurate RP-HPLC method for the Simultaneous estimation of Sumatriptan succinate and Naproxen Sodium in Bulk and Tablets. The resolution of two drugs was achieved on XTerra C18 (150mm x 4.6mm i.d., 3.5mm particle size) column with UV detection at 284nm and the mobile phase consists of Buffer and Acetonitrile (25:75 v/v). Using chromatographic conditions described Sumatriptan succinate and Naproxen Sodium were well resolved with mean retention times of 2.622 and 4.070 min, respectively. Linear response (r>0.999) was observed over the range of 30-70µg/ml for Sumatriptan succinate and 20-60µg/ml for Naproxen Sodium. The lower limit of quantification and lower limit of detection was 10.02 and 3.0 for Sumatriptan succinate and 10.05 and 2.99 for Naproxen Sodium. The Validation parameters were performed according to the ICH guidelines and the proposed method can be useful in the routine analysis for the determination of Sumatriptan succinate and Naproxen Sodium in Pharmaceutical dosage...
Read More
Posted by admin on Sep 1, 2012 in |
In recent years, there has been a great deal of interests in developing sustained-release systems which can prolong the therapeutic effect, decrease adverse side effects, and reduce administration frequency. Nowadays, the oral sustained-release preparations account for a larger market share comparing to other sustained-release forms, mainly because of its noninvasive pain-free administration. However, the hostile environment of gastrointestinal tract and first-pass effect may lead to low bioavailability of some drugs, such as some proteins, peptides, and hormones. In this paper, the latest research progresses of some new-model sustained-release injectable dosage forms were introduced, including microsphere, microcapsule, liposome, polymeric micelle, and in situ forming...
Read More
Posted by admin on Sep 1, 2012 in |
Trypsin inhibitor (AATI) was purified from the seeds of Achyranthes aspera to homogeneity by conventional methods and its antimicrobial activity was tested on selected pathogenic microbes. The inhibitor significantly affected the growth of Proteus vulgaris followed by Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Klebsiella pneumonia with zones of inhibition recorded as 28mm, 26mm, 25mm, 20mm and 14mm respectively. No inhibition, however, was observed with Staphylococcus pneumonia strain. Minimum inhibitory concentration (MIC) values of AATI supported that Proteus vulgaris and Bacillus subtilis were the most sensitive strains against the inhibitor. AATI did not differentiate gram positive and gram negative bacteria in its antibacterial activity. The trypsin inhibitor was ineffective against fungal strains Asperigillus niger, Fusarium oxysporum, Alternaria alternate and Candida albicans...
Read More
Posted by admin on Sep 1, 2012 in |
Thiazolidinediones (TZDs) were widely used for the treatment of type 2 diabetes. Recent studies have shown that TZDs have paradoxical effects on cardiovascular diseases. The objective of the present study was to investigate the effect of TZDs (Rosiglitazone and Pioglitazone) in High Fructose Diet (HFD) induced hypertension in rats. HFD was given for 14 weeks. After 8 weeks of hypertension induction period, treatment phase was started with Rosiglitazone (ROSI 10 and 30 mg/kg, p.o.) and Pioglitazone (PIO 10 and 30 mg/kg, p.o.) to the respective groups which were continued till 6 weeks. Systolic Blood Pressure (SBP) was measured weekly and serum glucose, triglyceride, cholesterol and HDL-C were measured at the end of study period. In HFD fed rats hypertension was observed after 8 weeks. Treatment with the test drugs significantly reversed the changes in serum enzyme levels as well as SBP made by HFD feeding compared to the control group. The study concludes that TZDs possess antihypertensive effect as exhibited in the present experimental...
Read More
