Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
PURIFICATION AND BIOCHEMICAL CHARACTERIZATION OF NOVEL FIBRINOLYTIC PROTEASE PRODUCED BY MESOPHILIC BACILLUS CIRCULANS GD25
A novel fibrinolytic protease from Bacillus circulansGD25 was isolated and characterized for the fibrinolytic activity. The fibrinolytic protease was purified by ammonium sulphate fractionation (70%) and subjected to chromatographic methods like Sephadex G-50, DEAE –Sephadex A-50 columns. The purified enzyme has an approximately 38 kDa in size by SDS-PAGE and gel filtration. Optimum activity was...
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EVALUATION OF LEONOTIS NEPETAEFOLIA FOR ITS PHYTOCHEMICAL AND HEAVY METAL ANALYSIS
Phytochemical, HPTLC and Heavy metal analysis of Leaf of Leonotis nepetaefolia was done. Qualitative phytochemical screening of Leaf was done using different solvents which showed the presence of various vital secondary metabolites. Neutraceutical studies revealed the presence of carbohydrates, proteins and aminoacids. HPTLC studies confirmed the presence of flavonoids, diterpene, phenolic class o...
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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF TENOFOVIR DISOPROXIL FUMERATE AND EFAVIRENZ IN BULK AND FORMULATION
The objective of the present work was to develop a simple, rapid, accurate RP-HPLC method for the simultaneous estimation of Tenofovir disoproxil fumerate (TDF), Efavirenz in bulk and formulation. The chromatographic separation was achieved by isocratic mode of elution by using Agilent Zorbax Eclipse XDB C18 (150 x 4.6mm, particle size 5µm) analytical column. The mobile phase consisting of Aceton...
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COMPARATIVE STUDY OF ANTIULCER ACTIVITY OF METHANOLIC EXTRACTS OF WATTAKAKA VOLUBILIS (LINN.F.) STAF AND TABEBUIA ROSEA (BERTOL.) DC IN RATS
The aim of this study was to compare the antiulcer activity of methanolic extracts of Wattakaka volubilis (Linn.f.) Staf and Tabebuia rosea (Bertol.) DC in rats. The anti-ulcer effect was evaluated using Anti secretary model (chemical induced pylorus ligation). Ranitidine were used as standard drugs for ulcer studies. The extracts were administered orally at 500 mg/kg. The result of the present st...
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EFFECTS OF PREMNA INTEGRIFOLIA LINN. ROOTS EXTRACTS IN CCL4 INDUCED TOXICITY IN RATS
Premna integrifolia Linn. roots are used in the Indian system of medicine for the treatment of diabetes, inflammation, liver disorders etc. The present study was aimed to investigate the antioxidant activity of Premna integrifolia L. (Family: Verbenaceae) in CCl4 (carbon tetrachloride) induced oxidative stress in Sprague- Dawley rats. CCl4 injection induced oxidative stress by a significant rise i...
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FORMULATION & EVALUATION OF BUFFERED PANTOPRAZOLE SODIUM TABLET
The aim of this study was to prepare buffered tablets of acid labile drug, Pantoprazole sodium for oral administration using buffering agents to protect a drug from gastric fluid. Its mechanism of action was inhibition of H+/K+-adenosine triphosphate, an enzyme present in the gastric parietal cells. The tablets were prepared by wet granulation method. The formulations contain sodium carbonate, sod...
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2023
FORMULATION DEVELOPMENT AND EVALUATION OF MUCOADHESIVE MICRO-SPHERES OF SALBUTAMOL SULPHATE BY USING A NATURAL POLYMER
Salbutamol sulphate (SS) loaded microspheres were prepared by solvent evaporation method with combination of Sterculia foetida gum in various proportions. A total of eighteen formulations were prepared in different oil phases i.e., liquid paraffin and sunflower oil. Those prepared from liquid paraffin L1-L9 and those...
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A STUDY ON BIOPOLYMERIC NANOPARTICLES AS AN EFFECTIVE CARRIER FOR ANTIDEPRESSANT DRUG DELIVERY SYSTEM
Drug delivery is the most essential feature in drug administration facility and the design of Nanosystems makes the action more consistent an appropriate. Polymer nano particles bind efficiently to the drug and disperse the drug proficiently into the system. The efficacy of many drugs is often limited by their potential to reach the site of therapeutic action. In most cases (conventional dosage fo...
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FORMULATION AND RELEASE CHARACTERISTICS OF HPMC MATRIX TABLETS OF METOPROLOL SUCCINATE
The objective of this study was to design and evaluate oral sustained drug delivery system for Metoprolol succinate using pH sensitive polymer HPMC and sodium alginate and to evaluate its efficacy in reducing the hypertension. The drug filler blend was mixed with various concentrations of hydrophilic polymers such as HPMC, sodium alginate and combination of both the matrixing agents. The tablets w...
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SYNTHESIS OF SOME- 6- SUBSTITUTED- 6H- PYRROLO [3, 4-D] PYRIDAZINE DERIVATIVES AND THEIR EVALUATION FOR IN-VIVO ANTI-CONVULSANT ACTIVITY IN ALBINO RATS
Present studies on the synthesis and evaluation of anticonvulsant activity of some 6- Substituted- 6H- Pyrrolo [3, 4-d] Pyridazine derivatives. In the preliminary screening for anticonvulsant activity in albino rats, all the synthesized compounds were found to be active, even more than standard at dose 50mg/kg body weight....
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