A series of tetrazol derivatives 1(a-c) and 2(a-c) were synthesized by Mannich base reaction. Synthesized compounds 1(a-c) and 2(a-c) were confirmed by IR, ¹H NMR, ¹³C NMR, mass spectral, and elemental analysis. Synthesized compounds 1(a-c) and 2(a-c) were screened for dental plaque bacteria and cytotoxicity activity. The compound 1b was highly active against Enterococcus feacalis in antibacter...
Esomeprazole is a proton pump inhibitor which reduces gastric acid secretion through inhibition of H+/K+-ATPase in gastric parietal cells. By inhibiting the functioning of this enzyme, the drug prevents formation of gastric acid. Esomeprazole is combined with the antibiotics, clarithromycin and amoxicillin (or metronidazole in penicillin-hypersensitive patients) in the 7-14 day eradication triple ...
Antibiotic resistance continues to pose a significant problem in the management of bacterial infections despite advances in antimicrobial chemotherapy and supportive care. Therefore, it is necessary to search the other alternatives that can be effective in the treatment of these infections. The present work was aimed to evaluate the antibacterial and antibiotic-potentiation activities of lemon aga...
FORMULATION AND DEVELOPMENT OF NOVEL AND STABLE DOSAGE FORMS OF LAMIVUDINE AND TENOFOVIR DISOPROXIL FUMARATE TABLETS BY WET GRANULATION TECHNIQUE
Antiretroviral drugs are medications used for treatment of infection caused by retroviruses, primarily HIV. Different classes of antiretroviral drugs act at different stages of the HIV life cycle. No individual antiretroviral drug has been demonstrated to suppress an HIV infection for prolong treatment. Antiretroviral drugs must be taken in combinations in order to have a lasting effect. Combinati...
EFFECT OF GALANTAMINE WITH NEUROPHARMACOLOGICAL BENEFITS IN WISTAR RATS MODELS OF EPILEPSY AND BEHAVIOUR
Involvements of oxidative damage, deficiency of acetylcholine and cognitive impairment have been reported in the pathophysiology of epilepsy. It has been demonstrated that cholinesterase is degranulated at the site of a lesion it cause brain disorder leading to epilepsy. Cholinesterase inhibitor (Galantamine) inhibits the release of cholinesterase thus it benefits in epilepsy. So the aim of the st...
COMPARATIVE STUDY ON FILTER EFFICIENCY OF DIFFERENT BRANDS OF CIGARETTES BY MICROSCOPIC AND SPECTROSCOPIC TECHNIQUES
Internationally there has been research on large scale for determination of efficiency of cigarette filters but in India it still remains a topic of discussion. Being the second largest consumers of tobacco and tobacco products and one of the largest and fastest growing consumers of cigarettes, such studies need to be undertaken at a greater level to assess the risk and hazards of cigarette smokin...
PHYTOCHEMICAL SCREENING, QUANTITATIVE ANALYSIS OF FLAVONOIDS AND MINERALS IN ETHANOLIC EXTRACT OF CITRUS PARADISI
Like most other plants Citrus paradisi contain various secondary metabolites with great potentials. The aim of this paper is to evaluate the phytochemicals by using quantitative and qualitative analysis of ethyl acetate, ethanol, n-hexane and aqueous extracts with the help of standard techniques. The findings from quantification and phytochemical screening showed the presence of alkaloids, flavono...
COMPARATIVE STUDY OF PHARMACOGNOSTIC PARAMETERS, ANTIOXIDANT AND ANTICHOLINESTERASE POTENTIAL OF BRASSICA NAPUS AND BRASSICA OLERACEA VAR. ACEPHALA
Introduction: Green leafy vegetables are known for their anti-alzheimer potential. There are many leafy vegetables, however, that have not been examined scientifically for this activity. The present study was designed to evaluate antioxidant and antiacetylcholinesterase activities of two Brassica species namely B. napus and B. oleracea var. acephala, along with the comparison of their pharmacognos...
Quinolones are the organic compounds that act against the DNA-gyrase enzyme, a type II topoisomerase. Norfloxacin is one such quinolone which is characterized by a piperazinemoiety at C-7 position. This moiety plays a significant role in determining the antibacterial spectrum and potency and serves as a site amenable to significant modification. N-Mannich bases have proved to be potential prodrug ...
AQUA DISTILLATION ENHANCES THE ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF ROSA DAMASCENA MILL.; A PILOT STUDY
Rosa damascena Mill. also known as Damask rose, Persian rose or Gul-e-Muhammadi of Rosaceae family is an aromatic small plant cultivated all over the world for its visual beauty, fragrances and therapeutic potential. The plant is rich in tannins, flavonoids, glycosides, carboxylic acids and ascorbic acid. In addition to its aromatic properties, the plant possesses laxative, anti-oxidant, anti-bact...