Pregnancy can be the most paranormal and exciting time for expectant mother. Nature provides us with many tools for supporting both the mother and baby through this time of growth and renewal, to strengthen the spirits and body to promote a healthy pregnancy and birthing process. Pregnant and lacting mother need to be educated on the need for caution when using herbs during pregnancy and lactation...
Despite of tremendous advancement in drug delivery the oral route of drug administration is the most important method of administration of drug for systemic effect. The parenteral route is not routinely used for self administration of medication. It has been known for centuries that buccal and sublingual administration of drug solute is rapidly absorbed into the reticulated vein, which lies undern...
The bioavailability of some orally administered botanical extracts is erratic and poor due to limited gastro-intestinal absorption. Bioavailability can be improved by using new delivery systems which can enhance the rate and the extent of solubilization into aqueous intestinal fluids and the capacity to cross biomembranes. Phospholipids based drug delivery system have been found promising for bett...
The manufacture of bi-layer tablets, produced by the sequential compaction of loose powder layers has recently become of increased interest within the pharmaceutical industry due to the tailored release profiles of active ingredients that may be obtained. In a bi-layer configuration, the immediate release layer of the bi-layer tablet has worked as the loading dose and the sustained release layer h...
The plant Tephrosia purpurea L. is commonly known as Unhali. T. purpurea (Leguminosae) is a copiously branched perennial herb. Present work was undertaken to study antioxidant potential of the plant. Dried ethanol and aqueous extracts plant were screened for in-vitro antioxidant activity by DPPH assay and nitric oxide screening methods. Results showed that IC50 value of aqueous extract in DPPH ass...
The advent of nanotechnology lead to invention of many dosage forms. Effective targeted drug delivery systems have been a dream for a long time, due to several major drawbacks, a practical approach has been developed for the formation of discrete functionalized particles, which have been termed as ‘Nanosponge’. The development of new colloidal carrier called Nanosponges has the potential to so...
ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF PEELS, PULPS AND SEED KERNELS OF THREE COMMON MANGO (MANGIFERA INDICAL L.) VARIETIES IN SRI LANKA
Mango products are well demanded by consumers due to their unique flavor and mango pulps are developed as various products while mango peels and seeds are the major agro-industrial wastes in canned fruit manufacture and fruit juice processing. Hence the aim of the present study was to investigate on their bioactive phenolic compounds in mango byproducts. Extracts of pulps, seed kernels and peels w...
This overview firstly highlights biology of endophytic microbes from medicinal plants as well as their chemistry with emphasis on the important merging of microbiology and natural products chemistry and its role in improving our current knowledge of endophytic associations in medicinal plants. Secondary metabolites of medicinal plants-derived endophytes reported in recent years are grouped accordi...
ASSESSMENTS OF ADHERENCE TO HYPERTENSION MANAGEMENTS AND ITS INFLUENCING FACTORS AMONG HYPERTENSIVE PATIENTS ATTENDING BLACK LION HOSPITAL CHRONIC FOLLOW UP UNIT, ADDIS ABABA, ETHIOPIA-A CROSS-SECTIONAL STUDY
Background: In Ethiopia 10.6% and Addis Ababa, 30% of the population has been estimated to have hypertension. Adherence to medication therapy and lifestyle change is an aspect of patients’ care that is often overlooked and should be evaluated as a crucial part of cardiovascular management. Objective: The aim is to assess adherence and influencing factors of adherence to hypertensive managemen...
ANTIBACTERIAL EVALUATION, REDUCING POWER ASSAY AND PHYTOCHEMICAL SCREENING OF MORINGA OLEIFERA LEAF EXTRACTS: EFFECT OF SOLVENT POLARITY
Moringa preparations have been cited in the scientific literature as having antibiotic, antitrypanosomal, hypotensive, and antispasmodic, antiulcer, anti-inflammatory, hypo-cholesterolemic, and hypoglycemic activities, as well as having considerable efficacy in water purification by flocculation, sedimentation, antibiosis. To evaluate the antioxidant activity of Moringa oleifera leaf extracts an...