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BIOACTIVE COMPOUND IN CURCUMA CAESIA (ROXB.) FROM BASTAR AND ITS SPECTRAL ANALYSIS BY HPLC, UV-VISIBLE, FT-IR, NMR, AND ESI-MS
The increasing failures of chemotherapeutics and antibiotic resistance exhibited by pathogenic microbes have led to the screening of several medicinal plants for their potential antimicrobial activity. Thus, the present endeavour deals with the exploration of antibacterial efficacy of Curcuma caesia (Roxb.) (Family Zingiberaceae) against bacterial cultures procured from IMTECH, Chandigarh as a scr...
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1800
FORMULATION AND EVALUATION OF ALCOHOL RESISTANT DOSAGE FORMS OF GLIPIZIDE
Oral controlled release pellet formulations of glipizide were prepared using extrusion spheronization technique. Pellets provide specific advantages in controlling the drug release and increasing the absorption of the active ingredient. The major drawback for these systems is dose dumping which is very prominent in presence of alcohol. In the present study, attempt was made to prepare alcohol resi...
4058
1759
DESIGN AND EVALUATION OF AMOXICILIN TRIHYDRATE FLOATING GRANULES PREPARED BY MELT GRANULATION TECHNIQUE
The purpose of this study was to design and evaluate Amoxicillin trihydrate floating granules by melt granulation technique using Gelucire 43/01 and Campritol 888 ATO as lipid carriers. Polymers HPMC K4M and Ethyl Cellulose as release rate modifiers. The granules were evaluated by FTIR studies, differential scanning calorimetry, Scanning Electron microscopy, drug content, in vitro floating ability...
4058
1965
ANTIBACTERIAL, INSECTICIDAL AND IN VIVO CYTOTOXICITY ACTIVITIES OF SALIX TETRASPERMA
The present study was designed to investigate antibacterial, insecticidal and in vivo cytotoxic activities of the methanol: ethylacetate (1:9) extract of leaves, barks and roots of Salix tetrasperma. Antibacterial test were done against five Gram-positive and four Gram-negative bacteria. Bark extract was active against all tested microbial species and the highest activity was shown against Escheri...
4056
1616
EVALUATING HYPOLIPIDEMIC POTENTIAL OF KASNI SEED (CICHORIUM INTYBUS) PREPARATIONS IN NEWLY DIAGNOSED PATIENTS OF METABOLIC DISORDER
Objective: To evaluate hypolipidemic potential of Kasni (Cichorium intybus) seed preparations combined with oral hypoglycemic agent in treatment of patients of newly diagnosed type 2 DM. Methods: Newly diagnosed 90 patients of Type2DM, age 35-65years, of either sex were divided into 3 groups. Each group having 30 patients (19 male and 11 females) matched with each other in terms of age and sex. In...
4056
1707
DEVELOPMENT AND IN VITRO EVALUATION OF FLOATING DRUG DELIVERY SYSTEM OF VERAPAMIL HCl
Gastro retentive controlled release drug delivery system of Verapamil HCl was formulated to increase the gastric retention time of the dosage form with controlling the drug release pattern. Different grades of hydroxy propyl methyl cellulose derivatives; Methocel K4M and Methocel K15MCR were incorporated for their gel forming properties. Tablet buoyancy was achieved by incorporating a mixture of g...
4055
1627
PHARMACOLOGICAL EFFICACY OF METHANOLIC EXTRACT OF THE PLANT GINKGO BILOBA, AGAINST ISOPROTERENOL INDUCED CARDIAC TOXICITY IN RATS
Ginkgo Biloba is a potent antioxidant dietary source for human health. Oxidative stress through generation of free radicals damages the myocardium in different experimental condition. The present research was designed to evaluate the cardio protective role of chronic oral administration of Ginkgo biloba leaf extract against Isoproterenol induced myocardial injury. Male Wistar albino rates were ran...
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1681
CHARACTERIZATION AND PHYSICAL STABILITY EVALUATION OF SNAKEHEAD FISH (OPHIOCEPHALUS STRIATUS) POWDER NANOEMULSION
Snakehead fish powder containing albumin has macromolecule size which is difficult to penetrate into membrane cell. So, It was formulated into nanoemulsion utilizing the best comparison of surfactant, co-surfactant and oil. Nanoemulsion of snakehead fish powder was characterized by particle size analyzer. The snakehead fish were extracted by atomizer (-40 °C, 1atm) to gain powder which was formul...
4055
1725
SYNTHESIS OF NOVEL IMIDAZO [1, 2-a] PYRIDINE FOR THEIR POTENT ANTI-CONVULSANT ACTIVITY
Synthesis of a Derivatives of imidazo[1,2-a]pyridines with potent activity. Synthetic approaches allowing for variation of the 2-Amino Pyridines as well as other imidazopyridine substituents are outlined and resulting effects on anticonvulsant activity are highlighted. An experimental evaluation of anticonvulsant activity of synthesized Imidazo[1,2-a]pyridine derivatives by Maximal Electro Shock (...
4055
2002
INVESTIGATION ON THE IN VITRO ANTIOXIDANT, ANTIMUTAGENIC AND CYTOTOXIC POTENTIAL OF THYMUS VULGARIS L. HYDRO-ALCOHOLIC EXTRACT
Aim: To evaluate the in vitro antioxidant, antimutagenic and cytotoxic property of hydro-alcoholic extract of Thymus vulgaris L. by subjecting it to free radical scavenging, Ames and MTT assay respectively. Methods: Powdered Thyme leaves were extracted in a Soxhlet apparatus using 70% ethanol to obtain a dry extract. The extract was assessed for its total phenolic, tannin, flavonoid and flavono...
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1619