EFFECT OF ETHANOLIC EXTRACT PROPOLIS TRIGONA SPP. MALANG INDONESIA ON ISOLATE STAPHYLOCOCCUS AUREUS BIOFILM ARCHITECTURE FROM CHRONIC RHINOSINUSITIS A CONFOCAL LASER SCANNING MICROSCOPIC STUDY
Biofilm in chronic rhinosinusitis (CRS) is the infection by bacteria, which is difficult to overcome. It has recurrent infections, mucosal inflammation, and postoperative symptoms. Propolis is a natural product that is potential as an anti-biofilm choice. The purpose of this study was to determine the ethanolic extract propolis (EEP) effect on the morphology of Staphylococcus aureus biofilm. The p...
Eurycomanone from the roots of Eurycoma longifolia Jack (ELJ) has been reported to exhibit anticancer activity. Four of ester eurycomanone derivatives: eurycomanone dibutyrate, eurycomanone monovalerate, eurycomanone dimethoxybenzene, and eurycomanone disuccinate were synthesized for knowing their activities on cancer cell lines T47D, MCF-7, Hela, WIDR and Vero cells. The cancer activity was evalu...
Ulcerative colitis is gaining more prominence these days because of its complications (both local and systemic), impairing the quality of life of patient and increased morbidity and mortality rate. For instance, a case was reviewed which proved the role of clinical pharmacist in the treatment plan and in providing a cost effective therapy. The review of the case resulted in a dosage error and pres...
Expansion of secondary metabolites from marine resources mainly from echinoderms has been a subject of intense research due to massive bioactive nature. Isolation of new secondary metabolites from sea stars has been found to be highly polar. An initial assessment and validation of these compounds are necessary to assess human risk. Zebrafish are used as a part of a diverse phase of the drug discov...
An HPTLC method was developed for qualitative and quantitative estimation of catechin, quercetin and β-carotene in the marketed and in house polyherbal formulation Maharishi Amrit Kalash (MAK-5). The method was developed using precoated HPTLC silica gel 60 F254 as stationary phase and toluene: ethyl acetate: formic acid (12:12:2, v/v/v) as mobile phase for catechin and quercetin and petroleum eth...
Oxidative stress has been recommended as a contributory factor in complication and progression of diabetes. The aim of the study was to evaluate the effects of Rhizophora mucronata Leaves on streptozotocin generated oxidative stress induced diabetic nephropathy in rats. Forty Wistar rats were randomly divided into normal control, diabetic untreated and diabetic treated with ethanolic extract of Rh...
STUDY OF TOTAL PHENOLICS, TOTAL TANNINS ANTIOXIDANT POTENTIAL AND ANTIMICROBIAL ACTIVITY OF AILANTHUS EXCELSA L
Ailanthus excelsa leaves were evaluated for antimicrobial activity against clinical isolates obtained from patients with eye and skin infections and also for its antioxidant potential. The bacterial isolates obtained were identified to be S. aureus, P. aeruginosa, E. coli and the fungal isolates were identified as Aspergillus niger and Penicillium. The extract showed a maximum zone of inhibition a...
POLYELECTROLYTE COMPLEXATION AND IONOTROPIC GELLATION: THE POTENTIAL NOVEL APPROACH TO DESIGN HYDROGEL PARTICULATE FOR SUSTAINED, MODULATED DRUG DELIVERY SYSTEM: A REVIEW
The interest in using natural and chemically modified polysaccharides as a part of drug development has increased in the past two decades. For potential carriers in controlled, modulated drug delivery, great interest has also been focused on biopolymer-based hydrogels. Due to their advantages like biocompatibility, biodegradability, and low cost, biopolymers have been widely used in the developmen...
PHYTOCHEMICAL ANALYSIS AND DETERMINATION OF ANTIMICROBIAL, ANTIOXIDANT AND ANTICANCER ACTIVITY OF THE LEAF ETHANOLIC EXTRACTS OF PIPER SARMENTOSUM ROXB. IN LAPUYAN ZAMBOANGA DEL SUR, PHILIPPINES
Piper sarmentosum Roxb. belongs to the genus Piper in which traditional application described as remedy for several diseases. Considering its vast potential as effective pharmacological agent, a study was conducted to assess the phytochemical and biological activities of P. sarmentosum leaf extracts, with particular focus on their anti-microbial, anti-oxidant and anticancer properties. Results for...
Albizia procera is a genus of albizia, the member of legume family (fabaceae) and subfamily Mimosoideae. Albizia procera is tree with open canopy, occurs naturally in a wide distribution from India and Myanmar through South-East Asia to Papua New Guinea and Northern Australia. On basis of our study, Albizia procera has the high economic potential to be applied in pharmaceuticals, pharmacognosy, tr...