Volume 16 (2025) - Issue 5, May
Review Articles
EPLONTERSEN: A NEW HOPE FOR CARDIAC COMPLICATIONS IN ATTR POLYNEUROPATHY
Transthyretin is essential for transporting retinol and thyroxine, produced mainly in the liver. TTR amyloidosis occurs when misfolded TTR aggregates form amyloid fibrils, leading to organ dysfunction. FAP (Familial amyloid polyneuropathy linked to mutations like the V30M variant, causes progressive sensory and autonomic neuropathy with a poor prognosis if untreated. TTR-related cardiomyopathy inv...
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A HOLISTIC PERSPECTIVE ON PSYCHOGENIC MALADY: ALZHEIMER
Alzheimer’s disease (AD) is an irrevocable most run-of-the-mill neurodeteriorating disease which comprises of lapses in the memory due to the disfigurement of synapse & neurons that leads to numerous types of dementia. As per the outline via (WHO) ICD-10 Mental & Behavioural Classification of Dementia, AD is persuaded by distinctive peculiarities of encephalon by either accretion of Amyl...
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ADVANCING DERMATOLOGICAL CARE: THE ROLE OF MICROSPONGES IN PERSONALIZED TOPICAL TREATMENT
Personalized medicine represents a transformative approach in healthcare, particularly in dermatology, where treatments are tailored to individual patient profiles. Microsponges, as advanced drug delivery systems, offer significant advantages in this context by enhancing the efficacy and safety of topical treatments. This review explores the fundamentals of microsponges, their mechanisms of drug l...
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URINARY DYNAMICS IN CHRONIC KIDNEY DISEASES
This review explores the intricate physiology of urine formation and its critical relationship with chronic kidney disease (CKD). Urine formation involves three key processes: glomerular filtration, tubular reabsorption, and tubular secretion, which work together to maintain homeostasis by regulating fluid balance and waste elimination. In CKD, these functions are impaired due to progressive damag...
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A REVIEW ON RECENT ADVANCEMENT IN PORTABLE BIOSENSOR FOR HEALTH MONITORING
The use of biosensors and devices as instruments for health, education, and prevention has garnered a lot of attention in recent years. Personalized therapy depends on accurate and timely monitoring of biological markers and drug effectiveness, which is made feasible by biosensing devices in medications. The creation of the first real biosensor for oxygen sensing touches on the idea of biosensors....
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ARTIFICIAL INTELLIGENCE IN DRUG DEVELOPMENT
Artificial intelligence (AI) is rapidly transforming the drug development process, offering innovative solutions to streamline and accelerate the discovery of new therapeutics. Traditionally, drug development has been a time-consuming and costly endeavor, often taking over a decade and billions of dollars to bring a drug to market. AI, with its ability to analyze vast amounts of complex data, has ...
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MACHINE LEARNING STRATEGIES FOR DRUG DISCOVERY AND DEVELOPMENT
This review paper provides a comprehensive overview of the role of machine learning (ML) in drug discovery and development within the pharmaceutical industry. It begins by outlining the foundational concepts of machine learning, highlighting its ability to enhance decision-making and improve accuracy through data analysis. The paper emphasizes the growing adoption of ML techniques across the pharm...
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KASABACH-MERRITT SYNDROME – A COMPREHENSIVE REVIEW
Haemangiomas are vascular lesions caused by abnormal blood vessel proliferation, especially in children. Kasabach-Merritt syndrome (KMS) is a rare and life-threatening thrombocytopenia and consumptive coagulopathy associated with aggressive vascular tumors in infancy and younger children. Kasabach-Merritt phenomena is a unique phenomenon in kaposiform hemangioendotheliomas (KHE) and tufted angioma...
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PHARMACEUTICAL AND BIOMEDICAL WASTE MANAGEMENT: AN OVERVIEW ON PLANT LAYOUT AND LOCATION
Biomedical and Pharmaceutical waste management is essential for safeguarding public health as well as environmental sustainability. Efficient waste management systems are crucial to minimize the adverse impact of biomedical waste. This article gives the key aspects of bio- medical and pharmaceutical waste management including plant location, land requirement, area, machines and equipment, infrastr...
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ENDANGERED ETHNO-MEDICINAL PLANT, CORDIA MACLEODII (GRIFF.) HOOK. F. AND THOMSON –– A BRIEF REVIEW
Cordia macleodii is an endangered ethnomedicinal plant found in dry deciduous forest areas of India. It is one of the 13 species belonging to the genus Cordia of the Boraginaceae family, commonly known as Dahipalas or Dahiman. The main identifying feature of this plant is that any injury to the adaxial surface of the leaf will result in persistent black markings. This plant species is at risk of e...
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TECHNOLOGICAL INNOVATIONS FOR MANAGEMENT OF KIDNEY STONE
The kidney is an important organ in waste filtration, plays a central role in maintaining body homeostasis. The management of kidney stones includes several techniques over the period of time which involve Percutaneous Nephrolithotomy (PCNL), Shock wave lithotripsy (SWL) and Ureteroscopy (URS). Ureteroscopy has undergone considerable innovations over the last few decades. Laser technologies have f...
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RECENT ADVANCES IN ORAL THIN FILM DRUG DELIVERY SYSTEMS: A REVIEW
Several fast-dissolving drug delivery systems have been designed to address issues like accurate dosing in liquid dosage formulation (suspension, emulation, syrup etc.) and swelling problems in solid dosage form (capsule, Tablet etc.). To fill these gaps fast-dissolving drug delivery system have been designed to address these issues. Biggest advantage of having Oral thin Film is, it can be taken w...
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SIGNIFICANT PROGRESS IN THE TREATMENT OF EXTRAPULMONARY TUBERCULOSIS: A COMPREHENSIVE REVIEW
Extrapulmonary tuberculosis (EPTB) accounts for a significant proportion of TB infections worldwide; however, its diverse clinical manifestations and tissue-specific involvement make diagnosis and treatment challenging. Recent years have seen substantial improvements in both the diagnosis and treatment of EPTB. Bedaquiline, delamanid, and pretomanid have revolutionized the treatment of multidrug-r...
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ADAPTING AYURVEDA FOR SPACE EXPLORATION: WELLNESS STRATEGIES BEYOND EARTH
Introduction: The space environment induces distinct modifications in astronaut physiology that necessitate the attention of medical professionals and researchers. These alterations stem from various space related factors including radiation, disrupted sleep-wake cycles and notably the absence of Earth's gravitational pull, which has traditionally been crucial for establishing normal bodily functi...
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Research Articles
A UNIQUE POLYHERBAL FORMULATION FOR COGNITIVE ENHANCEMENT AND MENTAL HEALTH SUPPORT
In an increasingly fast-paced world, the rising prevalence of anxiety and mental health disorders highlights the critical need to preserve cognitive well-being. While mental illnesses often result from complex biological, psychological, and environmental interactions, their precise origins remain elusive. Conventional medicine offers various treatments, but alternative approaches, like nervine ton...
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COMPARATIVE STUDY ON SAFETY AND EFFICACY OF THE DECOCTIONS OF SESAMUM INDICUM, NIGELLA SATIVA AND ITS COMBINATION ON POLYCYSTIC OVARY SYNDROME
This study investigated the efficacy and safety of three herbal decoctions for managing Polycystic Ovary Syndrome (PCOS), a condition affecting 2–26% of women globally and considered incurable within allopathic medicine and offers symptomatic treatments. This randomized, single-blind clinical trial, conducted between February 2022 and June 2024, enrolled 90 PCOS patients diagnosed by the Rotterd...
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REMARKABLE ANTI-TRYPANOSOMA CRUZI ACTIVITY IN SELECTED SALVADORAN PLANT SPECIES
In Latin America, Chagas is one of the most prevalent diseases, and current chemotherapy with benznidazole and nifurtimox is ineffective in chronic phase. Therefore, the development of new drugs, especially for the chronic stage of the infection, is urgently needed. Performing an in-vitro anti-trypanosome assay, we analyzed 114 plant species from Salvadoran flora, resulting in 34 active plants aga...
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OPTIMIZATION OF THE GROWTH CONDITIONS FOR THE ENHANCED PRODUCTION OF ANTI-DIABETIC MOLECULE BY PENICILLIUM SP
Diabetic mellitus, a prevalent metabolic disorder characterized by chronic hyperglycaemia, poses significant health challenges globally. This study focused on optimizing growth parameters to enhance the anti-diabetic activity of Penicillium sp 8, isolated from paddy soil. Initial screening of different media revealed that Potato Dextrose Broth (PDB) exhibited the highest anti-diabetic activity. Su...
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CEREBROVASCULAR ACCIDENT ASSOCIATED HEMIPARESIS AND HEMIPLEGIA: COPING STRATEGIES AND SUPPORT
Background: Cerebrovascular Accident (CVA) ranks as the third leading cause of mortality globally and contributes significantly to chronic adult disabilities. Hemiparesis, the most prevalent post-stroke mobility impairment, affects approximately 75% of stroke survivors, substantially reducing their quality of life. This study aims to investigate CVA-associated Hemiparesis and Hemiplegia, focusing ...
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COMPARATIVE ANALYSIS OF THE BACTERICIDAL AND ANTIBIOTIC MODULATORY ACTIVITIES OF THE STEM BARK EXTRACTS OF GMELINA ARBOREA ROXB AND OROXYLUM INDICUM (L.) KURZ
Medicinal plants play pivotal roles in novel drug discovery or combinatorial drug surveillance against emerging infectious diseases. This study aims to explore and compare the bactericidal and antibiotic modulating activities of stem barks of Gmelina arborea Roxb. and Oroxylum indicum (L.) Kurz against two pathogenic bacterial strains, i.e., Escherichia coli and Staphylococcus aureus. Methanolic s...
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APPLICATION OF QbD APPROACH FOR ROBUST ANALYTICAL METHOD DEVELOPMENT OF SUNITINIB MALATE BY UHPLC
Objective: Sunitinib malate is an oral, potent multi-targeted TKI that displays antitumor and anti-angiogenic actions. The core focus of the present research work is to establish an innovative QbD-based analytical method for the estimation of Sunitinib malate in solid dosage form by ultra-high performance liquid chromatography (UHPLC). Materials and Methods: The change in independent variables, wa...
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DEVELOPMENT AND IN-VITRO ASSESSMENT OF A BILAYER TABLET FOR GLIBENCLAMIDE AND PIOGLITAZONE HCL: A NOVEL APPROACH TO DIABETES MANAGEMENT
The research study aims to prepare and characterize bilayer tablets that combine Glibenclamide, a sulphonyl urea and Pioglitazone HCl, a thiazolidinedione for enhancing glycaemic control in Type 2 Diabetes. The bilayer design incorporates an immediate-release layer of Glibenclamide for rapid onset of action and a sustained-release layer of Pioglitazone HCl to maintain prolonged therapeutic levels....
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A COMPARATIVE STUDY: QUALITY OF WATER PURIFIED WITH TERMINALIA CHEBULA AND TERMINALIA BELLERICA BASED ON THE TRADITIONAL EVIDENCE FROM SIDDHA LITERATURE
Water is an essential ingredient for all living things to exist on earth. Ancient Siddha texts suggest that soaking some therapeutic plants may purify water. The current study aims to assess the water quality after being soaked with Terminalia chebula (Kadukkai) and Terminalia bellerica (Thantrikkai). Three distinct pots containing two liters of drinking water each were taken from Chembaramapakkam...
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SEROPREVALENCE AND CLINICO-EPIDEMIOLOGICAL PROFILE OF CHRONIC HEPATITIS B AND C PATIENTS IN A TERTIARY HOSPITAL
This descriptive observational study was conducted at Government Medical College and Dr. Susheela Tiwari Memorial Government Hospital, Haldwani, Uttarakhand, to evaluate the seroprevalence and clinico-epidemiological profile of chronic Hepatitis B (HBV) and Hepatitis C (HCV) among patients. Over a two-year period, 7,149 outpatients were screened, identifying 38 HBV-positive cases (0.53%) and 141 H...
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IN-VITRO PHARMACEUTICAL QUALITY CONTROL TESTING: A COMPARITIVE STUDY OF JANAUSHADHI ORAL ANTIDIABETIC DRUGS WITH REPUTED BRANDS AVAILABLE IN INDIA
This study evaluates the pharmaceutical quality of metformin tablets, both generic and branded, available in India. Metformin, a primary medication for managing type 2 diabetes was chosen due to its widespread use and critical role in diabetes treatment. Using in-vitro methods compliant with Indian Pharmacopoeia standards, several quality control parameters were assessed, including hardness, friab...
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FACILE SYNTHESIS OF ZN-AG DOPED FUNCTIONAL NANOPARTICLES BY CO-PRECIPITATION TECHNIQUE USING TAMARINDAS INDICA LEAVES & THEIR ANTIMICROBIAL APPLICATIONS
The synthesis of metal oxide nanoparticles has emerged as a burgeoning field of research due to its promising applications in advancing technological frontiers. Particularly, the utilization of biologically derived nanomaterials has gained significant traction within the realm of nanotechnology. Tamarindus indica plant extract has demonstrated efficacy as a viable precursor for the synthesis of si...
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ANTIMICROBIAL PROFILE OF SALMONELLA SPECIES ISOLATED AT TERTIARY CARE HOSPITAL WESTERN INDIA
Background & Objective: India is home to two infectious diseases caused by Salmonella: typhoid and paratyphoid fever. The medication of choice for S. typhi is ceftriaxone, a third-generation cephalosporin. Study was carried out on the Surveillance of Enteric Fever in India to ascertain the prevalence, clinical manifestation, and trajectory of antimicrobial resistance (AMR). This work aimed to ...
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COMPARATIVE ANALYSIS OF NUTRITIONAL PROPERTIES, SYNTHESIS OF PECTIN, RESINS AND GREEN SURFACTANT FROM THREE VARIETIES OF MORINGA OLEIFERA LEAVES
In the present era, plant derived green products are gaining a lot of importance due to their ecofriendly nature, unique chemical compositions and mode of action. In the present study, three varieties of Moringa oleifera, namely Shyama- black color variety (most found), Shveta - white color variety and Rakta - red color variety (less found) were used for the synthesis of biosurfactant, pectins and...
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THE EFFECT OF INHALED CORTICOSTEROIDS ON ABSOLUTE EOSINOPHILS COUNT
Background: Patients with respiratory diseases are frequently treated with inhaled corticosteroids (ICS) to lower the likelihood of exacerbations. Research to date indicates that ICS treatment has a significant impact on eosinophils counts, which is a phenomenon with wider consequences. Therefore, to maximize the benefits of ICS therapy, it is necessary to investigate the intricate interplay betw...
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A STUDY ON PREVALENCE AND ANTIMICROBIAL RESISTANCE PATTERN OF ENTEROCOCCI ISOLATED FROM PATIENTS WITH BACTEREMIA IN A TERTIARY CARE HOSPITAL IN AHMEDABAD
Background: The emergence and spread of Vancomycin, Linezolid and combined linezolid/vancomycin resistance in Enterococcus species (LVRE) is a major therapeutic challenge. Vancomycin-resistant Enterococci are an important cause of healthcare-associated infections. Linezolid and Teicoplanin are currently approved for the treatment of VRE; however, resistance to these antimicrobials appears to be i...
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TO REPORT THE PHYTOCHEMISTRY & PHARMACOLOGICAL (ANTIPYRETIC ACTIVITY) POTENTIAL OF QUERCETIN & CRUDE EXTRACT OBTAINED FROM CYNODON DACTYLON: AN INDIAN DOAB GRASS
The research rigorously investigates the bioactive potential of Cynodon dactylon, specifically focusing on its antipyretic properties attributed to quercetin, a flavonoid compound. Cynodon dactylon, a perennial grass, has been traditionally used in various medicinal practices, prompting scientific inquiry into its pharmacological benefits. The study involved meticulous extraction and isolation of ...
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ARETROSPECTIVE OBSERVATIONAL STUDY: EVALUATING THE APPROPRIATENESS OF ANTIBIOTIC DOSING IN CHRONIC KIDNEY DISEASE PATIENTS AT A TERTIARY CARE HOSPITAL
The renal system helps in the urinary excretion of drugs in unchanged form or metabolites. Since a majority of the drugs are eliminated by the kidneys, impairment in renal function can lead to drug accumulation, toxicity, and therapeutic failure. As a result, patients with impaired renal function require careful dose modifications. The purpose of this study was to determine the most frequently pre...
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DRUG-INDUCED URTICARIA: IMPLICATED DRUGS, REACTION RECOVERY TIME AND CAUSALITY ASSESSMENT -A FIVE-YEAR RETROSPECTIVE STUDY
Introduction: Cutaneous Adverse drug reactions presenting as urticaria are the most frequent local and systemic adverse reactions (ADR). Urticaria is a skin disorder resulting from the vascular reaction of the skin characterized by erythema and wheal formation due to a localized increase of vascular permeability. It affects up to 20 % of the population at some point during their life and can be ac...
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PHYTOCHEMICAL SCREENING AND EVALUATION OF ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF DIFFERENT PARTS OF OLAX DISSITIFLORA OLIVER (MUSSIRO)
Pharmaceutical sciences face challenges related to antibiotics toxicity and microorganism resistance. Olax dissitiflora (mussiro) is traditionally used in Mozambique for skin diseases treatment and beauty. The research aims to bring scientific studies for its antimicrobial and antioxidant properties. The hydroethanolic extracts of leaves, stem and stem bark of Olax dissitiflora species were evalua...
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