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SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF MORPHOLINE MANNICH BASE DERIVATIVES
In the present study 10 morpholine mannich base derivatives were synthesized by three component reaction of morpholine, N-phenylacetamide and various substituted benzaldehydes. Progress of the reaction was monitored by thin layer chromatography and the compounds synthesized were characterized by ATR and 1HNMR techniques. Antimicrobial activity of the synthesized compounds was evaluated against gra...
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COLON TARGETED MATRIX TABLET OF BIODEGRADABLE SWELLABLE POLYMERS
The colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. Targeting of drugs to the colon via oral administration protect the drug from degradation or release in the stomach and small inte...
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ROLE OF ACUTE PHASE PROTEINS STATUS IN CHRONIC ALCOHOLIC LIVER DISEASES
Back ground: Alcoholic cirrhosis is a condition of irreversible liver disease due to the chronic inflammatory and toxic effects of ethanol on the liver. Acute alcoholic hepatitis occurs in habitual drinkers, often a period of increased alcohol intake. Although, the clinical features may mimic acute viral hepatitis. Progression of liver fibrosis to cirrhosis is dangerous as well as potentially life...
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STUDY OF THE EFFECT OF SODIUM VALPROATE ON ENHANCEMENT OF MONOAMINE MEDIATED BEHAVIOURAL RESPONSES AFTER ELECTROCONVULSIVE SHOCK (ECS) ADMINISTRATION IN RATS
Objectives: To obtain the data regarding the effects of sodium valproate on enhancement of monoamines mediated behavioural responses following administration of ECS for ten days to rats. Methods: Forty rats were selected for the study in which tonic-clonic seizures were developed fully after giving single maximal electroconvulsive shock (150V, 210mA). Four groups (n= ten in each) were received dif...
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SYNTHESIS OF N-(ALKYL OR ARYL)-2-(1H-BENZOTRIAZOL-1-YL)-ACETAMIDES AS SELECTIVE COX-2 INHIBITOR
Microwave assisted organic synthesis (MAOS) has emerged as frontier in pharmaceutical research for synthesis of newer drugs and implementing GREEN chemistry. Arylacetamides are pharmaceutically interesting as they show various biological activities such as analgesic, local anesthetic, antiarthritic, antiarrhythmic activities, etc. In arylacetamides the nature of aromatic ring and its substituent i...
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INCREASED INSULIN RESISTANCE, DYSLIPIDEMIA, PRO-INFLAMMATORY MARKERS AND ENDOTHELIAL DYSFUNCTION IN CASTRATED MALE RATS: ROLE OF TESTOSTERONE REPLACEMENT
Molecular effects of androgens on cardiovascular system are variable in nature and are concentration dependent. In spite of the evidences favoring possible involvement of reduced endogenous androgens in the pathogenesis of atherosclerotic vascular disease, there is no certain role of exogenous testosterone supplementation in normal or hypogonadal males to slow down the progression of atheroscleros...
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CHARACTERIZATION AND PHYSICAL STABILITY EVALUATION OF SNAKEHEAD FISH (OPHIOCEPHALUS STRIATUS) POWDER NANOEMULSION
Snakehead fish powder containing albumin has macromolecule size which is difficult to penetrate into membrane cell. So, It was formulated into nanoemulsion utilizing the best comparison of surfactant, co-surfactant and oil. Nanoemulsion of snakehead fish powder was characterized by particle size analyzer. The snakehead fish were extracted by atomizer (-40 °C, 1atm) to gain powder which was formul...
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STANDARDIZATION OF SIDDHA POLYHERBAL FORMULATION PANCHABAKIYA CHOORANAM THROUGH ICPOES AND FTIR TECHNIQUES
Siddha system of medicine is a traditional medicinal system being followed mainly in South India. It is better known as one among the AYUSH medicinal system. The present study aims to standardize the Siddha poly-herbal formulation Panchabakiya chooranam (PBC), which is mentioned in the Siddha classical text Anuboga vaidya Brahma ragasyam indicated for stomach burn, burning sensation in anus and di...
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DISSOLUTION ENHANCEMENT OF POORLY WATER SOLUBLE EPROSARTAN BY HOT MELT EXTRUSION TECHNIQUE
Objective: The prodigious challenge in the pharmaceutical industries was to enhance the solubility and the permeability of those drugs as key factors to improve their bioavailability. Various techniques have been used to improve the drug water solubility and release profile, and solid dispersions are considered to be the most successful techniques. The aim of the present study was to improve the s...
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STABILITY INDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF PANTOPRAZOLE AND LEVOSULPIRIDE IN PHARMACEUTICAL DOSAGE FORM
Simple, sensitive, and rapid stability indicating RP-HPLC method for simultaneous estimation of Pantoprazole and Levosulpiride in pharmaceutical dosage form was developed and validated. The analysis was carried out on Hibar C18 column (250 × 4.6 mm, id, 5µ) and the mobile phase composition was 10 mM ammonium acetate (pH 4.0 adjusted using acetic acid): Acetonitrile in the ratio of 20:80% v/v wit...
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