The objective of the study is to design gastro retentive drug delivery systems for Amoxycillin trihydrate. It was prepared with the objective to obtain site-specific drug delivery for the stomach and to extend its duration of action. The sustained release of amoxicillin is desired because of its short biological half-life. The preparation was carried out by using guar gum as a carrier in the form ...
EVALUATION OF LEVOFLOXACIN VS. NORFLOXACIN; EFFECT ON BLOOD GLUCOSE PROFILE IN ALLOXAN INDUCED DIABETIC ALBINO RATS- A COMPARATIVE STUDY
Flouroquinolones (FQ) used commonly for treatment of community and hospital-acquired infections, has been prefixed with multiple adverse effects. Amongst them the glycemic variability has been attention seeking. Drug induced dysglycemia can be acute or persistent and severe too. The present study is designed to evaluate and compare the actions of Levofloxacin vs. Norfloxacin in altering blood gluc...
In the present study,FDDS of Famotidine, a copmpetative inhibitor of histamine H2 receptors were prepared by using natural gums viz. xanthan gum and guar gum at different drug to gum ratio using sodium bicarbonate and citric acid as gas generating agents and lactose as diluent.FDDS tablets were prepared by wet granulation technique using PVP K30 as granulating agent. The prepared FDDS tablets were...
Ischemic heart disease (IHD) is the major cause of morbid-mortality in most countries. The involvement of oxidative stress (OS) in the development of atherosclerosis, ischemic cardiopathy triggering phenomen, has been investigated. Serum total homocysteine (Hcy) concentration was measured by fluorescence polarization immunoessay. Plasma levels of substances reacting with thiobarbituric acid (TBARS...
COMPARATIVE STUDY OF OVERLAPPING GENES IN THE GENOMES OF MYCOPLASMA HOMINIS AND MYCOPLASMA PENETRANS
Overlapping genes are pairs of adjacent genes whose coding regions are partially or entirely overlapping. Overlapping genes in prokaryotes are a means to minimize genome size and increase the density of genetic information. Overlapping genes play an important role in genome reduction of Mycoplasmas during the course of their degenerative evolution. In this study overlapping genes in the genomes of...
Proniosomes based drug delivery systems have potential as a significant drug carrier in a variety of therapeutic applications. The objective of the present study was to investigate in vitro sonophoretic transdermal delivery of Losartan Potassium (LP) across albino rat skin using proniosomal gel and its comparison with aquasonic gel. Proniosomes of LP were fabricated with L-a-lecithin (egg yolk), c...
The management of eye disorders by chemical drugs without any side effects is still a challenge to the medical system. But the herbal medicines have potential to overcome the limitations associated with conventional drugs. Therefore; many efforts have been made to identify new medicinal plants from different sources because of their effectiveness, fewer side effects and relatively low cost. Approx...
ANTIBACTERIAL ACTIVITIES OF THE METHANOL EXTRACT AND FRACTIONS OF THE LEAF OF ERIOSEMA PSORALEOIDES (LAM.) G. DON (LEGUMINOSAE)
Eriosema psoraleoides leaves have been reported to be used in traditional African medicine to treat cuts and wounds, hence the present investigation of its antibacterial activity using the agar pour plate method. The leaves contain tannins and flavonoids. A methanol extract was obtained from the leaves by maceration, and then the n-hexane and ethyl acetate fractions were obtained from this. Stat...
Moxifloxacin (MOX) is a fourth-generation synthetic fluoroquinolone antibacterial agent with many important therapeutic properties. Fluorescence measurement was used to study the interaction of MOX with herring sperm DNA (Hs-DNA) in Tris-HCl, buffer of pH 7.4. The intercalative binding mode and a static quenching mechanism were confirmed by the Stern-Volmer quenching rate constant (Kq) of 5.61...
The aim of this study was to prepare buffered tablets of acid labile drug, Pantoprazole sodium for oral administration using buffering agents to protect a drug from gastric fluid. Its mechanism of action was inhibition of H+/K+-adenosine triphosphate, an enzyme present in the gastric parietal cells. The tablets were prepared by wet granulation method. The formulations contain sodium carbonate, sod...