A PRELIMINARY INVESTIGATION OF TUMOR TAKE INHIBITORY ACTIVITY OF ETHANOLIC LEAF EXTRACT OF MURRAYA KOENIGII LINN. IN MICE
The present study was undertaken to explore the tumor take inhibitory effects of ethanolic extract of Murraya koenigii in rodents. Tumor take inhibitory activity was investigated in hybrid mice (of C57BL strain + Swiss albino strain). Preventive group animals were injected daily with the extract at dose of 50mg/kg body weight i.p. for 10 consecutive days. The animals were observed for the growth o...
The present work was undertaken to justify that Vigna radiate (green moong bean) is helpful in reversing signs of memory loss in aged mice. Passive Avoidance Paradigm (PAP) and Elevated Plus Maze (EPM) were employed as exteroceptive behavioural models and ageing- induced amnesia served as interoceptive behavioural model. Moong bean sprouts (2% and 4% w/w MBS) were administered to mice along with ...
PROTECTIVE EFFECTS OF FERULIC ACID AGAINST LIVER CHOLESTASIS INDUCED BY ETHINYLESTRADIOL IN ADULT FEMALE RATS
The aim of the present article was to examine the protective effect of ferulic acid against liver cholestasis in female rats treated with ethinylestradiol (EE). The daily oral administration of the ferulic acid at a concentration of 40 mg/kg body weight for 15 days to rats treated with EE (100 µg/kg body weight for 5 days) resulted in a significant protection against EE-induced decrease in plasma...
SYNTHESIS AND CHARACTERIZATION OF TRANSITION METAL COMPLEXES OF N’-[(2Z, 3E)-3-(HYDROXYIMINO) BUTAN-2-YLIDENE] BENZOHYDRAZIDE
Synthesis and characterization of Co(II), Ni(II), Cu(II) and Pd(II) complexes of ligand N'-[(2Z,3E)-3-(hydroxyimino) butan-2-ylidene] benzohydrazide are reported. The ligand is monobasic and bidentate in nature. The molar conductivities reveal that all the metal complexes are non-electrolyte. The metal complexes have been characterized on the basis of spectral and magnetic studies. Co(II) ion form...
STUDIES ON PHYTOCHEMICAL SCREENING – GC-MS CHARACTERIZATION, ANTIMICROBIAL AND ANTIOXIDANT ASSAY OF BLACK CUMIN SEEDS (NIGELLA SATIVA) AND SENNA ALEXANDRIA (CASSIA ANGUSTIFOLIA) SOLVENT EXTRACTS
As science encourage most of the medicinal plants as supreme source of unlimited chemical compounds which are of great interest in pharmacological preparations. The present investigation was aimed to study Nigella sativa seeds and Cassia angustifolia leaf solvent extract (petroleum ether, methanol and aqueous solutions) for phytochemical screening, GC-MS characterization, Antimicrobial and Antioxi...
“Soda” is one of the humors in the body which should be in normal level for being healthy. If “soda” increases in the body, some undesirable symptoms appear. In order to eliminate the excess “soda”, at first it should be maturated. There are different formulations in Iranian traditional medicine references as “Monzig-e-soda” which is a way of maturation of black bile. In one of the...
ANTI-MICROBIAL, OVICIDAL, LARVICIDAL, ANTI-DIABETIC AND CYTOXICITY ACTIVITY OF SILVER NANOPARTICLES FROM BROWN SEAWEED (STOECHOSPERMUM MARGINATUM)
The present study aimed to green synthesis the nanoparticles using bioactive compounds from unique seaweeds and testing its application for anti-microbial, anti-diabetic, ovicidal, larvicidal and cytotoxic activity. Seaweeds are marine non- flowering plants have much of the secondary metabolites and had not been explored widely. There are very limited amount of literature are there for seaweeds. S...
ANTICONVULSANT ACTIVITY OF AQUEOUS EXTRACT OF EUPATORIUM BIRMANICUM DC. LEAVES ON SEIZURE INDUCED BY PTZ IN ALBINO MICE, ALONE AND IN COMBINATION WITH ETHOSUXIMIDE
Objective: To evaluate the anticonvulsant activity of aqueous extract of Eupatorium birmanicum DC. leave (EB) alone and in combination with ethosuximide against seizure induced by PTZ in albino mice. Method: Aqueous extract of EB leaves was prepared using Soxhlet apparatus. The albino mice were fed with EB at 3 doses (200, 400 & 800 mg/kg). One hour after feeding, pentylenetetrazole (PTZ) was ...
Povidone-Iodine Ointment was prepared using polyethylene glycol base by fusion method and the gel was prepared using Poloxamer 407 as a gelling agent by cold process. The different characteristics of povidone-iodine ointment and gel were compared from the results obtained for assay and total, available and complex iodine contents. These values were comparable with marketed formulations. The formul...
DEVELOPMENT AND VALIDATION OF STABILITY-INDICATING UPLC METHOD FOR THE DETERMINATION OF BRIVARACETAM, ITS RELATED IMPURITIES AND DEGRADATION PRODUCTS
A novel stability-indicating mass compatible gradient Reverse Phase Ultra-Performance Liquid Chromatographic (RP-UPLC) method was developed for the quantitative determination of purity of brivaracetam drug substance samples in the presence of its impurities and degradation products. The method was developed using waters acquity UPLC BEH SHIELD RP18 (100 mm x 2.1 mm, 1.7 µm) column with mobile pha...