Volume 1 (2010) - Issue 7, July
RATIONALE BEHIND THE COMBINATION OF SULFONYLUREA AND METFORMIN IN DIABETES MELLITUS
The prevalence of diabetes in India has been growing by leaps and bounds. The statistics in this regard are quite alarming. It is obvious that in a country like India, the rising prevalence of diabetes with its complications is likely to produce severe constraints on health care budgets in future. This explosion of diabetes in India has been viewed with serious concern by the WHO and the Internati...
A COMPREHENSIVE PHARMACOGNOSTIC REPORT ON VALERIAN
Herbalism is a traditional medicine practice based on the utilization of plants and plant extracts. In herbalism ‘Valerian’ is a boon medicine for several ailments. Valerian (Valerian officinalis) is a naturally occurring Ayurvedic medicine widely grown in the temperate zones of Europe, North America and Asia and is a safe herbal supplement indicated in various ailments, chief being for the sy...
IN VITRO PROPHYLACTIC CATARACT PREVENTION STUDY ON GLUCOSE INDUCED CATARACT BY QUERCETIN AND ALPHA- TOCOPHEROL
The antioxidants such as quercetin and alpha- tocopherol were subjected for in vitro prophylactic cataract prevention study on glucose induced cataract model. Goat lenses were incubated in artificial aqueous humor containing 55 mM glucose with test drugs in different concentrations at room temperature for 72 h. Biochemical parameters studied in the lens were electrolytes (Na+, K+), Na+- K+- ATPase...
DEVELOPMENT AND EVALUATION OF FAST DISINTEGRATING TABLETS OF SALBUTAMOL SULPHATE BY SUPERDISINTEGRATING AGENTS
The purpose of this research was to develop fast disintegrating tablets of Salbutamol Sulphate using superdisintegrating agents. Recently fast disintegrating drug delivery system have started gaining popularity and acceptance as new drug delivery system, because they are easy to administer and lead to better patient compliance. Salbutamol Sulphate is a selective β2 receptor agonist widely used as...
SAFETY AND MULTIPLE DOSE PHARMACOKINETICS OF PALIPERIDONE ER IN INDIAN SCHIZOPHRENIC PATIENTS
Paliperidone is a new active substance, belonging to the class of atypical antipsychotic, and is the active metabolite of a well-known active substance, risperidone that has been used for the last 3 years. A randomized, double-blind, multicentric, study to evaluate the safety and efficacy of Paliperidone ER compared to Olanzapine in patients with Schizophrenia was conducted in Indian schizophrenic...
ANTIOXIDANT AND PHYTOCHEMICAL POTENTIAL OF WILD EDIBLE MUSHROOM TERMITOMYCES RETICULATUS: INDIVIDUAL CAP AND STIPE COLLECTED FROM SOUTH EASTERN PART OF INDIA
Antioxidant and phytochemical properties of an ethanolic extracts from the wild edible mushroom Termitomyces reticulatus and their individual parts (Cap and Stipe) were evaluated. Reducing power, β-carotene bleaching, ABTS and DPPH radicals scavenging activity were used to evaluate their antioxidant activity. Antioxidant components like total phenol, flavonoid, β-carotene and lycopene were also ...
A QUALITY ASSESSMENT AND PHYTOCHEMICAL SCREENING OF SELECTED REGION OF WITHANIA SOMNIFERA DUNAL
Withania somnifera Dunal. (ashwagandha) is widely used in Ayurvedic medicine, the traditional medicinal system of India. It is an ingredient in many formulations prescribed for a variety of musculoskeletal conditions (e.g., arthritis, rheumatism), and as a general tonic to increase energy, improve overall health and longevity, and prevent disease in athletes, the elderly, and during pregnancy. In ...
HYDROALCOHOLIC EXTRACTION OF MANGIFERA INDICA (LEAVES) BY SOXHLETION
The genus Mangifera indica belongs to the family Anacardiaceae and comprises of 40 species distributed in tropical and sub-tropical parts of South East Asia, Africa and Latin America The resin is useful in cutaneous disease .the juice of kernel is snuffed to stop nasal bleeding. A decoction of the leaves with a little honey added is given in aphonia, the loss of voice. Mid ribs of the leaves calci...
BLOOD CHOLESTEROL LOWERING EFFECT OF ADENANTHERA PAVONINA SEED EXTRACT ON ATHEROGENIC DIET INDUCED HYPERLIPIDEMIA RATS
The effect of Adenanthera pavonina (AP) seed extract on the blood cholesterol level of atherogenic diet rats was evaluated. Twelve adult male Wistar rats divided into 3 groups of 4 animals each were used and were treated orally with normal saline (Control group), atherogenic diet (Positive control) and 200mg/kg of AP seed extract (treatment) over a 4-week period. The present study was undertaken t...
IMPROVEMENT OF DISSOLUTION BEHAVIOR OF PARACETAMOL USING SOLID DISPERSION TECHNIQUE
Paracetamol is an important anti-inflammatory and analgesic drug widely used in biological disorders. One of major problems with this drugs is its low solubility thus dissolution rate in biological fluid, which results into poor bioavailability after oral administration. In this study polyvinyl pyrrolidone (PVP) is used to enhance bioavailability of paracetamol. Paracetamol and PVP are used in 1:1...
NOVEL METHOD FOR SIMULTANEOUS ESTIMATION OF CIPROFLOXACIN HYDROCHLORIDE AND OFLOXACIN BY REVERSE PHASE-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (RP-HPLC)
A novel method was developed for the determination of fluoroquinolones such as ciprofloxacin hydrochloride (CPL) and ofloxacin (OFX) by isocratic reverse phase-high performance liquid chromatography (RP-HPLC) coupled with UV detection. The developed method was rapid, accurate, reproducible, economical and sensitive for the simultaneous estimation of ciprofloxacin hydrochloride and ofloxacin. Fluor...
PHYTOCHEMICAL SCREENING ON THE STEM BARK OF ANTHOCEPHALUS CADAMBA (ROX B.) MIQ.
The present work deals with development and standardization of phytochemical screening for quantification of methanolic extract of medicinal plant stem bark of Anthocephalus cadamba (Roxb.)Miq. The scientific parameter is necessary to identify the exact plant material and to find its quality and purity. The present study deals with various, physical evaluation and preliminary phytochemical screeni...
ANTI BACTERIAL ACTIVITY OF 3- (4- ARYL SUBSTITUTED- 3 – YL) – THIAZOLIDIN- 4 – ONE AND THEIR DERIVATIVES
This study involves synthesis of 3- [4- aryl substituted- 3 - yl] - thiazolidin- 4 – one - 5- acetic acid by microwave oven induced synthesis method. Synthesized compounds were screened for anti-microbial activity by MIC and zone inhibition tests against various gram positive organism and gram negative organisms respectively. The microbiological assay is based upon a comparison of the inhibition...
OPTIMIZATION OF EFFECT OF SUPERDISINTEGRANTS AND SUBLIMING AGENT ON ORODISPERSIBLE TABLET OF ONDANSETRON RESINATE
Ondansetron is a serotonin 5HT3 antagonist; anti emetic drug. Bitter taste of the ondansetron is a major problem in ensuring patient compliance. Resinates of ondansetron were prepared with Indion 234 and loading process was optimized. A 3² factorial design was used for formulation development of orodispersible tablet of these taste masked resinates. The amount of subliming agent (camphor) and sup...