Transdermal drug delivery system (TDS) is not practically for delivery of materials whose final target is skin itself. Application topical agents generally offer many problems such as rashes, skin irritancy and burning sensation etc due to higher percutaneous absorption of drugs on the skin. Some conventional dosage e.g., gels and ointments which are often aesthetically unappealing, greasiness and...
The present article is a descriptive study of the performances of ethosomes and proniosomes as specialized delivery systems for transdermal drug delivery system. Vesicular systems, such as ethosomes and proniosomes are used in cosmetic and pharmaceutical products to encapsulate ingredients, to protect ingredients from degradation, to increase bioavailability, and to improve cosmetic performance....
GASTRORETENTIVE DRUG DELIVERY SYSTEM: AN APPROACH TO ENHANCE GASTRIC RETENTION FOR PROLONGED DRUG RELEASE
Oral route has been the most convenient and accepted route of drug delivery. Owing to tremendous curative benefits of the oral controlled release dosage forms are being preferred as the interesting topic in pharmaceutical field to achieved improved therapeutics advantages. Gastroretentive drug delivery system is novel drug delivery systems which has an upper hand owing to its ability of prolonged ...
VISUAL ESTIMATION AND SPECTROPHOTOMETRIC DETERMINATION OF TANNIN CONTENT AND ANTIOXIDANT ACTIVITY OF THREE COMMON VEGETABLE
Antioxidant activities of different vegetables Bitter gourd, Tomato and Spinach (Momordica charantia, Lycopersicon esculentum, Spinacia oleracea) were determined. In addition, rapid visual estimation of tannin content, total phenolic, tested for their free radical scavenging activity (FRSA) in the DPPH (1, 1-dephenyl- 2-picrylhydrazil radical) of those samples were assessed. A new technique was us...
A budding interest in Nanopharmaceuticals had generated a number of advancements throughout recent years with a focus on engineering novel applications. Nanophytomedicines are prepared from active phytoconstituents or standardized extracts. The world market for nanomedicine is estimated to reach $130.9 billion by the fiscal year 2016. Liposome nanoparticle (NP) with entrapped doxorubicin was repor...
Most of the new chemical entities coming out from High-throughput screening in drug discovery process are failing due to their poor solubility in the water. Poorly water-soluble drugs show many problems in formulating them in conventional dosage forms. One of the critical problems associated with poorly soluble drugs is too low bioavailability. The problem is even more complex for drugs belonging ...
WHAT SUITS BEST FOR ORGAN WEIGHT ANALYSIS: REVIEW OF RELATIONSHIP BETWEEN ORGAN WEIGHT AND BODY / BRAIN WEIGHT FOR RODENT TOXICITY STUDIES
Organ weight analysis is an important endpoint for identification of potentially harmful effects of test compounds in toxicology studies. Organ weight differences are often accompanied by differences in body weights between treatment groups which make the organ weight interpretation more difficult. We have evaluated the relationship between organ weight and body/brain weight based on statistical a...
Indian literatures like Ayurveda and various ancient literatures have stated herbal remedies for a number of human ailments. Annona reticulata which is commonly known as bullock's-heart in English and Ramphal in Hindi and Marathi is having various pharmacological activities such as antioxidant, anticancer, analgesic and CNS depressant, antimalarial, anthelmintic, in syphilis and few more. Some c...
STUDY OF ANTITUSSIVE POTENTIAL OF GLYCYRRHIZA GLABRA AND ADHATODA VASICA USING A COUGH MODEL INDUCED BY SULPHUR DIOXIDE GAS IN MICE
Cough is the most common symptom of respiratory diseases. When cough becomes serious, opioids are effective, but they have side effects like sedation, constipation. Therefore, there is a need to have effective antitussive agent which do not have respiratory depressant activity. The present study was carried out to evaluate antitussive activity of Glycyrrhiza glabra and Adhatoda vasica using a coug...
ASSESSMENT OF CYTOTOXICITY AND ANTIBACTERIAL ACTIVITIES OF ETHANOLIC EXTRACTS OF KALANCHOE PINNATA LINN. (FAMILY: CRASSULACEAE) LEAVES AND STEMS
Objective: In the present work, the leaves and stems of Kalanchoe pinnata Linn. (Family: Crassulaceae) have been investigated for screening phytochemicals, cytotoxicity and antibacterial activities. Materials and methods: Brine shrimp lethality (BSL) bioassay was used as a pre-screening method for cytotoxic effect. Ethanolic extract of the plant was tested by using this method. The agar disc di...