DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF GLICLAZIDE AND METFORMIN HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM BY SIMULTANEOUS EQUATION METHOD
A simple, rapid, accurate, precise, specific and economical spectrophotometric method for simultaneous estimation of Gliclazide (GLC) and Metformin hydrochloride (MET) in combined tablet dosage form has been developed. It employs formation and solving of simultaneous equation using two wavelengths 227.0 nm and 237.5 nm. This method obeys Beer’s law in the employed concentration ranges of 5-25 μ...
Chalcones are 1, 3-diphenyl-2-propene-1-one, consist of two aromatic rings linked by a three carbon α, β-unsaturated carbonyl system. The chemistry of chalcones has generated intensive scientific studies throughout the world. Especially interest has been focused on the synthesis and biodynamic activities of chalcones. These are considered to be precursors of flavonoids and isoflavonoids. The aim...
Traditional remedies and preparation used for the treatment of skin, or the folk preparations used for healing skin diseases are known to be as Cosmeceuticals and cosmetics. The desire of gook looking and to be beautiful gave a huge market for the cosmetics. This is not a new tradition for human to look good; it has been a long ancient follow through for both the sexes to be presentable by beauty....
ANTIRHEUMATOID ACTIVITY OF AQUEOUS EXTRACT OF PIPER LONGUM ON FREUNDS ADJUVANT-INDUCED ARTHRITIS IN RATS
Aqueous extract of the fruits of the plant Piper longum was studied for their Anti rheumatoid activity in Freunds Adjuvant Induced Arthritis Rats with the dose of 200 and 400 mg/kg p. o. The administration of extract reported significant reduction in paw swelling on 4th, 8th, 14th and 21st day after sub-plenter administration of Complete Freunds adjuvant. The paw swelling was measured as a volume ...
Withania somnifera belongs to the Solanaceaefamily, commonly known as Ashwagandha, Indian ginseng or Winter cherry. It is an important commercial medicinal crop, considered as similar to Panax ginseng in Chinese medicine. Different parts of this plant are used in traditional medicine for the treatment of various ailments. It provides defense against diseases, adverse environmental factors and help...
The present study was undertaken to find out the potential of gum from Almond gum to act as a binder and release retardant in tablet formulations. No significant work has been reported to use it as a tablet binder. The effect of almond gum and pvp on the release of diclofenac sodium was studied. The FT-IR spectroscopic studies of drug, gum and mixture indicated no chemical interaction. Seven formu...
Indian literatures like Ayurveda and various ancient literatures have stated herbal remedies for a number of human ailments. Annona reticulata which is commonly known as bullock's-heart in English and Ramphal in Hindi and Marathi is having various pharmacological activities such as antioxidant, anticancer, analgesic and CNS depressant, antimalarial, anthelmintic, in syphilis and few more. Some c...
EVALUATION OF ANALGESIC AND NEUROPHARMACOLOGICAL ACTIVITIES OF METHANOLIC RHIZOME EXTRACT OF HEDYCHIUM CORONARIUM
This study was aimed to investigate analgesic and neuropharmacological actions of the methanolic extract of rhizomes of Hedychium coronarium. The analgesic activity was evaluated for its central and peripheral pharmacological actions using tail immersion method and acetic acid-induced writhing test in mice respectively. The extract, at the doses of 100, 200 and 400 mg/kg body weight, produced a si...
PHYTOCHEMICAL INVESTIGATION AND CHROMATOGRAPHIC EVALUATION OF THE ETHANOLIC EXTRACT OF WHOLE PLANT EXTRACT OF DENDROPHTHOE FALCATA (L.F) ETTINGSH
The present study was aimed to investigate phytochemicals present in the whole plant extract of Dendrophthoe falcata and development of new solvent system for thin layer chromatography of ethanolic (whole plant) extract of medicinal plant Dendrophthoe falcata. The extract showed presence of Carbohydrates, Sterols, Glycosides, Flavonoids and Phenolic compounds. For TLC, new solvent system developed...
BIOSYNTHESIS AND CHARACTERIZATION OF SILVER NANOPARTICLES USING ENDOPHYTIC FUNGI ASPERGILLUS CONCIUS, PENICILLIUM JANTHINELLUM AND PHOMOSIS SP.
The present study of seventy one endophytic fungi isolated from Avicennia marina, Suaeda monica and Rhizophora mucronata plant leaf. Among 34 genera and 71 species was identified by Lactophenol cotton blue mounting techniques. To induce the biosynthesis of silver nanoparticles (AgNO3) using Aspergillus conicus, Penicillium janthinellum and Phomosis sp. And evaluate their antimicrobial potential. T...