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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 9 (2018) - Issue 3, March

Review Articles

 
Title
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1.

NATURAL COLORANTS FROM PLANTS FOR WELLNESS INDUSTRY

Colorants are widely used in food, cosmetics, pharmaceutical, nutraceutical and textile industry to improve customer perception and acceptability. The hazardous effects and legislation of synthetic dyes minimize its applications thus the search for natural pigments is in trend. Plant natural pigments are widely used as alternative not only because of their high availability as colouring agent, but...

H. Mohd-Nasir, N. Abd-Talib, S. H. Mohd-Setapar *, L. P. Wong, Z. Idham, A. C. Casillas and A. Ahmad

Centre of Lipid Engineering and Applied Research (CLEAR), Ibnu Sina Institute for Scientific and Industrial Research, Universiti Teknologi Malaysia, Johor, Malaysia.

DOI: 10.13040/IJPSR.0975-8232.9(3).836-43

836-843

2945

1066

2.

ANXIETY DISORDERS AND HERBAL MEDICINES

Anxiety is a common and normal phenomenon, involving multiple brain regions, including amygdala, locus ceruleus and frontal cortex. Moreover, multiple brain transmitters regulate the presence and severity of anxiety; these include classical transmitters such as gamma amino butyric acid, serotonin, and dopamine, as well as neuropeptides that include corticotrophin releasing hormone, substance P, ne...

R. Gani* and Z. A. Bhat

Department of Pharmaceutical Sciences, Pharmacognosy Division, University of Kashmir, Hazratbal, Srinagar, Jammu and Kashmir, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).844-53

844-853

2439

733

3.

EFFLUX PUMPS: AN OVERVIEW

Antibiotic efflux pumps appear a major component of microbial resistance to many classes of major antibiotics namely the tetracycline, the macrolides, and the fluoroquinolones. These are totally synthetic, amphiphilic compounds with no known ‘natural’ counterpart, antibiotic efflux appears sufficient per se to confer a medium or high level of resistance, defeating medically applicable treatmen...

N. Sikri, S. Dalal* and R. Taneja

Department of Biotechnology, Kurukshetra University, Kurukshetra, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).854-61

854-861

1987

717

4.

SOLID LIPID NANOPARTICLES: A PROMISING DRUG DELIVERY SYSTEM

Solid lipid nanoparticle is the forfront of the rapidly developing field of nanotechnology and as an alternative to other traditional colloidal carriers like liposomes, polymeric nanoparticles and emulsions as they have advantages like controlled drug release and targeted drug delivery with increased stability. Objective: Solid lipid nanoparticles (SLNs) consist of spherical solid lipid particles ...

I. D. Raut*, R. C. Doijad and S. K. Mohite

Rajarambapu College of Pharmacy, Kasegaon, Walwa, Sangli, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).862-71

862-871

1998

679

5.

MULTILAYERED TABLET: A NOVEL APPROACH FOR ORAL DRUG DELIVERY

Multi-layer tablet is a new era for winning development of controlled release formulation along with various features to provide successful drug delivery. Bi-layer tablets can be crucial option to avoid chemical incompatibilities between active pharmaceutical ingredients (APIs) by physical separation and to facilitate the development of different drug release profiles. Multi-layer tablet is approp...

S. More*, S. Ghodekar, B. Rane, K. Bavaskar, M. Patil and A. Jain

Shri D. D. Vispute College of Pharmacy and Research Centre, Panvel, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).872-82

872-882

3847

858

6.

AN UPDATE OF PHARMACOLOGICAL ACTIVITY OF PSIDIUM GUAJAVA IN THE TREATMENT OF VARIOUS DISEASES

Psidium guajava is a small medicinal tree that is native to South America and Brazil is among the world’s top producers and most of the country’s production is destined for the food industry. It is popularly known as guava and has been used traditionally as a medicinal plant throughout the world for a number of diseases. It contains important phytoconstituents such as tannins, triterpenes, fla...

R. K. Bijauliya*, S. Alok, M. Kumar, D. K. Chanchal, M. Sabharwal and R. D. Yadav

Department of Pharmacognosy, Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).883-93

883-893

1672

437

7.

THE COMPLITE REVIEW ON ANALYTICAL AND FORMULATION TECHNIQUES OF GLIPIZIDE

Glipizide is second generation Short acting sulfonylurea prescribed for treatment of type II diabetes Mellitus. It is with short biological half-life of 3.4 ± 0.7 hrs and metabolized in the liver and excreted in the urine largely as inactive metabolites. The clinical and pharmaceutical analysis of drug requires analytical procedures along with pharmacokinetic and pharmacodynamic data with stabili...

R. Balkate, S. Baokar, H. Joshi * and R. Patil

Department of Pharmaceutics, Shivnagar Vidya Prasarak Mandal’s College of Pharmacy, Malegaon (Bk), Baramati, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).894-01

894-901

1149

673

8.

A PHARMACOLOGICAL AND TOXICOLOGICAL REVIEW OF LAWSONIA INERMIS

Herbal medicines are in great demand in the developed as well as developing countries for primary healthcare because of their wide biological and medicinal activities, higher safety margins and lesser costs. Lawsonia inermis L. is commonly known as Henna or Mhendi and abundantly available in tropical and subtropical areas. Henna belongs to lythraceae, also known as the loosestrife family. Ancient ...

M. Ponugoti

Department of Pharmacology, Hindu College of Pharmacy, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).902-15

902-915

2128

700

9.

A REVIEW ON TOMATO LYCOPENE

Lycopene, a non-provitamin a carotenoid, found in tomatoes, processed tomato products and other fruits, due to which red to pink coloration is observed. Among all the dietary carotenoids, lycopene is one of the most potent naturally and abundantly occurring antioxidant. Lycopene has unique structural features and chemical features which contribute to specific biological properties and pharmacologi...

N. Mehta*, P. Patani and I. Singhvi

Arihant School of Pharmacy and Bioresearch Institute, Adalaj, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).916-23

916-923

2121

624

Research Articles

 
Title
Views
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10.

TGF-β INCREASES CYTOTOXIC EFFECT AND SENESCENCE INDUCED BY PI3K/ AKT/ MTOR INHIBITOR IN HUMAN COLORECTAL CANCER CELLS

Although NVP-BEZ235 and XAV-939 have been shown a promising result in the treatment of colorectal cancer (CRC), our data is little with regard to the effect of environmental cytokine on this drugs. In order to explore the reaction of CRC to this novel therapy, the current study proposes to investigate the inhibitory effect of NVP-BEZ235 and/or XAV-939 in CRC cells in combination with TGF-β as a t...

R. Karami, A. Soltani and M. Ghatrehsamani*

Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.

DOI: 10.13040/IJPSR.0975-8232.9(3).924-31

924-931

1769

590

11.

COMPARATIVE ANTIOXIDANT POTENTIAL OF AQUEOUS AND ACETONE / WATER EXTRACTS OF GRAINS AND BRANS OF GRANIFEROUS SORGHUM [SORGHUM BICOLOR (L.) MOENCH] HYBRID GUANIPA 71 IN VITRO

Sorghum is an important food source with substantial nutritional value. An in vitro antioxidant evaluation of different extractions of graniferous sorghum [Sorghum bicolor (L.) Moench] hybrid Guanipa 71 was proposed here. Acetone / water extracts of both grains and brans revealed strong antioxidant properties by reducing Fe3+ (22.9% and 42.3%) and chelating Fe2+ (47.3% and 32.4%), respectively. Mo...

G. J. T. Salazar, S. M. P. Duavy, S. A. Adefegha, A. A. Boligon, A. F. Morel, J. B. T. da Rocha, N. B. V. Barbosa and A. Ecker*

Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil.

DOI: 10.13040/IJPSR.0975-8232.9(3).932-44

932-944

1129

585

12.

OLMESARTAN MEDOXOMIL-LOADED SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS: DESIGN, IN-VITRO CHARACTERIZATION, AND PHARMACOKINETIC ASSESSMENTS IN RABBITS VIA LC – MS/MS

Olmesartan medoxomil (OLM) is a lipophilic (log P = 4.31) antihypertensive drug suffering from limited oral bioavailability in humans (26%) due to its low aqueous solubility, uncontrolled enzymatic conversion to the active metabolite (Olmesartan; OL) and efflux by drug resistance pumps. Surmounting such limitations via incorporation of OLM into self-nanoemulsifying drug delivery systems (SNEDDS). ...

M. I. El-Assal*, M. A. El-Gendy, M. I. Tadros and O. N. El-Gazayerly

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University, Cairo, Egypt.

DOI: 10.13040/IJPSR.0975-8232.9(3).945-55

945-955

1402

555

13.

CHEMICAL COMPOSITION, ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF THE ESSENTIAL OIL OF DETARIUM MICROCARPUM GUILL. AND PERR. LEAVES FROM BURKINA FASO

Chemical composition and biological activities of the essential oil of Detarium microcarpum leaves were assessed in vitro. The essential oil was obtained using a Clevenger type apparatus and analyzed by GC and GC/MS. The essential oil was investigated for antioxidant power using the DPPH radical scavenging method and the FRAP test. Antimicrobial activity of the essential oil was also evaluated by ...

Z. Semde*, J. Koudou, C. Zongo, M. K. Somda, G. Figueredo, L. Ganou and A. S. Traore

Centre de Recherche en Sciences Biologiques Alimentaires et Nutritionnelles, Université Ouaga I JKZ, Ouagadougou, Burkina Faso.

DOI: 10.13040/IJPSR.0975-8232.9(3).956-64

956-964

1281

603

14.

CHARACTERISTICS OF DIGESTION IN HIGH-PRODUCING COWS: DEPENDENCE ON THE FAT CONСENTRATION IN THE RATION DRY MATTER

Lipid metabolism in animals has recently gained growing interest among researchers. Among organic compounds, it is only protein and nucleic acids that for a long time have remained in primary focus of research, though lipids are now known to be essential for the origin of life and development of organic forms. Metabolic processes are very active in the bodies of high-producing cows. Large amounts ...

S. Y. Smolentsev*, L. E. Matrosova, E. L. Matveeva, A. E. Ivanova, V. P. Korosteleva, A. R. Nurgalieva, D. R. Sharafutdinova and A. Z. Karimova

Agrarian Technology Institute, Mari State University, Lenin Square 1, Yoshkar-Ola City, Russia.

DOI: 10.13040/IJPSR.0975-8232.9(3).965-74

965-974

1600

526

15.

INVESTIGATION OF THE EFFECTS OF ETHANOL SEED EXTRACT OF GARCINIA KOLA ON HEMATOLOGICAL AND HEPATORENAL INDICES IN WISTAR ALBINO RATS

Garcinia kola is a known herbal plant which is widely consumed for many ethnomedicinal uses. This study was aimed at determining the effect of ethanol extract of G. kola seeds on levels of hematological as well as blood indices of liver (aspartate transaminase, alanine transaminase, alkaline phosphatase, total protein, and albumin) and kidney function (creatinine and urea). Extract (50, 100, 200 o...

J. S. Aprioku

Department of Experimental Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, East-West Road, Choba, Rivers State, PMB, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.9(3).975-80

975-980

1193

378

16.

THE BIOACTIVE POTENTIALS OF OLEA EUROPAEA SUBSPECIES AFRICANA A FOLKLORIC MEDICINAL PLANT AMONG KHOSA TRIBE IN THE EASTERN CAPE PROVINCE, SOUTH AFRICA

The dramatic increase in the burden of chronic non-communicable diseases (NCDs) in emerging economies has become a huge challenge and as such led to increased reliance on folkloric medicine for NCDs management. Consequently, wild Olea europaea leaves were assessed for medicinal potentials, as they are commonly used as a traditional therapy for these diseases in Eastern Cape, South Africa. The anti...

A. A. Adegborioye, B. C. Iweriebor*, S. O. Okoh, U. U. Nwodo, L. C. Obi and A. I. Okoh

Applied and Environmental Microbiology Research Group, Department of Biochemistry and Microbiology, University of Fort Hare, Alice, Eastern Cape, South Africa.

DOI: 10.13040/IJPSR.0975-8232.9(3).981-95

981-995

1082

400

17.

ROLE OF AUTO FLUORESCENCE IN APOPTOSIS ANALYSIS OF MCF-7 AND MDA-MB231 HUMAN BREAST CARCINOMAS TREATED WITH THYMOQUINONE

Thymoquinone (TQ) is the major active component of black seed essential oil which possess encouraging effects against cancer cells. The antitumor activities of TQ were verified in breast carcinoma in-vitro and in-vivo. Most of the times, the cellular responses to apoptosis, after TQ treatment, are evaluate by flow cytometry using annexin V-propidium iodide (PI) staining method. Although flow cytom...

A. Soltani, G. T. Hafshejani and M. Ghatrehsamani*

Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.

DOI: 10.13040/IJPSR.0975-8232.9(3).996-01

996-1001

1153

318

18.

ISOLATION AND IDENTIFICATION OF ANTIBIOTIC PRODUCING MICROORGANISMS FROM SOIL

Antibiotics are most important commercially used secondary metabolites, produced by many soil microorganisms i.e., bacteria and fungi and employed in wide range. Most important antibiotics used today are of microbial origin. The emergence of the antibiotic resistance and need of broad spectrum antibiotics is in focus and in demand. In present study, soil samples from different areas were collected...

A. Rafiq, S. A. Khan, A. Akbar*, M. Shafi, I. Ali, F. U. Rehman, R. Rashid, G. Shakoor and M. Anwar

Department of Microbiology, University of Balochistan Quetta, Pakistan.

DOI: 10.13040/IJPSR.0975-8232.9(3).1002-11

1002-1011

5421

745

19.

PATHOPHYSIOLOGICAL STATUS OF SERUM ANTIOXIDANT, MACRO-MINERALS AND TRACE ELEMENTS IN PATIENTS WITH METABOLIC SYNDROME IN BANGLADESH

This study was undertaken to elucidate the serum antioxidant (Vitamin C), macro - minerals (Ca, Na, and K) and trace elements (Zn, Fe) concentration of in patients with metabolic syndromes. Metabolic syndrome was examined by following the definition developed by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATPIII). Serum Vitamin C was estimated by phenyl-hydrazine spe...

M. S. Rahman, K. Hasan, Md. S. Hussain, Md. S. Millat, N. Sen, M. S. Islam*, Md. S. Sarwar, W. Noor, A. Kar, S.M.N. Uddin and K. Yokota

Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.9(3).1012-22

1012-1022

1096

323

20.

COMPARATIVE STUDY OF OCIMUM BASILLICUM AND ITS ENDOPHYTIC ACTINOMYCETES STREPTOMYCES FLAVOVIRIDIS A3WK: EVALUATION OF ANTIOXIDANT, ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITY

Endophytic actinomycetes are the potential source for obtaining novel bioactive compounds. Present study evaluates the chemical constituents in Ocimum basillicum and its endophytic actinomycetes. Eleven endophytic actinomycetes were isolated from O. basillicum plant. Among eleven, one isolate was characterized by 16S rRNA and identified as Streptomyces flavoviridis A3WK. A comparative analysis of ...

W. Khanam and S. K. Vootla*

Department of Microbiology and Biotechnology, Karnatak University, Dharwad, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1023-34

1023-1034

1132

411

21.

PHYTOCHEMICAL INVESTIGATION, ANALGESIC AND ANTIPYRETIC ACTIVITIES OF ETHANOLIC EXTRACT OF KARIYAT

An ethanolic extract of Kariyat (Andrographis paniculata) was prepared by using Soxhlet extractor. Kariyat ethanolic extract (KEE) was subjected for phytochemical investigations and screened for analgesic and antipyretic activities in experimental animals. High performance thin layer chromatography (HPTLC) and gas chromatography mass spectrometry (GC-MS) investigations indicated presence of steroi...

S. A. Nitave ⃰ , N. B. Chougule and K. Koumaravelou

Centre for Research and Development, PRIST University, Vallam, Thanjavur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1035-43

1035-1043

1102

389

22.

EFFECTIVENESS OF DIPEPTIDYL PEPTIDASE – 4 INHIBITORS IN STREPTOZOTOCIN INDUCED NEURODEGENERATIVE MICE

Introduction: Neurodegenerative diseases are incurable and debilitating condition that results in progressive degeneration and / or death of nerve cells. Anti-oxidants, Antihyper-glycemics and insulin sensitizing agents are reported for reducing cognitive dysfunction in diabetes. Decreasing GLP-1 degradation using Dipeptidyl Peptidase-4 (DPP-4) inhibitors has been shown to be effective for treatin...

R. J. Vaidya*, N. H. Chauhan, B. A. Vyas and S. A. Shah

Maliba Pharmacy College, Ukatarsadia University, Tarsadi, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1044-50

1044-1050

1029

373

23.

DESIGN UTILIZING BILE SALT SURFACTANTAND IN VITRO EVALUATION: IMIDAZOLE CLASS DRUG NASAL SPRAY FOR TREATMENT OF NASAL CONGESTION

The objective of the present work is to develop the meter dose nasal formulation of xylometazoline hydrochloride with a view to improve the effectiveness as nasal decongestion. The 32 factorial experimental design was employed for optimization of sodium cholate (X1) and PEG 400 concentration (X2) in the formulation. All the possible experimental trials were carried out according to design layout. ...

F. Bhuva * and L. D. Patel

Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1051-61

1051-1061

979

339

24.

EXTRACTION AND CHARACTERIZATION OF THE GUM ISOLATED FROM ARAUCARIA HETEROPHYLLA

Objective: Nature has given ginormous resources to mankind since time immemorial. Amidst of various natural sources, products from plant origin endure more of commercial importance. Gums and resins are plant based reserves occupying a prime place among Non-Wood Forest Produce (NWFP). It is a most challenging aspect to isolate and characterise eco rich gums and resins from trees which can be widely...

R. Gayathri* and R. S. Ganapathy

Faculty of Pharmacy, Karpagam Academy of Higher Education, Karpagam University, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1062-67

1062-1067

2132

468

25.

FORMULATION AND EVALUATION OF HYDRALAZINE HYDROCHLORIDE MOUTH DISSOLVING TABLET FOR THE MANAGEMENT OF ECLAMPSIA AND PRE-ECLAMPSIA

Eclampsia and Pre-Eclampsia is an acute and life-threatening complication during pregnancy. Hydralazine hydrochloride is one of the drugs of choice in treating this condition. The purpose of the present research work was to formulate the Mouth Dissolving Tablets by using different methods and provide a suitable patient convenience dosage form to enhance the bioavailability and provide quick onset ...

S. M. Kumar* and R. S. Ganapathy

Faculty of Pharmacy, Karpagam University, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1068-76

1068-1076

1303

363

26.

ANTIDIABETIC ACTIVITY OF HEARTWOOD OF TECOMELLA UNDULATA SEEM. AND HISTOLOGY OF ORGANS IN STREPTOZOTOCIN-NICOTINAMIDE INDUCED DIABETES MELLITUS IN EXPERIMENTAL RATS

Objective: The main objective of the present work was to analyze the therapeutic potential of various fractions of ethanolic extract of Tecomella undulata Seem. heartwood in streptozotocin - nicotinamide (STZ-NA) induced diabetes in experimental rats. Materials and methods: Diabetes was induced in the experimental rats by injecting nicotinamide and streptozotocin intraperitonealy at an interval of...

R. Rohilla*and M. Garg

Department of Pharmaceutical Sciences, Hindu College of Pharmacy, Sonipat, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1077-85

1077-1085

819

361

27.

PHYTOCHEMICAL INVESTIGATION AND HEPATOPROTECTIVE EFFECT OF SCOPARIA DULCIS AGAINST CARBON TETRACHLORIDE INDUCED LIVER DAMAGE IN RATS

The objective of the present study is to carry out the photochemical investigation and hepatoprotective activity study of different extracts of Scoparia dulcis. Scoparia dulcis Linn. belongs to the family Scrophulariaceae and have ruminate medicinal properties. The different extracts of this plant were prepared by successive extraction with petroleum ether, chloroform and ethanol. These extracts (...

P. K. Patra*, S. K. Shete and S. Dange

Sree Dattha Institute of Pharmacy, Sheriguda, Ibrahimpatnam, Ranga Reddy, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1086-92

1086-1092

786

377

28.

NON-TARGETED ANALYSIS AND CYTOTOXIC ACTIVITY OF HAMELIA PATENS JACQ.

In the present study we have done non-targeted analysis of extract from Hamelia patens Jacq. by GC/MS and estimated the inhibitory concentration (IC50) of the extract in three human tumor cell lines MCF-7, H-460 and SF-268. Hamelia patens is an herbaceous perennial plant of family Rubiaceae. Parts of the plant are used in Peruvian and Mexican folk-medicine. Dried leaves of Hamelia patens were extr...

S. Kumar, R. Bodla*and R. Kant

Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), New Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1093-99

1093-1099

924

359

29.

DOCKING STUDIES OF GANODERMA LUCIDUM

Ganoderma is a miracle edible mushroom with unique composition and miraculous health benefits. The investigation aimed to elucidate interactions for the active compounds of Ganoderma lucidum namely Ganoderol A, Ganoderol B, Ganoderal A and Ganoderic Acid Y with Lanosterol 14 alpha demethylase enzyme using molecular docking software Arguslab. The effect of ganomycin1 and 2 as an inhibitor against H...

A. Gupte, A. Palande, S. Venkata and R. Pol *

School of Biotechnology and Bioinformatics, D. Y. Patil University, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1100-05

1100-1105

990

338

30.

PHARMACOLOGICAL ACTIVITY OF SILVER NANOPARTICLES SYNTHESIZED USING STEMODIA VISCOSA AQUEOUS EXTRACT

The Pharmacological effects of silver nanoparaticle of Stemodia viscosa aqueous plant extract on albino wistar rats was explored. The plant extract 40 ml was added to 10 ml of 10mM silver nitrate aqueous solution and kept at room temperature for synthesizing silver nanoparaticle. Diabetes was induced in overnight fasted mice by single intra-peritoneal injection of 55 mg/kg of Streptozotozin (STZ),...

K. Sudharameshwari* and K. Karthigaiselvi

Department of PG Biochemistry, V. V. Vanniaperumal College for Women (Autonomous), Virudhunagar, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1106-11

1106-1111

970

352

31.

OPTIMIZATION AND IN-VIVO EVALUATION OF OCULAR FILMS OF AN ANTI-INFLAMMATORY AGENT

The present study focuses on the treatment of ocular inflammation with objectives of reducing the frequency of administration, obtaining controlled release and greater therapeutic efficacy of drug (Keterolac tromethamine) using ocular films. Various combinations were designed for different batches of ocular films as per factorial design study with 0.5 % w/v concentration by solvent evaporation met...

A. Kumar*, B. K. Tiwari and S. Kumar

R. V. Northland Institute, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1112-19

1112-1119

938

289

32.

A VALIDATED LC-MS/MS METHOD FOR PHARMACOKINETIC STUDY OF AFATINIB IN HEALTHY RABBITS

A liquid chromatography-tandem mass spectrophotometric (LC–MS/MS) method was developed for quantification of Afatinib in rabit plasma employing Solid Phase Extraction (SPE) technique. Developed method was validated for specificity, precision, accuracy, recovery, and stability characteristics. Chromatographic separation was achieved on Gemini, 5µ C18, 50 × 4.60 mm with 30:70 v/v of 10 mM ammoni...

B. Chandramowli* and B. B. Rajkamal

Mewar University, Chittorgarh, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1120-28

1120-1128

1089

352

33.

A NOVEL APPROACH FOR TOPICAL GEL CONTAINING SMEDDS LOADED WITH HERBAL DRUG

The present study was approached to prepare SMEDDS loaded herbal drug (THDC4-0475RD) for the arthritis through topical delivery by gel formulation(s). The efficiency of prepared SMEDDS and SMEDDS loaded gel to enhance the delivery of anti arthritic drug were also evaluated. Labrafil and Stelliester were used as oil phase. Cremophor used as surfactant and sodium caprylate, cutina HR pH, Lutrol Micr...

X. F. Grace*, K. Krishnaraj, C. Darsika, H. B. Pushpalatha and P. S. Chaudhari

Department of Pharmaceutics, Faculty of Pharmacy, Sri Ramachandra University, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1129-40

1129-1140

1167

335

34.

EFFECT OF LACTOSE, L-HPC GRADES ON FLOW PROPERTIES OF MICRONIZED TADALAFIL FORMULATED AS SOLID DOSAGE FORM

Tadalafil belongs to BCS class IV and recommended for treatment of erectile dysfunction. Micronization technique is used by researchers to improve its solubilization and dissolution rate. The conventional tabletting excipients pose challenge especially with micronized drug particles. The current research work aimed to study the effect of some speciality excipients on flow properties of micronized ...

H. Kanekar* and A. Khale

Department of Pharmaceutics, Humera Khan College of Pharmacy, Oshiwara, Jogeshwari (West), Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1141-46

1141-1146

2855

428

35.

A NOVEL HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF CHLORPHENIRAMINE MALEATE AND DEXTROMETHORPHAN IN BULK AND PHARMACEUTICAL FORMULATION

Chlorpheniramine maleate and Dextromethorphan are used in treatment of cough caused by allergies and the common cold by decreasing intra ocular pressure. The present study was designed to develop and validate a simple, sensitive, precise and accurate reverse phase high performance liquid chromatographic (HPLC) method for simultaneous determination of Chlorpheniramine maleate and Dextromethorphan i...

B. Sirigiri, P. Chengalva*, S. A. Parameswari and G. Aruna

Department of Pharmaceutical Analysis, Krishna Teja Pharmacy College, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1147-51

1147-1151

1528

420

36.

STATISTICAL OPTIMIZATION FOR DEVELOPMENT OF COLON TARGETED pH DEPENDANT METRONIDAZOLE GRANULES USING FULL FACTORIAL DESIGN

The objective of this study was to evaluate and optimize Eudragit concentration and coating level on metronidazole release from granules for colon delivery using 32 full factorial design. Independent variables selected were Eudragit conc. (10, 15 and 20%) and coating level (10, 15 and 20%), the evaluated responses were percent drug release at 5 h, 24 h and time to release 50% of the drug. The diss...

K. Sukhbir*, D. Arora, R. K. Narang and G. Aggarwal

Department of Pharmaceutics, I. S. F. College of Pharmacy, Moga, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1152-59

1152-1159

916

318

37.

ENCAPSULATION OF CURCUMIN IN SILVER NANOPARTICLE FOR ENHANCEMENT OF ANTICANCER DRUG DELIVERY

In the proposed work, enhancement of anticancer potential of curcumin extracted from Curcuma longa Linn. by encapsulated in the silver nanoparticle. Curcumin was extracted from Curcuma longa by Soxhlet method. Curcumin is a kind of poly phenols which was widely used because of its medicinal application. Curcumin shows poor solubility and low absorption rate therefore its silver nanoparticles was f...

S. Garg* and A. Garg

Department of Chemistry and Pharmacy, Rani Durgawati Vishwavidhyalaya, Jabalpur, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1160-66

1160-1166

1959

551

38.

BIOLOGICAL STUDIES ON LEAVES AND STEMS OF BEGONIA PICTA

Aim / Background: Aim of this study is to provide scientific evidences that supports the traditional use of Begonia picta; helps to prepare Begonia picta Ayurvedic and / or allopathic formulation for immediate use of herb. Methods: In present study biological screenings were done by following Cytotoxicity pre-screening by Brine shrimp lethality bioassay, anti-hyperglycemic activity evaluation by o...

S. Nisha*, K. D. Prasad and I. Renuka

National Model College for Advance Learning, Tribhuvan University, Kathmandu, Nepal.

DOI: 10.13040/IJPSR.0975-8232.9(3).1167-75

1167-1175

1082

0

39.

CURCUMIN ADMINISTRATION ATTENUATES ACCUMULATION OF MERCURIC CHLORIDE IN VITAL ORGANS OF EXPERIMENTAL RATS AND LEADS TO PREVENT HEPATIC AND RENAL TOXICITY

Mercury is a hazardous, environmental and industrial pollutant, and causes several health issues related to various organs such as brain, kidney, gut, liver. In 2013, Environmental Protection Agency, USA, reported a higher concentration of mercury (5.8 µg/L) in approximately 1.4 million women (2.3% of total USA population) of reproductive age. Based on this prevalence, it was estimated that more ...

A. Agarwal and P. N. Saxena*

Toxicology Laboratory, Department of Zoology, School of Life Sciences, Dr. Bhim Rao Ambedkar University, Agra, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1176-82

1176-1182

1034

339

40.

IN VITRO REGENERATION OF MEDICINAL PLANT EPHEDRA GERARDIANA

Ephedra gerardiana is an important medicinal plant used as Somalata in Indian Ayurvedic system of medicine and as traditional Chinese medicine since several thousand years. Plant is known to contain valuable secondary metabolite such as ephedrine and pseudo ephedrine. These secondary metabolites are utilized for several medicinal purposes. The present study describes the in vitro regeneration of E...

I. Rautela, M. Dhiman, M. D. Sharma and P. Misra*

Department of Molecular and Cellular Engineering, Jacob Institute of Biotechnology and Bioengineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1183-88

1183-1188

1183

339

41.

EFFECT OF CLASSICAL HERBO – MINERAL SIDDHA FORMULATION AGASTHIYAR KUZHAMBU FUMIGATION THERAPY ON SILAIPUN (VARICOSE ULCER) – A CASE STUDY

Siddha system is one of the ancient systems of medicine. In this system the herbals, metals, minerals and animal products has been used to prepare the medicines for treating various illness. Siddha medicines are divided into internal medicines and external medicines, in which Pugai maruthuvam (Fumigation therapy) is one of the external therapies. Agasthiyar Kuzhambu is one of the classical herbo m...

S. Sivakkumar*, L. Juliet and V. Banumathi

National Institute of Siddha, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1189-93

1189-1193

2181

345

42.

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME METHYL 4-(1H-BENZO[d] IMIDAZOL-2-YL) PHENYL CARBAMODITHIOATE AMINE DERIVATIVES

Benzimidazole is a heterocyclic aromatic organic compound which has been an important pharmacophore and privileged structure in medicinal chemistry. Substituted benzimidazoles have considerable interest as compounds with a wide spectrum of biological activity and low toxicity. In the present study, a new series of benzimidazole thiourea derivatives are synthesize and screened for antibacterial and...

L. P. Singh*, O. P. Tiwari and Brijyog

Institute of Pharmacy, Harish Chandra P.G. College Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1194-00

1194-1200

770

355

43.

STUDY OF MICROBIAL DIVERSITY IN ULVA LACTUCA FROM NORTH WEST COAST OF GUJARAT, INDIA

Seaweeds form economically important component of marine ecosystems worldwide. A wide range of beneficial and detrimental interactions exists between seaweeds and epiphytic as well as endophytic bacteria. Diversity study can be used to retrieve ecological information about community partner that relates the degree of stability of that community. The present work deals with the study the microbial ...

G. G. Patel, V. Patel and M. C. Thakur*

Department of Biotechnology, Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1201-12

1201-1212

1135

364

44.

PRODUCTION OF SINGLE CELL PROTEIN FROM SUGARCANE USING FUNGI

Single cell protein is a protein extracted from cultured algae, yeasts, or bacteria and used as a substitute for protein-rich foods, especially in animal feeds or as dietary supplements. Many types of animal feeds contain single cell proteins. It can also be called biomass, bioprotein or microbial protein. The word single cell protein which was coined in the 1960 is considered to be appropriate si...

P. V. Kamala Kumari*, Y. S. Rao, V. R. Vaishnavi and D. Sowjanya

Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1213-17

1213-1217

2029

521

45.

SPECTROPHOTOMETRIC AND STABILITY INDICATING RP-HPLC METHOD FOR ESTIMATION OF RANOLAZINE IN TABLET DOSAGE FORM

A spectrophotometric and reverse phase high performance liquid chromatography methods has been developed for the estimation of Ranolazine in bulk and pharmaceutical dosage form. For UV spectrophotometric method Ranolazine shows maximum absorbance at 273 nm with the concentration ranges of 20-150 µg/mL. The detection limit and quantification limit were found to be 1.23 and 5.21 µg/mL, respective...

V. Patel*and S. Pandya

L. B. Rao Institute of Pharmaceutical Education and Research, Khambhat, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1218-25

1218-1225

1207

382

46.

FAST DISSOLVING TABLETS OF FEXOFENADINE HYDROCHLORIDE BY MELT TECHNOLOGY: FORMULATION AND CHARACTERIZATION

The objective of present study was formulation and evaluation of fast release tablets of Fexofenadine hydrochloride. Fexofenadine hydrochloride is an anti-histamine with selective H1-receptor antagonist activity. In this investigation fast release tablets of Fexofenadine hydrochloride were prepared using cross povidone as a superdisintegrants by melt technology method. The Fourier transform infrar...

B. Gupta* and S. Kumar

NKBR College of Pharmacy and Research Centre, Hapur Road Phaphunda, Meerut, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1226-30

1226-1230

1400

348

47.

ANALYSIS OF ANTIMICROBIAL USAGE PATTERN: A RETROSPECTIVE OBSERVATIONAL STUDY

Objective: Antimicrobials have become one of the most misused therapeutic agents resulting in resistance. Present study was carried out to evaluate the antimicrobial drug utilization pattern. Method: A retrospective, observational record based study was done in hospitalized patients from medicine and surgery department of tertiary care hospital of central India over a period of one year. Result: A...

S. Rode and H. Salankar*

Department of Pharmacology, Shri Shankaracharya Institute of Medical Sciences, Junwani, Bhilai, Durg, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1231-36

1231-1236

1001

383

48.

EVALUATION OF ANTIMICROBIAL ACTIVITY OF MYCELIA AND SPOROCARP OF ENTOLOMA SPECULUM

Antimicrobial activity of mycelia and Sporocarps has been adequately worked out but comparative studies of both has not done in detail. The present work is to compare the antimicrobial activity of mycelia and sporocarps of Entoloma speculum. It is a saprophytic, white fleshy fungi, belongs to Entolomataceae. The collected fruiting bodies were dried, powdered and subjected for secondary metabolites...

J. K. Kodiyalmath* and M. Krishnappa

Department of P.G. Studies and Research in Applied Botany Kuvempu University, Shankaraghatta, Shimoga, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1237-41

1237-1241

1072

346

49.

COMPARISON OF EFFICACY OF FERROUS CALCIUM CITRATE vs FERROUS ASCORBATE ON Hb STATUS IN ANAEMIC PREGNANT WOMEN

Objectives:  To compare the efficacy of ferrous calcium citrate with ferrous ascorbate on Hb levels in anaemic pregnant women. Method: In this observational study, patients receiving ferrous ascorbate with elemental iron 100 mg were allocated to group A and those receiving ferrous calcium citrate with elemental iron 50 mg allocated to group B. After recording the baseline data, their Hb levels, s...

S. S. Halemani*, K. Lakkol and A. Acharya

Subbaiah Institute of Medical Sciences, Shimoga, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1242-46

1242-1246

2984

536

50.

PHYTOCHEMICAL SCREENING AND IN-VITRO ANTIOXIDANT ACTIVITY OF EVOLVULUS ALSINOIDES EXTRACTS

Free radicals are atoms or groups of atoms with an unpaired number of electrons and can be formed when oxygen interacts with certain molecules. Once formed these highly reactive radicals can start a chain reaction, like dominoes. These free radicals become more lethal when they react with important cellular components such as DNA, or the cell membrane. Cells may function poorly or die if this occu...

M. K. Yadav *, S. K. Singh, J. S. Tripathi and Y. B. Tripathi

Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1247-50

1247-1250

937

361

51.

ANTIHYPERTENSIVE EFFICACY OF ROUWOLFIA TETRAPHYLLA – ROOT OF THE PLANT ON UNINEPHRECTOMIZED DOCA – SALT HYPERTENSIVE RATS

The plant Rouwolfia tetraphylla has been used traditionally as antihypertensive and has been proven scientifically to possess high antioxidant and hepato-protective activity. This study was designed to check the potential of medicinal plants in treatment of hypertension which will be helpful to reduce the side and adverse effect of allopathic antihypertensive drugs. During the experimental period,...

R. Gadhvi ⃰ , M. N. Reddy and M. Nivserkar

Department of Biotechnology, Shree Bapalal Vaidhya Botanical Research Center, Veer Narmad South Gujarat University, Surat, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1251-55

1251-1255

1038

332

52.

PROTECTIVE EFFECT OF QUERCETIN ON BISPHENOL A – INDUCED ENZYMATIC CHANGES IN TESTIS OF MICE

Bisphenol A is well known endocrine disturbing chemical. Evidence has demonstrated that exposure to certain levels can cause toxic effect in humans and laboratory animal models. Quercetin is consistently the most active of the flavonoids in experimental studies. The present investigation was an attempt to evaluate the effect of Bisphenol A on testis and its amelioration by quercetin. Inbred Swiss ...

S. Samova*, H. Doctor and R. Verma

Department of Zoology, School of Sciences, Gujarat University, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(3).1256-62

1256-1262

1027

348

53.

PREPARATION OF A TRADITIONAL POLY HERBAL PRODUCT AND STABILITY ASSESSMENT OF THE DOSAGE FORM

“Soda” is one of the humors in the body which should be in normal level for being healthy. If “soda” increases in the body, some undesirable symptoms appear. In order to eliminate the excess “soda”, at first it should be maturated. There are different formulations in Iranian traditional medicine references as “Monzig-e-soda” which is a way of maturation of black bile. In one of the...

H. R. M. Esfahani, H. Hajimehdipoor*, N. Dorri, L. Ara, B. Eslami, S. Fahimi and S. M. H. Kojoori

Traditional Medicine and Materia Medica Research Center, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

DOI: 10.13040/IJPSR.0975-8232.9(3).1263-67

1263-1267

864

328

54.

CHEMOMETRIC ANALYSIS OF PARACETAMOL AND METACLOPROMIDE IN BINARY DRUG COMBINATIONS

In this study, the stomach environment of paracetamol and metaclopramide active substances was prepared with the aid of chemometric method and UV spectrophotometer and their concentrations were measured at certain ratios. Spectra of these two active substances were observed separately in UV spectroscopy at different concentrations. Spectra of paracetamol and metaclopromide were observed by UV spec...

G. P. Ertokuş* and M. Yildiz

Department of Chemistry, Faculty of Science and Art, Süleyman Demirel University, Isparta, Turkey.

DOI: 10.13040/IJPSR.0975-8232.9(3).1268-73

1268-1273

1241

365

55.

THE EDGE-PADMAKAR-IVAN INDEX OF THE TITANIA NANOTUBES TiO2(m,n)

Let G(V,E) be a simple connected graph. For an edge e=uv, mu(e) is the number of edges lying closer to the vertex u than v, analogously define mv(e). The edge version of PI index of a graph G is defined as .Nano-structured TiO2 has been widely used in various applications such as biosensors, solar cells and biomaterials. Synthesis of nano-structured Titanium dioxide (TiO2) such as Nanotubes, Nano-...

J. Zheng, M. R. Farahani, M. K. Jamil, M. K. Siddiqui and X. Zhang*

School of Information Science and Engineering, Chengdu University, Chengdu, China.

DOI: 10.13040/IJPSR.0975-8232.9(3).1274-80

1274-1280

839

337

56.

AQUEOUS EXTRACT OF CENTELLA ASIATICA AS A POTENTIAL ANTI-KELOID AGENT

Centella asiatica (CA) is a reputed medicinal plant that has been shown to have pharmacological effect on skin wound healing. The aim of the study was done to assess the effects of aqueous extract of CA on human dermal fibroblasts in an in vitro model of wound healing. Dermal fibroblasts were cultured with or without supplementation of aqueous extract of CA. Viability and proliferation of the fibr...

R. B. H. Idrus*, M. H. M. Yunus , S. F. Simat , N. Q. A. V. Sainik, M. I. Adenan and A. B. Saim

Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Malaysia.

DOI: 10.13040/IJPSR.0975-8232.9(3).1281-90

1281-1290

1128

352

57.

CHARACTERIZATION OF ANDROGRAPHOLIDE IN INCLUSION COMPLEX USING BETA CYCLODEXTRIN

Andrographolide (AG) is a purified isolate of chemical synthesis resulted from sambiloto herbs (Andrographis paniculata Nees.), which has various pharmacological actions such as anti-inflammatory, hepatoprotector, antidiabetic, inhibition of replication of the HIV virus, antimalarial, anti-arthritic, anti-hyperlipidemic, anticancer, antimicrobial, immunomodulator and antiparasitic. To enhance the ...

S. S. A. M. S. B. F. Prasetyo*, I. Wientarsih, D. Sajuthi and V. Juniantito

Faculty of Veterinary Medicine, Bogor Agricultural University, Dramaga, Bogor, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.9(3).1291-96

1291-1296

1060

343

58.

IN-VIVO ANTIFUNGAL ACTIVITY OF THE AERIAL PART OF ANVILLEA RADIATA BY USING A NEW METHOD OF STORAGE BY COATING GRAIN

The aim of the present study is to evaluate the antifungal effect of Anvillea radiata and to test the storage efficiency of soft wheat by coating. Phytochemical screening conducted on the Anvillea radiata extracts revealed the presence of the elements has known medical and physiological activities. Our results show a correlation between the plant part, extract concentrations and mold species. In g...

M. Snoussi *, M. Najett, M. Boumediene and M. Abdelallah

Laboratory of Plants, Resources and Food Security in Semi-arid Areas, South-West of Algeria, University of Bechar, Bechar, Algeria.

DOI: 10.13040/IJPSR.0975-8232.9(3).1297-00

1297-1300

839

304

59.

TREATMENT AND DIAGNOSTIC PATTERN OF OSTEOPOROSIS IN BANGLADESH

Osteoporosis is defined as low bone density with micro architectural deterioration of bone tissue leading to enhanced bone fragility and increased fracture risk. Knowing the treatment pattern of osteoporosis is imperative in achieving better health outcomes. Thus the purpose of our study was to assess the treatment pattern of osteoporosis in 8 different medical colleges and hospitals in Bangladesh...

A. A. Faysal *, N. Tanjia, T. Fannana, M. Khalil and M. A. Sayed

Department of Pharmacy, East West University, Jahurul Islam City, Aftabnagar, Dhaka, Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.9(3).1301-06

1301-1306

1740

344

60.

COMPARATIVE ANALYSIS OF CHEMICAL AND PHYTOCHEMICAL COMPOSITIONS OF FOUR SELECTED MEDICINAL PLANTS AND EVALUATION OF ANTIDIABETIC PROPERTIES OF AQUEOUS EXTRACTS OF TRIGONELLA FOENUM-GRAECUM AND COMBINATION OF TRIGONELLA FOENUM-GRAECUM – MOMORDICA CHARANTIA

The present study was designed to compare the chemical and phytochemical compositions of Momordica charantia, Azadira chtaindica, Trigonella foenum-graecum and Phyllanthus emblica and subsequently, antidiabetic activities of T. foenum-graecum and a combination of polyherbal extract of T. foenum-graecum and M. charantia were evaluated on alloxan induced diabetic mice. The proximate and phytochemica...

Mukit MG, Raza MS, Ud-Daula A, Azhar BS and Mijanur Rahman ATMM*

Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.9(3).1307-16

1307-1316

1048

291