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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 1 (2010) - Issue 1, January

Review Articles

 
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1.

IN-VITRO AND IN-VIVO MODELS FOR ANTIOXIDANT ACTIVITY EVALUATION: A REVIEW

Antioxidants are gaining a lot of importance as a panacea for a large number of life-style diseases like aging, cancer, diabetes, cardiovascular and other degenerative diseases etc. owing to our sedentary way of life and stressful existence. Added to these are the deleterious effects of pollution and exposure to harmful chemicals. All the above cause may accumulation of harmful free radicals. The ...

JOSEPH NM*, SABHARWAL MONIKA, SHASHI ALOK, MAHOR ALOK, RAWAL SHRUTI

School Of Pharmacy, College of Health Sciences, Mekelle University *, Mekelle, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(1).1-11

1-11

8034

2020

2.

DIABETIC NEUROPATHY: STILL A CHALLENGE IN PHARMACOLOGY.

Diabetic neuropathy is one of the most serious microvascular complications of diabetes, which appears in about 50% of the patients suffering from diabetes. It is a nerve disorder caused by diabetes, characterized usually by numbness, pain or tingling in the feet or legs, which can lead to serious problems. Patients with diabetic neuropathy suffer from various types of pain. The underlying mechanis...

RAWAL SHRUTI*, SHASHI ALOK, MAHAJAN N, MAHOR A, JOSHI A, SHARMA P, SAROHA M.

Department of Pharmaceutical Sciences, Lovely School of Pharmacy, Lovely Professional University*, Phagwara, Punjab., India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(1).12-28

12-28

3377

1165

3.

AN ANALYTICAL REVIEW OF PLANTS FOR ANTI DIABETIC ACTIVITY WITH THEIR PHYTOCONSTITUENT & MECHANISM OF ACTION

Diabetes and its different types is an age old disease for clinicians since centuries. Many aspects of Diabetes needs to be explored with respect to physiological actions of insulin and the various clinical features of this disease such as tissue complication , since this is life style disease , so proper treatment in relation to diet and anti diabetic agents is emphasized In fact, herbal treatmen...

Shanti Bhushan Mishra *, CH. V. Rao, S.K. Ojha, M. Vijayakumar, A. Verma and S. Alok

Department of Pharmacognosy, Roorkee College of Pharmacy *, Roorkee (Uttarakhand), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(1).29-46

29-46

17682

6920

Research Articles

 
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1.

VALIDATED LIQUID CHROMATOGRAPHIC ULTRAVIOLET METHOD, FOR THE QUANTIZATION OF LEVETIRACETAM IN HUMAN PLASMA USING LIQUID – LIQUID EXTRACTION

A simple, sensitive and rapid high performance liquid chromatography method with UV detection (215nm) was developed and validated for the quantification of Levetiracetam in human plasma. Following a single-step liquid–liquid extraction with diethyl ether/dichloromethane (70/30 v/v), the analyte and internal standard (Zonisamide) were separated using an isocratic mobile phase, mixture of buffer (...

Prashant Tripathi et al.

Micro Therapeutic Research Labs Pvt. Ltd., Chennai, India

DOI: 10.13040/IJPSR.0975-8232.1(1).1-9

1-9

3364

1276

2.

EVALUATION OF ANTIASTHMATIC ACTIVITY OF TECTONA GRANDIS LINN. BARK

Various extracts of Tectona grandis Linn. bark were screened for antiasthmatic activity by using different in-vivo animal models like clonidine induced catalepsy, haloperidol induced catalepsy, milk induced leucocytosis and eosinophilia. The observation of this study indicated that the Tectona grandis bark having antihistaminic activity inhibited clonidine-induced catalepsy and not inhibited halop...

Dhirendra V. Goswami et al.

Department of Pharmacognosy, Pravara Rural College of Pharmacy, Loni, (M.S.) India

DOI: 10.13040/IJPSR.0975-8232.1(1).10-17

10-17

3464

1247

3.

EVALUATION OF PHYTOCHEMICAL SCREENING AND ANTI-FERTILITY ACTIVITY OF CURCUMA AROMATICA SALISB

The practice of traditional medicine for the control of fertility in most parts of India is based on the uses of plant medicines for many years. The fact that herbal medicines have been employed for such a long time does not guarantee their efficacy and safety. The aim of the present study was, therefore, to carry out phytochemical screening, efficacy and safety studies on one of the traditionally...

DAS TRISHNA *, MISHRA SHANTI BHUSHAN, BASAK MRINMOY, MOHANTY J.P., SHIL DIBYENDU

Girijananda Institute of Pharmaceutical Sciences, Guwahati (Assam), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(1).18-22

18-22

4701

1382

4.

IN-VITRO CYTOTOXIC ACTIVITY OF METHANOLIC EXTRACT OF HEMIDESMUS INDICUS R.BR.

Natural products represent a reservoir of diverse templates and are being tapped to outsource novel anticancer agents. Hemidesmus indicus R.Br.(Fam: Asclepidaceae) has been reported to be useful for the treatment of inflammation, cuts, wounds, burns, snake bite, skin and blood diseases, ulcers, immunological disorders . In the present study, the methanolic extract of the roots of Hemidesmus indicu...

DAS SAUMYA*, DAS MANAS K. , MITRA MAZUMDER P., DAS S., BASU PRIYA S.

Institute of Pharmaceutical Technology, Noida Institute of Engineering and Technology*, Greater Noida, U. P., India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(1).23-26

23-26

3252

1212

5.

COMPARATIVE IN-VITRO EVALUATION OF VITEX LEUCOXYLON LINN. BARK FOR ANTIOXIDANT ACTIVITY

Cellular damage arising from free radical is one of the fundamental mechanism underlying a number of human neurodegenerative disorder like diabetes, inflammation, Alzheimer’s disease, autoimmune pathologic and digestive system disorder. Thus antioxidant plays an important role in the treatment of such disease. The present study aims at a comparative evaluation of ethyl acetate, hexane and methan...

AKHTAR MD S., SHUKLA PADMINI*, SHUKLA PRABODH, SHASHI ALOK, MAHOR ALOK

Department of Pharmacy,Pranveer Singh Institutes of Technology,Bhaunti, Kanpur (U. P.), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(1).27-33

27-33

3737

1209

6.

SYNTHESIS OF PHENYL HYDRAZINE SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AND THEIR BIOLOGICAL ACTIVITY

Condensation of o-phenylene diamine with chloro acetic acid gave 2-chloromethyl benzimdazole, which undergoes halide replacement with phenylhydrazines to give the corresponding NN' disubstituted hydrazines. The synthesized compounds were subjected to microbiological screening and In- vitro anti-inflammatory activity.  ...

VENKATARAMANA HS C., SINGH A., TIWARI A.*, TIWARI V.

Department of Pharmaceutical Chemistry, M. S. Ramaiah College of Pharmacy*, Bangalore, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(1).34-38

34-38

5926

2074

7.

PHYTOCHEMICAL INVESTIGATION AND CHROMATOGRAPHIC EVALUATION OF THE ETHANOLIC EXTRACT OF WHOLE PLANT EXTRACT OF DENDROPHTHOE FALCATA (L.F) ETTINGSH

The present study was aimed to investigate phytochemicals present in the whole plant extract of Dendrophthoe falcata and development of new solvent system for thin layer chromatography of ethanolic (whole plant) extract of medicinal plant Dendrophthoe falcata. The extract showed presence of Carbohydrates, Sterols, Glycosides, Flavonoids and Phenolic compounds. For TLC, new solvent system developed...

SAHU VINOD K. *, IRCHHAIYA RAGHUVEER, SHASHI ALOK, GURJAR HIMANSHU

Department of Pharmacology, Institute of Pharmacy, Bundelkhand University, Jhansi (U.P.), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(1).39-45

39-45

4485

2236

8.

CHROMATOGRAPHIC METHODS OF FRACTIONATING SEVERAL CHEMICAL CONSTITUENTS IN PHYLA NODIFLORA

Phyla nodiflora Linn., Synonym- Lippia nodiflora Rich also known as Jala-pippali is an important herb which can be used medicinally.The aim of the present study is to fractionate several chemical constituents in Phyla nodiflora. Chromatography was used for designing of multi component solvent system for different extracts where, for methanolic extract Hexane: Toluene: Ethyl acetate (2: 1.5: 0.5); ...

KAUR AMRINDER* AND SHUKLA J.V.

Department of Ayurvedic Pharmaceutical Sciences, Lovely Faculty of Applied Medical Sciences, Lovely Professional University*, Chaheru, Phagwara (Punjab), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(1).46-55

46-55

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