MICROWAVE IRRADIATED SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING STUDIES OF 3-((SUBSTITUTED-BENZO[D]THIAZOL-2-YLAMINO)METHYL)-5-(PYRIDIN-4-YL)-1,3,4-OXADIAZOLE-2(3H)-THIONE
A series of new Mannich base derivatives were designed, synthesized by conventional and non-conventional microwave method, compared and evaluated for their antimicrobial and anti-mycobacterial activity. Structures of the newly synthesized compounds were assigned on the basis of elemental analysis, IR, 1H NMR, 13C NMR and mass spectral studies. The bioactive assay showed that Mannich base derivativ...
Multiple causes of liver diseases that will affect the health related quality of life and are dispersed globally. It is difficult to diagnose the different stages of liver disease. Scores like Child Pugh Score(CPS), Model For End Stage Liver Disease(MELD), Monoethylglycinexylidine(MEGX), Von willibrand factor (vWF) etc are used to detect the progression of liver disease like hepatitis, cirrhosis, ...
ENHANCED ANTIMICROBIAL ACTIVITY OF PROBIOTICS THROUGH SELENIUM NANOPARTICLES ENRICHMENT AGAINST GASTROINTESTINAL PATHOGENS
The decrease in susceptibility towards commonly administered antibacterial agents is due to excessive use of antibiotics every now and then, due to which the resistance toward these antibiotics is developed in pathogens. To overcome the problem of resistance in pathogenic microbes, the study of incorporation of Selenium metal to probioticts supplement was carried out. Antimicrobial activity of ind...
COMPARATIVE STUDY OF OCIMUM BASILLICUM AND ITS ENDOPHYTIC ACTINOMYCETES STREPTOMYCES FLAVOVIRIDIS A3WK: EVALUATION OF ANTIOXIDANT, ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITY
Endophytic actinomycetes are the potential source for obtaining novel bioactive compounds. Present study evaluates the chemical constituents in Ocimum basillicum and its endophytic actinomycetes. Eleven endophytic actinomycetes were isolated from O. basillicum plant. Among eleven, one isolate was characterized by 16S rRNA and identified as Streptomyces flavoviridis A3WK. A comparative analysis of ...
Bisphenol A is well known endocrine disturbing chemical. Evidence has demonstrated that exposure to certain levels can cause toxic effect in humans and laboratory animal models. Quercetin is consistently the most active of the flavonoids in experimental studies. The present investigation was an attempt to evaluate the effect of Bisphenol A on testis and its amelioration by quercetin. Inbred Swiss ...
Some biogenic amine like Histamine, cadaverine and putrescine have been confirmed as useful chemical indicators to estimate bacterial spoilage of foods, particularly fish and fish products, cheese, meat and fermented foods. Histamine is toxic at high intakes, while cadaverine and putrescine potentiate the effects of Histamine. Histamine has regulated level of 200 mg/kg (200 ppm). Basic princ...
Metals are able to form a large number of oxides. These metal oxides play an important role in many areas of chemistry, physics and material science. An important metal oxide known as magnesium oxide (MgO) having good reactivity is widely used in producing electronics, catalyst, ceramics, oil, paint etc. Magnesium oxide nanoparticle is non-toxic and need a small amount, so it is suitable for the d...
MUCOADHESIVE MICROPARTICLES OF CARBOXYMETHYL CHITOSAN FOR SITE SPECIFIC DELIVERY OF PANTOPRAZOLE: FORMULATION AND IN VITRO CHARACTERIZATION
Carboxymethyl chitosan, a water soluble modified carboxymethyl substituted chitosan derivative have distinct and unique properties, rendering them effective to form selective permeable mucoadhesive film or membranes. In the formulation of chitosan microsphere an acidic environment is essentially required that may degrade acid sensitive moiety, peptide or protein drugs. Mucoadhesive microparticle o...
FORMULATION, DESIGN AND CHARACTERIZATION OF MUCOADHESIVE BUCCAL FILM OF NEBIVOLOL USING FACTORIAL DESIGN
The present investigation was to formulation and development of fast dissolving mucoadhesive buccal film of nebivolol by using solvent casting method. Nebivolol is a third-generation cardio selective β1-blocker undergoes extensive metabolism in the liver, gastrointestinal disturbance, abdominal pain after its oral administration and resulting in to a poor (10-12%) bioavailability. In order to imp...
Dengue fever is an important public health problem in tropical and sub-tropical Continent. Recently the number of severe forms of the disease, dengue hemorrhagic fever, and dengue shock syndrome are increased. Dengue virus, a arbo-virus responsible for dengue fever and spread through its vector, Aedes aegypti. Controlling the mosquito is the good strategy to prevent this disease. The traditional c...