This study aims to evaluate the in-vitro and in-vivo antioxidant activity of different extracts prepared from the aerial parts of Arthrophytum scoparium. Polyphenols flavonoids and tannins contents were determined. The acute toxicity of ASE was carried out based on OECD during two weeks to ascertain the LD50. In sub-acute toxicity, a 100, 200 and 400 mg/kg/day extract was orally administrated for ...
FORMULATION AND CHARACTERIZATION OF DRUG IN ADHESIVE TRANSDERMAL PATCHES OF BUFLOMEDIL HYDROCHLORIDE
The purpose of this research was to develop a drug-in-adhesive type transdermal drug delivery system containing drug, buflomedil hydrochloride, pressure sensitive adhesive (PSA), Duro-Tak 387-2052 by the solvent evaporation technique. Different concentrations of penetration enhancers; oleic acid and isopropyl myristate (IPM) were used to enhance the transdermal permeation of buflomedil hydrochlori...
The core finding of the present preclinical study demonstrated that, administration of increasing doses of Agmatine is remarkably neuroprotective in male wistar rats against 6-Hydroxydopamine induced neurotoxicity. Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease with multiple motor and non-motor features that contribute to the impairment of health-related quality of...
The antioxidant activity of pomegranate fruit was evaluated using in vitro tests. Phenol content was more in G-137, 11.8±0.11 mg/g dry wt followed Arakta variety 10.1±0.05 mg/ g dry wt., respectively flavonol and flavonoid content was high in mrudula 3.5±0.05 mg/g dry wt, 7.0±0.05 mg/g dry wt., and proanthocyanin content was high in Bhagwa variety 19.62±0.05 mg/g dry wt, Anthocyanin conte...
Capsaicin, the pungent ingredient of red pepper, is used topically to treat different types of neuropathic pain, in rat model of vincristine induced neuropathic pain we tried to investigate the effect of capsaicin on sciatic nerve through electrophysiological and histopathological studies. We found that treatment of animals with vincristine results in significant decrease in sciatic nerve conducti...
ANTI-INFLAMMATORY AND ANTIHYPERCHOLESTEROLEMIC ACTIVITY OF ROSA CENTIFOLIA, CORIANDRUM SATIVUM AND CYNODON DACTYLON
Hypercholesterolemia is one of the major conditions that are prevalent in today’s world, the significant causes being unhealthy food habits and lifestyle or abnormal genetic conditions. HMG CoA reductase is an important rate-limiting enzyme in the mevalonate pathway that synthesizes cholesterol. Biosynthesis of cholesterol in the liver can be reduced significantly by inhibiting HMG CoA reductase...
Scope: In recent years, governments and industries worldwide have invested billions of dollars in nanotechnology research and development, and proponents predict that it will offer numerous benefits to society. Objectives: To evaluate the toxicity of Cerium in nanomaterials and in bulk form in rats by repeated daily oral treatment for 28 days by monitoring the effects on animal and also to assess ...
Metformin HCl (MH), is an oral anti-diabetic drug with less bioavailability, and a BCS class III, short plasma half-life as well as narrow absorption window. The objective of this research work is to obtain better delivery of MH to the upper part of GIT by increasing the mean residence time (MRT) in the stomach. For this, Gastroretentive swellable and floating sustained release tablets were prepar...
Nanoparticles have attracted the interest of many research groups and had been utilized in an increasing number of fields during the last decades. Various methods can be used to produce nanoparticles such as ionic gelation, solvent evaporation, microemulsion, emulsion cross linking and precipitation. This review covers the general description, preparation and the detailed description of crucial pa...
STUDIES ON PENETRATION ENHANCERS IN CORPORATED CREAM OF CLOBETASOL-17-PROPIONATE: DEVELOPMENT AND IN VITRO EVALUATION
Topical corticosteroids have long been the chronic stage in the treatment of steroid responsive dermatitis. Creams containing 0.05% w/w Clobetasol-17-propionate (CP) as active ingredient are categorized as super potent class I topical dermatological corticosteroids. For the drug molecule to reach the cutaneous microcirculation, enhance, the systemic circulation, have to transverse both the lipophi...