Anti-diabetic activity of hydro-alcoholic extract of Chrysophyllum cainito frutis (CCE) was investigated against experimentally induced diabetics in rats using alloxan and streptozotocin (STZ). Acute toxicity study was performed and hydro-alcoholic extract of CCE was found to be safe at a dose of 2000 mg/kg bodyweight. Two doses 200 mg/kg and 400 mg/kg b.w p.o. of the CCE were subjected for the ev...
ANTI OBESITY ACTIVITY AND BENEFICIAL EFFECTS OF METHANOLIC EXTRACT OF DESMOSTACHYA BIPINNATA IN HFD AND PROGESTERONE INDUCED OBESITY IN RATS AND MICE
Obesity is very serious and concerned problem these days. From the first human civilization, research is going to find the drugs to treat obesity and its complications. Despite availability of many drugs in market to treat obesity, no single drug is ideal for treating all sorts of problems caused by obesity. So the research is going on finding perfect drug. Prior going to evaluating drugs on hum...
HISTAMINE SUBTYPE 3 RECEPTOR ANTAGONISTS: CURRENT STATUS WITH FUTURE PROSPECTS IN DRUG DISCOVERY AND DRUG DEVELOPMENT
The histamine H3 receptor is an G protein-coupled receptor that regulates neurotransmission in the central nervous system and plays a major role in cognitive and homeostatic functions. The third histamine receptor was discovered in 1983 by a traditional pharmacological approach, consisting of assessing the inhibitory effect of histamine on its own release from depolarized rat...
Cancer is an uncontrollable incurable disease with abnormal growth and proliferation of cells. Thyroid cancer is caused due to the thyroid hormone effects on growth, development and homeostasis in mammals. Thyroid cancer is the most common endocrine malignancy. Thyroid hormone is encoded by two types of thyroid receptors that are TRα and TRβ. TRα is functionally divided in two types TRα1 and T...
RELEASE OF CEFUROXIME AXETIL FROM MATRIX TABLETS – EFFECT OF DIFFERENT HIGH VISCOSITY HYDROXYPROPYL METHYLCELLULOSE POLYMERS ON IN VITRO EXTENDED RELEASE
Extended release hydrophilic matrix tablet formulations of cefuroxime axetil were developed and evaluated to observe the effect of different high viscosity hydroxypropyl methylcellulose (Methocel® K100M, K100M CR and K100LV CR) polymers on in vitro drug release. Fifteen different formulations (F1-F15) were prepared by direct compression. The results of the physical parameters and assay were found...
ESTIMATION OF QUERCETIN BY HIGH PERFORMANCE CHROMATOGRAPHY AND ANTIFUNGAL ACTIVITY OF MOSS PHILONOTIS REVOLUTA
Bryophytes- the small, slow growing group of plants is stockroom of naturally occurring materials. They contain a high number of biologically active compounds, however their use as a natural fungicides is negligible. In the recent years bryophytes has emerged as a potential biopharming tool for production of complex biopharmaceutiticals. In order to evaluate potential use of bryophytes as an antif...
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR TENOFOVIR SOLID LIPID NANOPARTICLES
Tenofovirdisoproxilfumarate (TDF) is an essential component of highly active antiretroviral therapy (HAART) for HIV infection used in the treatment of human immunodeficiency virus (HIV) Type-1 patients. A stability-indicating HPLC method for the determination of TDF in solid-lipid nanoparticles was developed and validated. Chromatographic analysis was performed in a Agilent 1260 Infinity series, e...
DETECTION AND ISOLATION OF RESTRICTION ENDONUCLEASE LIKE TOPOISOMERASE FROM THERMOPHILIC BACILLUS SUBTILUS STRAIN RC1
Aims: Detection and isolation of restriction endonucleases like topoisomerase Thermophilic Bacillus subtilus strain RC1. Methods and results: Topoisomerase like enzyme activity is detected from thermophilc Bacilus sp. The isolated enzyme is partially characterized. The molecular weight of the enzyme is ~ 33 KDa and the optimum temperature for the activity is 37 0C. The crude and gel purified e...
WHEN HEALTH POLICIES AND PROFESSIONALS’ NEEDS COLLIDE: A QUESTIONNAIRE-BASED STUDY ON PHARMACY TECHNICIANS IN EGYPT
Introduction: Expanding technicians’ role allows pharmacists to focus on patient care. In Egypt, the health authorities refuse to admit technicians’ role. In the draft amendments to the law, the “technician” was removed from the pharmacy workforce. Despite the high pharmacist density; technicians manage shifts alone. Technicians’ role is unclear and they have no educational programs resu...
Adhatoda vasica Nees. has been used in India for more than 2000 years. The drug contains leaf, stem, flower, fruit and seeds. The fruit which holds the most potentialof the herb is a small capsule with four seeds. No reports are available for the pharmacognostical study of the seed, hence the present study was undertaken to investigate the macroscopic, microscopic, powder microscopic, physicochemi...