Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
ANTI-ATHEROSCLEROTIC POTENTIAL OF PIOGLITAZONE AND N-ACETYLCYSTEINE
Atherosclerosis involves disturbances in endothelium and the resultant cascade of inflammatory reactions involving generation of ROS (Reactive Oxygen Species). Peroxisome proliferator-activated receptor-g (PPAR-g) receptors are more expressed during atherosclerosis process and its stimulation results in inhibition of formation of atherosclerotic plaque. N-acetylcysteine (NAC) stimulates GSH (gluta...
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1022
SUPPRESSIVE EFFECT OF TEUCRIUM POLIUM ON OXIDATIVE DAMAGES AMONG EXPERIMENTAL STEATOHEPATITIS
Non-alcoholic steatohepatitis (NASH) is a metabolic disorder of the liver that may progress to fibrosis or cirrhosis. In the present study, we examined the possible preventive effect of an extract of Teucrium polium L. (Lamiaceae), a plant with high flavonoid content and antioxidant activity, on experimental NASH. To induce NASH, a methionine and choline deficient (MCD) diet was given to N-Mary ra...
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1151
ASSESSMENT OF CYTOTOXICITY, ANTIOXIDANT AND FREE RADICAL SCAVENGING ACTIVITIES OF THE ETHYLACETATE EXTRACT OF CALLIANDRA PORTORICENSIS ROOT BARK
Calliandra portoricensis a medicinal plant, is widely use in the treatment/management of various diseases in Nigeria. The ethyl acetate extract of the Calliandra portoricensis root bark were tested to evaluate the cytotoxicity, antioxidant (in vitro) and free radical scavenging activity. The different assay methods, including total antioxidant activity, free radical (nitric oxide, hydroxyl radical...
2855
1153
SALINE WATER AS SOURCE OF CANCER DRUGS: ANTI- CANCER METABOLITES FROM MARINE SPONGES
Oceans and its ecosystem comprise an untapped source for many potential drugs. Marine sponges which inhabit mainly in the saline ocean water are considered as one of the oldest form of life. Due to intense concentration of various sponge species and other organisms co- existing in limited extent marine habitats, necessarily makes them highly competitive and complex. Hence most of the sponge specie...
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1198
SIMULTANEOUS ESTIMATION OF RABEPRAZOLE SODIUM AND CINITAPRIDE HYDROGEN TARTRATE IN COMBINED PHARMACEUTICAL FORMULATION
Three simple, rapid, precise and accurate spectrophotometric methods have been developed for simultaneous analysis of Cinitapride Hydrogen Tartrate (CNT) and Rabeprazole Sodium (RAB) in their combined dosage form. Method A, Simultaneous equation method (Vierodt’s method) applies measurement of absorptivities at two wavelengths, 265.6 nm (λmax of Cinitapride Hydrogen Tartrate) and 282.6 nm, (λm...
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“MANOVA OVER ANOVA”- A BETTER OBJECTIVE IN BIOEQUIVALENCE STUDY
Bioequivalence studies should be conducted for two products marketed by different licensees, containing same active ingredient(s), must be shown to be therapeutically equivalent to one another order to be considered interchangeable. The bioequivalence of two formulations of the same drug can be determined based on the absence of significant differences in primary pharmacokinetic properties of bioa...
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PEGINESATIDE- A NOVEL ERYTHROPOIETIN MIMETIC AGENT FOR THE TREATMENT OF ANAEMIA IN CHRONIC RENAL FAILURE PATIENTS
Anaemia associated with chronic kidney disease (CKD) affects the overall health of the patients leading to increased morbidity and mortality. Erythropoietin stimulating agents (ESAs) have been the standard of care for the treatment of such patients since last 20 years. These agents have the potential to increase mean haemoglobin levels in both pre dialysis and dialysis maintenance phases hence low...
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FORMULATION AND EVALUATION OF ANTACID ANALGESIC TABLET
The present study deals with formulation of a combined analgesic and antacid effervescent tablets. Paracetamol is the model drug used. It is poorly soluble in the water and hence the formulation is in the form of an effervescent tablet so that the disintegration time of the drug is not hindering the action. The mixture of magnesium and aluminium hydroxide is used as the model antacid. The present ...
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EVALUATION OF WOUND HEALING ACTIVITY OF LEAF EXTRACT OF DODONAEA VISCOSA JACQ INALLOXAN INDUCED DIABETIC WISTAR ALBINO RATS
The present study was undertaken to evaluate the wound healing activity of leaf extract of Dodonaea viscosa Jacq in diabetic wistar albino rats. Wound is defined as a loss or breaking of cellular and anatomic or functional continuity of living tissue. Normal wound healing response begins the moment the tissue is injured. Wound healing is the process of repair that follows injury to the skin and ot...
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DEVELOPMENT AND CHALLENGES FACING FOR INSULIN ORAL DELIVERY
The Present study focuses on the challenges facing the development of oral insulin the fact we have no formulation in market, being an attractive and advantageous over the regular injections. Physiological and biological factors of the insulin has great influence for the development of an oral formulation with many difficulties regarding the stability over gastric pH and proteolytic enzymes, selec...
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