The current study involves evaluation of antioxidant potential of selected nutraceuticals like barley grass juice (Hordeum vulgare L.), ethanolic extracts of cashew apple (Anacardium occidentale L.) and sea lettuce (Ulva reticulata F.) in in-vitro experimental model using goat liver slices at different concentrations (100, 200, 400, 800 and 1600 mg/kg, p.o). The oxidative stress was induced using ...
EFFICACY AND COMPLICATIONS OF PROLONG LINEZOLID THERAPY IN METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) INFECTED SUBCUTANEOUS ABSCESS MODEL IN WISTAR RAT
Linezolid has a better choice for the eradication of both community and hospital acquired methicillin-resistant Staphylococcus aureus (MRSA) infections, but its use is limited because of its complications. The study elucidated the efficacy and complications of prolonged therapy of linezolid in MRSA infected rats. The rats were rendered neutropenic by an intraperitoneal injection of cyclophosphamid...
PREVALENCE OF MEASLES VIRUS INFECTION AMONG VACCINATED AND NON-VACCINATED CHILDREN IN NORTHERN INDIA
Introduction: Measles virus (MeV) is still a common acute illness caused by viruses belonging to the family Paramyxoviridae and genus Morbillivirus. The objective of this study was to determine the prevalence of MeV in both vaccinated and unvaccinated children and consecutively, testing the efficacy of MeV vaccination among children in north India. Materials and Methods: A total of 323 blood sampl...
PHYTOCHEMICAL AND GC-MS ANALYSIS OF OLEORESIN OF DIPTEROCARPUS GRACILIS BLUME: AS A BASIC CONSIDERATION FOR HUMAN REMEDY
Dipterocarpus gracilis Blume is one tropical species of Dipterocarps which is included in the red list IUCN as a rare and endangered tree species. In consideration of Dipterocarpus gracilis Blume conservation and sustainability of its oleoresin, this present study aimed to determine specific characteristics of oleoresin origin of Dipterocarpus gracilis Blume as an establishing basis for appropriat...
ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF BCS CLASS II DRUG RITONAVIR USING LIQUISOLID TECHNIQUE
BCS class II drugs usually suffer inadequate bioavailability as a dissolution step is the absorption rate-limiting step. In this work, the effect of solubility increase at the main absorption site for these drugs was investigated using ritonavir as a drug model. The liquidsolid technique was applied to prepare ritonavir per-oral tablets of high dissolution rate using versatile non-ionic surfactant...
EFFECT OF ETHANOLIC EXTRACT PROPOLIS TRIGONA SPP. MALANG INDONESIA ON ISOLATE STAPHYLOCOCCUS AUREUS BIOFILM ARCHITECTURE FROM CHRONIC RHINOSINUSITIS A CONFOCAL LASER SCANNING MICROSCOPIC STUDY
Biofilm in chronic rhinosinusitis (CRS) is the infection by bacteria, which is difficult to overcome. It has recurrent infections, mucosal inflammation, and postoperative symptoms. Propolis is a natural product that is potential as an anti-biofilm choice. The purpose of this study was to determine the ethanolic extract propolis (EEP) effect on the morphology of Staphylococcus aureus biofilm. The p...
FORMULATION DEVELOPMENT OF LYOPHILIZED FLOATING BEADS CONTAINING GINGER EXTRACT AND NIGELLA SATIVA OIL
Lyophillized floating beads have been investigated as a possible gastro-retentive dosage forms containing Ginger (Zingiber Officinalis) extract ( ZOE) and Nigella Sativa oil (NSO). Emulsion gelation method was used in preparation of ZOE-NSO entrapped floating alginate beads. Drug content and floating properties of the beads were found to be satisfact...
Eurycomanone from the roots of Eurycoma longifolia Jack (ELJ) has been reported to exhibit anticancer activity. Four of ester eurycomanone derivatives: eurycomanone dibutyrate, eurycomanone monovalerate, eurycomanone dimethoxybenzene, and eurycomanone disuccinate were synthesized for knowing their activities on cancer cell lines T47D, MCF-7, Hela, WIDR and Vero cells. The cancer activity was evalu...
DEVELOPMENT OF AN HERBAL ENERGY DRINK USING MEDICINAL PLANT EXTRACTS AND FURTHER STATISTICALLY ANALYSING THE SENSORY PROPERTIES BY ANALYSIS OF VARIANCE (ANOVA)
Energy drinks (EDs) are caffeine-based beverages that commonly contains large amount of carbohydrates, sugar, health supplements and various energy stimulants, such as ginseng and vitamin B, to name a few. These drinks are marketed for young people actively involved in sports or overworking hours, as natural alternatives that increases fun and improve physical and cognitive performances such as...
Expansion of secondary metabolites from marine resources mainly from echinoderms has been a subject of intense research due to massive bioactive nature. Isolation of new secondary metabolites from sea stars has been found to be highly polar. An initial assessment and validation of these compounds are necessary to assess human risk. Zebrafish are used as a part of a diverse phase of the drug discov...