VALIDATED STABILITY INDICATING LIQUID CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL, TRAMADOL AND DICYCLOMINE IN TABLETS
A new simple stability indicating reversed-phase liquid chromatographic method has been developed and validated for simultaneous estimation of Paracetamol, Tramadol and Dicyclomine in combined pharmaceutical dosage form. An Agilent Zorbax SB C18 (250mmx4.6mm, 5microns) column with mobile phase containing ammonium acetate: acetonitrile (700:300 v/v) was used. The flow rate was maintained at 1.0 mL/...
BUCCAL MIDAZOLAM: COULD IT BE AN ALTERNATIVE FOR I/V DIAZEPAM FOR ACUTE SEIZURES IN MALNOURISHED CHILDREN
Acute convulsive disorders are the most frequent neurological disorders in children which require emergency drug treatment. Immediate management of a convulsive episode is must as, delay can lead to status epilepticus, which is a significant cause of neurological morbidity and mortality among children. Benzodiazepines especially diazepam is often used as first line and routinely administered intra...
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPLC METHOD FOR QUANTITATIVE DETERMINATION OF RELATED SUBSTANCES PRESENT IN ELETRIPTAN HYDROBROMIDE DRUG SUBSTANCE
An efficient and sensitive RP-HPLC method was developed and validated for the estimation of related substances in Eletriptan hydrobromide drug substance which were identified and characterized by LCMS, FTIR, 1HNMR, 13CNMR techniques. The method was carried out on a Purosphere STAR RP-8e column at temperature 20°C using a phosphate buffer at pH 4.0 and solvent mixture consists of acetonitrile, wat...
Cyanobacteria or blue green algae have an extraordinary potential of producing secondary metabolites which can be an ultimate source of newer drugs for future. The purified strain Anabaena showed best photoautotrophic growth at 28oC with specific growth and generation time were 0.098 and 10.0 hr respectively. The better biomass production and antibacterial activity on 30th days of culture. 16 cyan...
In the present study, a new series of 2, 4, 5- trisubstituted imidazoles derivatives were synthesized taking different aldehydes as substitutions. The preliminary characterization of synthesized compounds identified by physical constants determination and TLC. The chemical structures were confirmed by means of IR, 1H-NMR and Mass spectral data. The synthesized compounds were screened for their ant...
The present study was carried out to investigate the diuretic activity of the ethanolic extract of Teucrium polium L. Capitatum (Lamiaceae)in normal albino rats. The diuretic activity of extract was evaluated by determining the urine volume and electrolyte concentration in albino rats (n=4). Furosemide (20 mg/kg) was used as the reference diuretic drug while normal saline (0.9%) was used as contro...
APPLICATION AND COST-EFFECTIVENESS OF LAMP (LOOP-MEDIATED ISOTHERMAL AMPLIFICATION) TECHNOLOGY FOR AUTHENTICATION OF MEDICINAL PLANTS PODOPHYLLUM HEXANDRUM ROYLE
We have developed a novel LAMP-based molecular marker for easy and fast identification of Podophyllum hexandrum Royle (Indian May apple). It is an important medicinal plant valued all over the world. It have both anti-cancer (pro-oxidant ability) and radioprotective (antioxidant ability) effects respectively. The LAMP-based molecular was constructed based on genomic DNA of P. hexandrum that amplif...
Carbonic anhydrases (CAs, EC 188.8.131.52), are a superfamily of metalloenzymes in higher vertebrates, including humans. Sixteen distinct isoenzymes of CA are known to exist in mammals and most of these isoenzymes have been extensively investigated in terms of their biochemical properties, tissue distribution, and genetic control. There are cytosolic isozymes (CA I, CA II, CA III, CA VII and CA XIII), ...
A STUDY ON ATTITUDE AND SATISFACTION OF PATIENTS TOWARDS UNANI AND AYURVEDIC HEALTH CARE SERVICE WITHIN MEDICAL PLURALISM IN THE CONTEXT OF BANGLADESH
Unani and Ayurvedic heath care system is considerable areas of medical treatment in Bangladesh where patient can avail it from different Govt. or private hospital. This cross-sectional study was undertaken to find out the satisfaction of patients attending in this health care system from January to April 2014. A total of 240 respondents were interviewed with an interviewer administered semi-struct...
PHARMACOGNOSTICAL INVESTIGATION AND EVALUATION OF FICUS CARICA FRUIT EXTRACT FOR ADAPTOGENIC ACTIVITY
Ficus carica is the common fig fruit belonging to the family Moraceae, The Pharmacognostical studies of the half ripened fruits were carried out using the various micro-chemical tests. The dried fruits were subjected to extraction using 90 % ethanol and this extract was further evaluated for the adaptogenic activity. Swim Endurance test in mice and Cold Stress model in rats was used to screen the ...