Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
COMPARATIVE STUDY OF OVERLAPPING GENES IN THE GENOMES OF MYCOPLASMA HOMINIS AND MYCOPLASMA PENETRANS
Overlapping genes are pairs of adjacent genes whose coding regions are partially or entirely overlapping. Overlapping genes in prokaryotes are a means to minimize genome size and increase the density of genetic information. Overlapping genes play an important role in genome reduction of Mycoplasmas during the course of their degenerative evolution. In this study overlapping genes in the genomes of...
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DESIGN OF QUINOLONE DERIVATIVES AS POTENTIAL ANTIBACTERIAL USING MOLECULAR DESCRIPTORS
In the present work in mathematical modeling, quantitative structure activity relationship (QSAR) studies were performed on some quinolone derivatives as a potential antibacterial agent using statistical work. The regression analysis of the data has shown that the activities of the compound can be modeled excellently in bi-parametric model.A heurisimatedtic algorithm selects the best multiple line...
3422
1427
FORMULATION AND IN VITRO EVALUATION OF SALBUTAMOL SULPHATE SUSTAINED RELEASE TABLET BY USING FLOATING DRUG DELIVERY TECHNOLOGY
The present study involves in the preparation and evaluation of floating tablets of Salbutamol sulphate by direct compression method by using the hydrophilic polymer such as hydroxy propyl methyl cellulose (HPMC), Sodium carboxy methyl cellulose, Dextrin and Carbopol. Sodium bicarbonate, Tartaric acid and citric acid were incorporated as gas generating agent. The study aims to achieve different fo...
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1852
NEW POTENTIAL ANTIMALARIAL AGENTS: SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME SCHIFF BASE LIGAND AS ANTIMALARIAL AGENTS
Plasmodium falciparum is the protozoan parasite responsible for the majority of life-threatening cases of human malaria, causing more than one million deaths a year. The global emergence of drug-resistant malarial parasites necessitates identification and characterization of novel drug targets. At present, α-carbonic anhydrase (CA) genes are identified in limited numbers of parasites in both prot...
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1607
STRUCTURE MODIFICATION OF RITONAVIR WITH CARBAZOLE; SYNTHESIS AND CHARACTERIZATION
The core moiety of ritonavir (2S, 3S, 5S)-5-(tert-butyloxycarbonyl)amino-2-amino-3-hydroxy-1,6-diphenylhexane (7) on condensation with oxirane of carbazole (8) in isopropyl alcohol at reflux and deprotected with mineral acid gave compound 10. Coupling of compound 10 with carbamate amino acid (11a-15c) in the presence of EDAC.HCl and HOBt at room temperaturegave ritonavir analogues containing carba...
4320
1921
SYNTHESIS, CHARACTERISATION AND ANTIFUNGAL STUDIES OF Cu (II) HALIDE COMPLEXES OF SOME STERYL DERIVATIVES OF SUBSTITUTED BENZIMIDAZOLES
Complexes of Copper (II) halides with steryl derivative of 2- methylbenzimidazole (stmbz), 2-ethylbenzimidazole (stebz) and 2-benzylbenzimidazole (stbbz) of composition CuL2X2 (L = stmbz, stebz and stbbz and X = Cl, Br) have been prepared and characterised. The magnetic susceptibility e.p.r. data, electronic absorption pattern and i.r. spectral studies of complexes indicated distorted octahedral e...
3458
1620
HISTAMINE SUBTYPE 3 RECEPTOR ANTAGONISTS: CURRENT STATUS WITH FUTURE PROSPECTS IN DRUG DISCOVERY AND DRUG DEVELOPMENT
The histamine H3 receptor is an G protein-coupled receptor that regulates neurotransmission in the central nervous system and plays a major role in cognitive and homeostatic functions. The third histamine receptor was discovered in 1983 by a traditional pharmacological approach, consisting of assessing the inhibitory effect of histamine on its own release from depolarized rat...
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2849
ARE THE MELATONIN SUPPLEMENTS POTENTIAL TREATMENT OPTIONS? A SYSTEMATIC REVIEW
Introduction: Melatonin is a neuro-hormone secreted from the pineal gland and involved in various regulatory activities in body. Ever-increasing use of melatonin supplements and enlarging research evidences make the authors undertook the review to arrive at a qualitative conclusion whether melatonin supplements can act as potential treatment options or not. Methodology: A comprehensive search w...
6832
1962
A REVIEW ON ANIMAL MODELS OF DEPRESSION
As described by the world health organization (WHO), depression is the most common and serious disorder leading to suicide. Numbers of synthetic drugs are available for the treatment of this fatal disease, but are associated with serious complications. A wide diversity of animal models has been used to examine antidepressant activity. These range from relatively simple models sensitive to acute tr...
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INDIAN NATURAL ZEOLITE CATALYZED SYNTHESIS OF β-AMINOHETERONAPTHOL AND THEIR POTENT ANTIMICROBIAL EFFICACY
A highly resourceful, elegant, simple and green technique with exceptionally facile reaction conditions of one pot three component reaction was applied to synthesized series of novel mannich base having an array of biologically and pharmaceutically active novel heterocycles. The present protocol offered a valuable alternative to known methods and will find applications in the field of green synthe...
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