Posted by admin on Aug 31, 2022 in |
Phenol was used as a sole carbon source for the perchlorate biodegradation as reported for the first time. Isolated bacterial species Pseudoxanthomonas sp. isolated from a sewage sludge consortium was found to reduce perchlorate while taking phenol as electron acceptor. The growth and perchlorate degradation were analyzed in a batch system along with the degradation profile of phenol by the microbial culture. The effect of the co-pollutants (nitrate, chlorate, nitrate, phosphate) was also considered as part of the present study, where nitrate was found to be the most significant. Perchlorate was significantly removed by the culture involving subsequent phenol degradation in a continuous packed bed system anaerobically from synthetic...
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Posted by admin on Aug 31, 2022 in |
Cancer is defined as a condition where cancerous cells multiply out of control in the body. It severely affects the human population on a global basis. New therapies are constantly needed to prevent and treat this life-threatening disease. Natural-derived compounds are attracting scientific and research interest due to their substantially fewer side effects than the current cancer treatment. Plants produce secondary metabolites with anticancer properties and are being examined for their potential to be used as clinical drugs. Amazingly, antineoplastic activity has been reported even in most commonly found locally dwelling plants like ginger, turmeric, garlic, and Ashwagandha, besides their use in other illnesses by the local community. However, many medicinal plants are yet to be properly unveiled for their potential as anti-cancerous agents. They need extensive research and valuable resources for in-depth studies like identification, isolation, in-situ studies, bioequivalence studies, and in-vitro, ex-vivo, or in-vivo studies. This review summarizes the role of bioactive compounds in cancer, the mechanism by which compounds show anticancer activity, and the list of...
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Posted by admin on Aug 31, 2022 in |
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that permanently damages and disables the joints if left untreated. Much research is being carried out; however, any detailed information that could impart knowledge of all the major aspects in an undivided form is still lacking. This review attempts to revive the existing knowledge on RA and provides comprehensive data and current information about the classification criteria for the diagnosis of rheumatoid arthritis and treatment protocol for the management of Rheumatoid arthritis. Early and accurate diagnosis is essential as it can slow down the progression of the disease, permanent joint damage and disability in up to 90% of RA patients. This article also focuses on various diagnostic modalities which help in the diagnosis of RA, and synthetic medicines available for the cure of RA. It provides a section about non-pharmacological and herbal treatment options available for the management of Rheumatoid...
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Posted by admin on Aug 31, 2022 in |
Telmisartan has a strong, nonpeptide antagonist with long-acting angiotensin II type-1 (AT 1) receptor to treat essential hypertension. It is classified as a BCS class II medication, meaning it has poor solubility and high permeability. Because of their capacity to minimise toxicity and change bioavailability, niosomes are becoming increasingly essential in medication delivery. Telmisartan-loaded niosomes were created by adjusting the span 60 and cholesterol ratios in a thin film hydration technique and then assessed for vesicles size, entrapment efficiency and drug release. Batch N6 fulfilled all the requirements and hence it was selected as an optimized formulation of noisome. This investigation supports the use as carriers for developed niosomes to enhance the administration of Telmisartan by oral...
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Posted by admin on Aug 31, 2022 in |
Objective: This study gives an overview of prescribing pattern of antibiotics in children in our tertiary care teaching hospital. Methods: It is a prospective observational study carried out on paediatric in-patients with a sample of 160 patients based on age, inclusion, and exclusion criteria for a period of 6 months. The patient’s data were collected using a patient case record form and the data analysis was done. Results: Out of 160 patients data that were collected, the results showed that the majority of gender which were admitted to the hospital were male children 89 (55.62%), and many were from the age group of early childhood (6-12 years) 64 (40.00%). Respiratory tract infections were the diagnosis most commonly analyzed; overall, 236 prescribed antibiotics, cephalosporins 121 (51.21%) were commonly evident, and parenteral 161 (68.22%) – route of administration was observed to be followed more than other routes. Conclusion: Antibiotic Resistance is a worrisome factor worldwide, challenging treatment regimens. Surgeons & Physicians worldwide find it difficult to cope with the increased resistance...
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