Mucoadhesive microcapsules of sodium valproate, an anticonvulsant used in the treatment of epilepsy and in migraine, have been prepared from sodium alginate, hydroxypropylmethyl cellulose-K4M, carbopol 934P & sodium CMC using 10% w/v calcium chloride solution by ionic gelation method. Drug: polymer ratios were 1:1 in all the formulations and polymer mixtures employed were 4:1, 5:1, 6:1, 7:1 ...
Solid dispersion is one of these methods, which was most widely and successfully applied to improve the solubility, dissolution rates and consequently the bioavailability of poorly soluble drugs. The solid dispersions based on the concept that the drug is dispersed in an inert water-soluble carrier at solid state. Several water soluble carriers such as methyl cellulose, urea, lactose, citric...
Eclipta prostrata Linn. (Asteraceae) popularly known as "Bhringaraj" is a very useful medicinal plant in India. The aim of the present study is to evaluate the anti-inflammatory activity of ethanolic extract of leaves of Eclipta prostrata. The anti-inflammatory effects were investigated by employing acute inflammatory model; Carrageenan induced paw edema and Sub-acute inflammatory model; formalin ...
HYPOLIPEDEMIC EFFECT OF CYNODON DACTYLON ON HISTOPATHOLOGICAL STUDY AND DNA FRAGMENTATION ANALYSIS IN EXPERIMENTALLY INDUCED HYPERCHOLESTEREMIC RATS
Hypercholesteremia is one of the risk factors for coronary artery disease. The present study highlights the efficacy of Ayurvedic herbal formulation Cynodon dactylon (Bermuda grass) on histopathological study and DNA fragmentation analysis in experimentally induced hypercholesteremic rats. Four groups of rats were employed namely control, hypercholesterolemia rats (4% Cholesterol＋1% cholic acid)...
CELLULOSE AS SOLE SUBSTRATE FOR BIO ETHANOL PRODUCTION: DEVELOPMENT OF STRUCTURAL MOLECULAR MODEL OF ENDOGLUCANASE III FROM TRICHODERMA REESEI USING BIOINFORMATIC TOOLS
One of our greatest challenges in improving nation’s economy is to reduce the dependence on imported petroleum products. To accomplish this, we need a variety of alternative fuels, which includes ethanol produced from cellulosic materials. Cellulose is a rich natural biopolymer on earth and most dominating agricultural waste. Apart from the fossil fuels, bioethanol is used as chief renewable ene...
We identified genes in Fouquieria splendens ssp. breviflora (Fouquieriaceae) that were expressed due to water deficits. RNA was extracted from dehydrated stem samples that were collected directly from Camargo, Querétaro following hydration for two weeks. The plants were grown in two states, drought and hydrated. We then performed subtractive hybridization. The obtained sequences were inserted int...
The aim of the present work is to increase the gastric residence time of Lamivudine by preparing it into gastro retentive floating tablets whereby making it available at its site of absorption and to achieve an extended action for a time period of 24hrs and to reduce the dosing frequency to once a day, using release retardant polymers METHOCEL, POLYOX and CARBOPOL. The compatibility of the drug wi...
In diabetes, infertility is a common complication in diabetic men and experimental animals. The aim of this study was to investigate the protective effect of methanolic leaf extract of Clerodendrum infortunatum (MECI) on programmed cell death in the testicular damage resulting from streptozotocin (STZ) induced diabetes in rats. Diabetes was induced by a single intraperitoneal injection of STZ (50 ...
EFFECT OF STANDARDIZED EURYCOMA LONGIFOLIA EXTRACT ON ROSIGLITAZONE METABOLISM IN THE OLD NORMAL MALE RAT HEPATOCYTES: A MECHANISM STUDY
Eurycoma longifolia has been widely used by society as an aphrodisiac especially in Indonesia, Vietnam and Malaysia. However, only few studies have been published related to the herb-drug interaction. Previous study showed that the standardized extract of E. longifolia affected phase I rosiglitazone metabolism especially in the old male rat hepatocytes for both diabetic and normal rats. The presen...
Probiotics are defined as “Live microorganisms” which when administered in sufficient amounts confer a health benefit to the host. They are consumed as microbial food supplements.The mechanism of action of probiotics is associated with their ability to enhance immune response, compete with pathogenic microbes for adhesion sites, to antagonize these pathogens and production of antimicrobial sub...