Volume 5 (2014) - Issue 5, May
Review Articles
ADVANCEMENT IN ENDOPHYTIC MICROBES FROM MEDICINAL PLANTS
This overview firstly highlights biology of endophytic microbes from medicinal plants as well as their chemistry with emphasis on the important merging of microbiology and natural products chemistry and its role in improving our current knowledge of endophytic associations in medicinal plants. Secondary metabolites of medicinal plants-derived endophytes reported in recent years are grouped accordi...
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ACHYRANTHES ASPERA: A POTENT IMMUNOSTIMULATING PLANT FOR TRADITIONAL MEDICINE
Achyranthes aspera L. (family: Amaranthaceae), an erect and much branched diffuse herb is a medicinal plant, frequently found in tropical and warmer regions as weed. The plants are reported to contain following major classes of compounds: fatty acids, a number of oleonic acid, bisdesmosidic, triterpenoid based saponins, ecdysterone, n-hexacos-14- enoic, oleanolic acid, triacontanol, spinasterol,di...
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A REVIEW ON ANTI-VENOM ACTIVITY OF SOME MEDICINAL PLANTS
In almost every part of the world, where venomous snake occur, numerous plant species are used as folk medicine to treat snake bite. The mortality associated with snake bites is a serious public health problem as the estimated death incidence per year is about 1,25,000 globally. In India, about 35,000 to 50,000 people reportedly die of snake bite; although, unreported cases may be even more in rur...
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ANTIEMETIC DRUGS AS A NASAL DRUG DELIVERY – A REVIEW
Antiemetic drugs are used in the treatment of nausea and emesis. Development of novel delivery systems for antiemetic drugs, as an alternative to conventional preparations, is essential in terms of good patient compliance and improving bioavailability. The nasal route offers exclusive superiorities, such as rapid and high drug absorption, and high patient compliance. Consequently, a considerable a...
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A COMPREHENSIVE REVIEW: BERGENIA LIGULATA WALL – A CONTROVERSIAL CLINICAL CANDIDATE
Bergenia ligulata Wall is considered amongst the high valued medicinal herbs and one of the important examples of controversial drugs which is popularly known as ‘Paashanbheda’ (meaning ‘to dissolve the stone’) in Indian systems of medicine. The phytochemical studies have shown the presence of many secondary metabolites belonging to coumarins, flavonoids, benzenoids, lactone, carbohydrate,...
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RECENT TRENDS IN PROBIOTICS AND HEALTH MANAGEMENT: A REVIEW
Probiotics are defined as “Live microorganisms” which when administered in sufficient amounts confer a health benefit to the host. They are consumed as microbial food supplements.The mechanism of action of probiotics is associated with their ability to enhance immune response, compete with pathogenic microbes for adhesion sites, to antagonize these pathogens and production of antimicrobial sub...
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EMULGEL: AN EMERGENT TOOL IN TOPICAL DRUG DELIVERY
In comparison among the other groups of semisolid preparations, the use of gels has been emerged both in cosmetics and in pharmaceutical preparations because of its unique array of features. Despite of providing several benefits the category gel faces limitations in delivering hydrophobic drug molecules via skin. So in order to cover up this lacking a recent emulsion based approach is bein...
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CONTROLLED DRUG RELEASE FOR POORLY WATER SOLUBLE DRUGS- A ROLE OF POLYMERIC NANOPARTICLES
In the treatment of health related dysfunctions, it is desirable that the drug reaches its site of action at a particular concentration and that this therapeutic dose range remains constant over a sufficiently long period of time to alter the process. Delivery of hydrophobic molecules and proteins has been an issue to poor bioavailability following administration. Thus, micelle carrier systems are...
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Research Articles
THE EFFECT OF DI-BUTYL PHTHALATES (DBP) AND DI (2-ETHYLHEXYL) PHTHALATES (DEHP) ON FEMALE RATS FERTILITY
Phthalate esters are industrial chemicals widely used in cosmetics, plastics bottles and medical devices, and the risk of exposure to phthalates is on the increase. In recent years, many studies have been carried out on the possible health hazards of phthalates, including the effect on reproduction. In this studyrats were injected twice weekly with Di-butyl Phthalates (DBP) or Di (2-Ethylhexyl) ...
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PHYTOTHERAPY AS NEW APPROACH TO TREAT SCORPION ENVENOMATION: EXPERIMENTAL STUDY
Citrullus colocynthis is a wild common plant in arid and semi arid areas of Algeria which are characterized by high incidence of scorpion envenomation. It is used in Algeria to treat many diseases. In order to optimize and develop new therapeutic strategies for scorpion envenoming, a phytotherapeutic approach has been investigated. Pharmacological properties of Citrullus colocynthis were evaluated...
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PREPARATION AND CHARACTERIZATION OF SOLID LIPID NANOPARTICLES THROUGH RAPID EXPANSION OF SUPERCRITICAL SOLUTION
Rapid expansion of supercritical solution (RESS) has provided a promising alternative to produce ultrafine particles of heat-sensitive materials. Stearic acid is a good lipid for development of solid lipid nanoparticles (SLNs) in drug delivery systems. Therefore, currently, much research on the micronization of stearic acid is going on. In this study, formation of submicron stearic acid was report...
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SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL ACTIVITIES OF PYRIMIDINE DERIVATIVES CONTAINING 2-PYRAZOLIN-5-ONE
A new series of thiazolo [3',2';1,2] pyrimido [5,4,e] pyrimidines and thiazolo [3',2';1,2] [1,2,4] triazolo [3'',4''-c]pyrimido [5,4-e] pyrimidines linked to 2-pyrazolin-5-one moiety were prepared by derivatization of the hydrazine functionality of the heterocyclic hydrazine with various reagents. The newly synthesized compounds were characterized by elemental analyses and spectroscopic techniques...
3029
0
PHYSICAL-CHEMICAL CHARACTERIZATION, ANATOMICAL AND SEASONAL EVALUATION OF THUJA OCCIDENTALIS L. (CUPRESSACEAE)
Thuja occidentalis L. is a plant widely used therapeutically. Having seen the necessity to standardize the vegetal drug and to evaluate the interference of certain environmental and seasonal factors on the synthesis of metabolites, notably flavonoids, this work considered anatomical and physical-chemical characterization assays for the aforesaid vegetal drug, in addition to phytochemical prospecti...
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IN VITRO SUSCEPTIBILITY OF PLASMODIUM FALCIPARUM TO LUMEFANTRINE AND ANALYSIS OF POLYMOPHYSIMS IN PFMDR-1 GENE ISOLATES FROM ABIDJAN (CÔTE D’IVOIRE)
Context: Malaria endemic disease remains the most common tropical parasitic disease in the world. According to the World Health Organization (WHO), malaria is the first endemic disease of which humanity is paying a heavy price. Malaria is a major public health problem in Côte d'Ivoire. Objective: To evaluate the in vitro chemosensitivity to Lumefantrine (LUM) and analyze Pfmdr-1gene polymorphism ...
2891
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PHYTOCHEMICAL ANALYSIS, TOXICITY AND ANTIBACTERIAL ACTIVITY OF BENIN MEDICINAL PLANTS EXTRACTS USED IN THE TREATMENT OF SEXUALLY TRANSMITTED INFECTIONS ASSOCIATED WITH HIV/AIDS
Phytochemical screening of thirteen medicinal plants used in the treatment of sexually transmitted infections (STI), HIV/AIDS in Benin, showed that mucilage, gallic tannins and anthocyanins were the most common chemical groups. Water-ethanol (HE): 4/6 v/v, aqueous (A) and dichloromethane (DCM) extracts were prepared for each plant and tested for toxicity against shrimp larvae (Artemia salina Leach...
4247
1925
POLYMERIC NANOPARTICLES AS POTENTIAL CARRIERS FOR TOPICAL DELIVERY OF COLCHICINE: DEVELOPMENT AND IN VITRO CHARACTERIZATION
The aim of the present study is to develop a nanoparticle formulation as a potential carrier for topical drug delivery. Colchicine loaded Nanoparticles (Colchicine-NPs) were prepared by the double emulsion solvent evaporation method using biodegradable and non biodegradable polymers alone or as binary mixtures. Based on the evaluation of the entrapment efficiency, the particle size and the % drug ...
3697
2263
SOME TRANSITIONAL METAL IONS COMPLEXES WITH 3-{[(E)-(4-FLUOROPHENYL) METHYLIDENE] AMINO} BENZOIC ACID AND ITS MICROBIAL ACTIVITY
Some transitional metal ions complexes with 3-{[(Z)-(4-hydroxyphenyl) methylidene] amino} benzoic acid with general formula [M(L2)xH2O], [where M = Mn(II),Co(II), Ni(II),Cu(II), Zn(II), Pd(II) and Pt(II)metal ions and L=3-{[(E)-(4-fluorophenyl) methylidene] amino} benzoic acid ] have been synthesized and characterized on the basis of elemental analysis, conductance, magnetic susceptibility, IR...
2701
1250
DESIGN AND EVALUATION OF DICLOFENAC SODIUM BUCCAL MUCOADHESIVE FILM BY SOLVENT CASTING TECHNIQUE
Mucoadhesive buccal patches containing diclofenac sodium were prepared using the solvent casting method. HPMC used as bioadhesive polymer and different ratio of propylene glycol and glycerin also used. FT-IR and UV spectroscopic methods revealed that there is no interaction between Diclofenac sodium and polymers. The patches were evaluated for their physical characteristics like mass variation, dr...
5802
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ANTIDIARRHOEAL ACTIVITY OF LEAF EXTRACT OF ANOGEISSUS LATIFOLIA WALL IN EXPERIMENTALLY INDUCED DIARRHOEA IN RATS
Aim: To evaluate the antidiarrhoeal activity of methanolic leaf extract of Anogeissus latifolia. Material and Methods: The methanolic extract was evaluated using rodent animal models like castor-oil induced diarrhoea and castor-oil induced enteropooling. The phytochemical constituents were also planned to screen by using standardized methods. The plant is traditionally used for the treatment of...
3719
1006
FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING FILMS OF MONTELUKAST SODIUM
Montelukast Sodium is a leukotriene receptor antagonist (LTRA) used for the treatment of asthma and to relieve symptoms of seasonal allergies. In present research work an attempt has been made to prepare mouth dissolving films of Montelukast Sodiumwere prepared using different polymers like PVA, HPMC by solvent casting method. The fast dissolving oral film evaluated for folding endurance, swelling...
7268
3842
A PHARMACOPHORE BASED DRUG DESIGN APPROACH TO OVERCOME IMATINIB RESISTANCE AND GET MORE POTENT BCR-ABL TYROSINE KINASE INHIBITOR
BCR-ABL Tyrosine Kinase inhibitor is an ideal pharmacological target for Chronic Myeloid Leukemia (CML). After the effective use of Imatinib as a therapeutic agent for Chronic Myeloid Leukemia, resistance has been observed in much patience with the treatment of Imatinib. The main objective of this study is to develop some new novel BCR-ABL Tyrosine Kinase inhibitor for the treatment of Chronic Mye...
4424
1352
FORMULATION AND FINDING OUT THE EFFICACY OF THE HERBAL HAIR OIL OVER SIMPLE COCONUT OIL (PURIFIED) – A FORMULATION AND CLINICAL STUDY IN BANGLADESH
Hair fall is a very common phenomenon and a matter of concern within whatever young or aged. This study is formulated a herbal hair oil and made a clinical trial over selected person under the research and development unit at Routi Herbal Limited. To see the efficacy of the experimental oil made up of Kala Jera Toil (Nigella sativa) Narkal Toil (Cocos nucifera) Amloki (Emblica officinalis) Henna (...
31174
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DESGINING, METHOD DEVELOPMENT AND STANDARDIZATION OF PROCESS FOR EXTRACTION OF MARKER COMPOUND FROM TERMINALIA CHEBULA FRUIT
The present study is done to study and optimize the process of enzyme-assisted extraction of Chebulinic acid from the dried fruit of Terminalia chebula. A selective extraction process after the treatment with enzymes is proposed by using 30% (v/v) methanol which releases increased yield of the Chebulinic acid, present in the dried fruit compare to aqueous extract. The optimal conditions were as fo...
3715
1418
AN IN SILICO STUDY ON HIV-1 PROTEASE WILD-TYPE AND MUTANT WITH INHIBITORS FROM ANNONA SQUAMOSA
Human immunodeficiency virus (HIV) is a lent virus that cause acquired immunodeficiency syndrome (AIDS), a state in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. HIV-1 protease is a retroviral aspartyl protease (retropepsin) that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV Wild type ...
2906
1627
EVALUATION OF ANTIOXIDANT POTENTIALS OF SELECTED INDIAN MEDICINAL PLANTS
Oxidative stress is found to be one of the major causes of health hazards in the present global scenario. The traditional herbs and medicinal plants have been investigated for the presence of natural antioxidants, which have incredible effects in the prevention of various oxidative stress associated diseases. The objective of present investigation is to assess the antioxidant capacity and phytoche...
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1135
EFFECT OF DIFFERENT EXCIPIENTS AND PACKAGING MATERIALS ON COMMERCIAL PREPARATION OF PROBIOTIC FORMULATION
Probiotic formulations are now widely accepted throughout the world for therapeutic applications as these organisms have a long history of safe use (GRAS). There are two main challenges to make a probiotic formulation viable for commercial utilization. The first one is the quality of health attributes that the probiotic organisms can confer and the second one is the stability of the formulation ti...
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ANTI-ULCER EFFICACY AND SAFETY OF ANDA LEGHYAM A POLYHERBAL SIDDHA FORMULATION
Anda leghyam (AL) a herbo-animal Siddha formulation is administered for Gunmam (Acid peptic diseases) by many Siddha physicians popularly. Anti ulcerogenic activity of the AL has been studied using Aspirin-Pylorus ligation induced gastric ulcer methods (four groups/method, n=6, Aspirin 400mg/kg, Omeprazole 10mg/kg, AL 250,500mg/kg) in wistar albino rat models. Animals were sacrificed and their sto...
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EVALUATION OF α – AMYLASE INHIBITORY ACTIVITY OF SOME CLINICALLY USED DRUGS
Finding out the alternative uses of the clinically proven and time tested drugs can be one of the best options for drug discovery research. In view of this the present study was carried out to evaluate α-amylase inhibitory activity of the some of the commonly used drugs. The drugs were procured as gift samples from pharmaceutical companies and were evaluated for in-vitro α-amylase inhibitory act...
8225
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ANTIOXIDANT ACTIVITY OF SOYMIDA FEBRIFUGA ROXB. A. JUSS
In this present study, we investigated the phytochemical constituents screening and in-vitro antioxidant activity of hydro-alcoholic (methanol 70%v/v) extracts of Soymida febrifuga bark. Soymida febrifuga is a huge tree bearing deciduous foliage and having a tough bark belonging to the family Meliaceae. Traditionally the different parts of plant such as root, leaves, bark, and flower are used for ...
6732
2217
EVALUATION OF ANTI ULCER AND IN-VITRO ANTIOXIDANT ACTIVITIES OF AQUEOUS AND METHANOLIC EXTRACTS OF NEOLAMARCKIA CADAMBA LEAVES AND BARK IN WISTAR ALBINO RATS
The antiulcer activity of Aqueous and Methanolic extracts of Neolamarckia cadamba leaves and bark was investigated in Pylorus ligation and Aspirin induced ulcer models in Wistar albino rats. In both models the common parameter determined was ulcer index. Aqueous extract of Neolamarckia cadamba leaves (AENCL) at dose of 200mg/kg and 400 mg/kg produced significant inhibition of gastric lesion induce...
4688
1850
ORAL DISSOLVING FILMS OF CHLORPHENIRAMINE MALEATE
In this present study, we investigated phytochemical constituents screening and In-vitro antioxidant activity of hydro-alcoholic (methanol 70%v/v) extracts of Soymida febrifuga bark. Soymida febrifuga is a huge tree bearing deciduous foliage and having a tough bark belonging to the family Meliaceae. Traditionally the different parts of plant such as root, leaves, bark, and flower are used for vari...
5434
3935
SYNTHESYS AND SCREENING OF ANALGESIC ACTIVITY OF SOME NOVEL PYRAZOLE
The present study was aimed to study the analgesic potency of some new pyrazole compounds. Various Quinazolinone clubbed Pyrazole derivative compounds (7a1, 7a2, 7b1, 7b2) were synthesized by using anthranilic acid as starting material as per standard chemical procedure. The synthesized compounds were characterized by physical and spectral analysis by using UV-visible spectrophotometer, Fourier tr...
3865
1457
PHYTOCHEMICAL SCREENING AND ANTIFUNGAL ACTIVITY OF SEMECARPUS ANACARDIUM L. (AN ANTI-CANCER PLANT)
The spread of antibiotic resistant pathogens is one of the most serious menaces to successful treatment of microbial diseases. Medicinal and aromatic plants are widely used as traditional medicines and constitute a major source of natural organic compounds. Semecarpus anacardium Linn (Family: Anacardium), is a plant well known for its medicinal value in Ayurvedic and Siddha system of medicine. The...
6288
2574
DEVELOPMENT OF VALIDATED RP-HPLC METHOD FOR QUANTITATIVE ESTIMATION OF RIVASTIGMINE HYDROGEN TARTRATE IN TRANSDERMAL DRUG DELIVERY SYSTEM
A fast simple sensitive precise, accurate and reproducible RP-HPLC method was developed and validated for the analysis of rivastigmine hydrogen tartrate in transdermal drug delivery system. Rivastigmine tartrate is soluble in water so it was used as solvent. The separation was conducted by using C-18 RP-HPLC column which was maintained at ambient temperature.The mobile phase consist 0.01M ammonium...
4709
2654
TOTAL PHENOLIC CONTENT AND ANTIOXIDANT POTENTIAL OF CUCURBITA MAXIMA (PUMPKIN) POWDER
As Antioxidant potential of many plants is mainly due to phenolic components such as phenolic acid, phenolic diterpense therefore total phenolic content and antioxidant potential of cucurbita maxima. (Pumpkin) powder was determined respectively by using Folin-Ciocalteu reagent and diphenyl-picryl-hydrazyl (DPPH) assay. In this method the antioxidants present in the plant extracts reacted with DPPH...
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EVALUATION OF PORTULACA OLERACEA LINN. FOR HYPOGLYCAEMIC EFFECTS
Hypoglycaemic and anti-hyperglycaemic effects of Portulaca oleracea Linn. (POL) was evaluated in experimental rat models in vivo. The aqueous extract of POL was subjected to preliminary toxicity screening by an acute toxicity study in Wister albino rats. The POL was found to be safe in the doses used and there was no mortality up to a dose of 3000mg/kg orally after 24 hours. Hypoglycaemic effect...
2963
1261
GC-MS PROFILING AND ANTHELMINTIC ACTIVITY OF ANTIGONON LEPTOPUS LEAVES
The study was designed to determine the phytocomponents and in-vitro anthelmintic activity of chloroform fraction of methanolic extract of Antigonon leptopus leaves. GC-MS analysis of chloroform fraction of the methanolic extract of Antigonon leptopuswas performed on a GC–MS equipment (Thermo Scientific Co. Thermo GC-TRACE ultra ver.: 5.0, Thermo MS DSQ II). The extract under study has been scre...
3943
2158
EVALUATION OF ANTIADIPOGENESIS ACTIVITIES OF SELECTED SPECIES OF CARALLUMA R. BR., BOUCEROSIA WIGHT & ARN. AND PREGNANE STEROID ON CELL LINES.
Back ground: The study was designed to determine antiadipogenesis properties of crude methanolic extracts from four species of Caralluma R.Br. such as Caralluma adscendens (Roxb.) R. Brown var. attenuata (Wight) Grav. & Mayur. (CAA), Caralluma adscendens (Roxb.) R. Brown var. fimbriata (Wall.) Gravely & Mayur. (CAF), Caralluma stalagmifera C.E.C. Fisch. (CS) and Caralluma stalagmifera C.E....
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1512
CATHEPSIN D LEVEL IN THE HUMAN GINGIVAL TISSUES AND SERUM OF PERIODONTITIS SUBJECTS
This study investigates the level of cathepsin D activity in the serum and gingival tissues of periodontitis subjects and healthy individuals. The cathepsin D activity (spectrophotometric assay) was measured in the gingival tissues and serum of control healthy individuals (group I) and periodontitis subjects (group II). Inflamed gingival tissue was obtained from 15 periodontitis patients (9 males ...
4755
1315
EVALUATION OF ACUTE TOXICITY STUDY AND HAIR GROWTH PROMOTING ACTIVITY OF TRICHUP TABLET
Hair loss problems can affect physical and mental health of human and have particular relevance during the aging process. In an effort to find solution of such problems, an attempt has been made to evaluate the hair growth promotion activity of a herbo-mineral Ayurvedic formulation, Trichup Tablet. Safety of drug was also evaluated by conducting acute toxicity study as per OECD guideline. For eval...
3968
1724
IN VITRO QUALITATIVE AND QUANTITATIVE PHYTOCHEMICAL ANALYSIS OF ETHANOLIC AND 50% ETHANOLIC EXTRACTS OF TINOSPORA CORDIFOLIA, MOMORDICA CHARANTIA, CUCURBITA MAXIMA AND RAPHANUS SATIVUS
Phytochemicals are non-nutritive chemical constituents of plants which occur naturally in it such as Steroid, Terpenoids, Tannins, Carotenoids, Flavonoids, Alkaloids and Glycosides. The aim of the present study was to carryout qualitative and quantitative phytochemical analysis of ethanolic and 50% ethanolic extracts of Tinospora cordifolia (stems), Momordica chirantia (fruit), Cucurbita maxima (f...
4060
4443
ISOLATION AND CHARACTERIZATION OF MICROBES PRODUCING BACTERIOCIN FROM CURD, RAW MILK AND SOIL AND ITS PRESERVATIVE EFFECTS
Bacteriocins are proteinaceous substance produced by bacteria to inhibit the growth of similar or closely related bacterial strains. They are typically considered to be narrow spectrum antibiotics produced by both gram negative and gram positive range of bacteria which possess antimicrobial properties and inhibitory towards sensitive strains. Bacterocins are safer than antibiotic. They can be used...
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FORMULATION AND DEVELOPMENT OF FLAVOXATE HYDROCHLORIDE EXTENDED RELEASE CAPSULES
Flavoxate Hydrochloride is an antispasmodic, mainly used for treating painful urination, urgency of urination and incontinence. The primary objective of the study was to formulate extended release capsules of Flavoxate hydrochloride to reduce dosing frequency and decreasing the associated side effects. The extended release capsules were formulated using extrusion spheronisation process with ethyl ...
3772
3321
IN VITRO ANTI-INFLAMMATORY AND ANTI-ARTHRITIC ACTIVITY IN METHANOLIC EXTRACT OF COCCULUS HIRSUTUS (L.) DIELS. IN VIVO AND IN VITRO
The present study deals with the in vitro anti-inflammatory and anti-arthritic activity in methanolic extracts of in vivo (leaf and stem) and in vitro (callus) plant parts of Cocculus hirsutus. The previous phytochemical analysis of methanolic extract of Cocculus hirsutus has indicated the presence of several physiologically active phytochemicals such as phenols, ...
6656
3402
SPECTROPHOTOMETRIC DETERMINATION OF MEROPENEM IN BULK AND INJECTION FORMULATIONS BY 1, 2 NAPHTHO QUINONE 4-SULPHONIC ACID (NQS) REAGENT
A simple and cost effective spectrophotometric method is described for the determination of Meropenem (MP) in pure and pharmaceutical formulations. The method is based on the formation of dark yellow colored chromogen when the drug reacts with 1, 2 naphtho quinone -4-sulphonic acid sodium salt (NQS) reagent in alkalline medium. The method involves the addition of excess NQS of known concentration ...
3659
1973
ANTI- CONVULSANT PROFILE OF AQUEOUS EXTRACT OF SAPINDUS LAURIFOLIA IN EXPERIMENTAL ANIMALS
Objective: The aim of the present study was to evaluatethe anti convulsant property of aqueous extract of Sapindus laurifolia in Pentylenetetrazole (PTZ) and MES induced convulsions in experimental models. Materials & Methods: The purpose of this study is to explore the anticonvulsant activity of ethanolic extract of Momordica tuberosa using Pentylenetetrazole and maximal electric shock induce...
3162
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DESIGN AND EVALUATION OF TOPICAL HYDROGEL FORMULATION OF DICLOFENAC SODIUM FOR IMPROVED THERAPY
Topical gel preparations are intended for skin application or to certain mucosal surfaces for local action or transdermal penetration of medicament or for their emollient or protective action. Topical delivery of drugs can be achieved by incorporating drug into the gel matrix for effective delivery of drugs, thus avoiding first pass metabolism and for increased local action in pain management and ...
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COMPARISON OF GC-MS ANALYSIS OF PHYTOCHEMICALS IN THE ETHANOLIC EXTRACTS OF MARCHANTIA LINEARIS LEHM & LINDENB. AND MARCHANTIA POLYMORPHA L. (BRYOPHYTA)
Bryophytes have unique aroma, taste and possess bioactive potential compounds with medicinal properties. Chemical studies of the bryophytes were limited in India due to the small size and expertise in identification of the species. Many of the bryophytes are used as folklore medicine by local tribes. The solvent extracts results poor yield leads to insufficient for testing biological activity. I...
4327
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IN VITRO EVALUATION OF ANTIMICROBIAL ACTIVITY OF MORINGA OLEIFERA AND MOMORDICA CHARANTIA SEEDS
The aqueous and methanol extracts of the seeds of Moringa oleifera (Family: Moringaceae) and the seeds of Mormordica charantia (Family: Cucurbitaceae) were screened for their antimicrobial activity against three human pathogenic bacterial strains and three fungal strains by agar-well diffusion assay. The pattern of inhibition varied with the solvent used for extraction and the microorganisms tes...
4704
1729
FORMULATION AND EVALUATION OF PREDNISOLONE LOADED MICROSPONGES FOR COLON DRUG DELIVERY: IN-VITRO AND PHARMACOKINETIC STUDY
The purpose of this study was to develop prednisolone-loaded microsponges for colon specific drug delivery. The microsponges formulations were prepared by quasi-emulsion solvent diffusion method employing eudragit RS 100 as a polymer. The compatibility of the drug with formulation components was established by Fourier Transform Infra-Red (FTIR) spectroscopy. Afterwards, microsponge formulations we...
5765
2805
PHYTOCHEMICAL, ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC STUDY OF CRUDE HYDROALCOHOLIC EXTRACT OF AERIAL PARTS OF MARRUBIUM VULGARE L. IN NORMAL AND STREPTOZOTOCIN INDUCED-DIABETIC WISTAR RATS
The phytochemical screening, the antihyperglycemic and antihyperlipidemic effects of crude hydroalcoholic extract of aerial parts ofMarrubium vulgare L. were evaluated in normal and Streptozotocin- induced diabetic in Wistar rats. First, the preliminary phytochemical test to identify the chemical constituents of crude hydroalcoholic extract of aerial parts of M. vulgare was carried. Next, the rats...
3515
1354
EXTRACTION, ISOLATION AND CHEMICAL STRUCTURE ELUCIDATION OF DAIDZEIN FROM BARK OF ACACIA ARABICA (LAM.) WILLD OF BHOPAL, MADHYA PRADESH, INDIA
Purpose: To extract, isolate and identify daidzein from the bark of Acacia Arabica (Lam.) Willd of Bhopal, Madhya Pradesh, India. Methods: Succesesive methanolic extract from the bark of Acacia arabica was subjected to column chromatography and fractionated by benzene, n-butanol, and acetone successively. Eluents having similar Rf values were pooled together. These pools were subjected to flavonoi...
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PHARMACOGNOSTICAL INVESTIGATION AND EVALUATION OF FICUS CARICA FRUIT EXTRACT FOR ADAPTOGENIC ACTIVITY
Ficus carica is the common fig fruit belonging to the family Moraceae, The Pharmacognostical studies of the half ripened fruits were carried out using the various micro-chemical tests. The dried fruits were subjected to extraction using 90 % ethanol and this extract was further evaluated for the adaptogenic activity. Swim Endurance test in mice and Cold Stress model in rats was used to screen the ...
4555
2027
A NOVEL METHOD OF ECONOMICAL CULTIVATION OF MEDICINALLY IMPORTANT MUSHROOM, GANODERMA LUCIDUM
Ganoderma lucidum has been widely used as a herbal medicine in many pacific countries. Ithas been worshipped as a kind of herbal medicine, the emperors of the great Japanese and Chinese dynasties drank with their special teas and mushroom concoctions to achieve greater vitality and longer life. A protocol has been developed for the cultivation of G. lucidum on billets of Poplar (Populus deltoides)...
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EVALUATION OF ANALGESIC ACTIVITY OF SOME NOVEL SUBSTITUTED L-ARGININE ANALOGUES
A series of novel L-arginine analogues were synthesized characterized and screened for analgesic activity by acetic acid induced analgesia model. The purity of the synthesized compounds has been characterized by various analytical techniques such as UV, FTIR and TLC. The synthesized compounds were evaluated for analgesic activity by acetic acid induced analgesia in mice using paracetamol as the st...
2732
1183
FORMULATION AND EVALUATION OF ANTHRALIN MICROEMULSION GEL USING KARANJ OIL
The present research work was conducted to formulate and evaluate Anthralin microemulsion gel using Karanj oil with an objective of improving solubility of the Anthralin. The pseudo ternary phase diagrams were developed for combinations of Karanj oil as the oil phase, Span-20 as surfactant and as Capryol 90 as cosurfactant using water titration method. Microemulsions obtained were analyzed for top...
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EVALUATION OF IN-VITRO ANTI-OXIDANT ACTIVITY OF SOME SYNTHESIZED NOVEL L-ARGININE ANALOGUES
A series of novel L-arginine analogues were synthesized and screened for in-vitro anti-oxidant activity by Nitric oxide (NO) scavenging and 1-1-diphenyl-2-picrylhydrazyl (DPPH) scavenging methods. The purity of the synthesized compounds has been characterized by various analytical techniques such as UV, FTIR and TLC. The synthesized compounds were evaluated for in-vitro anti-oxidant activity by NO...
2749
1133
EVALUATION OF EFFICACY AND SAFETY OF GEMIFLOXACIN IN CHRONIC BRONCHITIS PATIENTS
The study aimed to assess the efficacy and safety of Amoxicillin/Clavulanate 625 mg and Amoxicillin/Clavulanate 1 gram in chronic bronchitis patients. Chronic bronchitis, a type of COPD defined by a productive cough that lasts for 3 months or more for at least 2 years, other symptoms include wheezing and breathlessness, upon exertion. It is caused by recurring irritation to the epithelium of bronc...
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1106
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC ASSAY METHOD FOR DETERMINATION OF LORNOXICAM IN SELF EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS) FORMULATION
The objective of the present work was to development and validation of stability indicating RP-HPLC assay by applying different stress degradation conditions on lornoxicam in Self Emulsifying Drug Delivery System (SEDDS) formulation. HPLC separation was achieved on analytical technique using C-18 column and mobile phase of Acetonitrile: Methanol (65:35, v/v) at a UV detector. The lornoxicam drug c...
3610
1462
FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF VERAPAMIL HYDROCHLORIDE
Sustained release matrix tablets reduce the frequency of the dosing and increase the effectiveness of the drug by localization at the site of action, providing uniform drug delivery. Sustained release matrix tablets of verapamil hydrochloride were prepared by using HPMC K15M, Xanthan and Guar Gum polymers with different concentration in various batches of the formulations to facilitate the drug re...
6400
1635
FORMULATION & EVALUATION OF ITOPRIDE HCL SUSTAINED RELEASE PELLETS P.
The present work is aimed to formulate Itopride HCl sustained release pelletsusing ethyl cellulose N50 such ashydrophobic polymer by employing the solution/suspension layer technique. The drug excipients compatibility study was carried out by Furor Transform Infrared spectroscopy (FTIR) which reveals no interaction between drug and excipients. Total 12 batches were formulated. Six formulations wer...
5936
3689
STEREOSTRUCTURE, ANTIMICROBIAL AND CYTOTOXIC ACTIVITY OF CYCLO-HEXENE, CYCLOHEXANOL AND PYRIDINE DERIVATIVES SYNTHESIZED FROM CHALCONES
The main objective of this work is to study the stereostructures and biological activity of some highly substituted cyclohexenes, cyclohexanols and the intermediates there in. In order to get the desired cyclohexenes, the synthesis of cyclohexanols 2,4-bis(4-chlorobenzoyl)-1-(4-chlorophenyl)-3,5-bis(4-methoxyphenyl)-and 2,4-bis(4-chlorobenzoyl)-1,3,5-tris(4-chlorophenyl)-cyclohexan-1-ols (1b a...
3307
1613