EXPLORING THE POSSIBLE MECHANISM OF ALBIZIA LEBBECK COMPONENTS BINDING WITH DRUG TARGETS OF BRONCHIAL ASTHMA –AN INSILICO AND CLINICAL ANALYSIS
Asthma is a multi factorial disease characterized by airflow obstruction, wheezing and dysonea and for this many genes are responsible. In this study, an attempt has been made to identify genes along with the proteins encoded by them which are responsible for Asthma along with clinical trials. In the practice of Ayurveda, it’s well established that shirish (Albizia lebbeck) can be used as a trea...
ETHNOGYNAECOLOGICAL DISORDERS OF MEDICINAL PLANTS USED BY TRIBAL PEOPLE IN GEDAMALAI, NAMAKKAL DISTRICT, SOUTHERN EASTERN GHATS, TAMIL NADU
The present exploration is an attempt to an ethnobotanical study was conducted in Eastern Ghats of Tamil Nadu, for the investigation of a medicinal plant used to treat several diseases by the local health healers by Gedamalai Tribes, Namakkal District. Data were collected during March 2015-January 2016. Quantitative analysis, including the informant consensus factor and use-value was performed to ...
Quetiapine is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. The aim of the present study is to evaluate the effect of manufacturing process on critical quality attribute on In-process parameters (Granules). Quetiapine fumarate was selected as a model drug for sustained release drug delivery system manufactured ...
STABILITY INDICATING ASSAY FOR DILTIAZEM AND ITS METABOLITES IN HUMAN PLASMA BY ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY FOR PHARMACOKINETIC APPLICATION
A simple and sensitive Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry method was developed to perform a stability study of diltiazem and its metabolites in human plasma using various buffer reagents at a different strength. The method was applied for the quantification of diltiazem and its two major metabolites N-desmethyl diltiazem and desacetyl diltiazem in human plasma. The an...
SENSITIVE AND RAPID ESTIMATION OF SARECYCLINE, AN ANTIBIOTIC DRUG IN SPIKED HUMAN PLASMA BY LC-MS/MS
Sarecycline, a narrow spectrum tetracycline-derived antibiotic, is used to treat moderate to severe Acne vulgaris. The current study is aimed at developing a simple, sensitive and accurate liquid chromatography-tandem mass spectrometric (LC/MS/MS) method and validating the same for determination of sarecycline in human plasma. Zorbax, SB C18, 4.6 mm × 75 mm, 3.5 μm, 80 Å column, 10 mM ammonium ...
Emergence of Mycobacteria that are resistant to common antibiotics necessitate development of novel antibacterial drugs. The complexity of mycobacterial cell envelope plays an important role in its defense against antimicrobial activity of human immune system. The cell wall of Mycobacteria constitutes a set of carbohydrate-containing molecules. Glycosyltransferases, the glycan processing enzymes p...
ANTIOXIDANT AND BRINE SHRIMP LETHALITY BIOASSAY OF PECTIN FROM GRAPE FRUIT (CITRUS PARADISI) AND LEMON (CITRUS LIMON)
Pectin is a complex polysaccharide and has been used in food and pharmaceutical industries. The current study aimed to determine antioxidant and cytotoxic activities of pectin from peels of grape fruit (GP) and lemon (LP) by ferric reducing power (FRP) assay and brine shrimp lethality bioassay respectively. In addition, antioxidant and cytotoxic activities of GP and LP were compared with food-grad...
IMPACT OF BIOGAS AS PREDISPOSING FACTORS UPON BRONCHIAL ASTHMA (BA) AND CHRONIC OBSTRUCTIVE PULMONARY DISORDER (COPD) AMONG HOUSEWIVES
This study aimed to assess the prevalence of the modifiable risk factors like prolonged kitchen stay, dietary pattern, cooking methods in outpatient (Housewives) bronchial asthma (BA) and chronic obstructive pulmonary disorder (COPD). This prospective observational study was carried out in Pulmonary Medicine Department in a Multispecialty Tertiary Care Hospital in Kerala, India. A total of 126 [BA...
MONITORING AND ANALYSIS OF ADR IN PATIENTS COMING TO PSYCHIATRY OPD WITH DEPRESSION AT A TERTIARY CARE HOSPITAL IN NORTHERN INDIA
AIM: To monitor the adverse drug reactions due to various antidepressants prescribed in patients coming to psychiatry OPD with depression at a tertiary care hospital in northern India. Methods: This was a prospective observational longitudinal study conducted for a period of 12 months in a tertiary care outpatient facility. Patients who fulfilled the inclusion and exclusion criteria and those who ...
Transdermal drug delivery system (TDDS) involving HPMC-PVA patches were prepared as matrix-dispersion system with Pioglitazone HCl (PH) or Gliclazide (GZ) and drug release pattern from these patches were evaluated in-vitro as well as in-vivo. It has been found that 82.41% of Pioglitazone HCl and 70.12% of Gliclazide were released in-vitro in the period of 12 hours and the release patterns was zero...