Prostaglandin endoperoxide synthases, usually known as cyclooxygenases (cyclooxygenase-1 and cyclooxygenase-2), catalyze a key step in the formation of biologically effective prostaglandins. In recent times, a cyclooxygenase-1 variant protein, called cyclooxygenase-3 used to be found and characterized. COX-3 is studied recent along with significant margin for the formation of anti-inflammatory, an...
Cyclocondensation of α-bromo ketones with thiourea afforded 4-substituted 1, 3-thiazole-2-amines. These compounds on further treatment with α-bromo ketones afforded 3, 6-disubstituted imidazo[2, 1-b][1, 3]thiazole (1a-1j). All the synthesized compounds were confirmed for their structure by FTIR, 1H NMR and GSMS spectra and tested in vitro for their anti-microbial activity by cup plate method aga...
MICROWAVE ASSISTED SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NEWLY SYNTHESIZED 1, 3, 4-THIADIAZOLE DERIVATIVE OF GUAR GUM
A new derivative of Guar gum, incorporated with 1, 3, 4-thiadiazole nucleus was synthesized by using a new green and efficient synthetic approach. Guar gum is a biodegradable polymer having numerous applications in various industries. Thiadiazole compounds are well known in the therapeutic world due to their pharmacological importance. The newly synthesized derivative was characterized by IR, H1 N...
THE EFFECT OF INTAKE DUCK EGG YOLK ON BODY WEIGHT, LIPIDS PROFILE AND ATHEROSCLEROSIS DISEASES IN MALE WISTAR RATS
Duck egg yolks contained fat and higher cholesterol than chicken eggs. A high-fat diet has caused obesity to impact for the development of diseases such as type II diabetes, stroke, atherosclerosis, hypertension, cardiovascular disease and certain forms of cancer. The purpose of using laboratory animals determined the effects of duck egg yolk to body weight, lipids profile, and atherosclerosis dis...
A NOVEL RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF DICYCLOMINE AND ETHYL MORPHINE IN BULK AND PHARMACEUTICAL FORMULATION
The present study was designed to develop and validate a simple, sensitive, precise and accurate RP-HPLC method for simultaneous estimation of dicyclomine and ethylmorphine in bulk and tablet dosage form. The chromatographic separation was achieved on Discovery C18 column (250 × 4.6 mm, 5 µm) as stationary phase with a mobile phase of water (pH 5.4 adjusted with orthophosphoric acid): acetonitri...
ENHANCED MECHANISM OF METAL NANOPARTICLES USING SYZYGIUM CUMINI AS A POTENTIAL SYNTHESIZER AND ITS INHIBITORY EFFECT
In recent years metallic nanoparticles, represent one of the most comprehensively studied materials because of their application in biology The synthesis of silver nanoparticles using biological entities has received immense attention in the area of research. Medicinal plants have attracted interest over antibiotics due to a rapid increase in the rate of infections, development of antibiotic resis...
ANTIOBESITY, ANTIHYPERLIPIDEMIC AND ANTIDIABETIC AGENTS OF PROTO-CATECHUIC ACID IN HIGH FATTY DIET ALONG WITH ALLOXAN INDUCED DIABETES
Aim: The present investigation was carried out by evaluating the effect of protocatechuic acid (PCA) on a high-fat diet (HFD) along with a low dose of alloxan-induced hyperglycemia in male Wistar rats. Methods: In the present study, administration of high fatty diet (HFD) for 45 days along with low dose of alloxan (80 mg/kg) in rats on 30 days produced significant high fatty diet in the, body we...
PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF ETHANOLIC EXTRACT OF THE ARTOCARPUS HIRSUTUS LAM. LEAVES
Artocarpus hirsutus Lam. is a common plant with a variety of folk medicinal value. The present study was conducted to evaluate the phytochemical and pharmacological properties of the ethanolic extract of Artocarpus hirsutus. The screening for various phytochemicals was conducted by using various standard procedures. Acute toxicity of the extract was determined by using OECD guidelines 423. The ant...
IMPACT OF PROBIOTICS LACTOBACILLUS RHAMNOSUS AND LACTOBACILLUS CASEI ON LIPOGLYCEMIC AND ANTIOXIDATIVE STATUS OF DIABETIC RATS
Probiotics are live microorganisms, which when administered in adequate amounts confer a health benefit. There are very limited studies on antidiabetic effect of lactic acid bacteria despite their potentiality in reducing the risk of diabetes onset. The present study explored the effect of administering live culture of L. rhamnosus [MTCC No 8712] and L. casei [MTCC No 1408] in STZ induced diab...
Picrorhiza kurroa Royle ex Benth, belongs to the family Scrophulariaceae has gained immense medicinal value in Ayurvedic as well as in modern medicines including antioxidant, anti-inflammatory, anti-pyretic, immunomodulatory, anticancer, hepato-protective, etc. The present study aimed to ascertain analgesic and antipyretic activities of rhizome extracts of Picrorhiza kurrooa in Wister rats. Methan...