EVALUATION OF TOTAL PHENOLICS, FLAVONOID CONTENTS AND IN-VITRO ANTIOXIDANT PROPERTIES OF CATHARANTHUS PUSILLUS (APOCYNACEAE)
Objective: Present study was aimed to evaluate the total phenolic, flavonoid content and in vitro antioxidant activity of petroleum ether, benzene, ethyl acetate, methanol and ethanol extracts of whole plant of Catharanthus pusillus. Methods: Antioxidant activity have been tested using various antioxidant model systems viz., DPPH, hydroxyl, superoxide, ABTS and reducing power. Results: Methanol ex...
Numerous carbazole derivatives were designed by the Chemsketch software followed by 3D optimization. Docking studies were performed using AUTODOCK 4.2.6 software to check their binding interactions with eukaryotic topoisomerase-I, based on the crystal structure of Human Topoisomerse-I-DNA complex (PDB ID: 1A35). Results of docking studies of designed carbazole derivatives were compared on the ba...
The ethanol extract of Solanum surratense(EESS)(Family: Solanaceae) root was investigated for its anti-diabetic effect in Wistar Albino rats. Diabetes was induced in Albino rats by administration of single dose of Alloxan monohydrate (150mg/kg). The ethanol extract of Solanum surratense at the dose of 200mg/kg and 400mg/kg, p.o. was administered as single dose per day to diabetes induced rats for ...
This project involves in the development of sustained release matrix tablets of Gemigliptin. Which is an oral anti-hyperglycemic agent designed for the management of non insulin dependent diabetes mellitus (NIDDM). The basic goal of therapy is to achieve a steady sate blood level that is therapeutically effective and non toxic for an extended period of time. The objective in dosage form design is ...
ASSESSMENT OF ANTIHYPERTENSIVE DRUGS UTILIZATION PATTERN IN BUTAJIRA ZONAL HOSPITAL, BUTAJIRA TOWN, SOUTH ETHIOPIA
Background: Many factors contribute for prevalence of high blood pressure including poor treatment compliance, lack of access to health care and lack of physician adherence to therapeutics. In Ethiopia, routine health care report is incomplete and erratic and 90% individuals diagnosed with hypertension do not properly adhere to treatment. The present study was carried out to assess the antihyperte...
THE IMPORTANCE OF DOMINANT HAND AT PLACEBO EFFECT OF INERT SPRAY TO MUSCULAR FATIGUE INDUCED EXPERIMENTALLY
Purpose: Placebo effect is a phenomenon where the patient's symptoms can be relieved by a false treatment in pharmacological aspects, most likely because of the patient expectations or believes that the treatment will have success. So, it is a psychological response to the treatment, without being accompanied by the improvement of physical condition. Placebo is often defined as: “Substance or pr...
COMPARATIVE ANALYSIS OF HPTLC, SECONDARY METABOLITES AND ANTIOXIDANT ACTIVITIES OF TINOSPORA CORDIFOLIA STEM POWDERS
Aim of this study was to develop a HPTLC fingerprint profiles of Tinospora cordifolia stems powdered by different procedures viz; Sample 1 (fresh aqueous powder), 2 (freeze drying powder), 3 (aqueous freeze drying powder) and Sample 4 (dry powder). The study also includes qualitative, quantitative secondary metabolites and the antioxidant potential of all the samples. Result of various physiochemi...
The nutritional supplements are the natural food supplements, and other related products used to boost the nutritional content of the diet. These nutritional supplements have been of interest to research because of their antioxidant property by consumption of food and drinks. The present study deals with a comparative evaluation of antioxidant and anti-inflammatory effects of marketed nutritional ...
The core moiety of ritonavir (2S, 3S, 5S)-5-(tert-butyloxycarbonyl)amino-2-amino-3-hydroxy-1,6-diphenylhexane (7) on condensation with oxirane of carbazole (8) in isopropyl alcohol at reflux and deprotected with mineral acid gave compound 10. Coupling of compound 10 with carbamate amino acid (11a-15c) in the presence of EDAC.HCl and HOBt at room temperaturegave ritonavir analogues containing carba...
EFFICACY OF SECURIDACA LONGEPEDUNCULATA ON THE PARAMETERS OF BLOOD GLUCOSE LEVEL AND PULSE RATE OF ENVENOMED ALBINO RATS
The study was undertaken to investigate the in vivo activity of aqueous and ethanol extracts of Violet plant, Securideca longepedunculata leaves and root bark against snake venom of Naja nigricollis and blood glucose level along with pulse rate in experimental albino rats. Healthy adult albino rats weighing 250-300g were used and randomly divided into five groups for in vivo anti-snake venom activ...