UTILIZATION OF MAIZE EXTRACT FOR THE SYNTHESIS AND CHARACTERIZATION OF GOLD NANOPARTICLES AT ROOM TEMPERATURE
In present work, the gold nanoparticles have been prepared through green synthesis using maize extract at room temperature, the maize extract was used as reducing and stabilizing agents for AuNPs (gold nanoparticles), synthesized gold nanoparticles were confirmed by the color change of the aqueous solution, and the PH of the solution was 7.8, after the confirmation, green gold nanoparticles were c...
TOWARDS SUCCESSFUL ADAPTATION OF PLASMODIUM KNOWLESI TO LONG-TERM IN-VITRO CULTURE IN HUMAN ERYTHROCYTES
Plasmodium knowlesi, a simian malaria parasite, is widely used as a malaria model and now characterized as a clinically significant parasite that can lead to outbreaks throughout most countries in Southeast Asia. Despite its importance, both fundamental and clinical studies of P. knowlesi have been impeded by the lack of a convenient in-vitro culture system partly due to the parasite’s preferenc...
Present study highlights that plant as a source of medicine has been inherited and is an important component of the health care system in India. Ziziphus mauritiana fruit (Rhamnaceae), one of the medicinally important plants commonly found in subtropical countries, was chromatographically evaluated in the present work for the identification of various phytochemical compounds found in it. The phyto...
Costus pictus is rhizomatous medicinal herb, commonly known as “Insulin plant,” well known for its therapeutic properties. Many important and beneficial aspects of C. pictus are reported, which includes anti-diabetic, anti-microbial, anti-cancer, anti-oxidant, anti-fertility, anti-helminthic, diuretic, anti-inflammatory properties. The present review focus on the literature survey based on the...
THE TREATMENT OF TRAMADOL WITH CREAM CONTAINING 3.33% DOXEPIN AND 0.05% CAPSAICIN ON THE OVERALL IMPROVEMENT OF QUALITY OF LIFE IN POST HERPETIC NEURALGIA PATIENTS
The main purpose of the study was to examine the effect of QoL of PHN patients after the treatment of tramadol (50mg-200mg), with topical cream containing 3.33% doxepin and 0.05% capsaicin and clinical correlations with CYP2D6 polymorphism. The study was prospective, non-responders versus responders, conducted in 246 outpatients of PHN undergoing tramadol treatment for 4 weeks. Rescue analgesia gi...
THE EFFECT OF MEDIA AND FERMENTATION CONDITION TOWARD ANTIBACTERIAL ACTIVITIES OF BACILLUS SP. DA11 ASSOCIATED WITH SARCOPHYTON SP.
The emergence of antibiotic-multidrug resistant microorganisms is an essential issue in the health sector. Consequently, the exploration of new antimicrobial compounds from many promising resources is urgently required. Soft coral-associated bacteria are potential as antimicrobial compound producers. This study aims to get the best medium and fermentation conditions in the production of secondary ...
Garcinia mangostana L. pericarp (GMP) has been known as a traditional medicine in Asian countries. The bioactive from GMP has been recognized to be related to complex phenolic compounds linked with free radical scavenging activity. This research aimed to study the effects of topical formulation types (gel, oil in water cream and water in oil cream) of GMP extract on the in-vitro release and in-vit...
ENHANCEMENT OF DISSOLUTION OF CLOPIDOGREL MINI-TABLETS IN INTESTINAL FLUIDS WITH THE AID OF IN-SITU ACIDIFYING AGENT
The main objective of the present study is to enhance the dissolution of clopidogrel bisulphate in intestinal fluids by formulating into mini-tablets with in-situ acidifying agent mini-tablets. The solubility data reveals, Clopidogrel bisulphate is freely soluble in pH 2.0 and the solubility decreases with increase in pH. Whereas, with weak acid, the solubility of clopidogrel is increased at pH 5....
A NOVEL RP- HPLC METHOD FOR THE QUANTIFICATION OF CABOZANTINIB IN ACTIVE PHARMACEUTICAL INGREDIENTS AND PHARMACEUTICAL DOSAGE FORMS
A simple, specific, accurate reversed-phase high performance liquid chromatographic method was developed for the quantification of Cabozantinib. Although extensive studies on Cabozantinib have been developed for determining Cabozantinib in human place and urine by LC-MS, studies on the pharmaceutically active ingredient and formulation are scarce. The effective separation was achieved through BDS ...
Objective: Studies have shown that sorafenib an anti-cancer agent has a neuroprotective effect. This study evaluated the neuroprotective activity of sorafenib in 6-OHDA induced rat model of Parkinson’s disease. Methods: 6-OHDA was injected into the forebrain bundle through the stereotaxic apparatus to induce fast and severe degeneration in dopaminergic neurons of substantianigra. The animals wer...