PREPARATION AND PHYSICAL CHARACTERIZATION OF CISPLATIN CHITOSAN NANOPARTICLES BY ZETA NANOSIZER “PRIME STEP FOR FORMULATION AND DEVELOPMENT”
The ultimate aim of this research work is to develop a cisplatin loaded chitosan nanoparticle system (CCNP) to facilitate the release of cisplatin in a more sustained manner to improve therapeutic efficacy via the reduction of its toxicity. As a step-in formulation studies the work has been limited to studying the various physical characters of CCNP using a zeta nanosizer. The chitosan polymer was...
A VALIDATED LC METHOD FOR THE DETERMINATION OF CHIRAL PURITY OF (R)-3-((1-METHYLPYRROLIDIN-2-YL) METHYL)-5-(METHYLSULFONYLMETHYL)-1H-INDOLE: A KEY RAW MATERIAL OF ELITRIPTAN HYDROBROMIDE
A simple and accurate normal phase liquid chromatographic method was developed for the determination of chiral purity of (R)-3-((1-methylpyrrolidin-2-yl) methyl)-5-(methylsulfonylmethyl)-1H-indole, R-isomer used as key starting raw material in the manufacturing of Elitriptan hydrobromide bulk drug. Chromatographic separation between (R)-3-((1-methylpyrrolidin-2-yl) methyl)-5-(methylsulfonylmethyl)...
Middle East Respiratory Syndrome (MERS) is viral respiratory illness that was lately recognized in human. It was first testified in Saudi Arabia in 2012 and has since spread to numerous other countries, as well as the United State. Record people well-known as infected with MERS-CoV developed numerous acute respiratory illnesses, including fever, cough and shortness of breath. Middle East Respirato...
The present work deals with formulation of topical gels containing aqueous extract of P. acerifolium seeds and also evaluation of prepared gels against some Gram-positive and Gram-negative bacteria. The antibacterial activity of various P. acerifolium seed extracts was measured through determining minimum inhibitory concentration (MIC) by cube dilution method and zone of inhibition by disc diffusi...
NLC are innovative vehicles introduced to overcome some limitations of SLN. Particularly, NLC, composed of a solid lipid and a certain content of liquid lipid (oil), show improved drug entrapment efficiency and an increased stability during storage with respect to SLN. Furthermore, NLC, maintaining their solid state, can control the API release from the matrix. To formulate Nanostructure lipid car...
STRUCTURAL DOCKING STUDIES AND BIOLOGICAL EVALUATION OF SOME NEWLY SYNTHESIZED SCHIFF BASE DERIVED QUINAZOLINONE DERIVATIVES
Present studies describe the synthesis of a series of Schiff base derived quinazolinone derivatives (6-14) with the aim to have better anti inflammatory agents. The prepared compounds were characterized using chemical and spectral (IR, NMR and Mass) studies. Pharmacological evaluation of the newly synthesized derivatives indicated that compounds 8, 11 and 14 exhibit significant anti-inflammatory...
There are some herbal contraceptives that have the property to avoid the embryo implantation. Trigonella foenum-graecum Linn. is used in folk medicine as alcoholic and aqueous preparations for prevention of pregnancy. Pregnane- progesterone is one of the important steroid has direct connection with contraceptive activity. Pregnane is a C21 steroid and indirectly, a parent of progesterone. The ...
Polyunsaturated Fatty Acids (PUFA) have been shown to be of major importance in the prevention and treatment of a range of human diseases and disorders. A number of microorganisms have been shown to produce and accumulate PUFA. In the current study we have isolated 86 lipid producing microbes from various sources like a river from northern India, lakes from southern India and marine environments o...
EVALUATION OF THE ANTIDEPRESSANT ACTIVITY OF TRIBULUS TERRISTRIS IN DIABETIC DEPRESSION IN RAT MODEL
Tribulus terristris is a well known medicinal plant as anti-inflammatory, antimicrobial and nephroprotective etc. It is a very good drug for urinogenital problems, hepatic problems, oxidative stress etc. The aim of the study is to compare the depression induced by PCPA and STZ treated diabetic depression in mice and which could be restored by the ethanolic exact of fruits of Tribulus terristris ...
SCOPE AND EVALUATION OF SAPODILLA PECTIN IN PHARMACEUTICAL SOLID AND LIQUID ORALS WITH ESPECIAL REFERENCE TO ITS EFFECT ON VARIOUS PHYSICO-MECHANICAL PROPERTIES UPON BOTH SOLID AND LIQUID DOSAGE FORM
The aim of this study was to understand and study the role and effect of different concentration of sapodilla pectin as a binding agent in tablet formulations and also its on the effect on physical evaluation of suspension. For this purpose two model drugs paracetamol and ibuprofen were selected and granules were made by wet granulation using different concentration of pectin. The tablets were fir...