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LIVER SPECIFIC DRUG TARGETING STRATEGIES: A REVIEW
Drug delivery to liver is one of the most challenging research areas in pharmaceutical sciences. The some physiological barrier such as opsonization, mechanical entrapment by pulmonary vascular bed, uptake by RES represents an insurmountable obstacle for a large number of proteins and drugs, including antibiotics, antineoplastic agents and antiviral agents to target liver disorders. Therefore, var...
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IMMOBILIZATION AND ESTIMATION OF ACTIVITY OF YEAST CELLS BY ENTRAPMENT TECHNIQUE USING DIFFERENT MATRICES
Background: It becomes clear that living processes were based on the action of enzymes. Cell immobilization serves as a useful tool for the immobilization of intracellular enzymes. The purpose of study is to improve economically important processes by attaching the yeast cells to matrices. Methods: In this analytical study by using mixed models of matrices like (sodium alginate alone, sodium algin...
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SPECTROPHOTOMETRIC DETERMINATION OF PARACETAMOL DRUG USING 8-HYDROXYQUINOLINE
A rapid and simple spectrophotometric method is reported here for the determination of paracetamol in a commercially available tablet formulation. The method is based on the diazotization of hydrolyzed paracetamol with 8-hydroxyquinoline as a coupler to form stable azo dyes color solution. The concentration of drug paracetamol was investigated by spectrophotometrically. The azo dyes formed with 8-...
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PHYLLANTHUS RETICULATUS POIR. – AN IMPORTANT MEDICINAL PLANT: A REVIEW OF ITS PHYTOCHEMISTRY, TRADITIONAL USES AND PHARMACOLOGICAL PROPERTIES
The medicinal plants are widely used by traditional medical practitioners for curing various diseases in their day to day life. In traditional system of medicine different parts of Phyllanthus reticulatus are used for curing various ailments. Bark is used as astringent and diuretic. Leaves are antidiarrheal and roots are used for asthma. Fruit of the plant is used in inflammation. Phyllanthus reti...
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THIRD GENERATION MATERIALS FOR WOUND DRESSINGS
An ideal wound Dressing need to be redefined based on the nature of wound and wound classifications. Since generations, wound have been defined as self-healing process, but chronic wounds and other wound requires handling and care from different parameters like moist conditions, biocompatibility, microbial infection to mention a few. Traditional methods have been continuously worked upon to delive...
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EMULGEL-NOVEL TOPICAL DRUG DELIVERY SYSTEM–A COMPREHENSIVE REVIEW
Emulgel systems are currently of attention to the pharmaceutical scientists because of their substantial potential to act as drug delivery vehicle by incorporating a broad range of drug molecules. These are either emulsion of water in oil type or oil in water, which is gelled by mixing it with a gelling agent. Incorporation of emulsion into gel makes it a dual control release system & also inc...
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POLIO: A REVIEW
Postpolio syndrome (PPS) may affect survivors of paralytic poliomyelitis and is characterised by a complex of neuromuscular symptoms leading to a decline in physical functioning. The effectiveness of pharmacological treatment and rehabilitation management in PPS is not yet established. To review systematically the effects of any treatment for PPS compared to placebo, usual care or no treatment. Po...
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PHYTOCHEMISTRY AND PHARMACOLOGY OF OXALIS CORNICULATA LINN.: A REVIEW
Many herbal remedies have been employed in various medical systems for treatment and management of different diseases. The plant Oxalis corniculata Linn. has been used in different system of traditional medication for the treatment of diseases and ailments of human beings. β-sitosterol, betulin, 4-hydroxybenzoic acid, ethyl gallate, methoxyflavones, apigenin, and 7-O-β-D-glucopyranoside were pre...
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SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUGS: A REVIEW
Many water insoluble drugs present in class 2 and it is characterized by low solubility and high permeability. Solubility of drug can be enhancing by increasing of dissolution rate. Many solubilization techniques are available for increasing of solubility as well as permeability like micronization, coacervation, complexation, solid dispersion, and cosolvent. Poorly soluble and dissolution profile ...
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HERB-DRUG INTERACTIONS: AN OVERVIEW OF MECHANISMS AND CLINICAL ASPECTS
Millions of people today use herbs either as food or in the form of medicine along with prescription and non prescription medications. Although considered natural and safe, many of these herbs can interact with other medications, causing either potentially dangerous side effects and/or reduced benefits from the medication. Both pharmacokinetic and pharmacodynamic mechanisms are involved in these i...
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