BACOPAMONNIERA, A NOOTROPIC HERB ALLEVIATES ABNORMAL MOLECULAR AND IMMUNOHISTOCHEMICAL CHANGES EVOKED BY CHRONIC EXPOSURE OF METHYLMERCURY IN RAT CEREBELLUM
Methylmercury (MeHg), a highly toxic environmental pollutant, induces oxidative stress and dysfunction in many cell types. Bacopa monniera is a perennial herb, and is used as a nerve tonic in ayurveda, a traditional medicinal system in India. This study was aimed to evaluate the effect of Bacopa monniera extract (BME) on MeHg-induced toxicity in rat cerebellum. Male Wistar rats were administered w...
ANTIFUNGAL GLYCEROGELATIN: ATTEMPT AT FORMULATION AND EVALUATION OF A POTENTIAL TRANSUNGUAL DRUG DELIVERY SYSTEM
Onychomycosis representing about 30% of mycotic cutaneous infections is the fungal infection that affects the nails. Although not life-threatening, it adversely affects the psychology of the patient whose nails become yellow, discolored, brittle, and unsightly. It may also pose serious problems in immunocompromised individuals. The current market of products for the treatment of onychomycosis incl...
PHYSICOCHEMICAL CHARACTERIZATION, MICROBIOLOGICAL QUALITY CONTROL AND TOXICITY EVALUATION OF THE HIDROETHANOLIC EXTRACT FROM CHENOPODIUM AMBROSIOIDES LINN
Chenopodium ambrosioides Linn, member of the National List of Medicinal Plants of Interest to SUS (RENISUS), is used to treat different diseases and shows good potential to generate products of interest to the Brazilian Unified Health System “Sistema Único de Saúde” (SUS). However, the use of herbal derivatives implies the control of their quality and the evaluation of their toxicity. Pharma...
The study was aimed to investigate the activity of hydroalcoholic extract of Cucumis sativus in gastric ulcerated rats. Anti ulcer activity was evaluated via oral administration of HACS at the dose 250, 500 and 1000mg/kg thrice in a day for 5 days before pyloric ligation ulceration, indomethacin and ethanol induced ulceration. Various parameters such as ulcer index, gastric volume, pH of gastric j...
HIV since its invention has become global burden. In last two decades of the HIV prevalence many anti-retroviral drugs have been developed. Poor countries like India have started central government funded programmes to tackle the menace of the HIV. These programmes have been started because many people cannot afford costly ART drugs. In this review article, we have discussed current ART regimens a...
The use of medicinal plants as raw material in the production of drugs is again gaining popularity. Monechma ciliatum has many traditional uses and applications in African folk’s medicines, e.g. the seed's powder macerated in water and drunk or burnt as an inhalation for treatment cold and allergic conditions. The aim of this study is to formulate a suitable dosage form (tablets) from Monechma c...
The interaction of losartan potassium (LP) with bovine serum albumin (BSA) was studied by fluorescence quenching in combination with UV–Vis spectroscopic method under near physiological conditions. The fluorescence quenching rate constants and binding constants for BSA–LP system were determined at different temperatures. The fluorescence quenching of BSA by LP is due to static quenching and en...
NATURAL OCCURRENCE OF MYCOFLORA AND DETERIORATION OF TOTAL ALKALOIDS AND GLYCOSIDES AMOUNTS IN STEREOSPERMUM CHELONOIDES DC. ROOTS UNDER STORAGE
In the present study, total 15 fungal species isolated from roots of drug Stereospermum chelonoides DC. such as: Fusarium solani, F. lateritum, F. semitectum, F. oxysporum, Aspergillus ochraceus, A. niger, A. terreus, Theilavia terricola, Papulaspora immerse, Scytallidium thermophilum, Didymostilbe sp., Cunningamella elegans, Aphanomyces sp., Sordaria fimicola and Mucor praini. Species of Fu...
Crataeva tapia L. (Family- Capparaceae) is an important medicinal tree, commonly called as ‘Varuna’. The plant has been reported to possess several medicinal properties. Propagation of Crataeva tapia L. is mostly by seeds, but germination percentage is very low mainly due to presence of hard seed coat. Conservation and propagation of species using biotechnological tools like plant tissue cultu...
A series of 2,4-diaminotriazines were synthesized as Mycobacterium tuberculosis(Mtb) dihydrofolatereductase (DHFR) inhibitors. These derivatives were evaluated in whole cells by employing resazurinmicrotitre plate assay (REMA) against MtbH37Rv. Further, these were tested against other gram positive and gram negative bacterial strains to check specificity for Mtb. Cytotoxicity assessment was perfor...