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VALIDATED HPTLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF EMTRICITABINE AND TENOFOVIR IN DRUG FORMULATION
A simple, precise, specific and accurate high-performance thin-layer chromatographic method has been developed for the simultaneous determination of Emtricitabine (EMB) and Tenofovir (TEN) in pharmaceutical dosage form. The separation was carried out on Merck HPTLC aluminum plates of silica gel 60 F254, (20×10 cm) with 250 μm thickness using toluene: ethylacetate: methanol in the ratio (2:8:1 v/...
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ASSESSMENT OF POTENTIAL EFFECT OF ANTIEPILPETIC DRUGS ON LIPID PROFILE AND C-REACTIVE PROTEIN AS PREDICTORS OF VASCULAR DISEASE IN EPILEPSY PATIENTS
Epilepsy is a neurological disorder which often requires lifelong treatment with antiepileptic drugs (AEDs). Prolonged use of AEDs is associated with changes in vascular risk markers. Hence, the study was designed to evaluate the effect of older generation AEDs (carbamazepine and phenytoin) and newer generation AED (levetiracetam) monotherapy on the markers of vascular risk in epilepsy patients. T...
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SYNTHESIS AND ANTI-MYCOBACTERIAL ACTIVITY OF SOME NOVEL ANACARDIC ACID DERIVATIVES FROM CASHEW NUT SHELL LIQUID
Synthesis and anti-mycobacterial activity of some novel derivatives of anacardic acid viz., 2-Ethoxy-6-pentadecyl benzamide (APHK-1), 1-(2-methoxy-6-pentadecylbenzyl)-4-hydroxy ethylpiperazine (APHK-2), 1- (2-hydroxy-6-pentadecyl)- N- (hydroxyl ethylaminoethyl) benzamide (APHK-3) and compounds 20-34 from saturated anacardic acid which was obtained from natural product cashew nut shell liquid (CNSL...
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BIOEFFICACY OF PREMNA CORYMBOSA ROTTL. (VERBANACEAE) WITH SPECIAL REFERENCE TO ITS ANTIOXIDANT ACTIVITY
In the present investigation, the bioefficacy of an indigenous plant was investigated with special reference to its antioxidant potential. Antioxidant effects of Methanolic, Chloroform and Ethyl acetate extracts of the leaves of Premna corymbosa Rottl. (family Verbenaceae) were tested based on DPPH (1, 1-diphenyl-2-picryl-hydrazyl), phosphomolybdenium assay, superoxide radical scavenging activity,...
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DEVELOPMENT AND VALIDATION OF RP-HPLC AND SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF ATORVASTATIN AND AMLODIPINE IN PHARMACEUTICAL DOSAGE FORMS
A simple, rapid, precise, accurate, sensitive and time consuming reverse phase high performance liquid chromatography (RP-HPLC) and spectrophotometric method for simultaneous estimation of atorvastatin and amlodipine in pharmaceutical dosage forms have been developed and validated. Drug was resolved on a C18 column (Phenomenex phenyl hexyl column, 250mm* 4.6mm i.d, 5um). Utilizing mobile phase of ...
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IMPACT OF VITAMINS IN PREVENTION OF RISK FACTORS ASSOCIATED WITH TYPE-2 DIABETES MELLITUS
Diabetes mellitus is one of the most common metabolic disorders that cause micro and macro vascular complications. Because of additive effects of hyperglycaemia and hyperlipidaemia for cardiovascular disease, serum lipid and glucose level should be closely monitored in diabetes. Chronic Hyperglycaemia resulting from diabetes has profound effects on nearly every system of the body. The toxic effect...
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DEVELOPMENT OF A POLYHERBAL CAPSULE FOR THE TREATMENT OF HYPERLIPIDAEMIA
Hyperlipidaemia is mentioned as one of the life-style-related diseases as much as so for diabetes. In the present study an attempt was made to develop herbal capsules, which are containing the extract of Murraya koenigii and Achyranthus aspera. One of the major concerns in designing new formulation is that the active ingredient should be compatible with all the excipients and packaging material co...
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EVALUATION OF ANTIMICROBIAL POTENTIAL OF BAUHINIA BLAKEANA FLOWERS
In this study, the phytochemicals and their antimicrobial potential of flowers of Bauhinia blakeana of Fabaceae Family were evaluated. The selected microbes for the antimicrobial study were E. coli, Enterobacter sp., Proteus sp., and Klebsiella sp. Ethanolic extract was prepared by continuous hot percolation method using Soxhlet extractor, and Antimicrobial activity was tested by Agar well diffusi...
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ANTIOXIDANT EFFECT OF ALOE VERA IN EXPERIMENTALLY INDUCED DIABETES MELLITUS
The aim of the present study was to evaluate antidiabetic and antioxidant potential of Aloe vera (AV) in alloxan induced diabetes in albino rabbits. Experimental Diabetes was induced in rabbits with alloxan(80mg/Kg body weight)and animals showing fasting blood glucose levels more than 250mg/dl were considered as diabetics and divided into four groups of six each (n=6). Group I: Normal cont...
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PREVALENCE OF CHRONIC PERIODONTITIS AMONG POST MENOPAUSAL WOMEN- HORMONE REPLACEMENT THERAPY A REMEDY?
Menopause is a stage which every woman has to pass through. Menopausal stage brings physical changes as well as microbial changes in the oral cavity. The latter change is often left unnoticed, or it is neglected. The important feature during menopause is a rapid decline in the level of the hormone estrogen. Due to the gradual to a rapid drop in the level of the hormone, there is a lower absorption...
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