Volume 15 (2024) - Issue 12, December
Review Articles
DIVERSITY ROLES OF X-RAY IN CONTEMPORARY SCIENCE – AN OVERVIEW
The multifaceted applications of X-ray instrumentation across industrial, medical, forensic, and security domains. In industrial settings, X-ray instrumentation serves as a cornerstone for non-destructive testing, ensuring product quality and streamlining manufacturing processes. In the medical field, these instruments play a pivotal role in diagnostic imaging, offering crucial insights for effect...
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EXPLORING THE EVOLUTION OF PATCHES AND IMPACT OF SMART PATCHES ON DRUG DELIVERY: A COMPREHENSIVE REVIEW
This comprehensive review investigates the evolution of patches and the transformative impact of smart patches on drug delivery. Beginning with a historical overview of patches, the review examines the advancements that led to the development of smart patches. It explores the design principles, functionalities and applications of smart patches in drug delivery, highlighting their potential to revo...
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A REVIEW ON THE ANTISPASMODIC POTENTIAL OF SOME TRADITIONAL MEDICINAL PLANTS OF INDIA
For the treatment of many illnesses and disorders, including gastrointestinal (GI) ailments, several medicinal plants have been used. Most children and adolescents often suffer from GI illnesses, which have overlapping clinical manifestations in diagnosis and treatment requirements. In order to address the symptoms of smooth muscle contraction and cramping in gastrointestinal illnesses as well as ...
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REVIEW ON HETEROCYCLIC COMPOUNDS SYNTHESIS AND EVALUATION
Among all the organic compounds, heterocyclic compounds are the most common and varied class. It has been possible to synthesis a considerable number of heterocyclic molecules thus far. Heterocyclic compounds are getting more and more prevalent due to extensive synthetic study and their synthetic utility. In the realm of medical chemistry, these molecules are useful in several ways. Some common us...
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A BRIEF REVIEW ON ANTIUROLITHIATIC POTENTIAL OF TRADITIONALLY USED MEDICINAL PLANTS FROM UTTARAKHAND HIMALAYAS
Urolithiasis, commonly known as kidney stone disease, is a prevalent and painful condition resulting from the formation of calculi in the urinary system. This review aims to elucidate the antiurolithiatic properties of medicinal plants, focusing on urolithiasis and stone formation mechanisms. The ethnopharmacological approaches to managing kidney stones highlight the historical and cultural signif...
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ROLE OF NOVEL DRUG DELIVERY SYSTEMS IN INSULIN RESISTANCE
Reduced sensitivity of muscles or tissues to insulin is known as insulin resistance. The non-pharmacological management of diabetes, which involves exercise and food modification, has been the primary emphasis of diabetic self-management. Pharmacological therapy includes combination products, phytoconstituents, and oral antihyperglycemics. The limitations of currently available drugs have caused t...
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A BRIEF REVIEW ON VARIOUS ASPECTS OF NANOPARTICLES
Nanotechnology is the idea of using medicines as a small machine inside the human body to detect and treat various diseases. Nanotechnology consists of deformation, separation, and consolidation of material from atoms and molecules due to its quick movement across the small capillaries. It allows immediate treatment to the targeted cells and also has fair use in oncology. Nanotechnology aims to re...
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Research Articles
FORMATION OF INCLUSION COMPLEX OF ANTI-INFLAMMATORY TRITERPENOID CABRALEONE (DN12) WITH HYDROPHILIC BETA CYCLODEXTRIN POLYMER (β-CD-P)
The main objective of this study was to improve the solubility of the triterpenoid cabraleone (DN12) and to investigate the anti-inflammatory activity of the complex. DN12 was stabilized by a complex formation with β-cyclodextrin polymer (β-CD-P) in a molar ratio of 1.0:1.0. The DN12 extract and the cyclodextrin complex have been equilibrated in ethanol at 25°C for approximately 24 h. The β-cy...
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ACUTE AND SUB-ACUTE ORAL TOXICITY STUDIES OF ARTABOTRYS THOMSONII OLIV (ANNONACEAE) LEAVES AQUEOUS EXTRACT IN WISTAR RAT
Artabotrys thomsonii is a medicinal plant used in the African pharmacopoeia for the treatment of various diseases. It was therefore important to assess its potential risk to human and animal health. This study highlights the acute and sub-acute effects of the toxicological profile of A. thomsonii leaves aqueous extract. The extract was prepared using the traditional protocol, then administered ora...
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WOUND-HEALING PROPERTY OF THE FORMULATED OINTMENT USING EXTRACTED CURCUMIN FROM THE CURCUMA LONGA L. (FAM. ZINGIBERACEAE) POWDER AMONG DIABETES-INDUCED SPRAGUE-DAWLEY RATS
Diabetes mellitus can lead to impaired healing of wounds and can cause life-long complications. Curcumin is reported as one of the promising therapeutic agents in the management of impaired wound healing in diabetics. This study aimed to formulate a wound-healing ointment from the extracted curcumin and evaluate its efficacy among diabetes-induced rats. The extract was subjected to organoleptic ev...
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ISOLATION AND CHARACTERIZATION OF CANDIDA SPECIES IN ICU PATIENTS: A PROSPECTIVE OBSERVATIONAL STUDY FROM KUMAON REGION, UTTARAKHAND, INDIA
Background: Fungi have emerged as major cause of human diseases since early 1980s. In hospitalized patients with serious underlying diseases and those having immunocompromised state, opportunistic fungal infections bring about a substantial increase in morbidity and mortality. Aim and Objectives: Isolation and characterization of Candida species in ICU patients of Dr. Susheela Tiwari Government Ho...
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EVALUATION OF CYANIDIN-3-O-GLUCOSIDE FROM DIFFERENT BLACK RICE VARIETIES OF MANIPUR UTILIZING FTIR SPECTROSCOPY AND HPTLC METHOD
Black rice is a rice species, Oryza sativa Linne (Gramineae), which is sticky, high in nutrients, and primarily grown in Asia. In recent years, the health benefits of black rice varieties have been reported due to the presence of a bioactive compound, anthocyanin, which has highly potent activity with high macronutrients. The present study aimed to evaluate and quantify the metabolites, focusing o...
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OPTIMIZING AEGLE MARMELOS TISSUE CULTURE: STERILIZATION, HORMONAL COMBINATIONS, AND PERMEABILIZATION STRATEGIES FOR ENHANCED SECONDARY METABOLITE PRODUCTION
This study focuses on optimizing the tissue culture of Aegle marmelos, a medicinal plant with diverse pharmacological properties. The research fine-tuned sterilization methods, identifying a 2% sodium hypochlorite solution as the most effective. Callus induction experiments revealed the optimal hormonal combination for Aegle marmelos as MS medium + Auxin-2,4-D (0.5 mg/l) + Cytokinin-BAP (1.5 mg/l)...
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ANTIDIABETIC ACTIVITY OF PLANT EXTRACTS OF TRIGONELLA FOENUM-GRAECUM IN STREPTOZOTOCIN (STZ) – INDUCED DIABETIC RATS
Introduction: The primary cause of type 2 diabetes is the body's inability to respond to insulin or produce adequate insulin. Diabetes mellitus (DM) is a metabolic disease that causes persistent hyperglycemia. It has been demonstrated that Trigonella foenum-graecum (TFG), often known as fenugreek, has anti-hyperglycemic effects on both humans and animals with type I and type II diabetes. Fenugreek...
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DEVELOPMENT, CHARACTERIZATION, AND EVALUATION OF TOPICAL GEL FORMULATED WITH LULICONAZOLE-LOADED SOLID LIPID NANOPARTICLES
Luliconazole is an antifungal medication effective against various fungi, especially filamentous fungi like dermatophytes. This study aimed to develop a topical drug delivery system for luliconazole to reduce the active drug dose, improve patient compliance, minimize side effects, and enhance local absorption and activity. Solid lipid nanoparticles (SLNs) were formulated using stearic acid and pol...
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DESIGN, GREENSYNTHESIS AND MOLECULAR DOCKING STUDIES OF A NOVEL 2,4,5- TRIPHENYL IMIDAZOLE DERIVATIVE
The design and synthesis of a novel 2,4,5- Triphenyl imidazole derivative has been achieved using a green chemistry approach. These compounds were synthesized by using a sustainable catalytic material and solvent free one-pot reaction where benzil, aromatic aldehydes, ammonium acetate and acid chloride were reacted under microwave irradiation. This method offers several advantages including simpli...
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DEVELOPMENT AND EVALUATION OF FLASH RELEASE ORAL WAFER CONTAINING ANTIBIOTIC
In the 21st century, human lifestyle has been faster than previous. People of this generation require faster results of each and everything which leads to change in lifestyle. Due to this immediatism invention of rapid release dosage forms are immerging in pharmaceutical market, from which Oral wafer is one of the dosage forms which provides rapid release of the drug. These oral wafers can be admi...
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GREEN SYNTHESIS OF SILVER NANOPARTICLES USING PLANT LEAF EXTRACTION OF TRADESCANTIA ZEBRINA: SYNTHESIS AND CHARACTERIZATION
Nanoparticles are primary to nanoscience and nanotechnology, presenting powerful process over different fields. However conventionally synthesized by using physical and chemical methods, these strategies always suffer from harmful issues. To highlight these approach, eco-friendly and less toxic green synthesis methods have been established. These methods involve natural sources such as medicinal p...
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DEVELOPMENT AND EVALUATION OF A HERBAL COSMETIC CREAM FROM THE STANDARDIZED EXTRACT OF OCIMUM BASILICUM LEAVES
Objective: The present study aimed to develop and evaluate herbal cosmetic cream by incorporating standardized Ocimum basilicum leaf extracts to exert its anti-oxidant potential as anti-wrinkle properties. Methodology: The hydro-alcoholic and aqueous extracts were prepared and standardized through high-performance thin-layer chromatography studies using the mobile phase ethyl acetate - acetic acid...
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PREPARATION AND EVALUATION OF INSULIN MICROPARTICLES BASED GEL FROM NATURAL SOURCES FOR NASAL DELIVERY
Ionotropic gelation, a characteristic property, has become one of the easy, simple and mild ways of encapsulating variety of drugs, enzymes, and proteins, prepared by various Polysaccharides. The externally crosslinked beads with calcium chloride and zinc chloride were suitable for water soluble and low molecular weight drugs. Insulin, encapsulated in a calcium pectinate gel / Sodium alginate bead...
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A CROSS-SECTIONAL QUESTIONNAIRE BASED STUDY ON KNOWLEDGE, ATTITUDE AND PRACTICE OF PHARMACOVIGILANCE AMONG SECOND PROFESSIONAL MBBS STUDENTS
Background: Integrity is the cornerstone of pharmacovigilance. Underreporting is the main issue being faced by Pharmacovigilance programme. It is our moral duty as law-abiding citizens and medical professionals to report adverse drug reactions (ADRs) in order to protect patients' health. Aim and Objective: To study about the knowledge, attitude, practice of Pharmacovigilance among second professio...
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ASSESSING HYPERLIPIDEMIA ROLE IN THE ETIOLOGY OF CARDIAC ARREST: CASE-CONTROL STUDY
Introduction: Hyperlipidemia, characterized by elevated lipid levels, is linked to increased cardiovascular disease risk. This study explores whether hyperlipidemia heightens the likelihood of cardiac arrest, stemming from its role in atherosclerosis and coronary artery disease. The objective was to determine if individuals with hyperlipidemia face a higher risk of cardiac arrest, underscoring the...
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A RETROSPECTIVE STUDY ANALYSING THE PREVAILING MALARIA TRENDS IN CHHATTISGARH
Introduction: Malaria is a seasonal disease and endemic in Chhattisgarh, as a large number of cases and deaths are reported from the tribal-dominated districts of Chhattisgarh. The distribution of these malaria parasites can vary across different regions of India due to climate, geography, mosquito vector species present, human population dynamics, and socio-economic conditions. Aims and Objective...
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PRODUCTION OF BIODEGRADABLE PLASTIC FROM SOIL MICROORGANISMS
The present investigation aimed to design a biodegradable plastic from soil microorganisms that produce PHB (Polyhydroxy-butarate). The microorganism was isolated using a specifically designed medium as per the requirement and identified the organism by Sudan black and gram staining methods. Their biochemical identification was done by the Indole test. Then extraction of PHB was done through the c...
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RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF VIBEGRON IN PURE AND PHARMACEUTICAL DOSAGE FORM
An accurate, sensitive, precise, fast isocratic reverse phase HPLC technique has been developed and validated for the quantification of Vibegron in the pure and pharmaceutical dosage form. The best separation was achieved on a 250 mm x 4.6 mm ID., 5µ-particle size Inertsil®-Octadecyl-Silyl-3V-Reverse-Phase-C18-column with 0.05M Ammonium dihydrogen orthophosphate in water: acetonitrile (60:40...
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FORMULATION AND EVALUATION OF CONTROLLED POROSITY OSMOTIC TABLET OF DILTIAZEM HYDROCHLORIDE
Diltiazem HCl is a newer class of antiarrhythmic agent and available in market tablets as a controlled and extended-release formulation. The release pattern is influenced by atmosphere, pH, the presence of food and other physiological conditions of GI tract. This is possible by formulating and osmotic tablets. A controlled porosity osmotic tablet of diltiazem HCl was formulated by incorporating le...
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OUR EXPERIENCE OF USING TOPICAL HAEMOCOAGULASE (BOTROCLOT) IN ARRESTING EAR, NOSE, THROAT AND HEAD AND NECK BLEED IN A TERTIARY CARE CENTER
Introduction: Topical haemocoagulase (Botroclot) is a fractionated snake venom extract which acts as procoagulant and augments healing. In our study we ascertain the various causes of bleeding in routine clinical practice and evaluate the efficacy of this agent in arresting minor bleeding. Aim and Objective: To ascertain the various causes of bleeding in routine ear, nose, throat (E.N.T.) practice...
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EXPLORING THE ANTIDEPRESSANT POTENTIAL OF CURCUMA LONGA RHIZOME: AN EXPERIMENTAL STUDY WITH ALBINO RATS
Background- Depression is a mental health condition with various symptoms including low energy, disrupted sleep, and suicidal ideation. Antidepressants have negative side effects and can cause drug interactions. Curcuma longa, a herbal extract, has shown potential in treating depression due to its antioxidant and anti-inflammatory properties. A study is planned to evaluate its antidepressant activ...
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MOLECULAR DOCKING SIMULATION ON ISATIN- A MAGICAL MOLECULE
Isatin is magical molecule widely used in drug discovery of many areas like anticancer, anti-inflammatory, antiviral, anti-convulsant, anti-tubercular, antimicrobial, antidiabetic most important it was found effective in COVID-19 as well as on Lumpy Skin Diseases. Isatin can be synthesized by different methods like Sandmeyer method, Gassman synthesis. Isatin was modified by researchers at C2, C3, ...
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TERATOGENIC EFFECTS OF AN ANTIEMETIC AGENT ROLAPITANT ON BRAIN OF DEVELOPING CHICK EMBRYOS: A MORPHOLOGICAL AND HISTOPATHOLOGICAL STUDY
The chick was chosen as a model because it is more readily available than rats or mice and its organogenesis is analogous to that of humans. Rolapitant is a highly potent, powerful antagonist of the neurokinin-1 receptor, featuring a high degree of infiltration to the brain. The study aimed to assess the morphological and histopathological analysis of the brain (cerebral cortex) of growing chick e...
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QUALITY OF LIFE OUTCOMES IN OBSESSIVE-COMPULSIVE DISORDER PATIENTS RECEIVING TREATMENT IN A NORTHERN INDIA TERTIARY CARE PSYCHIATRY OUTPATIENT DEPARTMENT
Background: Obsessive-Compulsive Disorder (OCD) is a chronic mental health condition that significantly impairs an individual’s quality of life (QOL), affecting physical, psychological, social, and environmental well-being. In India, particularly in Northern regions, OCD patients face unique socio-cultural and healthcare challenges, which may exacerbate the impact of the disorder. This study aim...
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FORMULATION & EVALUATION OF HERBAL TRANSDERMAL PATCH OF CENTELLA ASIATICA & LIQUORICE TO STUDY WOUND HEALING ACTIVITY
Wound healing remains a significant challenge in modern medicine, necessitating the exploration of innovative therapeutic strategies. Centella asiatica, a widely recognized medicinal herb, has garnered attention for its potential wound healing properties. This study aimed to investigate the efficacy of a Centella asiatica transdermal patch in promoting wound healing. These results suggest that the...
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IN-SILICO MOLECULAR DOCKING STUDIES OF FLAVANOIDS AS POTENTIAL ANTI-PARKINSONIAN AGENTS
Flavonoids are a class of Polyphenolic compounds found abundantly in plants. This study employs computational methods to predict the binding affinities and interaction patterns of selected flavonoids with the adenosine A2A receptor, Monoamine oxidase B (MAO-B enzyme), and Catechol-O-Methyltransferase (COMT enzymes). The docking simulations were performed using software packages such as iGEMDOCK wh...
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