Posted by admin on Sep 1, 2012 in |
Helminthiasis is infestation with one or more intestinal parasitic worms roundworms, whipworms , or hookworms in humans and animals. Presently, many synthetic drugs are available to treat Helminthiasis infection effectively, but suffer from number of side effects like abdominal pain, dizziness, headache, fever, nausea, vomiting, or temporary hair loss. Moreover, drug resistance is also another factor concerned with the use of these drugs. Thus, Herbal drugs need to be introduced as large number of medicinal plants are known for their antihelmintic activity with fewer or no side effects and are used by the ethnic groups across different parts of the world. But these medicinal plants need to be screened first for their in vitro and in vivo activity before putting them in use. Thus, many of these herbs have been scrutinized for their pharmacological and pre clinical studies. The present article describes review of promising in vitro efficacy of some medicinal plants having antihelmintic activity, which can be helpful in investigation and discovery of novel herbal...
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Posted by admin on Sep 1, 2012 in |
Allium sativum L. (Liliacea) is a perennial bulb with a tall, erect flowering stem. The bulb of the plant has been used in many parts of the world as a stimulant, carminative, antiseptic, expectorant, anthelmintic and diuretic. This study has been planned to assess the diuretic activity of fresh garlic bulb extract targeting the steroidal and triterpenoidal saponin content. The rats were randomly divided into 4 groups of 5 animal each as vehicle control (2 % tragacanth suspension), standard drug frusemide (20 mg/kg, p.o), and n-butanol extract (10 mg/kg and 20 mg/kg, p.o) treated. Urine was collected in a graduated cylinder and its volume was measured for next 5 hr. Na+, K+ and Cl– concentrations were measured. Phytochemical analysis of A. sativum n-butanol fraction showed presence of steroids, triterpenoidal saponins and carbohydrates. At 20 mg/kg dose onset of diuresis and total volume of urine formed was significantly (P<0.01-0.05) higher. Fifth hour urine volume at 20 mg/kg dose was 9.3 ml as compared to 5.5 ml of control. Extract at...
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Posted by admin on Sep 1, 2012 in |
A simple, sensitive and reproducible method was developed and validated for the simultaneous estimation of Diethylcarbamazine and Levocetirizine in its tablet formulation by reverse phase high performance liquid chromatography using Waters1515 HPLC with Diethylcarbamazine and Levocetirizine simultaneously. HPLC-PDA detector at the λmax of 253nm, using Hypersil-BDS C18 (250×4.6 mm. 5 μ) column. The mobile phase used was potassium dihydrogen orthophosphate buffer (pH: 5): acetonitrile (20:80 v/v) with isocratic flow (flow rate 1 ml/min) and the pH was adjusted with orthophosphoric acid. The compounds Diethylcarbamazine, Levocetirizine were eluted at 2.04, 5.54 min, respectively. The peaks were eluted with better resolution. The method was accurate with assay values of 99.67% and 99.81% w/w, precise (%RSD) with 0.3and 0.5, percentage recovery values of pure drug were in between 99.4% to 100% and 99% to 99.4% which are very sensitive with limit of detections (LOD)’s 2.42 and 0.08ppm and limit of quantification (LOQ)’s 7.42 and 0.2ppm, these results are within the range of limits 98% to 101% which indicates that the method was...
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Posted by admin on Sep 1, 2012 in |
Aim of present investigation was to isolate natural mucoadhesive agent from Ocimum americanum seeds and characterize through in vitro mucoadhesion methods, FTIR and DSC studies. Mucoadhesion force of isolated natural mucoadhesive agents and synthetic polymer Carbopol 934P was determined using in vitro mucoadhesion methods viz. Wihelmy’s method, falling sphere method and modified physical balance method. The research study reveals that the natural mucoadhesive agent isolated from Ocimum americanum seed was shown promising mucoadhesion strength. The formation of hydrogen bond by natural mucoadhesive agent with mucosa was confirmed by FTIR spectra showing carboxyl and hydroxyl groups. Natural mucoadhesive agent may be useful to formulate mucoadhesive drug delivery systems as it bears excellent mucoadhesion property and advantageous over synthetic polymers for less toxicity, biocompatibility, biodegradability and...
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Posted by admin on Sep 1, 2012 in |
Paracetamol is a widely used non-prescription analgesic and antipyretic medicine. The study was conducted to assess the comparative in-vitro quality control parameters through the evaluation of weight variation, hardness, friability, disintegration time and dissolution profile between the commercially available tablet brands of paracetamol. Tablets of two manufacturers of the formulation were evaluated in two groups A and B. The similarities were found between both the groups. Both tablet brands of paracetamol (1.0 to 1.6%) showed acceptable weight variation and friability (below 1%). Both tablet brands were somewhat different in their hardness, disintegration time and dissolution profile. It can be concluded that standard quality control parameters always should be maintained not for paracetamol but also for all kinds of medicine for getting better drug...
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