Objective: Recently, natural plants have received much attention as sources of biological active substances including antioxidants. In the present study we investigated In-vitro antioxidant activity of hexane, ethyl acetate and ethanol extracts of Solanum sisymbrifolium aerial parts. Methods: In-vitro antioxidant activity was evaluated for extracts by using free radicals Superoxide (Riboflavin pho...
METHOD DEVELOPMENT AND VALIDATION OF TULOBUTEROL IN API AND ITS PHARMACEUTICAL DOSAGE FORMS BY UV SPECTROPHOTOMETRY
A simple, accurate, sensitive and reproducible UV spectrophotometric method has been developed for the determination of Tulobuterol (TLB) in bulk and also in its pharmaceutical dosage formulations. The proposed method showed absorbance maxima at 212 nm. Beer's law is obeyed over a concentration range of 25-125µg/mL. The respective linear regression equation being Y =0.009x +0.014 for TLB. Results...
DESIGN, SYNTHESIS AND EVALUATION OF SOME NEW ISOXAZOLES, CYANO-PYRIDINES AND 1, 5 BENZOTHIAZEPINES AS ANTIMICROBIAL AGENTS
The title compounds (7a-f), (8a-f) and (9a-f) have been prepared from chalcones (6a-f) having s-triazine nucleus. These chalcones on cyclisation with hydroxyl amine hydrochloride in the presence of alkali and malononitrile in the presence of ammonium acetate give isoxazoles (7a-f) and cyanopyridines (8a-f) respectively. Chalcones (6a-f) on condensation with 2-amino thiophenol in the presence of gl...
There is no doubt that quite a number of obstacles are stumbling blocks to students’ practical skill acquisition. Such impediments could either be as a result of factors directly related to students, their lecturers or the institutions where the students are undergoing their training. This study identified the hindrances to practical skill development among the students in Kaduna Polytechnic, Ni...
EFFECT OF METFORMIN AND ROSUVASTATIN ON ERYTHROCYTES OF PATIENTS WITH SICKLE CELL DISEASE: AN IN-VITRO STUDY
Objectives: Sickle cell disease (SCD) is a common hereditary blood disease with a progressive clinical course and multiple end organs damage. Due to its intercalated pathophysiology, several trials have been conducted targeting its pathophysiology in an attempt to modify the clinical course and minimize complications. Metformin and rosuvastatin are known to have pleiotropic effects such as antioxi...
INCIDENCE OF HUMAN RHINOVIRUS COINFECTION WITH STAPHYLOCOCCUS AUREUS AMONG HIV PATIENTS SUFFERING FROM FLU LIKE ILLNESS
Background: Influenza and influenza like illness (ILI) is a common respiratory illness among HIV patients. ILI is caused by various respiratory viruses and bacteria other than influenza virus. The symptoms of ILI recover within a few days, but in HIV patients ILI with opportunistic coinfections may lead to serious complications and hospitalization. Objective: To determine the incidence of human rh...
SEMI-BATCH AND CONTINUOUS CARBOCHLORINATION OF ZIRCONIA IN A PILOT PLANT FLUIDIZED BED REACTOR: OPTIMIZATION OF OPERATING CONDITIONS VIA RESPONSE SURFACE METHODOLOGY
Zirconium tetrachloride was produced in a pilot plant fluidized bed reactor via the carbochlorination reaction of zirconia. Minitab software 17 was used for the design of experiment with response surface methodology (RSM) for both semi batch and continuous processes. The operating temperature (800-1200 °C), reaction time (30-90 min) and mean particle size (MPS) (70-130µm) were chosen as the rang...
SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND EVALUATION OF ANTI-TUMOR PROPERTIES OF NOVEL FATTYACID CONJUGATES OF 2, 4 AND 2, 6-DIISOPROPYLPHENOL
The present study enumerates the synthesis, spectroscopic characterization, and evaluation of antitumor properties of esters of two fatty acids viz., 5-hexenoic acid and iso- ricinoleic acid with 2, 4- or 2, 6-diisopropylphenol (Propofol). Propofol is a potent intravenous hypnotic agent which is widely used for the induction and maintenance of anesthesia and for sedation in the intensive care unit...
IN-VITRO ASSESSMENT, ISOLATION AND SPECTRAL ANALYSIS OF THE CHLOROFORM FRACTION OF DIOSPYROS KAKI FRUIT
Persimmon (Diospyros kaki Linn.), which belongs to the Ebenaceae family, have numerous bioactive compounds such as polyphenols, dietary fiber, carotenoids and minerals. This fruit possesses hypolipidemic and antioxidant properties and can be used in anti-atherosclerosis diets. The present paper reveals the phytochemical screening, Antioxidant, Anti-inflammatory activity and GC-MS Spectral analysis...
NATURE AND CAUSE OF TAKING PSYCHOTROPIC DRUGS: A CROSS-SECTIONAL HEALTH SURVEY IN NORTHERN REGIONS OF BANGLADESH
A health study was conducted in Northern Region of Bangladesh to determine the prevalence and cause of taking psychotropic drugs. The health survey was involved 615 patients who are taking psychotropic drugs and found 63.58% patient is male and 36.42% is female. The majority of patients are student (45.65%), housewife (19.02%) and service holder (13.33%). The age of patients is 15 - 24 years 35.93...