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A REVIEW ON DIVERSIFIED USE OF THE KING OF SPICES: PIPER NIGRUM (BLACK PEPPER)
Black pepper, the ‘King of spices’ (Piper nigrum L.), is a widely used spice, known for its pungent odour. From time immemorial, plant sources were used in traditional systems of medicine and day-to-day common use, such as in meal preparation and cosmetic purposes. This is due to their vast pharmacological potential with minimum side effects. Among the various species of the Piperaceae family,...
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STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION OF SUCRALFATE AND OXETACAINE IN BULK AND MARKETED FORMULATION BY RP-HPLC
The objective of present study is to develop and validate a method for the estimation of sucralfate and oxetacaine in suspension dosage form. An isocratic reversed phase high performance liquid chromatographic method was developed to estimate sucralfate and oxetacaine using thermohypersil BDS (4.6 x 150mm, 5). The mobile phase was prepared by mixing ammonium acetate (pH- 4.4) and methanol in th...
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A STUDY TO COMPARE EFFICACY OF METFORMIN-GLIMEPIRIDE VERSUS METFORMIN-TENELIGLIPTIN IN TYPE II DIABETIC PATIENTS
Diabetes mellitus relates a metabolic disorder of collective aetiology which is characterized by chronic hyperglycaemia caused due to disturbances of carbohydrate, lipid and protein metabolism due to impaired β cell function of pancreas or insulin resistance or both. Biguanides and Sulphonylureas are the most commonly prescribed drugs due to their efficacy and safety. A total of 60 patients were ...
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DOSE OPTIMIZATION OF CEFTRIAXONE-SULBACTAM COMBINATION IN PEDIATRIC USING IN-VITRO SYSTEMS AND STOCHASTIC SIMULATIONS APPROACHES
Increase in complexity and cost associated with pediatric safety and efficacy studies have reduced the interest of pharmaceutical companies to study bio-therapeutics in pediatric population. Dose recommendations are being made as per patient body weight or body surface area, with the assumption of linearity in body size dose adjustments. In the present study, newer approach i.e. flat fixed age-bas...
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FLOATING DRUG DELIVERY SYSTEM: A REVIEW
The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the types of floating drug delivery systems, principal and mechanism of floatation to achieve gastric retention. Drug delivery systems are those that float immediately upon contact with gastric fluids present promising approaches for increasing the bioavailability ...
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VARIOUS MEDICINAL PLANTS USED IN THE TREATMENT OF ANTICANCER ACTIVITY
Cancer is a major public health burden in both developed and developing countries. It is actually a group of many related diseases that all have to do with cells. It is one of the major causes of death worldwide where the number of cancer patients is in continuous rise. It is a major public problem whose estimated worldwide new incidence is about 6 million cases per year. It is the second major ca...
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APOPTOSIS: BASIC CONCEPTS, MECHANISMS AND CLINICAL IMPLICATIONS
Apoptosis, a well choreographed gene-directed cellular destruction, plays an important role in a variety of biological events, including morphogenesis, homeostatic maintenance of various tissues and removal of harmful cells while dysregulated apoptosis has been implicated in a variety of disease such as cancer, systemic and organ specific autoimmune disease and neurodegenerative disorders. Apoptos...
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FLAVONOIDS: THERAPEUTIC POTENTIAL OF NATURAL PHARMACOLOGICAL AGENTS
Flavonoids are the natural compound widely distributed in plant kingdom, it is responsible for the various colors exhibited by bark, leaves, flowers, fruits and seeds of plants. They are the secondary metabolites of plant with significant antioxidant properties. Flavonoids have antioxidant, sedative, antidepressant, anticonvulsant, anti-proliferative, anti-inflammatory, anti-microbial, anticancer,...
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HERB-DRUG INTERACTIONS: AN OVERVIEW OF MECHANISMS AND CLINICAL ASPECTS
Millions of people today use herbs either as food or in the form of medicine along with prescription and non prescription medications. Although considered natural and safe, many of these herbs can interact with other medications, causing either potentially dangerous side effects and/or reduced benefits from the medication. Both pharmacokinetic and pharmacodynamic mechanisms are involved in these i...
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WARFARIN RESISTANCE-MECHANISMS AND MANAGEMENT
Anticoagulants are a class of drugs commonly used to prevent the blood from forming dangerous clots that could result in a stroke.Warfarin is an oral anticoagulant. Warfarin differs from most other drugs in that the dosage required to achieve a desired therapeutic effect varies greatly among individuals. Resistance to warfarin has been described as the inability to prolong the prothrombin time or ...
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