CHEMICAL COMPOSITION OF ESSENTIAL OILS AND ANTIOXIDANT ACTIVITIES OF EXTRACTS OF TWO ENDEMIC PLANTS FROM ALGERIA
Essential oils extracted from two Algerian endemic plants Lavandula antineae and Thymus algeriensis were analyzed by the GC, the results showed the presence of a large amount of oxygenated sesquiterpenes in both species. Total phenolics and flavonoids content were determined according to the Folin-Ciocalteu method and the aluminum trichloride method, the antioxidant activities of two types of extr...
The purpose of this work is to evaluate the possibility of enzyme therapy through microencapsulation of serratiopeptidase (SP) in biodegradable nanoparticles of chitosan (CS). This drug has short biological half-life and thus frequent administration makes it a suitable candidate for controlled release. In this study, serratiopeptidase loaded chitosan nanoparticles were prepared by ionotropic gelat...
The aim of this study was to develop oil in water nanoemulsion of nimodipine intended for oral use. Nimodipine is a calcium channel blocker that has poor oral bioavailability (3-30%) due to its low solubility and first- pass metabolism. So, nanoemulsion of nimodipine increase its solubility and enhance its oral bioavailability. Pseudo -ternary phase diagrams were made by using aqueous titration me...
COMPARATIVE SYNTHESIS AND PHYSICOCHEMICAL CHARACTERIZATION OF SUBSTITUTED 2-METHYLQUINOLIN- 4(1H)-ONE BY VARIOUS CONVENTIONAL AND MICROWAVE METHODS
In the present work various conventional methods and microwave method for synthesis of substituted quinolone reported. Substituted anilines were taken as a starting material and reacted with ethyl acetoacetate in presence of catalytic amount of acid and cyclized by various cyclisation agents that give the title compounds which differ in its color intensity, reaction time as well in %yield. Based o...
COMPARATIVE EFFECT OF DIFFERENT HIGH FUNCTIONALITY EXCIPIENTS ON VARIOUS CHARACTERISTICS OF VARDENAFIL HCL TABLETS (BCS II DRUG)
Direct Compression is becoming a preferred manufacturing process in order to speed up the manufacturing and reduce costs. Although a major requirement for direct compression process is selection of excipients with the optimum physical characteristics that increase final flowability and compressibility of the ready for compression (RFC) tableting blend. By using combinations of excipients and novel...
ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF LEAF EXTRACTS OF THE INDIAN TRADITIONAL MEDICINAL PLANT WRIGHTIA ARBOREA
Introduction: Wrightia arborea (Apocynaceae) has been used in traditional medicine to treat ailments such as menstrual and renal complaints, snake-bites, tooth-ache and diarrhea. Objective: This study aimed to evaluate the phytochemical constituents, antioxidant, antimicrobial and antiproliferative activities of W. arborea leaf extracts. Materials and Methods: Total phenolic and flavonoid contents...
IMPROVING SOLUBILITY OF CURCUMIN IN AQUEOUS SYSTEM BY THE SELF-ASSEMBLY OF HYPERBRANCHED POLY(AMIDE-ESTER) AND CURCUMIN
In order to improve the water-solubility of curcumin, the complex between curcumin and hyperbranched poly(amide-ester) was formed by dispering the solid curcumin in hyperbranched poly(amide-ester) aqueous solution. The interaction process was characterized by UV-vis absorption spectroscopy, Fluorescence quenching method, Fourier transformation-infrared spectroscopy, thermogravimetric analysis. Flu...
COMPARISON OF POST PRANDIAL LIPID PROFILE AT AN INTERVAL OF 2 HOURS AND 4 HOURS IN PATIENTS OF CORONARY HEART DISEASE
Coronary heart disease (CHD) is widely prevalent both in the developed and developing countries and continues to be a leading cause of mortality despite recent advances in diagnostic facilities and treatment modalities. Recently it has been proposed that postprandial lipoprotein may be a better indicators of deranged lipoproteins metabolism and hence of atherosclerosis and CHD. The levels of non-f...
EFFECT OF COMBINATION THERAPY USING COW (BOS INDICUS) URINE DISTILLATE AND SOME INDIAN MEDICINAL PLANTS AGAINST SELECTIVE PATHOGENIC GRAM-NEGATIVE BACTERIA
Inconsequential use of broad-spectrum antibiotics results in the evolution of multiple drug resistant pathogenic gram-negative bacterial strains which is a global health threat and is responsible for high morbidity and mortality rates. This necessitated the search for new effective and safe treatment strategies. One such successful treatment strategy is combination therapy which comprises cow urin...
Liposomes have been established as a promising novel drug delivery vehicle in several different basic sciences. Liposomes are microscopic spheres with an aqueous core surrounded by one or more outer shells consisting of lipids arranged in a bilayer configuration. Liposomes are acceptable superior carriers having ability to encapsulate hydrophilic and lipophilic drugs and protect them from degradat...