Although technologies are emerging day to day and bioinformatics is also growing with number of databases developed, but being a very important factor in cancer invasion and metastasis, MMPs have no exclusive database. Matrix Metallo-Protienase (MMP) is a major class of proteolytic enzymes that plays a dominant role in ECM degradation. Every time researchers are searching and gathering information...
EFFECT OF THE PREGNANCY PERIOD PREPARATION CLASSES ON THE NUTRITIONAL BEHAVIOR OF THE POSTPARTUM PERIOD
Postpartum period is an important step because the mother's body needs to heal and recover, after pregnancy period and childbirth. So taking good care and a balanced diet in the postpartum period, plays an important role in the women's health. Thus, training of nutrition is so necessary at this period. The aim of this study was an evaluation the effect of the pregnancy period preparation classes o...
There is a lot of thrust on utilization of bioactive chemicals from plant systems and their significant effect on microorganisms. Ten species of plants of the family Euphorbiaceae have been used for our study they are, Croton bonpandianum, Euphorbia tirucalli, E. hirta, E. heterophylla, Jatropha curcas, J. glandulifera, J. multifida, Phyllanthus amarus, Ricinus cummunis, Pedilanthus tithymal...
In recent times, the use of natural antioxidants as ameliorative agents has become the focus of basic research. Allium sativum (garlic) is one such agent which has been proven to have antibacterial, antiseptic, antifungal, antiparasitic, anticoagulant and antitumor properties. The present investigation deals with the ameliorative effects of Allium sativum on the induced renal toxicity of the antim...
EFFECT OF AGE AND SEX UNDER IMATINIB MESYLATE THERAPY ON CHRONIC MYELOID LEUKAEMIA PATIENTS: A PILOT STUDY FROM INDIA
Among adults in India, Chronic myeloid leukemia (CML) is most common leukemia and accounts for 30% to 60% of all adult leukemias. Imatinib mesylate induces the highest rate of complete hematological and cytogenetic responses, but its efficacy is still debated in different sets of patients. Total 50 newly diagnosed patients of CML were enrolled. Patients receiving imatinib 400mg orally daily were m...
A REVIEW ON THE SYNTHESIS AND BIOLOGICAL ACTIVITIES OF PIPERIDIN-4-ONES K. P. Greeshma * and S. Muthulingam
Piperidine is a key structural motif in various alkaloids and a variety of compounds studied in medicinal chemistry. Though many methods have been developed for their construction, there is still need for noval approaches. Among the wide variety of heterocyclic compounds; piperidin-4-ones exhibit various biological activities. Synthesis and biological applications of piperidin-4-ones derivatives a...
PYRAZOLIDINE-3, 5-DIONE AND 2-METHYL-4-OXO-4H-THIOCHROMENE-8-CARBONYL CONJUGATES: SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL SCREENING
In this study, a novel series of heterocyclic compounds containing pyrazolidine-3, 5-dione nucleus has been synthesized. The compounds were synthesized in four steps; esterification of 2-mercaptobenzoic acid in an acidic medium to yield 2-mercapto-benzoic acid ethyl ester which was cyclized using ethyl acetoacetate to form 2-methyl-4-oxo-4H-thiochromene-8-carboxylic acid ethyl ester. These were re...
Cancer is a major public health burden in both developed and developing countries. It is an abnormal growth of cells in body that can lead to death and globally the numbers of cancer patients are increasing day by day. There are several medicines available in the market to treat the various types of cancer but no drug is found to be fully effective and safe. Herbal medicines have a vital role in t...
BIO-ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF ETHINYL ESTRADIOL WITH ETHINYL ESTRADIOL-D4 AS INTERNAL STANDARD IN HUMAN K2-EDTA PLASMA BY LC-MS/MS
A sensitive method was developed to determine Ethinyl Estradiol in human plasma by liquid chromatography-tandem mass spectrometric (LC–MS/MS). Separation of analyte and the Internal Standard (IS) Ethinyl Estradiol-d4 using SPE followed by LLE in plasma with TBME, was performed on a LC/MS/MS-API-5500 instrument with SB C18 HT (50mm×3.0mm) 1.8 µm columns at a flow rate of 0.300 ml/min with mobil...
Targeted drug delivery, known as smart drug delivery focuses on targeting the medicaments by increasing the residence time and the concentration of drug at the target site of the body (organs, cells, tissues) thus improving the efficacy of treatment and reducing the side effects. Various carriers that can be used in this type of delivery are liposomes, nanoshells, erythrosomes and resealed erythro...