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EVALUATION OF ANTICONVULSANT ACTIVITY OF SEMECARPUS ANACARDIUM (LINN.) NUT EXTRACT
The present study was undertaken to evaluate the locomotor effect of chloroform extract of Semecarpus anacardium (Linn.) (CHSA) by using photoactometer. Its anticonvulsant property was tested against maximal electroshock (MES)-induced convulsion (MESIC), pentalenetetrazol (PTZ)-induced convulsion (PTZIC), strychnine-induced convulsion (SIC), picrotoxin-induced convulsion (PIC), isoniazid (INH)-ind...
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NANOCOCHLEATE: A NOVEL APPROACH FOR DELIVERY OF BIOLOGICAL MOLECULES
Nanocochleate is a novel lipid-based drug delivery system in which the liposomal vesicles are converted into nanocochleate by the addition of Calcium divalent cation. This technology involves encochleation of the drug for overcoming problems such as poor solubility, poor permeability, and poor oral bioavailability. This novel lipid-based formulation approach is applicable for the category of drugs...
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2032
MOLECULAR DOCKING STUDIES OF BMS-378806 ANALOGS AS NOVEL HIV-1 GP120/CD4 INHIBITORS
AIDS, a pandemic disease caused by HIV has a high mortality rate. Therapeutic failures have risen due to the emergence of resistant viral strains and adverse side-effects of Anti-HIV drugs. Thus, there arises a need to develop novel and promising anti-HIV drugs. BMS-378806 (BMS-806) inhibits the initial stages of HIV-1 infection by blocking the binding of viral gp120 protein to host-cell CD4 recep...
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SYNTHESIS OF NOVEL IMIDAZO [1, 2-a] PYRIDINE FOR THEIR POTENT ANTI-CONVULSANT ACTIVITY
Synthesis of a Derivatives of imidazo[1,2-a]pyridines with potent activity. Synthetic approaches allowing for variation of the 2-Amino Pyridines as well as other imidazopyridine substituents are outlined and resulting effects on anticonvulsant activity are highlighted. An experimental evaluation of anticonvulsant activity of synthesized Imidazo[1,2-a]pyridine derivatives by Maximal Electro Shock (...
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2030
EXPLORING THE MEDICINAL PROPERTIES, THERAPEUTIC USES, AND ECO-FRIENDLY WATER FILTRATION POTENTIAL OF TULSI (HOLY BASIL): A COMPREHENSIVE REVIEW
In this comprehensive review, the medicinal properties of Tulsi are thoroughly explored, highlighting its esteemed therapeutic uses that are widely regarded as safe, cost-effective and efficacious owing to its abundant availability. Tulsi a member of the genus Ocimum and a revered medicinal plant native to India has garnered significant recognition and reverence for its profound healing capabiliti...
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PHYTOCHEMICAL INVESTIGATION, ANALGESIC AND ANTIPYRETIC ACTIVITIES OF ETHANOLIC EXTRACT OF KARIYAT
An ethanolic extract of Kariyat (Andrographis paniculata) was prepared by using Soxhlet extractor. Kariyat ethanolic extract (KEE) was subjected for phytochemical investigations and screened for analgesic and antipyretic activities in experimental animals. High performance thin layer chromatography (HPTLC) and gas chromatography mass spectrometry (GC-MS) investigations indicated presence of steroi...
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THE IMPACT OF FOOT REFLEXOLOGY MASSAGE ON ANXIETY CAUSED BY BLOOD TRANSFUSION IN CHILDREN WITH THALASSEMIA
Introduction: Based on the results of formerly conducted studies, the application of invasive methods, such as blood transfusion, for the treatment of children with thalassemia cause distress and anxiety symptoms in these children; therefore, it is attempted to apply non-invasive, non-pharmacological, simple, and inexpensive nursing practice to improve these deficiencies. Thus, the present study w...
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NEW VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE AND VALSARTAN IN PHARMACEUTICAL FORMULATION
A simple, specific, accurate and precise and stability indicating RP-HPLC method was developed and validated for the simultaneous estimation of Amlodipine Besylate and Valsartan in pharmaceutical formulation. The method was developed using Enable C 18G column (250 × 4.6 mm, 0.5 µm) with a mobile phase consisting of sodium acetate buffer (pH 5.0) and methanol (35:65% v/v) with a flow rate of 1 mL...
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PHARMACOLOGICAL EFFICACY OF METHANOLIC EXTRACT OF THE PLANT GINKGO BILOBA, AGAINST ISOPROTERENOL INDUCED CARDIAC TOXICITY IN RATS
Ginkgo Biloba is a potent antioxidant dietary source for human health. Oxidative stress through generation of free radicals damages the myocardium in different experimental condition. The present research was designed to evaluate the cardio protective role of chronic oral administration of Ginkgo biloba leaf extract against Isoproterenol induced myocardial injury. Male Wistar albino rates were ran...
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FORMULATION AND DEVELOPMENT OF BOSENTAN LOADED ONCE A DAILY TABLET FOR PULMONARY ARTERY HYPERTENSION USING LIPID MATRICES BY 32 FULL FACTORIAL DESIGN
To avoid problems of conventional therapy of drug delivery and reduced dose, sustained release matrix tablet of Bosentan was prepared using lipid base material as matrices. Primary screening of polymer was done by selecting different lipid base materials like Compritol 888 ATO, Precirol ATO 5, Eudragit RSPO, Glycerly monostearate (GMS) and cetosteryl alcohol. All the batches were prepared by direc...
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