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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 1 (2010) - Issue 11, November

Review Articles

 
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1.

NANOMEDICINE: A MAGICAL HOPE FOR THE MEDICAL WORLD

Emerging nanomedicine technologies could dramatically transform medical science as we know it today with their potential to address unmet medical needs and provide targeted therapy. Nanomedicine technologies could find an increasing place in various areas and applications of the healthcare sector including drug delivery, drug discovery and development, diagnostics and medical devices. The advent o...

V. Gupta *, D. S. Rathore and A. Bhandari

Faculty of Pharmaceutical Sciences, Jodhpur National University, Jodhpur (Raj.), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).1-6

1-6

1395

506

2.

ROLE OF HERBAL MEDICINES IN CANCER

Cancer is a genetic disease. The main causes of cancer are alterations of DNA, mutations, damage etc. Any herbs which may be a plant or a part of the plant that are used to maintain the health are called Herbal supplements or Phytomedicines. Plant extracts are generally prepared by boiling the herb in water. The goals of these herbal medicines include prevention and protection against cancer. The ...

P. Udaya Sri*, N. Vijaya Sree, S. Revathi, Y. V. V. Aswani Kumar & N. Divya Sri

Department of Biotechnology, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).7-22

7-22

1802

698

3.

HOT MELT EXTRUSION AND FREEZE PELLETIZATION: BETTER ALTERNATIVE FOR DRUGS HAVING STABILITY PROBLEM DUE TO PRESENCE OF WATER

Pelletization methods like solution layering, suspension layering or powder layering and extrusion-spheronization process is the most frequently used method for producing spherical pellets which utilizes a granulating liquid such as water, requires drying steps which is time consuming. Many drugs exhibit stability problem due to the presence of water during processing and residual water during sto...

Md. A. Rahman*, R. Harwansh, R. Biswas and Mohd. A. Mirza

SLT institute of Pharmaceutical Sciences, Guru Ghasidas Central University, Bilaspur, (C.G.), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).22-31

22-31

1663

708

4.

ANALGESIC AND ANTI-INFLAMMATORY HERBS: A POTENTIAL SOURCE OF MODERN MEDICINE

In recent time, scientific investigations of medicinal plants using indigenous medical systems has attracted a lot of attention globally. Nature has bestowed our planet with an enormous wealth of medicinal plants have been known for millennia and are highly esteemed all over the world as a rich source of therapeutic agents for the prevention and cure of diseases and ailments. Inflammation is compl...

Saikat Sen*, Raja Chakraborty, Biplab De , T. Ganesh, H. G. Raghavendra and Subal Debnath

Creative Educational Society’s College of Pharmacy, Kurnool, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).32-44

32-44

3488

1422

5.

PHARMACOVIGILANCE OF HERBAL MEDICINES: AN INTANGIBLE APPROACH

Herbal medicines make up an important module of the fashion toward alternative medicine. It is becoming ever more popular in today’s world as people seek out for natural remedies. These medicines have been used since the dawn of civilization to maintain health and to treat various diseases. To compete with the growing pharmaceutical market, there is an exigency to develop and scientifically vali...

P. Nainwal

Dev Bhoomi Institute of Pharmacy and Research, Dehradun, Uttarakhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).45-50

45-50

1922

619

Research Articles

 
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6.

PHYTOCHEMICAL COMPOSITION AND IN VITRO ANTIMICROBIAL ACTIVITY OF BAUHINIA RACEMOSA LAMK (CAESALPINIACEAE)

The aim of this study was to evaluate antimicrobial activity of the leaves of the Bauhinia racemosa L. In the current study, the aqueous and methanol extract of leaves of B. racemosa L. was tested against standard bacterial and fungal cultures. In vitro antimicrobial test was performed by agar well diffusion method on Mueller hinton agar and Sabouraud dextrose agar for bacterial and fungal culture...

Gaurav Kumar, L. Karthik and K. V. Bhaskara Rao*

Division of Environmental Biotechnology, School of Bio Science and Technology, VIT University, Vellore, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).51-58

51-58

1958

726

7.

EFFECT OF FRUIT EXTRACT OF ARTOCARPUS HETEROPHYLLUS IN ALLOXAN INDUCED DIABETIC RATS

The present study was aimed at evaluating the antidiabetic activity of aqueous extract of fruits of Artocarpus heterophyllus (Moraceae) in alloxan induced type- II diabetes in rats. The diabetic rats were administered aqueous fruit extract (250 and 500 mg/kg, p.o., n = 6) or vehicle (gum acacia solution) or standard drug glibenclamide (0.25 mg/kg) for 15 days. Blood samples were collected by retro...

Sanjay Jain, Rajani Sharma, Rakesh Barik*, Praveen Kumar and Deepika Bhatt

Department of Pharmacognosy, Smriti College of Pharmaceutical Education, Indore, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).59-64

59-64

1758

498

8.

COMPARATIVE PHARMACOGNOSTICAL STANDARDIZATION OF GENUS ANISOMELES LINN. R. BR. (LAMIACEAE) SPECIES IN INDIA

Comparative Pharmacognostical studies of Anisomeles Linn. R. Br. species (Lamiaceae) in India are carried out. These species are Anisomeles indica L. Kuntze (Syn. A. Ovata R. Br.) and Anisomeles malabarica L. R. Br. Ex Sims, which are highly found in throughout south (Deccan plateau) and northeastern India. The study conducted with the aim of drawing the Pharmacognostical standards for differentia...

Y. V. Ushir*, V. R. Chidrawar, S. K. Singh and K. N. Patel

Department of Pharmacognosy and Phytochemistry, Shree H. N. Shukla Institute of Pharmaceutical Education and Research, Rajkot, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).65-73

65-73

1840

1158

9.

MATERNAL AND NEONATAL OUTCOMES IN PREECLAMPSIA SYNDROME

Aim: The aim of the study was to determine the outcomes and complication of preeclampsia syndrome in pregnancies Methodology: It was a Prospective observational study conducted at Indira Gandhi memorial hospital, Shirpur, Dhule. In this study a total 971 primigravida and multigravida pregnant women was observed out of which, 73 preeclamptic pregnancies were reviewed from July 2009 to February 2...

Vitthal G. Kuchake*, Sunny G. Kolhe, Pitambar N. Dighore and S. D. Patil

Department of Clinical Pharmacy, R. C. Patel Institute of Pharmaceutical Education & Research, Shirpur, Dist: Dhule, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).74-82

74-82

1967

627

10.

ANTIDIABETIC, ANTIHYPERLIPIDAEMIC AND ANTIOXIDANT ACTIVITY OF WATTAKAKA VOLUBILIS (L. F) STAPF LEAVES IN ALLOXAN INDUCED DIABETIC RATS

The ethanol extract of Wattakaka volubilis (L. f) Stapf. (Family: Asclepiadaceae) leaf was investigated for its antidiabetic effect in Wistar Albino rats. Diabetes was induced in Albino rats by administration of alloxan monohydrate (150mg/kg, i.p). The ethanol extract of Wattakaka volubilis at a dose of 150mg/kg of body weight was administered at single dose per day to diabetes induced rats for a ...

A. Maruthupandian, V. R. Mohan* and R. Sampathraj

Ethnopharmacology Unit, Research Department of Botany, V. O. Chidambaram College, Tuticorin, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).83-90

83-90

1637

817

11.

AMELIORATIVE POTENTIAL OF CANNABIS SATIVA EXTRACT ON DIABETES INDUCED NEUROPATHIC PAIN IN RATS

Diabetes induced neuropathic pain is recognized as one of the most difficult type of pain to treat and conventional analgesics are well known to be partially effective or ineffective. Synthetic or natural cannabinoids are promising drugs to treat neuropathic pain. It has been reported that the effect of cannabinoid analgesics is not compromised in various experimental neuropathic pain model. The a...

Amita Arora*, Rajeev Taliyan and P. L. Sharma

I.S.F. College of pharmacy, Moga, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).91-99

91-99

1697

501

12.

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF SIMULTANEOUS DETERMINATION OF ATORVASTATIN CALCIUM AND AMLODIPINE BESILATE IN TABLET DOSAGE FORM BY RP-HPLC

A high performance liquid chromatography method was developed for the simultaneous separation and quantization of Atorvastatin calcium and Amlodipine besilate in combined pharmaceutical tablet dosage form. The chromatographic estimation was achieved by using mobile phase consisting of a mixture of phosphate buffer (1ml ortho phosphoric acid in 1000 ml 0f water) acetonitrile and methanol (53:43:4, ...

Antaryami Jena*, M. Madhu and S. Latha

Department of Pharmaceutical Technology, Anna University Tiruchirappalli, Tamilnadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).100-06

100-106

1632

671

13.

VALIDATED HPTLC METHOD FOR SIMULTANEOUS DETERMINATION OF LAMIVUDINE AND ABACAVIR SULPHATE IN TABLET DOSAGE FORM

A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed and validated for the simultaneous estimation of Lamivudine and Abacavir sulphate in combined dosage forms. The stationary phase was precoated silica gel 60F254. The mobile phase used was a mixture of (Acetone: chloroform: methanol 4: 4: 2 v/v/v). The detection of spot was carried out at 265...

T. Sudha, V. R. Ravikumar and P. V. Hemalatha

Department of Pharmaceutical Analysis, The Erode College of Pharmacy& Research Institute, Erode, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).107-11

107-111

2454

1293

14.

COMPARATIVE STUDY OF ANTIOXIDANT ACTIVITY BETWEEN ETHANOLIC AND AQUEOUS EXTRACT OF CLEOME RUTIDOSPERMA

Cleome rutidosperma is traditionally used in the treatment of paralysis, epilepsy, convulsions, spasm, pain and skin disease. Extraction of the aerial parts of the plant Cleome rutidosperma using water and ethanol and evaluation of their antioxidant activity has been envisaged in this present research work. Both the extracts exhibits significant antioxidant activity in DPPH, Nitric oxide and hydro...

Anup K. Chakraborty*, Manoj S. Charde, Harekrishna Roy, Satyabrata Bhanja and M. Behera

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jeypore College of Pharmacy, Rondapalli, Jeypore, Koraput, Odisha, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).112-16

112-116

1744

664

15.

EVALUATION OF ANTHELMINTIC ACTIVITY OF THE METHANOLIC EXTRACT OF AMORPHOPHALLUS PAEONIIFOLIUS TUBER

Methanolic extracts of the tuber of Amorphophallus paeoniifolius were investigated for its antihelmintic activity against Pheretima posthuma and Tubifex tubifex. The extract with the concentrations of 25, 50 and 100 mg/ml were tested in the bioassay, which involved determination of time of paralysis and time of death of the worms. The extract exhibited significant antihelmintic activity at highest...

Yadu Nandan Dey* and Ajoy Kumar Ghosh

Central Council for Research in Ayurveda and Siddha, Janakpuri, New Delhi, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).117-21

117-121

2264

829

16.

EVALUATION OF ANTIOXIDANT POTENTIAL OF TINOSPORA CORDIFOLIA AND TINOSPORA SINENSIS

A study was undertaken to evaluate the antioxidant potential of two species of Tinospora viz Tinospora cordifolia and Tinospora sinensis on a comparative basis. Aqueous and ethanolic extracts of both the species were subjected to in vitro antioxidant activity screening models such as DPPH, ABTS, nitric oxide and superoxide radical scavenging activity, inhibition of lipid peroxidation, reduction of...

Sanjay Jain, Bhumika Sherlekar and Rakesh Barik*

Department of Pharmacognosy, Smriti College of Pharmaceutical Education, Indore, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).122-28

122-128

2455

1006

17.

ANTIHELMINTIC ACTIVITY OF ETHANOLIC EXTRACT OF BARK OF MYRICA ESCULENTA

Myrica esculenta (Myricaceae), commonly known as ‘Katphala’, is an evergreen, sun-temperate tree. Phytochemical constituents reported in the bark are tannins mainly epigallocatechin-3-o-gallate, gallic acid, myricanone, myricanol and a yellow dye. The edible portion of the fruit is its pulp which contains reducing sugars, tannins and vit C. Myrica esculenta (M. esculenta) is known traditionall...

Vibhor K. Jain* and Bindu Jain

School of Pharmacy, Chouksey Engineering College, Bilaspur (C.G.), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).129-31

129-131

1605

759

18.

HYPOLIPIDEMIC AND HEPATOPROTECTIVE EFFECTS OF DIFFERENT FRACTIONS OF ETHANOLIC EXTRACT OF IMMATURE LEAVES OF MANGIFERA INDICA (LINN.) IN ALLOXAN INDUCED DIABETIC RATS

The study was undertaken to investigate the hypolipidemic and hepatoprotective effects of the different fractions (Petroleum ether, ethyl acetate and chloroform) of ethanolic extract of immature leaves of Mangifera indica. The different fractions of extract were administered intraperitonially as a single dose of 150 mg/kg body weight to alloxan induced diabetic rats and found to reduce blood lipid...

M. S. Hossain, M. Ahmed and A. Islam*

Department of Pharmacy, Bangladesh University, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).132-38

132-138

1898

823

19.

EVALUATION OF PHARMACOPOEIAL STANDARDS WITH REFERENCE TO AFTIMOON- WHOLE PLANT (CUSCUTA REFLEXA ROXB.)

The herbal single drug Aftimoon is botanically called as Cuscuta reflexa Roxb. (whole plant). In the recent past tremendous attempts are being made to evaluate the scientific standards for Traditional System of Medicine, particularly in Unani System of Medicine. The Physician of Unani System of Medicine has considered this drug as one of the important single drugs and this drug has been used exten...

Rampratap Meena*, A. K. Meena, S. Mageswari, D. Ramaswamy and S. Ahmed Khan

Regional Research Institute of Unani Medicine, Royapuram, Chennai, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).139-44

139-144

2652

1061

20.

ENHANCEMENT OF ANTIBACTERIAL ACTIVITY OF AMOXICILLIN BY SOME GHANAIAN MEDICINAL PLANT EXTRACTS

As part of our ongoing study to screen local herbs for their possible usefulness as anti-infectives, we assessed extracts from 16 medicinal plants for their antibacterial properties and their influence on the activity of amoxicillin. The minimum inhibitory concentrations (MIC) of amoxicillin against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli and Salmonella t...

Stephen Y. Gbedema*, Francis Adu, Marcel T. Bayor, Kofi Annan and Joshua S. Boateng

Departments of Pharmaceutics and Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences , Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).145-52

145-152

2269

771

21.

DETERMINATION OF PIOGLITAZONE HYDROCHLORIDE IN BULK AND PHARMACEUTICAL FORMULATIONS BY UV SPECTROPHOTOMETRIC METHOD

UV spectrophotometric method was developed and validated for the analysis of pioglitazone in tablets. The analyses were performed in Phosphate buffer (pH 7.4). Beer’s law was valid in concentration range of 10-50 mcg/ml and UV detection was done at 238 nm. The developed method was validated respect to linearity, precision, accuracy, selectivity / sensitivity applied to the determination of Piogl...

Pragati Shakya* and Kuldeep Singh

Faculty of Pharmacy, Integral University, Kursi Road, Lucknow, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).153-57

153-157

2079

828

22.

SYNTHESIS AND CYTOPROTECTIVE EFFICACY EVALUATION OF NEW DRDE-07 ANALOGUES AGAINST SULPHUR MUSTARD TOXICITY

Sulfur mustard is well known as toxic Chemical warfare agent and on contact with skin it produces blisters as well as systemic toxicity. In this study we have evaluated the efficacy of few analogues of S-2(2-amino-ethylamino) ethyl phenyls sulphide (DRDE-07) and a known radioprotector amifostine against SM induced toxicity in mouse. We have selected seven newly synthesized analogues of DRDE-07 for...

Shikha Sharma*, Neeti Jain, Uma Pathak, S C Pant and R Vijayaraghavan

Department of Pharmaceutical Sciences, Hari Singh Gaur University , Sagar (M.P.), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).158-68

156-168

1387

654

23.

ANAL CANAL CANCER TREATMENT BY CONCURRENT CHEMORADIOTHERAPY VERSUS RADIOTHERAPY ALONE: A COMPARATIVE STUDY

Aim: The aim of this retrospective study is analysis of results of patient treatment outcome when prescribing chemotherapy and radiotherapy as concomitant setup as compared to radiotherapy alone for patients with anal canal carcinoma and related complications of this mode of treatment. Materials and Methods: 24 patients of anal canal cancer (squamous cell carcinoma-17 and adenocarcinoma-7)of me...

M. K. Bharti*, A. Chauhan, P. Kaur, H. Singh and R. Sabharwal

Department of Radiotherapy, Pt. BDS PGIMS, Rohtak, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).169-73

169-173

1512

524

24.

AN EVALUATION ON GRAIN QUALITY UNDER POST HARVEST STORAGE IN SELECTED INDIAN WHEAT VARIETIES

Wheat belongs to the genus Triticum of the grass family, Poaceae. This genus is originated in tropical South west Asia, where it occurs in wild as well as in cultivated forms. Man has depended upon the wheat plant for thousands of years. Wheat (the Triticum spp.) is cultivated worldwide. The grain production varies from year to year and hence the grains should be stored strategically from years of...

Shiju Mathew

Ministry of Higher Education, Department of Natural Sciences, Aksum University, Aksum, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(11).174-77

174-177

1479

571