SCIENTIFIC EVALUATION OF VALLI PANCHMOOLA – DIFFERENT COMPOSITIONS THROUGH PHARMACOGNOSTICAL AND PHYTOCHEMICAL METHODOLOGY
Objective: This study aimed at ensuring the different compositions of Valli panchmoola using authentic herbs and establishing pharmacognostical, physicochemical, and phytochemical standards for the compositions. Methods: Compositions of Vallli panchmoola were prepared as per the formula and procedure mentioned in traditional texts and Ayurvedic Formulary of India. The prepared compositions were ev...
About 5-10% of individuals with the condition of prediabetes or intermediate hyperglycemia develop diabetes annually. Prediabetes can revert to normal glycaemic state as well. Reversion to normal glucose, even when transient, is associated with a significant 56% reduced risk of future diabetes independent of previous treatment. Prediabetes is associated with many microvascular as well as macro-vas...
Polycarpaea corymbosa has been used traditionally as medicine for the treatment of various ailments. In the present investigation an attempt has been made to quantify phenol, flavonoid and steroid in methanol extract of aerial and root parts of P.corymbosa Lam. by HPTLC method. Different compositions of the mobile phase for HPTLC analysis were tested in order to obtain high resolution and re...
DESIGN AND OPTIMIZATION OF ZIDOVUDINE LOADED URIDDALL MUCILAGE MICROSPHERES, USING BOX BEHNKEN METHOD
Objective: The objective of the current investigation is to study the combined influence of sodium alginate, uriddall mucilage and calcium chloride on drug encapsulation efficiency and particle size of microspheres. Zidovudine-loaded sodium alginate based uriddall mucilage microspheres were prepared by the solvent evaporation method. Further, optimization of the formulation was done using a three-...
Every drug has two facets and the sinister side is becoming more apparent every day, sometimes resulting in product recalls by regulatory agencies due to serious adverse effects. Monitoring of unwanted side effects of allopathic drugs administered alone, and in combination with other drugs or dietary products causing drug-drug and drug-herbal/food interactions were lacking earlier, but information...
IN-VITRO EVALUATION OF EFFECT OF HYDROALCOHOLIC MEDIA ON DRUG RELEASE FROM SUSTAINED RELEASE FORMULATION
In the recent development, worldwide consumption of alcohol has shot up in the past decade as a part of lavish and Gen next lifestyle changes. There have been innumerable instances of people consuming alcoholic beverages and drugs at the same time. Hence in our study, Diclofenac and Metformin were selected as representatives of highly prescribed and overused drugs. Hence, the present study was pla...
A simple, sensitive and specific RP-HPLC method was developed and validated for the determination of Orotic acid in bulk and capsule dosage form. Chromatography was carried out on an Enable C18G (250 × 4.6 mm i.d.,5µ) column using filtered and degassed mixture of acetonitrile and methanol in the ratio of 60:40% v/v as mobile phase at a flow rate of 1 ml/min and effluent was monitored at 280 nm. ...
RESPONSES OR EFFECT OF CEREBRAL MALARIA ON PLATELET COUNT, PLATELET FACTOR – 3 AND PLATELET AGGREGATE AVAILABILITY IN CHILDREN
Background and Objective: Malaria, a formidable global parasitic infection represent a major health problem in tropical countries in terms of geographical spread, high morbidity, severe mortality especially among children. This study investigated platelet function’s role and its strength to make platelet factor 3 (PF-3) available for coagulation in children with cerebral malaria. Subjects and...
DESIGN, SYNTHESIS AND IN-SILICO STUDY OF NOVEL SERIES OF 2-PHENYL- 3-(5-SULFANYL-1,3,4-THIADIAZOL-2-YL)-1,3-THIAZOLIDIN-4-ONE DERIVATIVES WITH POTENTIAL ANTI-TUBERCULAR ACTIVITY
In an attempt to identify potential new agents active against tuberculosis with Shikimate kinase as the target, a novel series of 2-phenyl- 3-(5-sulfanyl-1,3,4-thiadiazol-2-yl)-1,3-thiazolidin-4-one derivatives were synthesized by convenient one-pot three-component reaction of amine, aldehyde and mercaptoacetic acid on montmorillonite KSF clay as a solid acidic catalyst in good yields. The structu...
EVALUATION OF OCULOHYPOTENSIVE EFFECT OF ENALAPRILAT USING INTRAOCULAR PRESSURE (IOP) RECOVERY MODEL IN RABBITS
The present study was designed to evaluate the oculohypotensive effect of enalaprilat in comparison to timolol using an intraocular pressure (IOP) recovery model. The study was carried out in 18 adult albino rabbits of 2.5-3.0 kg which were divided into 3 groups.Group Ireceivednormal saline,group II received enalaprilat (0.1%) and timolol (0.5%) was administered in group III. IOP recovery model wa...