Volume 16 (2025) - Issue 8, August
Review Articles
ANDROGRAPHOLIDES, THE ACTIVE PHYTOCHEMICALS OF THE MEDICINAL PLANT ANDROGRAPHIS PANICULATA & THEIR IMMUNOMODULATORY EFFECTS
Andrographolides are bioactive compounds derived from the plant Andrographis paniculata that have gained attention for their potential as an immune modulator. Research indicates that andrographolides exhibit anti-inflammatory, antioxidant, and immunomodulatory properties. It can enhance the activity of immune cells, such as macrophages and T lymphocytes, and modulate cytokine production, which hel...
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ADVANCEMENTS IN ADA-SCID: A DETAILED COMPILATION WITH DIAGNOSTIC APPROACHES AND PROPOSITIONS OF NOVEL TREATMENT MODALITIES
The aim of the study is to evaluate the prevalence and impact of advancements in the diagnosis and treatment of Adenosine Deaminase Severe Combined Immunodeficiency (ADA-SCID) and propose novel strategies for improved management and therapeutic outcomes. A comprehensive review was conducted according to PRISMA guidelines, focusing on advancements in ADA-SCID. Gene variant data were analysed using ...
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BARRIERS TO MICRONUTRIENT SUPPLEMENTATION ADOPTION AND PRACTICAL CHALLENGES – AN INDIAN PROSPECTIVE ON THE PERSISTENCE OF MICRONUTRIENT DEFICIENCIES
Micronutrient deficiencies are an important driver of morbidity and mortality associated with non-communicable diseases. According to the World Health Organization, more than two billion individuals are micronutrient deficient worldwide, with India home to over half of them. India needs to actively fight against the severe effects of malnutrition since, despite the nation's strong economic growth ...
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SYSTEMATIC REVIEW: PHARMACOLOGICAL INTERACTIONS BETWEEN TRADITIONAL HERBAL MEDICINES AND MODERN PHARMACEUTICALS
Introduction: The use of traditional herbal medicines in conjunction with modern pharmaceuticals is a growing trend. However, the concurrent use of these therapies can lead to significant pharmacological interactions affecting drug metabolism, efficacy and safety. Objective: This systematic review aims to provide a comprehensive overview of pharmacological interactions between traditional herbal m...
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ARTIFICIAL INTELLIGENCE: A FUTURE OF PHARMACEUTICAL INDUSTRIES
Pharmaceutical technology has been using artificial intelligence more and more in recent years. This technology can help save time, money and also very helpful while improving understanding of the links between various formulation and process parameters. To tackle both specific and complex issues, artificial intelligence (AI) leverages human knowledge and gains knowledge from the solutions it gene...
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GLUCOCORTICOID INDUCED OSTEOPOROSIS: EXPLORING ALLOPATHIC THERAPIES AND TRADITIONAL MEDICINE SOLUTIONS
Osteoporosis is a Skeletal condition that generally develops with aging. The primary osteoporosis is more prevalent in women after menopause which is known as postmenopausal osteoporosis, and it also happens after the age of 75. Secondary osteoporosis is brought on by long-term usage of drugs like glucocorticoids or chronic underlying illnesses. Oral GC use ranges from 0.5 to 0.9% in the community...
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CURRENT APPROACHES AND FUTURE TRENDS IN BILAYER TABLETS FOR OBESITY TREATMENT
Obesity is a complicated global health issue that necessitates novel therapeutic methods, as traditional treatments frequently fail to fulfill the different patient needs. Bilayer tablets, an advanced oral drug delivery technology, combine immediate-release and sustained-release layers in a single dosage form, allowing for quick symptom relief while maintaining stable plasma drug concentrations. T...
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REVOLUTIONIZING MEDICINE: THE FUTURE BUCCAL FILM-BASED DRUG DELIVERY SYSTEM
This study explores buccal drug delivery as an alternative to traditional oral medications, emphasizing its advantages in bioavailability, drug stability, and therapeutic efficacy. Key formulation factors, including swelling index, drug content, folding endurance, and surface pH, are evaluated alongside various production techniques such as solvent casting, hot-melt extrusion, and freeze-drying. T...
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A SYSTEMATIC REVIEW ON EMULGEL
A topical drug delivery system involves applying medication to the skin for therapeutic effects or to treat skin disorders. Traditional gels often struggle to deliver hydrophobic drugs effectively, a challenge that can be overcome with emulgels. Emulgels, which combine emulsions and gels, create a dual-release control system that enhances medication efficacy. This innovation is essential in topica...
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SEXUAL AND REPRODUCTIVE HEALTH NEEDS OF REFUGEES: EXAMINING ACCESS, UTILIZATION AND INTERVENTION STRATEGIES
Sexual and reproductive health (SRH) is a critical component of public health, particularly for refugee populations who experience heightened vulnerabilities due to forced displacement, inadequate healthcare infrastructure, cultural barriers, and restrictive host-country policies. This review examines the complex barriers affecting refugees’ access to SRH services, categorizing them into structu...
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AQUASOMES: A NOVEL NANOPARTICULATE DRUG CARRIER
Aquasomes are a highly advanced nanoparticulate transport system in nanotechnology. It is mostly utilized for medication delivery. These carriers are differentiated by their three-layered structure, which includes a solid nanocrystalline core (often calcium phosphate or ceramic diamond), a polyhydroxyoligomeric film, and functional properties. The core is solid mechanical strength and stability, b...
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CAPSAICIN AS A PROMISING TREATMENT FOR NASO-RESPIRATORY DISEASES: A COMPREHENSIVE REVIEW
Background: Capsaicin, a bioactive compound derived from the dried fruit of the Solanaceae family, is widely recognized for its therapeutic potential. Its mechanism of action involves interaction with TRPV1 receptors, leading to analgesic effects and modulation of neurogenic inflammation. Objective: This review explores the therapeutic applications of capsaicin, particularly its role in treating n...
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Research Articles
BIOSYNTHESIS, PURIFICATION, AND CHARACTERIZATION OF MONK FRUIT SWEETENER, SIAMENOSIDE I
An efficient and high yield synthesis of Siamenoside I (1), from Mogroside V (2) is reported. Siamenoside I (1) was obtained by enzymatic hydrolysis of Mogroside V (2). Bioconversion process involved enzymatic modification followed by separation and purification processes, including reversed-phase chromatography. The final product, a dried white powder, undergoes several stages of concentration, r...
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DESIGN, SYNTHESIS, IN-SILICO STUDIES AND EVALUATION OF IN-VITRO ANTIDIABETIC ACTIVTY OF SOME NOVEL BENZIMIDAZOLE DERIVATIVES
New Benzimidazole derivatives were designed and synthesized. To explain the activity of new derivatives, we have explored the binding affinity of the compounds against α-amylase (PDB ID: 4W93), the target enzyme for the antidiabetic activity. α-amylase is considered as primary target because it converts starch into maltose, which is followed by the production and transportation of the glucose in...
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CHARACTERIZATION AND ANTIBACTERIAL EFFICACY OF ALBIZIA AMARA MEDIATED BIOGENIC SILVER NANOPARTICLES
Green Nanotechnology techniques have emerged in response to the growing need for sustainable and eco-friendly approaches to synthesize nanoparticles. The present study provides an endurable procedure for the green-mediated synthesis of silver nanoparticles (AgNPs) from Albizia amara leaf extract and its antibacterial potential. Various techniques like UV-Vis spectroscopy, FT-IR, XRD and FE-SEM wer...
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MOLECULAR MAVERICKS: EXPLORING CARBAMATE-HETEROCYCLE CONJUGATES IN THE QUEST FOR EFFECTIVE ALZHEIMER’S THERAPY
Alzheimer’s Disease is considered as the most common form of dementia, contributing to about 70% of the cases. The FDA approved Acetyl cholinesterase inhibitors and NMDA receptor antagonists only produce a symptomatic relief and raises the need for novel potential drug candidates for AD management. The various hypotheses on Alzheimer’s Disease reveal its multifactorial nature and thus these mu...
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FORMULATION AND EVALUATION OF HERBAL TREATMENT OF VITILIGO
Vitiligois depigmentation disorder, and it causes loss of melanocytes. Denaturation of melanocytes caused by oxidative stress, genetics, auto immune response and then synthesis of inflammatory mediators. Vitiligo is classified into two types segmental and non-segmental. There is various treatment to cure vitiligo and some treatment causes side effects. So, through herbal plants we can cure the dis...
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IN-VITRO HEPATOPROTECTIVE ACTIVITY OF METHANOLIC LEAF EXTRACT OF MURRAYA KOENIGII AGAINST CCL4 INDUCED HEPATOTOXICITY IN GOAT LIVER SLICE CULTURE
The purpose of the current investigation was to evaluate the hepatoprotective activity of methanolic leaf extract of Murraya koenigii in goat liver slice culture against carbon tetrachloride (CCl₄)-induced hepatotoxicity. The amount of cell damage caused by CCl₄ was measured by the release of marker enzymes such as alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase ...
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A PROSPECTIVE COHORT OBSERVATIONAL STUDY ON TYPE OF LOWER URINARY TRACT SYMPTOMS IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA
Patients with diagnosed BPH, suffer very frequently from lower urinary tract symptoms (LUTS). It is very crucial to find the types, prevalence, and impact of LUTS in association with age, glycaemic index, and modifiable risk factors for developing targeted management strategies. The research seeks to determine types of LUTS present in BPH patients across various age groups and their impact on QoL;...
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PREPARATION OF TWO NEW DERIVATIVES OF ELLAGIC ACID AND IN-SILICO STUDIES OF THEIR DRUG LIKE PROPERTIES
Till the nineteenth century, people worldwide were relying on herbal medicines for their health problems. Today, it is common knowledge that different parts of plants contain various phytochemicals. Phytochemicals exhibit variety of physiological activities and health benefits. Due to the side effects shown by synthetic medicines, there is increased interest in phytopharmaceuticals. There are many...
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EVALUATION OF KNOWLEDGE AND PERCEPTION AMONG THE PHARMACY STUDENTS ON USE OF PROBIOTICS AS AN ADJUNCT THERAPY WITH ANTIBIOTICS
The use of antibiotics to treat infections requires treatment of microbial communities in the gut which causes antibiotic-associated diarrhea (AAD) as a side effect. The number of people using probiotics to manage these effects remains low because there is insufficient awareness of their proper usage. An investigation examines pharmacy student understanding and perceptions about the co-administrat...
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PRONIOSOMAL GEL- AN EFFECTIVE TOOL FOR THE ENHANCED TOPICAL DELIVERY OF ECONAZOLE NITRATE
The use of topical drug delivery systems is becoming increasingly popular due to their convenience and effectiveness. However, the potential of proniosomal gel for delivering econazole nitrate topically has not been widely studied. This study focuses on designing and optimizing a proniosomal gel formulation of econazole nitrate to improve antifungal therapy. The proniosomal gel was prepared using ...
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SIMULTANEOUS ESTIMATION AND QUANTIFICATION OF ROSUVASTATIN AND FENOFIBRATE USING HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY (HPTLC) IN PHARMACEUTICAL DOSAGE FORM
A sensitive, specific and precise HPTLC method for simultaneous estimation of Fenofibrate and Rosuvastatin has been developed and validated. The method employed aluminium plates pre-coated with silica gel 60 F254 as the stationary phase. The solvent system consisted of n-Hexane: Acetone: Ethyl acetate: Glacial acetic acid (4: 5: 0.9: 0.1, v/v/v/v) which was found to give compact and dense spots fo...
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COST VARIATION ANALYSIS OF VARIOUS ANGIOTENSIN RECEPTOR BLOCKERS AVAILABLE IN THE INDIAN MARKET
Background: Analysis of price inconsistencies among various brands guides prescribing physicians. A cost-effective prescribing pattern safeguards good patient compliance and better treatment outcomes. Aims and Objectives: The study aimed to analyze the cost variation of different angiotensin receptor blockers available in the Indian market. Materials and Methods: The prices of angiotensin receptor...
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EVALUATION OF ANTIMICROBIAL ACTIVITY OF DIFFERENT EXTRACTS OF DATURA STRAMONIUM AGAINST MYCOBACTERIUM KANSASII
The aim of this study is to assess the antibacterial efficacy of the Datura stramonium seeds and leaves extracts against Mycobacterium kansasii. The antimicrobial experiments were performed using five doses (0.25µg/ml, 0.50µg/ml, 1µg/ml, 2µg/ml, 4µg/ml) of seeds and leaves extracts. The results showed notable inhibitory effects on Mycobacterium kansasii. The results indicated that the extract...
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IN-SILICO DESIGN, SYNTHESIS AND CHARACTERIZATION OF NOVEL COUMARIN DERIVATIVES AS EGFR INHIBITORS
In the search for novel anticancer drugs, coumarin derived chalcones were analysed using in-silico tools like chemdraw, chemsketch, molinspiration, CASTp, Argus lab etc. Epidermal growth factor receptor protein is involved in cell signaling pathways that control cell division and survival. Molecular docking studies of test compounds with the EGFR tyrosine kinase domain (PDB ID: 6LUD) protein provi...
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PERCEPTION ABOUT HEALTH STATUS, SELF MEDICATION PRACTICE AND QUALITY OF LIFE OF ADOLESCENTS IN WEST TRIPURA: A CROSS-SECTIONAL STUDY
Background: The study has been carried out to assess the perception health status, self-medication practice and quality of life of adolescents in West Tripura and to find out the factors affecting them. Methods: A cross-sectional study has been carried out in West Tripura district. The students of all the schools of randomly selected sub-division were the study population. For data collection, SF-...
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COMPARATIVE STUDY OF OXIDATION OF L-CYSTEINE AND DL- METHIONINE BY POTASSIUM PERMANGANATE IN ALKALINE MEDIUM
Kinetics of oxidation of L-cysteine and DL- Methionine by potassium permanganate in alkaline medium was studied spectro-photometrically at room temperatue. The reaction was found to be of first order with respect to amino acid, zero order with respect to oxidant and fractional order dependence on Alkali. It was found that the rate of the reaction increases with increase in concentration of [OH-]. ...
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EVALUATION OF ERRORS AND COMPLETENESS OF RESEARCH APPLICATION FORMS SUBMITTED TO THE INSTITUTIONAL ETHICS COMMITTEE (IEC) OF A TERTIARY CARE INSTITUTION: AN OBSERVATIONAL STUDY
Introduction: IECs seek a duly filled application form to provide the overview of the study as per ICMR guidelines in the process of review and to maintain study related records. Aim and Objectives: To evaluate the errors and completeness of research application forms submitted to IEC. Materials and Methods: The present study was undertaken after obtaining approval from IEC, GMC, Kathua. Applicati...
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GC-MS/MS: A TARGETED QUANTIFICATION OF POTENTIAL NITROSAMINE IMPURITIES IN APIXABAN
The detection and quantification of nitrosamine impurities in pharmaceutical products are critical due to their potential carcinogenicity. This study presents the development of a sensitive Gas Chromatography-Mass Spectrometry (GC-MS) method for the analysis of nitrosamine impurities in Apixaban drug substance. The method demonstrates high specificity, sensitivity, and compliance with regulatory g...
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A RETROSPECTIVE STUDY ON THE PATTERNS OF CERVICAL PAP SMEAR FINDINGS IN DIABETIC AND NON-DIABETIC WOMEN AT A TERTIARY CARE HOSPITAL
Introduction: Carcinoma cervix is one of the most common cancers accountings for 15% of all the cancers diagnosed in women. Diabetes mellitus is considered a main factor that increases the propensity to get genital infections, especially when uncontrolled. This analysis allowed us to identify an intriguing pattern that opens up new avenues for investigation. Aims and Objectives: To study the PAP s...
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