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NANOCOCHLEATE: A NOVEL APPROACH FOR DELIVERY OF BIOLOGICAL MOLECULES
Nanocochleate is a novel lipid-based drug delivery system in which the liposomal vesicles are converted into nanocochleate by the addition of Calcium divalent cation. This technology involves encochleation of the drug for overcoming problems such as poor solubility, poor permeability, and poor oral bioavailability. This novel lipid-based formulation approach is applicable for the category of drugs...
4051
1993
FORMULATION AND EVALUATION OF ALCOHOL RESISTANT DOSAGE FORMS OF GLIPIZIDE
Oral controlled release pellet formulations of glipizide were prepared using extrusion spheronization technique. Pellets provide specific advantages in controlling the drug release and increasing the absorption of the active ingredient. The major drawback for these systems is dose dumping which is very prominent in presence of alcohol. In the present study, attempt was made to prepare alcohol resi...
4050
1749
ANTI-INFLAMMATORY ACTIVITY OF SAMADERA INDICA LEAVES BY MEMBRANE STABILIZATION
The present work aims at evaluating the anti-inflammatory activity of Samadera indica by HRBC membrane stabilization. The prevention of hypotonicity induced HRBC membrane lysis was taken as a measure of the anti-inflammatory activity. The anti-inflammatory activity of the crude ethanol extract, aqueous extract of leaves part of Samadera indica were compared to that of the standard drug diclofenac....
4050
1764
BIOACTIVE COMPOUND IN CURCUMA CAESIA (ROXB.) FROM BASTAR AND ITS SPECTRAL ANALYSIS BY HPLC, UV-VISIBLE, FT-IR, NMR, AND ESI-MS
The increasing failures of chemotherapeutics and antibiotic resistance exhibited by pathogenic microbes have led to the screening of several medicinal plants for their potential antimicrobial activity. Thus, the present endeavour deals with the exploration of antibacterial efficacy of Curcuma caesia (Roxb.) (Family Zingiberaceae) against bacterial cultures procured from IMTECH, Chandigarh as a scr...
4050
1798
INVESTIGATION ON THE IN VITRO ANTIOXIDANT, ANTIMUTAGENIC AND CYTOTOXIC POTENTIAL OF THYMUS VULGARIS L. HYDRO-ALCOHOLIC EXTRACT
Aim: To evaluate the in vitro antioxidant, antimutagenic and cytotoxic property of hydro-alcoholic extract of Thymus vulgaris L. by subjecting it to free radical scavenging, Ames and MTT assay respectively. Methods: Powdered Thyme leaves were extracted in a Soxhlet apparatus using 70% ethanol to obtain a dry extract. The extract was assessed for its total phenolic, tannin, flavonoid and flavono...
4049
1615
A COMPARITIVE STUDY OF PHYTOCHEMICALS AND ANTIOXIDANT ACTIVITY AMONG TRADITIONAL MEDICINAL PLANTS
Acetone extracts of the three medicinal plants Sida cardifolia, Phyllanthus amarus and Adathoda vasica were assessed for phytochemical components qualitatively and quantitatively and antioxidant activity. The results revealed that all the three contained alkaloids, carbohydrates, flavonoids, tannins, anthocyanins, steroids and phenols. Saponins were absent in all the three extracts. Sida cardifoli...
4049
1601
ANTIOXIDANT POTENTIAL OF Mn2+ IN THE HUMAN EJACULATED SPERMATOZOA UNDER OXIDATIVE STRESS
Reactive oxygen species (ROS) formation from fertile volunteer donor measured by thiobarbuteric acid reactive substances (TBARS). Spermatozoal suspension was treated or not with nicotine and supplemented or not with Mn2+. The same protocol followed when we used ferrous ascorbate promoter system and calculates the Cmax and kc value of the reaction using Lineweaver-burk double reciprocal plot. For c...
4049
2052
PHARMACOLOGICAL EFFICACY OF METHANOLIC EXTRACT OF THE PLANT GINKGO BILOBA, AGAINST ISOPROTERENOL INDUCED CARDIAC TOXICITY IN RATS
Ginkgo Biloba is a potent antioxidant dietary source for human health. Oxidative stress through generation of free radicals damages the myocardium in different experimental condition. The present research was designed to evaluate the cardio protective role of chronic oral administration of Ginkgo biloba leaf extract against Isoproterenol induced myocardial injury. Male Wistar albino rates were ran...
4047
1675
ANTIDIABETIC AND ANTI-INFLAMMATORY EFFECT OF PROBIOTIC LACTOBACILLUS PARACASEI MCC3195 IN HIGH FRUCTOSE FED TYPE 2 DIABETIC RATS
The aim of this study was to investigate the antidiabetic and anti-inflammatory effects of probiotic Lactobacillus paracasei MCC3195 in high fructose fed type 2 diabetic rats. High fructose diet was used to induce type 2 diabetes in male albino wistar rats. L. paracasei MCC3195 was administered to rats at a single dose of 2x108 cfu/ml per rat for 8 week. The body weight, fasting blood glucose, ora...
4047
1559
SUSTAINABLE USE OF HIGH ALTITUDE MEDICINAL AND AROMATIC PLANT FOR SOCIO-ECONOMIC DEVELOPMENT IN UTTARAKHAND: A REVIEW
The present paper reveals the socio-economic benefits for the peoples of the Uttarakhand state. The demand for medicinal and aromatic plants of Uttarakhand is quite inflated, and many of these plants grow only in the Himalayan states. The State has diverse agro-geo climate conditions, which is most suitable for Medicinal and aromatic plant cultivation. Uttarakhand is blessed with a variety of soil...
4047
1805