Volume 1 (2010) - Issue 1, January
IN-VITRO AND IN-VIVO MODELS FOR ANTIOXIDANT ACTIVITY EVALUATION: A REVIEW
Antioxidants are gaining a lot of importance as a panacea for a large number of life-style diseases like aging, cancer, diabetes, cardiovascular and other degenerative diseases etc. owing to our sedentary way of life and stressful existence. Added to these are the deleterious effects of pollution and exposure to harmful chemicals. All the above cause may accumulation of harmful free radicals. The ...
DIABETIC NEUROPATHY: STILL A CHALLENGE IN PHARMACOLOGY.
Diabetic neuropathy is one of the most serious microvascular complications of diabetes, which appears in about 50% of the patients suffering from diabetes. It is a nerve disorder caused by diabetes, characterized usually by numbness, pain or tingling in the feet or legs, which can lead to serious problems. Patients with diabetic neuropathy suffer from various types of pain. The underlying mechanis...
AN ANALYTICAL REVIEW OF PLANTS FOR ANTI DIABETIC ACTIVITY WITH THEIR PHYTOCONSTITUENT & MECHANISM OF ACTION
Diabetes and its different types is an age old disease for clinicians since centuries. Many aspects of Diabetes needs to be explored with respect to physiological actions of insulin and the various clinical features of this disease such as tissue complication , since this is life style disease , so proper treatment in relation to diet and anti diabetic agents is emphasized In fact, herbal treatmen...
VALIDATED LIQUID CHROMATOGRAPHIC ULTRAVIOLET METHOD, FOR THE QUANTIZATION OF LEVETIRACETAM IN HUMAN PLASMA USING LIQUID – LIQUID EXTRACTION
A simple, sensitive and rapid high performance liquid chromatography method with UV detection (215nm) was developed and validated for the quantification of Levetiracetam in human plasma. Following a single-step liquid–liquid extraction with diethyl ether/dichloromethane (70/30 v/v), the analyte and internal standard (Zonisamide) were separated using an isocratic mobile phase, mixture of buffer (...
EVALUATION OF ANTIASTHMATIC ACTIVITY OF TECTONA GRANDIS LINN. BARK
Various extracts of Tectona grandis Linn. bark were screened for antiasthmatic activity by using different in-vivo animal models like clonidine induced catalepsy, haloperidol induced catalepsy, milk induced leucocytosis and eosinophilia. The observation of this study indicated that the Tectona grandis bark having antihistaminic activity inhibited clonidine-induced catalepsy and not inhibited halop...
EVALUATION OF PHYTOCHEMICAL SCREENING AND ANTI-FERTILITY ACTIVITY OF CURCUMA AROMATICA SALISB
The practice of traditional medicine for the control of fertility in most parts of India is based on the uses of plant medicines for many years. The fact that herbal medicines have been employed for such a long time does not guarantee their efficacy and safety. The aim of the present study was, therefore, to carry out phytochemical screening, efficacy and safety studies on one of the traditionally...
IN-VITRO CYTOTOXIC ACTIVITY OF METHANOLIC EXTRACT OF HEMIDESMUS INDICUS R.BR.
Natural products represent a reservoir of diverse templates and are being tapped to outsource novel anticancer agents. Hemidesmus indicus R.Br.(Fam: Asclepidaceae) has been reported to be useful for the treatment of inflammation, cuts, wounds, burns, snake bite, skin and blood diseases, ulcers, immunological disorders . In the present study, the methanolic extract of the roots of Hemidesmus indicu...
COMPARATIVE IN-VITRO EVALUATION OF VITEX LEUCOXYLON LINN. BARK FOR ANTIOXIDANT ACTIVITY
Cellular damage arising from free radical is one of the fundamental mechanism underlying a number of human neurodegenerative disorder like diabetes, inflammation, Alzheimer’s disease, autoimmune pathologic and digestive system disorder. Thus antioxidant plays an important role in the treatment of such disease. The present study aims at a comparative evaluation of ethyl acetate, hexane and methan...
SYNTHESIS OF PHENYL HYDRAZINE SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AND THEIR BIOLOGICAL ACTIVITY
Condensation of o-phenylene diamine with chloro acetic acid gave 2-chloromethyl benzimdazole, which undergoes halide replacement with phenylhydrazines to give the corresponding NN' disubstituted hydrazines. The synthesized compounds were subjected to microbiological screening and In- vitro anti-inflammatory activity. ...
PHYTOCHEMICAL INVESTIGATION AND CHROMATOGRAPHIC EVALUATION OF THE ETHANOLIC EXTRACT OF WHOLE PLANT EXTRACT OF DENDROPHTHOE FALCATA (L.F) ETTINGSH
The present study was aimed to investigate phytochemicals present in the whole plant extract of Dendrophthoe falcata and development of new solvent system for thin layer chromatography of ethanolic (whole plant) extract of medicinal plant Dendrophthoe falcata. The extract showed presence of Carbohydrates, Sterols, Glycosides, Flavonoids and Phenolic compounds. For TLC, new solvent system developed...
CHROMATOGRAPHIC METHODS OF FRACTIONATING SEVERAL CHEMICAL CONSTITUENTS IN PHYLA NODIFLORA
Phyla nodiflora Linn., Synonym- Lippia nodiflora Rich also known as Jala-pippali is an important herb which can be used medicinally.The aim of the present study is to fractionate several chemical constituents in Phyla nodiflora. Chromatography was used for designing of multi component solvent system for different extracts where, for methanolic extract Hexane: Toluene: Ethyl acetate (2: 1.5: 0.5); ...