In-vitro antibacterial and antifungal activity of Tridax procumbens plant parts (leaf and stem) were investigated by agar well diffusion method. The petroleum ether, methanol and aqueous extracts of the plant parts were tested against two bacterial strains i.e., Bacillus subtilis and Escherichia coli and two fungal strains i.e., Trichoderma reesei and Fusarium oxysporium. The results of antibacter...
THE PRACTICE OF SELF MEDICATION IN DIARRHEA AMONG SECOND YEAR MEDICAL STUDENTS IN A TERTIARY CARE HOSPITAL IN JHARKHAND
Over the counter (OTC) drugs are drugs easily available without the prescription of a registered medical practitioner (RMP) and self-mediation practices of these drugs are very common in medical students especially in diarrhea which mostly requires dehydration therapy only. But very few reports are available regarding the use of OTC antidiarrhoeal drugs. The aim of the study was designed to assess...
Objective: There is rapidly growing interest in the development of nanoparticles drug delivery mainly for anticancer drugs as it promises to solve problems to several related to anticancer drugs. The aim of present work was to formulate erlotinib loaded chitosan nanoparticles using probe sonication technique. The objective of the study was to investigate the effect of surface stabilizers and sonic...
The objective of the study was to investigate the effect of microemulsion on in-vitro skin permeation, percutaneous absorption of Irbesartan and to postulate probable mechanism of skin permeation. Microemulsion was prepared by aqueous phase titration method. Pseudoternary phase diagrams were constructed for the microemulsions. Thermodynamic stability study was carried out on selected microemulsion...
In the present study reports synthesis and development of 3-Chloro – N - ((5-chloro-1-tosyl-1H-benzo [d] imidazol – 2 - yl) methyl) - N arylquinoxalin-2-amines (5a-e) from 3-chloro-N-p-tolyl quinoxalin -2-amine (3) condensed with proporgyl bromide followed by adding 4-chloro-N1-tosylbenzene-1,2-diamine,by adopting simple procedure. All titled compounds were screened for their anti bacterial ac...
PREPARATION AND CHARACTERIZATION OF pH BASED CARBOPOL 934P IN-SITU HYDROGELS FOR THE TREATMENT OF HARMFUL BACTERIAL INFECTIONS
The purpose of the present study describes the preparation of pH based in-situ gel formulations were applied for the harmful bacterial infections by using carbopol 934P and HPMC derivatives. The simple procedure was adopted for preparing these formulations. To eliminate or reduced adverse systemic effects produce from bacterial conjunctivitis, topical route of administration, such as eye drops was...
Plants are an important source for the discovery of new products of medicinal value for drug development and plants secondary metabolites are unique sources for pharmaceuticals food additives, flavors, and other industrial values. The commercial importance of these secondary metabolites has resulted in a great interest in its production and in exploring possibilities of enhancing its production us...
NON ENZYMATIC AND ENZYMATIC ANTIOXIDANT STATUS OF WISTAR RAT ERYTHROCYTE AFTER DIETARY ZINC DEFICIENCY
Zinc deficiency is prevalent worldwide. The present study deals with the effect of dietary zinc deficiency on erythrocytes of Wistar rats. Male Wistar rats (40-50 g) were divided into 3 groups: control (ZC) fed 100 μg/g zinc; pair fed (PF) fed 100 μg/g zinc but the diet given was based on the diet consumed the previous day and zinc deficient (ZD) fed 1 μg/g zinc. The experiment was carried out ...
A REVIEW ON THE PHARMACOGNOSTICAL, ECOLOGY AND PHARMACOLOGICAL STUDIES ON MARINE RED ALGAE – HYPNEA VALENTIAE
Seaweeds are the potential marine living resources in the world. More than 20,000 seaweeds are distributed throughout the world, of which only 221 (1.1%) are commercially utilized, which includes 145 species for food and 110 species for phycocolloid production. The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of new active...
IN SILICO EPITOPE PREDICTION AND HOMOLOGY MODELING OF ENVELOPE SURFACE GLYCOPROTEIN GP160, PRECURSOR REGION FROM HUMAN IMMUNO DEFICIENCY VIRUS -1
The development of a highly effective AIDS vaccine will depend on the success of designing immunogens that will elicit immune response against broadly neutralizing antibodies to naturally circulating strains of HIV- can be done by reverse vaccinology. Reverse vaccinology is a good approach for provoking the broadly neutralizing antibody response by identifying the specific epitopes i.e. surface pr...