Posted by admin on Aug 31, 2024 in |
3D printing (a.k.a. fast prototyping or advanced manufacturing process) is estimated to be a highly innovative technology within the healthcare devices industry and pharmaceutical industry. With the use of digitally controlled material deposition straight from a computer-aided design, 3D printing technology can create 3D pharmaceutical items layer by layer. It facilitates the making of dosage forms such as composite products, personalized products, and products made on demand. Pharmacogenetic and pharmacokinetic features, age, weight, comorbidities, and other factors all influence the special needs of each patient, and three-dimensional (3D) printed medications have the potential to revolutionize the pharmaceutical business by providing individualized therapies. These supports provide the choice to alter the drug’s efficacy and safety. The capacity to manufacture very little of drugs with customized doses, forms, sizes, and release properties is the primary benefit of 3D printing technology. This method of producing drugs might make the idea of customized medications a reality for bettering patient care. Diverse three-dimensional printing methods have been developed to create innovative solids dosage forms....
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Posted by admin on Aug 31, 2024 in |
Lepromatous leprosy is a chronic infectious disease caused by Mycobacterium leprae, characterized by the extensive involvement of skin and peripheral nerves. While it commonly affects the cooler regions of the body, such as the extremities, ears, and face, involvement of the muzzle area is exceedingly rare. We present a unique case of lepromatous leprosy in a 42-year-old male, where the initial manifestation of the disease primarily occurred in the muzzle area. This case report highlights the atypical clinical presentation of lepromatous leprosy, which typically spares the central face and mucous membranes. The patient exhibited disfiguring nodules, erythema, and sensory loss in the muzzle area, leading to a delayed diagnosis due to the unusual site of involvement. A comprehensive clinical evaluation, histopathological examination, and microbiological confirmation were pivotal in establishing the diagnosis. The rarity of muzzle area involvement in lepromatous leprosy underscores the importance of maintaining a high index of suspicion for atypical presentations, especially in regions where leprosy is endemic. Early detection and multidrug therapy remain crucial in preventing...
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Posted by admin on Aug 31, 2024 in |
Background: A vaccine supply chain is the complex system of steps, processes, equipment, vehicles and locations involved in getting vaccines from their origin to their destination. Failure to understand and properly address this system can greatly reduce the impact of any vaccine. It is also necessary that the condition of cold chain equipment i.e., deep freezer and ice- lined refrigerator (ILR) is maintained appropriately and emergency plan in case of cold chain failure is followed adequately. Material and Methods: An observational cross-sectional study was carried out to assess the functioning of cold chain points after implementation of eVIN (electronic vaccine intelligence network) from January 2022 to August 2022. 34 out of 40 cold chain points in district Nainital who responded were visited and assessed. Collected data were compiled in MS Excel and analyzed using percentages. Result: The findings of this assessment suggest positive changes in the areas of vaccine utilization, stock management and distribution and documentation. The findings revealed that the exposure to sub‑zero temperature and >8°C occurred at...
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Posted by admin on Aug 31, 2024 in |
The present study was aimed to analyze the prescription pattern of the diabetic patients with clinical profile with specific objective to determine the current trend of anti-diabetic drugs. According to the report obtained from the study, the male patients are more prone to diabetes mellitus than females. Type 2 diabetes mellitus is widely observed where study was carried out. There is the need for change in the lifestyle of diabetic patients as per observed social habits. The diabetes patients were in the age group of 51-60 years. Hypertension affected more than 29.73% of diabetic patients according to the present study. The prescription pattern of antihypertensive drugs and cardiovascular drugs are based upon the guideline’s combination drugs by majority of the diabetic patients. The drugs pattern of oral hypoglycemic is also based upon the National list of essential medicines (NLEM 2015) and Dual therapy with metformin + Glimepiride is widely prescribed among these subjects. Proper dose calculations of insulin have been carried out based upon the BMI levels and various...
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Posted by admin on Aug 31, 2024 in |
Health care associated infections (HAIs) are frequently caused by Klebsiella pneumoniae (K. pneumoniae) which has a high level of antibiotic resistance pattern and the ability to form biofilms. In this research work, 105 K. pneumoniae was isolated from both inpatients and outpatients between January 2021 and January 2022 at the tertiary care hospital viz, Mahatma Gandhi Medical College and Research Institute (MGMCRI), India. The K. pneumoniae isolates were further analysed using morphological analysis of the colonies, microscopic examination, and biochemical testing. The Kirby Bauer disk diffusion method and adhesion quantitative assays were utilized for testing antibiotic susceptibility and biofilm- producing capacity. K. pneumoniae isolates were mostly derived from the urine specimens (42.9%) and pus (19.0%). Most of the K. pneumoniae were resistant to a wide range of antibiotics and is also well known to the ability to produce biofilm. This study shows that the biofilm producing K. pneumoniae has been a good resistant to Ceftriaxone/Cefotaxime (80.9%), Amikacin (78.7%), Piperacillin+ Tazobactam (79.8%), and Meropenem (79.8%). On the contrary among non-...
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