SYNTHESIS, CHARACTERIZATION AND IN VITRO ANTICANCER EVALUATION OF BIS-[1,5]-BENZOTHIAZEPINES AGAINST HUMAN BREAST CANCER CELL LINE MCF-7
Bis-[1,5]-benzothiazepines (3a-i) containing two 1,5-benzothiazepine nuclei in a single molecule were synthesized by cyclocondensation reaction of bis-chalcones (1a-i) with two equivalent of 2-aminobenzenethiol (2). All the synthesized compounds were characterized by IR, 1H NMR,13C NMR and mass spectral analysis. Anticancer activity of the synthesized compounds against human breast cancer cell lin...
Nature gives numbers of drugs and possibly has all solutions for human diseases. Till date, nature provides a large number of clinically useful drugs. Ulcer and liver diseases are major increasing health problems. Now a day number of drugs are used for the treatment of peptic ulcer and hepatic diseases, but these drugs have various types of side effect such as incidences of relapse, and drug inter...
This study aimed to evaluation of healing potential of Sambucus ebulus in full-thickness wound model in rats. A dorsal skin wound was created in rats. The 5% ointment applied to the wound area once a day for 12 days. Healing process was compared histologically between the groups. Parameters of wound healing were evaluated in the wound area. Extract improved wound contraction and closure. Histopath...
FORMULATION & OPTIMIZATION OF SUSTAINED RELEASE MATRIX TABLETS OF SIMVASTATIN USING RESPONSE SURFACE METHODOLOGY
The aim of the work is to formulate sustained release matrix tablets of simvastatin and to optimize them using Response Surface Methodology. The tablets were prepared by direct compression method and evaluated as per pharmacopoeia methodology. A central composite design for 2 factors at 3 levels each was employed to systematically optimize drug release profile. Concentration of HPMC K15M (X1) and ...
This study aims to design resveratrol loaded microemulsion (ME) topical formulation for use in skin cancer. Encapsulation of resveratrol can improve its intrinsic solubility and enhance penetration into the skin for topical use as an alternative to injectables. Preformulation studies by DSC and FTIR confirmed the compatibility of chosen excipients with resveratrol. Resveratrol loaded microemulsion...
Although technologies are emerging day to day and bioinformatics is also growing with number of databases developed, but being a very important factor in cancer invasion and metastasis, MMPs have no exclusive database. Matrix Metallo-Protienase (MMP) is a major class of proteolytic enzymes that plays a dominant role in ECM degradation. Every time researchers are searching and gathering information...
The aim of the present study was to prepare solid lipid nanoparticles (SLNs) of azathioprine to increase its permeability and to develop azathioprine loaded solid lipid nanoparticles (AZA SLNs) based transdermal film for topical administration with the aim of reducing systemic and gastro-intestinal side effects of the drug and achieve passive targeting of drug to the joint due to enhanced permeabi...
EFFECT OF THE PREGNANCY PERIOD PREPARATION CLASSES ON THE NUTRITIONAL BEHAVIOR OF THE POSTPARTUM PERIOD
Postpartum period is an important step because the mother's body needs to heal and recover, after pregnancy period and childbirth. So taking good care and a balanced diet in the postpartum period, plays an important role in the women's health. Thus, training of nutrition is so necessary at this period. The aim of this study was an evaluation the effect of the pregnancy period preparation classes o...
The synthesis of nanoparticles has become the matter of great interest in recent times due to its various advantageous properties and applications in various fields. Though physical and chemical methods are more popular for nanoparticle synthesis, the biogenic production is a better option due to eco-friendliness. Morinda coreia leaf ethanol extracts was screened for the synthesis of Silver nanopa...
Introduction: Antibiotics suppress the growth of or kill another microorganism at very low concentrations. Therefore this is the one of the supreme invention need of this era. Most bacteria are becoming resistant to various antibiotics, make a limitation for treating minor and major infectious. Hence, determining the resistance patterns in the geographical area will help in choosing and use of the...