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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 14 (2023) - Issue 3, March

Review Articles

 
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1.

CINCHONA EXHIBITS CANDIDATES AS A COMPLEMENTARY ANTIVIRAL ACTIVITY FOR SARS-COV-2: A NARRATIVE REVIEW

Aim and Objective: The coronavirus disease 2019 (COVID-19) pandemic, caused by the coronavirus-2 (SARS-CoV-2) that causes severe acute respiratory syndrome, is the world's most serious health issue. COVID-19 is currently without a precise and successful antiviral treatment. Phytochemicals provide a ray of hope for public well-being amid the pandemic, and much study is being done on them. Materials...

Manikantan Pappuswamy *, Arun Meyyazhagan and Aditi Chaudhary

Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1027-37

1027-1037

949

709

2.

APPLE SEEDS: PHYTOCHEMISTRY, MEDICINAL PROPERTY AND TOXICOLOGY

People throughout the world have long used various fruits, leaves, and plant parts as nutraceuticals and valuable sources of herbal treatments. Apples (Malus domestica) are a popular fruit with a high level of medicinal efficacy, whose seeds have also demonstrated a very high therapeutic and nutritional value when ingested in the right amount and form (apple seed flour or oil). Found in cold tempe...

Amrita Chakraborty, Jishnu Sarathi Deb, Moumita Saha and Sirshendu Chatterjee *

Department of Biotechnology, Techno India University, West Bengal, EM-4, Salt Lake, Sector- V, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1038-45

1038-1045

1430

521

3.

BIOLOGICAL ASPECTS OF NOVEL BENZOTHIAZOLE DERIVATIVES

The heterocyclic compounds are formed by the hetero atoms (O, S, N, etc.) in the cyclic ring system. These are mainly started from 3- membered to 10- membered heterocyclic rings. The compound containing heterocyclic molecules shows potent activity in various pharmacological targets. Benzothiazole is a fusion of a benzene ring with a 5-membered thiazole ring which is widely used in heterocyclic com...

Alpa Verma, Arun Kumar *, Syed Misbahul Hasan, Kuldeep Singh, Bhavana Dubey and Parul Mishra

Department of Pharmaceutical Chemistry, Integral University, Kursi Road, Lucknow, Utter Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1046-53

1046-1053

712

465

4.

RECENT ADVANCEMENT OF CARBAZOLE HYBRID: A PRIVILEGED SCAFFOLD IN NEW DRUG DISCOVERY

Carbazole comprises an important class of heterocycles. Carbazole is a tricyclic molecule having a coal tar carbon backbone. Also, it has the structural properties of numerous compounds used in electronics for manufacturing polymers or dyes and electroluminescent materials, owing to its luminous quality. It has been reported that diverse biological activities include anti-cytotoxicity, bacteria-re...

Seema Chahar Beniwal and Tarun Virmani *

School of Pharmaceutical Sciences, MVN University, Delhi-Agra Highway, NCR, Palwal, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1054-62

1054-1062

706

390

5.

KARKATSHRINGI (PISTACIA INTEGERRIMA): PHYTOPHARMACOLOGICAL REVIEW

Karkatshringi (Pistacia integerrima) is an essential Ayurvedic medicinal plant belonging to the family Anacardiaceae. The plant originated in India and grows in the ranges of the north-western Himalayas. It is distributed over China, Afghanistan, Pakistan, and Nepal. The flowers of this plant is small and red, fruits are shiny and brown. Galls are hollow, horn-shaped, bitter and used for medicinal...

P. V. Kadam, K. N. Yadav *, A. S. Karanje, R. J. Mukadam, D. K. Giram and M. J. Patil

Marathwada Mitra Mandal’s College of Pharmacy, Kalewadi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1063-70

1063-1070

1317

662

6.

A REVIEW OF THE EXTENT OF EXPLORED POTENTIAL FOR PHYTOCHEMICAL AND PHARMACOLOGICAL ACTIVITY OF DURANTA ERECTA LEAVES

Phytomedicines from herbal plants are widely used as a home remedy in ancient times to maintain the normal health of human beings. As per World Health Organization (WHO) estimation, nearly 75-80% of the population in the world utilizes medicinal plants for their primary health care. Duranta erecta itself has antioxidant and anti-microbial activities and has been used in Africa and Asia to treat a ...

Amit Sahu * and Deepak Jain

Department of Pharmacognosy, Mandsaur, Mandsaur, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1071-75

1071-1075

732

344

7.

A REVIEW ON PRECLINICAL PHARMACEUTICAL RESEARCH: PRINCIPAL AND COMMON ROUTES OF ADMINISTRATION IN SMALL RODENTS

Preclinical drug or pharmaceutical research in mouse and rat species is inevitable in the scientific investigations of a chemical substance or lead entity. The administration routes are the experimental study design, and regulatory requirements may influence the study of humans' intended therapeutic/clinical route. Specific route selection in the investigation of test substances must be profoundly...

A. W. There *, P. A. Chawale and A. G. Bais

School of Pharmacy, G. H. Raisoni University, Dhoda Borgaon, Chhindwara, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1076-97

1076-1097

471

297

8.

INSIGHTS INTO THE ROLES OF ANTIOXIDANTS IN CITRUS FRUITS

Citrus fruits are known for their nutritiousness. Role of vitamins and minerals play a major role in citrus fruits during plant-pathogen interactions. These fruits are the supreme fruit crops which contain flavonoids and phenolic compounds. These molecules benefit individuals who are all consuming and play an important role in fruit ripening and development. Mainly these molecules act as antioxida...

J. Raveena Jayam, Anith Kumar Rajendran, Muthusamy Suganthi and Senthilkumar Palanisamy *

Department of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1098-07

1098-1107

520

238

9.

A COMPREHENSIVE INSIGHT INTO ARTIFICIAL BLOOD

In hospitals, blood transfusions are a common occurrence. Because blood-related products are limited and have a range of adverse side effects, researchers have worked on artificial blood components for nearly 40 years. It is crucial to develop effective and selective alternatives for natural blood products. Artificial blood is a useful idea in transfusion medicine wherein clearly defined compounds...

A. V. More *, S. Y. Sayyed, P. G. Morankar, S. R. Churi, S. S. Gawli, R. A. Karande and R. Y. Gorade

St. John Institute Of Pharmacy and Research, St. John Technical Campus, Palghar, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1108-19

1108-1119

720

343

10.

ANTIOXIDANT PROPERTIES OF INDIAN MEDICINAL PLANTS IN THE REGION OF MAHARASHTRA AND TAMIL NADU: A REVIEW

India is the peninsula of the herbal hub, in which the ayurvedic system of medicine has flourished as enlightenment in the field of medicine. Plants had played a vital role since ancient times when people used plant derivatives as a source of the drug. Currently, some spices and medicinal plants have become the preponderant source of drug discovery in research for treating diverse forms of the dis...

Harapriya Sahoo and Prabhjot Singh Jassal *

School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1120-30

1120-1130

717

335

11.

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP AND GROUP-BASED QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP: A REVIEW

Structure-Activity relationship (SAR) only identifies the chemical group responsible for producing the target biological effect in the organism. It was first present in 1865, structural activity relationship was refined dates back to the nineteenth century and now it has advanced from QSAR to 3D QSAR. Quantitative Structure-Activity Relationships (QSAR) are attempted to correlate the structural an...

Sanket B. Bhatshankar and Amit S. Tapkir *

Department of Pharmaceutical Chemistry, PES Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1131-48

1131-1148

667

317

12.

GREEN SYNTHESIS OF NANOPARTICLES: A BRIEF STUDY

Nanoparticles are small particles ranging from 1 to 100 nanometers. The biological production of nanoparticles is cheaper than chemical production. Besides being cheaper, it is eco-friendly as well. This biological procedure is a bottom-up procedure where the extracts of natural products replace the chemical reducing agents. These reducing and stabilizing agents are found in plants and can be used...

Rituka Pandey and Tamalika Chakraborty *

Department of Life Science, Guru Nanak Institute of Pharmaceutical Science and Technology Panihati, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1149-60

1149-1160

663

317

13.

THE EFFECTIVENESS OF BETA-BLOCKERS VERSUS CALCIUM CHANNEL BLOCKERS IN RATE CONTROL OF ATRIAL FIBRILLATION IN AN EMERGENCY DEPARTMENT: A SYSTEMATIC REVIEW

Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. It is related to increased stroke, heart failure, and hospital admission. Therefore, this systematic review was conducted to compare the effectiveness of calcium channel blockers (CCB) with beta-blockers (BB) for acute rate control of AF in the emergency department. Methods: We systematically retrieved articles w...

Bruke Berhanu Billoro *, Abdikarem Mohamed Abdi , Belayneh Hamdela, Fekadu Negash Bereded and Bilgen Basgut

Department of Clinical Pharmacy, Faculty of Pharmacy, Near East University, Nicosia, Northern Cyprus, Mersin, Turkey.

DOI: 10.13040/IJPSR.0975-8232.14(3).1161-70

1161-1170

479

262

14.

NANOCOSMECEUTICALS: AN IMMERGING TREND IN PHARMACY

The global market size was valued at $ 380.2 billion in 2019 and is projected to reach $463.5 billion by 2027, registering a CAGR of 5.3% from 2021 to 2027. Cosmetics have become an in-dispersible feature of the modern lifestyle. The use of cosmetics has increased in males and women in daily routine, which complements the growth of global cosmetic market demand. The skin care industries are trying...

Preeti Bhimashankar Patil Vibhute

Department of Pharmaceutics, Sarojini College of Pharmacy, Kolhapur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1171-84

1171-1184

549

293

Research Articles

 
Title
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15.

ANTI-OSTEOPOROSIS ACTIVITY OF EUCOMMIA, CUSCUTA AND DRYNARIA EXTRACTS IN THE OVARIECTOMIZED RATS

To observe the effect of Eucommia, Cuscuta, and Drynaria (E.C.D.) extracts in ovariectomized rats and explore the possible mechanisms. Forty-five female Sprague Dawley rats were randomly divided into 5 groups: sham operation group (Sham), ovariectomized group (Model) and ovariectomized rats + treatment group (estradiol valerate of 104.17 mg/kg/day (EV), E.C.D. extracts of 50.08 mg/kg/day (E.C.D.-L...

X. Song, L. Li, Y. Wang, S. Wang *, X. Li, J. Wang, J. Zong, S. Zou and Z. Liu

Chenland Research Institute, 333 Songling Road, Laoshan District, Qingdao city, Shandong Province 266104, China.

DOI: 10.13040/IJPSR.0975-8232.14(3).1185-95

1185-1195

618

372

16.

THE ANTI-OXIDATIVE AND COGNITIVE PROPERTIES OF ZINGIBER OFFICINALE RHIZOME ETHANOL EXTRACT AND ITS DICHLOROMETHANE AND N-HEXANE FRACTIONS AGAINST ALUMINIUM CHLORIDE-INDUCED NEUROTOXICITY IN SWISS MICE

Aluminium neurotoxicity is implicated in Alzheimer's disease, this multifactorial disorder, with neurodegeneration and dementia as hallmarks. Aluminium toxicity is due to imbalances between free radicals and antioxidants formation, leading to oxidative stress. However, protection against aluminium toxicity is yet to be fully realized. Therefore, this study investigated Zingiber officinale (ZO) neu...

U. A. Inwang *, K. G. Davies, M. B. Ekong, C. P. Obasi, M. Onyebuenyi and A. R. Nwaji

Department of Physiology, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University, Ndufu Alike, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.14(3).1196-01

1196-1201

662

344

17.

PRELIMINARY SCREENING OF ANTI-CARIOGENIC PROPERTIES OF SELECTED MEDICINAL PLANTS AGAINST STREPTOCOCCAL DENTAL CARIES

Streptococcus mutans is the primary major causative agent of dental caries, with the ability to produce acid and form dental plaque. Streptococcus mutans adheres to the tooth surface via extracellular enzymes and produces dental plaque via extracellular polysaccharides synthesized from sucrose via glucosyltransferase and fructosyltransferase. This study aimed to look at the alternative antimicrobi...

M. Vishal * and N. Mallikarjun

Department of Studies and Research in Microbiology, Sahyadri Science College, Kuvempu University, Shivamogga, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1202-09

1202-1209

586

382

18.

mRNA EXPRESSIONPROFILINGOF GLUTATHIONE PEROXIDASE (GPX GENE) USING FIVE MEDICINAL PLANTS ON S. CEREVISIAE

Glutathione peroxidase gene expression profiling has been determined using budding yeast, S. cerevisiae, as a model organism mainly used for extensively reliable microbial studies of various cellular processes evolved in evolutionarily distant species. Roots of five medicinal plants were used: Withania somnifera, Terminalia arjuna, Ranunculus sceleratus, Bacopa monnieri and Acalypha indica. The ma...

Debanjana Prasad and Shailesh Solanki *

Department of Agriculture and Environment, Noida International University, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1210-19

1210-1219

622

337

19.

DESIGN AND CHARACTERIZATION OF TOPICAL ANTIBACTERIAL FORMULATION CONTAINING EXTRACT OF QUERCUS INFECTORIA GALLS

Presently, the surge in the consumption of herbal formulations is encouraged by several factors; the main factor is that they are relatively safe and effective. Plant extracts are considered an alternative source of synthetic drugs and are expected to produce promising results for treating several diseases. The present study aimed to formulate and evaluate antibacterial thermosensitive mucoadhesiv...

Akshada Rajesh Shendge * and Krishnamurthy Apparao Kamalapurkar

Department of Pharmaceutics, D. S. T. S. Mandal’s College of Pharmacy, Solapu, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1220-41

1220-1241

677

411

20.

REVERSE AGING IN SACCHAROMYCES CEREVISIAE THROUGH REDUCED TOR1 EXPRESSION AND REPLICATIVE LIFE SPAN MODELLING WITH CELL VIABILITY ASSESSMENT USING PHYTOCHEMICAL EXTRACTS ALPINIA GALANGAL, COMMIPHORA MUKUL, ACORUS CALAMUS AND MORSHELLA ESCULENTA

To study reverse aging in Saccharomyces cerevisiae (S. cerevisiae) by gene expression analysis of target of rapamycin (TOR1) induced autophagy and replicative life span modelling (RLS) using Alpinia galangal (A. galangal), Commiphora mukul (C. mukul), Acorus calamus (A. calamus) and Morshella esculenta (M. esculenta). Methanolic extraction of plants was carried out using maceration. Activation of ...

Nilanjana Prasad and Kashish Gupta *

Department of Biotechnology & Microbiology, Noida International University, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1242-52

1242-1252

523

247

21.

STUDY OF ANTINOCICEPTIVE EFFECT OF MELATONIN ALONE AND IN COMBINATION WITH PETHIDINE IN SWISS ALBINO MICE

Pain is the most common reason for physician consultation. Among the currently available analgesic drugs, opioids are the most efficacious but have many unacceptable adverse effects. Melatonin has been found to have antinociceptive potential in many animal and clinical studies that need further evaluation. The study aimed to assess the antinociceptive effect of melatonin alone and in combination w...

Kusum Kumari, Kumari Pallavi * and Keshav Kumar

Department of Pharmacology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1253-60

1253-1260

440

265

22.

MANNICH BASES OF 7-HYDROXY-4 -METHYL AND 4, 6, 7-TRIMETHYL COUMARINS AS POTENTIAL FUNGICIDES FOR ASPERGILLUS FLAVUS AND PYRRICULARIA ORZAE

Coumarin and its derivatives are widely used as scaffolds in synthesizing new heterocyclic systems. Numerous approaches especially involving nano-particle catalysts, have been developed to get new bioactive coumarin derivatives endowed with pharmacological and biological activities. The present work describes the reactivity and the new strategies for the synthesis of coumarin and its derivatives r...

Manoj Kumar Srivastava *, Brij Kishore Singh and Anamika Pandey

Department of Chemistry, Mahatma Gandhi P. G. College, Gorakhpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1261-64

1261-1264

417

219

23.

DEVELOPMENT AND EVALUATION OF HYDROCORTISONE-LOADED NIOSOMAL GEL

Objective: The present research work was to formulate optimize and evaluate hydrocortisone-loaded niosomal gel for the management of rheumatoid arthritis. Method: Niosomal gel was successfully prepared by lipid-thin film hydration process and optimized by using 23 full factorial designs using three independent variables (tween 80 concentration, cholesterol concentration, and sonication time) and t...

V. Choudhary, D. Rani *, N. Ghosh and M. Kaushik

Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1265-72

1265-1272

528

255

24.

AN RP-HPLC METHOD FOR THE QUANTITATIVE DETERMINATION OF REMDESIVIR IN INTRAVENOUS DOSAGE FORM

The worldwide epidemic of Coronavirus disease 2019 (COVID-19), caused by a new virus known as severe acute respiratory syndrome (SARS) coronavirus 2, has posed a growing threat to public health (SARS-CoV-2). The only antiviral drug authorized by the FDA for treating adult and pediatric patients hospitalized with a severe disease is remdesivir, which is given intravenously (IV). Although only a few...

Kashyap Thummar *, Malay Pandya, Nisarg Patel and Foram Rawat

Graduate School of Pharmacy, Gujarat Technological University, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1273-79

1273-1279

813

400

25.

BIOACTIVE METABOLITE PRODUCTION BY TRITIRACHIUM EGENUM ISOLATED FROM SOUTHEAST COAST OF ANDHRA PRADESH, INDIA

A study has been undertaken to isolate potent fungi from the South-east coastal zone of Andhra Pradesh. Among the 11 fungal strains isolated and screened, one potent strain with broad-spectrum antagonistic activity was found. Based on the morphological, cultural, and molecular characteristics, the potent strain was identified as Tritirachium egenum. Production of bioactive metabolites by the strai...

G. V. L. Bhavani and Vijayalakshmi Muvva *

Department of Botany and Microbiology, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1280-86

1280-1286

408

257

26.

DEVELOPMENT AND OPTIMIZATION OF TRANSDERMAL MICROEMUSION FORMULATION OF BCS CLASS II ANTIDIABETIC DRUG BY DOE

The main aim of present investigation was to examine the potential of a microemulsion formulation developed through simplex lattice design  as well as desirability function approach for transdermal delivery of BCS class II anti diabetic drug Glibenclamide. Pseudo-ternary phase diagrams were plotted by water titration method for multiple microemulsion formulations using oleic acid (oil), tween 80 ...

Ashish Srivastava * and Naresh Kalra

Lords College of Pharmacy, Lords University, Chikani, Alwar, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1287-99

1287-1299

417

213

27.

FORMULATION AND EVALUATION OF NABUMETONE LOADED TRANSFERSOMAL GEL

Nabumetone (NBT), a non-steroidal anti-inflammatory drug used to treat rheumatoid arthritis, is rapidly metabolized in the liver and is well known for its side effects along with its sensitivity to light; thus, it limits the formulation of a such drug when considered for skin formulations. Recently introduced a new type of carrier for bioavailability benefits and patient compliance, the “transfe...

P. M. Chaudhari * and S. J. Lokhande

Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1300-11

1300-1311

640

361

28.

UNRAVELING THE PHYTOCONSTITUENTS OF SCHLEICHERA OLEOSA AS AN ANTI-ARTHRITIC ACTIVITY: GC-MS ANALYSIS AND MOLECULAR DOCKING STUDIES

Rheumatoid arthritis is a systemic autoimmune and inflammatory disease that primarily affects the synovial joints and eventually destroys them. Schleichera oleosa is a plant of Indian provenance that exhibits anti-rheumatoid arthritis activity. The phytochemical constituents in the methanol extract of barks from Schleichera oleosa were identified using gas chromatography-mass spectrometry (GC-MS) ...

Shivani Singh, Shweta Paliwal, Tabish Qidwai and Sachidanand Singh *

Department of Biotechnology, Smt. S. S. Patel Nootan Science & Commerce College, Sankalchand Patel University, Visnagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1312-18

1312-1318

487

237

29.

A CROSS-SECTIONAL STUDY ON POLYPHARMACY IN ELDERLY PATIENTS AT A TERTIARY CARE HOSPITAL OF TRIPURA

Background: There is a significant link between polypharmacy and the emergence of adverse effects, drug interactions, and increased mortality among elderly patients. Polypharmacy and inappropriate prescription are matters of concern in elderly individuals; therefore, this study was done to find the pattern of polypharmacy among elderly patients. Methodology: A cross-sectional study was carried out...

Shubhaleena Debnath, Prithul Bhattacharjee, Lakshman Das *, Debasree Bhaumik, Ranjib Ghosh and Arindam Datta

Department of Pharmacology, Tripura Medical College & Dr. BRAM Teaching Hospital, Agartala, Tripura, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1319-29

1319-1329

467

228

30.

PHARMACOGNOSTICAL EVALUATION AND ANTIOXIDANT EFFECT OF SELECTED INDIAN MEDICINAL PLANTS

Since ancient times, herbal medicines have been utilized globally to prevent and cure a wide range of medical disorders. Despite the fact that they are employed in many different medical systems, it remains a challenge to ensure their quality control, proper scientific validation and standardization. Systematic validation and scientific regulation of natural formulations are required for the futur...

Sarita Chaurasia *, Saroj Yadav and P Mani Chandrika

School of Pharmacy, Sharda University, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1330-38

1330-1338

450

247

31.

DUAL WAVELENGTH SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL AND PIROXICAM IN THEIR COMBINED TABLET DOSAGE FORM

A simple, accurate, and precise dual-wavelength spectrophotometric method was developed to determine Paracetamol and Piroxicam in combined pharmaceutical dosage form simultaneously. The principle for the dual wavelength method is “the absorbance difference between two points on the mixture spectra is directly proportional to the concentration of the component of interest”. The pre‐requisite ...

Kinjal Parmar * and Shreyas Patel

Department of Quality Assurance, Parul Institute of Pharmacy and Research, Parul University, Post Limda, Waghodia, Vadodara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1339-43

1339-1343

1133

372

32.

DRUG UTILIZATION PATTERNS OF ANTI-DIABETIC AGENTSIN DIABETICS WITH CO-MORBIDITIES IN A TERTIARY CARE HOSPITAL: AN OBSERVATIONAL STUDY

Type 2 diabetes mellitus is a lifestyle disorder with a deficiency in insulin secretion or loss of insulin sensitivity in the body. As the prevalence is becoming more global, a focus was made on the innovation of analyzing the latest treatments. A prospective observational study on drug utilization patterns for diabetes was conducted on 119 diabetic patients admitted in a tertiary care hospital. A...

Aishwarya Dinakaran, Mohammad Anwar Sadat, Syed Mushfiq Quadri, Syed Yousuf Hussain Zaidi, Ravi Kumar Vemulapalli and Sailaja Rao Penakalapati *

Department of Pharmacology 6, Teegala Ram Reddy College of Pharmacy, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1344-51

1344-1351

470

303

33.

A COMPARATIVE RETROSPECTIVE AND PROSPECTIVE ANALYSIS OF EMERGING RESISTANCE IN EMPIRICAL ANTIBIOTIC TREATMENT AMONG LIVER CIRRHOSIS PATIENTS WITH SPONTANEOUS BACTERIAL PERITONITIS: AN INTERVENTIONAL STUDY IN A TERTIARY CARE HOSPITAL

Background: Previous hospitalization, nosocomial infection and specific risk factors like prolonged quinolone use for Spontaneous Bacterial Peritonitis prophylaxis can be related to drug-resistant bacterial infections and high mortality in liver cirrhosis. Aim and Objectives: To study the prescription pattern of antibiotics used in SBP, compare the efficacy and emerging resistance of antibiotics, ...

U. S. Arya Lekshmi, Aswathy Jyothy *, S. Athira Mohan, A. Arif Mohammed, M. S. Arya, N. J. Merlin and Shaiju S. Dharan

Ezhuthachan College of Pharmaceutical Sciences, Thiruvananthapuram, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1352-64

1352-1364

1089

222

34.

EFFECT OF SELENIUM-ENRICHED AZOLLA ON BIOCHEMICAL AND GROWTH PERFORMANCE PARAMETERS IN JAPANESE QUAILS (COTURNIX COTURNIX JAPONICA) BROILERS

Azolla is a fern plant through conducting 27 % of protein content and involves actively in bioremediation. So, this property of this plant is exploited in the production of chelated minerals. In this study, selenium-enriched azolla is evaluated with Japanese quails on the performance of growth and serological parameters. The present study is designed with 525 quails divided into 7 treatments, each...

C. Sreenivasa Reddy, M. Hanumantha Rao, N. Rajesh and Mohammed Abdul Kareem *

Department of Biochemistry, School of Sciences, Indira Gandhi National Open University, Delhi, New Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1365-71

1365-1371

550

299

35.

2D QSAR APPROACH TO DEVELOP NEWER GENERATION SMALL MOLECULES ACTIVE AGAINST SARS-COVID

We are in the half past of 2022, but still, we are facing the coronavirus pandemic situation. When a patient is hospitalized, only some FDA-approved drugs were administered to cure the patient. In treating coronavirus infection, nitazoxanide, granulocyte-macrophage colony-stimulating factor inhibitors, and various monoclonal antibodies are present. But all the molecules used in the treatment were ...

Supriyo Saha * and Dilip Kumar Pal

School of Pharmaceutical Sciences & Technology, Sardar Bhagwan Singh University, Dehradun, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1372-91

1372-1391

468

259

36.

NOVEL ANTI-DIABETIC POTENTIAL OF “SUGAR CARE” A MIRACLE DRINK EVALUATED ON HUMAN DIABETIC SUBJECTS

The herbal-based formulation “Sugar Care” a product of Miracle Drinks was assessed for an anti-diabetic property on 12 diabetic patients. Each patient was prescribed 15ml of Sugar Care (S10) morning and evening after meal and 15ml of cardiovascular care (S3) in the afternoon. Morning and night doses of sugar care were given along with 15ml of Liver Care (S4) and Renal Care (S5). After 30 days ...

S. M. Raju

Mallur Flora & Hospitality Pvt Ltd, R.T. Nagar Main Road, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1392-00

1392-1400

438

269

37.

CHEMICAL COMPOSITION, ANTIMICROBIAL AND ANTIOXIDANT PROPERTIES OF BARRINGTONIA ACUTANGULA BARK EXTRACT

Barringtonia acutangula (L.) Gaertn. (Family: Lecythidaceae), is a medium-sized tree found throughout India. It has been used in folk medicine to treat tuberculosis, skin disease, inflammation, hemorrhoids and diarrhea. The present study deals with in-vitro antioxidant, antimicrobial and GC-MS study on the bark extract of B. acutangula. In order to investigate the antioxidant activity, reduci...

Thrisha Venkatajalapathi

Department of Biochemistry, Ethiraj College for Women (Affiliated to University of Madras), Egmore, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1401-06

1401-1406

560

256

38.

ORGANOLEPTIC AND PHYSICAL CHANGES IN FRESH AND REPEATED USAGE OF COOKING OILS IN INDIAN HOUSES

Frying is one of the oldest food processing methods. Its popularity is related to the ease and speed of food preparation and sensory characteristics, such as unique flavor and taste. Nowadays, the consumption of deep-fried food has gained popularity which causes an increase risk of different disease conditions such as obesity, cardiovascular disease, diabetes, hypertension, etc. So, the validation...

S. Sasikala * and R. Vidhya

Department of Home Science, Queen Mary’s College, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1407-21

1407-1421

457

214

39.

STUDY ON MOLECULAR DOCKING OF ‘NUCLEOCAPSID (N) PROTEIN OF SARS-COV-2’ AND ‘MCF-7’

The process of eliminating viral infection and massive control from spreading furthermore by any variants may lead to a pandemic in the near future. On the other aspect, the impact of eradicating by the initial stage to prevent, treat carcinoma to decline the affected and death rate to maximum amount by Molecular Docking. The quickest and easiest method to search out the potential drugs is by anal...

M. Shree Legha and Amtuz Zehra

P.G. & Research Department of Zoology, Justice Basheer Ahmed Sayeed College for Women, Teynampet, University of Madras, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1422-34

1422-1434

500

258

40.

ANALYTICAL METHODS FOR THE DETERMINATION OF STATIN DRUGS USED IN DYSLIPIDEMIA AND HYPERCHOLESTEROLEMIA

Statins are the first line of defense in the treatment of dyslipidemia and hypercholesterolemia illness. HMG-CoA reductase inhibitors or statins are the most widely prescribed drugs for persons at risk of cardiovascular disease. Cardiovascular disease (CVD) is the leading cause of death and a major cause of morbidity around the world. Statins have the same mechanism of action, but their chemical s...

N. Tumung *, H. Jajo, S. Bairagi and B. Shrestha

Department of Pharmaceutical Analysis, Himalayan Pharmacy Institute, Majhitar, East Sikkim, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1435-41

1435-1441

456

221

41.

THIN LAYER CHROMATOGRAPHIC SEPARATION OF BENZODIAZEPINES BY SEVEN DIFFERENT SOLVENT SYSTEMS

Benzodiazepines are psychoactive drugs used to treat anxiety, epilepsy, convulsions, and psychiatric and sleeping disorders. These medicinal compounds possess considerable importance in forensic toxicology due to their tranquilizing, hypnotic, and anticonvulsant properties. Thus, identifying and separating these compounds found significance in pharmaceuticals. The high-performance liquid chromatog...

Anjali Sharma, Geeta Wadhvani, Sushil Kumar Sharma and Shobhana Sharma *

Department of Chemistry, S. S. Jain Subodh P. G. College, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1442-51

1442-1451

640

352

42.

COMPARISON OF EFFICACY OF DEXMEDETOMIDINE AND TRAMADOL FOR PROPHYLACTIC USE IN POST SPINAL ANAESTHESIA SHIVERING. A PROSPECTIVE RANDOMIZED CONTROLLED STUDY

Background: Shivering is one of the most troublesome and distressing experiences for the patient encountered intraoperatively following spinal anaesthesia. Tramadol is very commonly used in clinical practice for post-spinal shivering but has side effects. The study aimed to compare the efficacy of dexmedetomidine with that of tramadol for prophylactic use in post-spinal anaesthesia shivering. Meth...

J. Mahor, R. Godwin, M. Setiya, T. Garg * and R. Mehani

Department of Pharmacology, People’s College of Medical Sciences& RC, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1452-58

1452-1458

624

262

43.

MEDICATION REGIMEN COMPLEXITY ASSESSMENT IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND ITS IMPACT ON MEDICATION ADHERENCE AND GLYCEMIC CONTROL: A CROSS-SECTIONAL STUDY IN TERTIARY CARE HOSPITAL, SOUTH KERALA

Background and Aim: The prevalence of DM worldwide is estimated to be 415 million, which is anticipated to surpass 642 million in the next 25 years. Good glycaemic control reduces the incidence of complications associated with diabetes and thus improves microvascular diseases. Complexity can be regarded as the root cause of low adherence and thus result in interactions. This study aimed to evaluat...

Eliz John *, S. R. Gowri Parvathy, Himasanthosh, Gloris Mariam Chacko and Chitra C. Nair

Kerala University of Health Sciences, Kerala, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1459-66

1459-1466

569

278

44.

PRESCRIPTION ANALYSIS AND MONITORING OF ADVERSE DRUG REACTIONS OF ANTICANCER AGENTS IN TERTIARY CARE HOSPITAL

Objective: Cancer being a global threat and deadly disease, necessitate the use of anticancer agents. Hence, continuous drug utilization evaluation studies and Adverse Drug Reaction (ADR) reporting should be carried out in the oncology departments of health care systems. The objective of the study was to identify various types of cancer, assess commonly prescribed anticancer agents using WHO presc...

Shital M. Rede, Shruti R. Deshpande, Nikhat Shaikh, Jui D. Patil, Shraddha P. Devarshi *, Dayanand Kannur and Jayant P. Gawande

Department of Pharmacy Practice, Tathwade, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1467-76

1467-1476

952

314

45.

NEURO-PROTECTIVE POTENTIAL OF BETULINIC ACID AND ROTUNDIC ACID ON THE MERCURIC CHLORIDE INTOXICATED BRAIN OF ALBINO WISTAR RATS

Mercury is the more risky heavy metal for human health because of its ability to kill human nerve cells and its exposure to the environment through human activities, which implicate sewage drainage, agriculture, municipal, mining, incineration, and drainage of industrial wastewater. Mercury and its compounds cause toxic action in the body by several mechanisms, which mainly cause the nervous syste...

Muthaiyan Revathi * and Ganesan Jagadeesan

Department of Zoology, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1477-90

1477-1490

429

210

46.

DEVELOPMENT, OPTIMIZATION AND EVALUATION OF HERBAL GEL FORMULATION

Acne vulgaris is one of the most common chronic inflammatory skin diseases affecting more than 85% of adolescents worldwide. Quercetin, curcuminoids, and berberine HCl have anti-acne, anti-inflammatory, antibacterial, and antioxidant characteristics. This study aimed to develop, optimize and evaluate herbal gel containing quercetin, curcuminoids, and berberine HCl. A preliminary trial was conducte...

Kinjal Patel * and Maitreyi Zaveri

Department of Pharmacognosy, K. B. Institute of Pharmaceutical Education and Research, Kadi Sarva Vishwa Vidyalaya, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1491-99

1491-1499

545

315

47.

ASSESSMENT OF SERUM URIC ACID AND C-REACTIVE PROTEIN LEVELS IN TYPE 2 DIABETIC PATIENTS IN A TERTIARY CARE HOSPITAL

Introduction: The incidence and prevalence of diabetes and its complications has been significantly increased in recent times. C-reactive protein and hyperuricemia are early inflammatory markers associated with type 2 diabetes. Increased uric acid levels are known to be associated with endothelial dysfunction. The relationship between serum uric acid and inflammation in type 2 diabetes has not bee...

Pallavi Mahajan *, Rachna Sabharwal, Ashima Badyal, Pallav Sharma and Amarjeet Singh Bhatia

Department of Biochemistry, Government Medical College, Jammu, Kashmir, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1500-06

1500-1506

481

259

48.

EFFECT OF QUERCETIN ON HYPOXIA-REGULATED METASTATIC MARKERS IN AGGRESSIVE PANCREATIC CANCER CELLS UNDER HYPOXIC CONDITIONS

Tumor hypoxia is an important pathological condition that influences several signaling cascades in malignant cells, eventually leading to therapy resistance. Several natural bioflavonoids hold promise as anti-cancer agents. However, the effect of Quercetin on hypoxic pancreatic cancer cells is unknown. We analyze the effect of Quercetin on expression levels of metastatic markers HIF1α and E-cadhe...

Phani Bhushan Meka, Hiba Ahmed, Hajera Unissa, Huda Tahera, Mohammad Ahmed Waheed, Maryam Sadiq, Sumayya Afreen and Nazima Begum *

Vimta Labs Ltd, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1507-10

1507-1510

473

218

49.

QUALITATIVE ANALYSIS OF PHYTOCHEMICAL CONSTITUENTS OF CERTAIN ETHNOMEDICINAL PLANTS IN BHADRAVATHI TALUK OF SHIVAMOGGA DISTRICT, KARNATAKA

Medicinal plants are an abundant source of bioactive compounds, which have been used for thousands of years against different diseases because plants have antibacterial, anti-inflammatory, and antifungal activities. All of the medicinal plants that may be found on earth today have specific therapeutic use and importance. Our research work is based on the qualitative phytochemical studies of extrac...

S. P. Kavya * and N. Mallikarjun

Department of Studies and Research in Microbiology, Sahyadri Science College, Kuvempu University, Shivamogga, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1511-16

1511-1516

494

270

50.

PHYTOCHEMICAL SCREENING AND PHARMACOLOGICAL EVALUATION OF AEGLE MARMELOS LEAVES FOR SELECTIVE PSYCHOTROPIC ACTIVITY

Aegle marmelos, commonly known as Bael or Bilva, belonging to family Rutaceae, has been a tree of humongous significance since time immemorial. It has been used tremendously in ethnomedicine and ethnobotany owing to its spiritual connection. There are testimonials of its prolific use in Ayurveda, Unani and Siddha system of medicine. People also have found this tree of utility owing to its ecologic...

Swati Jain *, Ahmad Shamim and Farooqui Nasiruddin Ahmad

Translam Institute of Pharmaceutical Education & Research, Meerut, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1517-27

1517-1527

528

276

51.

EFFECT OF ANTINEOPLASTIC LOADED TRANSDERMAL PATCH IN DMBA-INDUCED BREAST CANCER

Background: The current study assessed the effect of an Antineoplastic-loaded transdermal patch in Dimethyl-benzanthracene (DMBA)-induced breast cancer. Materials and Methods: Different formulations composed of various concentrations of tamoxifen citrate, poly (SA: RA), glucose, and mannitol were formulated and evaluated in DMBA-induced breast cancer in female albino Wistar rats. Multiple parame...

Chandra Shekhar Sharma *, Prashant Kumar and Anurag Verma

Department of Pharmaceutics, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(3).1528-33

1528-1533

455

361