Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
VALIDATED STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF CAPECITABINE
A new stability-indicating high-performance liquid chromatographic method of analysis of capecitabine in pharmaceutical dosage form was developed and validated. The solvent system consisted of methanol: water (60:40% v/v). The retention time of capecitabine was 7.927 min at a flow rate of 1 ml/min on C-18 (Quails BDS, 250 × 4.6 mm, 5µ). Capecitabine was detected at 240 nm. The linear regression ...
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1607
EFFECTS OF AQUEOUS FRUIT EXTRACT OF HARITAKI (TERMINALIA CHEBULA) ON REGULATION OF HYPOTHYROIDISM
The thyroid, an important part of the human endocrine system, is involved in the regulation of oxygen use, basal metabolic rate, cellular metabolism, and growth. As it acts as a regulator for the body, abnormalities of the thyroid should be reckoned with, and measures to prevent such occurrences should be followed. Hypothyroidism can be described as the inability of the thyroid gland to produce su...
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1919
STABILITY INDICATING UPLC METHOD FOR SIMULTANEOUS ESTIMATION OF DAUNORUBICIN AND CYTARABINE
The main objective of the study was to develop an RP-UPLC method for the simultaneous determination and validation of the Daunorubicin and Cytarabine in the pharmaceutical dosage form. The technique was developed by using the Mobile phase containing Buffer 0.01N KH2PO4: Acetonitrile used in the ratio 50:50 v/v and X-Bridge C18 (2.1 × 100 mm, 1.6 µm) as a stationary phase at a flow rate of 0.3 ml...
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1403
A COMPARATIVE EVALUATION OF PERMEATION ENHANCERS FOR ROPINIROLE HYDROCHLORIDE A BCS CLASS III DRUG TO BE FORMULATED AS TRANSDERMAL DRUG DELIVERY SYSTEM
Ropinirole hydrochloride, a non-ergoline dopamine agonist, administered orally for the treatment of Parkinson's disease and restless leg syndrome and belonged to BCS class III drug having high solubility and low permeability. The objective of the present research study was to enhance the permeability of ropinirole hydrochloride by selecting a suitable permeation enhancing agent from different clas...
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GC-MS ANALYSIS AND ANTI-INFLAMMATORY ACTIVITY OF MUREX TRIBULUS
The aim of this study was to screen the presence of bioactive compounds through GC-MS analysis and carry out the ant-inflammatory test of the methanolic tissue extract of Murex tribulus, a spiny predatory gastropod that is widespread from the Central Indian Ocean to Western Pacific Ocean. The GC-MS analysis of the methanolic flesh extract revealed the presence of four bioactive compounds, 1, 2 dim...
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SUSTAINED RELEASE OPHTHALMIC IN-SITU GELS OF DORZOLAMIDE HCl FOR GLAUCOMA-AN APPROACH TO FORMULATION AND IN-VITRO EVALUATION
The objective of the present investigation was to formulate the thermosensitive ophthalmic in-situ gels of Dorzolamide HCl for the treatment of glaucoma. Dorzolamide HCl is presently available as conventional eye drops, which has demerits like pre-corneal elimination, lachrymal drainage and no sustained effect leading to poor bioavailability and hence there was a need to develop a better, stable a...
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1247
GREEN SYNTHESIS OF SILVER NANOPARTICLES FROM MUNTINGIA CALABURA FRUIT EXTRACT AND ITS BIOLOGICAL ACTIVITY
Synthesis of silver nanoparticles using fruit extract has been gaining considerable attention as an eco-friendly approach in green chemistry. The present work reports the synthesis of Muntingia calabura silver nanoparticles (McAgNPs) by the addition of an appropriate amount of Muntingia calabura fruit extract to the aqueous AgNO3 solution under constant stirring at room temperature for 24 h. The a...
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1253
BIOTHERAPEUTICS AS DRUGS, ITS DELIVERY ROUTES AND IMPORTANCE OF NOVEL CARRIERS IN BIOTHERAPEUTICS
Biopharmaceuticals or biologics are the therapeutic agents which are biomolecules (DNA, Protein, Peptide, RNA, antibodies) in nature. These are high molecular weight (300-1000000Da) molecules, which deify Lipinski rules. At present, a large portion of the market share is occupied by protein biotherapeutics. However, peptide-based therapeutics is replacing protein biotherapeutics, as the former has...
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ANTIBACTERIAL ACTIVITY AND DNA BINDING PROPERTIES OF BIVALENT METAL COMPLEXES WITH CUMINALDEHYDE BENZOYLHYDRAZONE (CABH)
Cobalt(II), nickel(II), copper(II) and zinc(II) complexes having the general formula ML2 (where, L= cuminaldehyde benzoyl-hydrazone, CABH) have been synthesized and characterized based on mass spectra, molar conductivity, FT-IR and UV-Vis spectral data. The complexes are found to be non-electrolytes. FT-IR data suggest that the CABH acts as a uni-negative bidentate ligand. The copper complex is in...
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QUANTITATIVE DETERMINATION OF LACOSAMIDE IN HUMAN PLASMA USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY AND ITS APPLICATION TO PHARMACOKINETIC STUDY
A simple, reliable, and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of lacosamide, an antiepileptic drug, in human plasma. The lacosamide and internal standard (IS) have been extracted by a simple liquid-liquid extraction method and separated on C18 (50 × 4.6 mm, 5μm) column with the mobile phase of 5mM ammoniu...
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