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SOLUBILITY AND DISSOLUTION ENHANCEMENT OF POORLY AQUEOUS SOLUBLE DRUG GEFITINIB BY SELF EMULSIFYING DRUG DELIVERY SYSTEM
The present research work was aimed at the enhancement of solubility and dissolution rate of Gefitinib by Self Emulsifying Drug Delivery Systems (SEDDS). Gefitinib is a BCS class II drug with poor aqueous solubility (oral bioavailability 60%). The saturated solubility of Gefitinib in different oils, surfactants and co-surfactants were determined. The excipients were screened and selected showing m...
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1897
DEVELOPMENT AND CHARACTERIZATION OF BILAYER TABLET CONTAINING TRAMADOL AND PREGABALIN AS A GASTRIC BUOYANT DRUG DELIVERY SYSTEM FOR COMBINATION PHARMACOTHERAPY OF NEUROPATHIC PAIN
Experiments were performed to design, develop and characterize bilayer buoyant tablets with Tramadol (TH), immediate release layer and Pregabalin (PGB), sustained release layer. Super disintegrants like crosscarmellose sodium and sodium starch glycolate, for IR layer where as Hydroxypropyl methylcellulose (HPMC-K4M, HPMC-K100M) and sodium carboxymethyl cellulose, as sustaining polymers for SR laye...
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ROLE OF COMMUNITY PHARMACIST; CARE OF HYPERTENSIVE PATIENTS
The community pharmacist, being an important member of the healthcare team and society, can make successful efforts to counsel the sufferer and guide him about this disease. Pharmacist is now becoming more patient oriented than product oriented and have brought many changes in life of patients. Hypertension or high blood pressure is a condition in which the blood pressure in the arteries is chroni...
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1571
DETERMINATION OF RIZATRIPTAN IN BULK AND ITS TABLET DOSAGE FORMS BY UV SPECTROSCOPIC METHOD.
Rizatriptan is a selective 5-HT1B/1D agonist which is used in the treatment of migraine headaches. Zero order spectroscopic method has been developed for the determination of rizatriptan. Rizatriptan in its 0.1 N HCl solutions was determined at the wavelength ranges of 220–400 nm by the spectroscopic method. Rizatriptan showed an absorption peak at 226 nm. Linearity ranges were found as 1-5 µg/...
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1775
NOVEL METHODS FOR THE VISIBLE SPECTROPHOTOMETRIC DETERMINATION OF PIPAZETHATE HCl AND CHLORPHENOXAMINE HCl IN PURE AND TABLET DOSAGE FORMS
Three rapid, simple, precise and sensitive visible spectrophotometric methods (A-C) have been developed for the determination of pipazethate hydrochloride (PZ-HCl) and Chlorphenoxamine hydrochloride (CPA-HCl) in pure and Tablet Dosage Forms. Both methods (A-C) involves the formation of intense yellow ion-association complex between drug(s) and either of picric acid (PA) or phenol red (PR) or chlor...
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1591
INCIDENCE OF POLYPHARMACY INDUCED DRUG INTERACTION IN A TERTIARY CARE HOSPITAL
Drug interaction represents a major problem in day- to- day practice. The incidence of adverse reactions increases almost exponentially as the number of drugs co prescribed rises, and this is in part due to interaction. Critically ill, chronically ill and elderly patients are particularly at risk of drug interactions due to polypharmacy as well as impaired homeostatic mechanisms. The study was aim...
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1603
EFFECTS OF CAPSAICIN ON RAT SCIATIC NERVE IN VINCRISTINE-INDUCED NEUROPATHIC PAIN MODEL
Capsaicin, the pungent ingredient of red pepper, is used topically to treat different types of neuropathic pain, in rat model of vincristine induced neuropathic pain we tried to investigate the effect of capsaicin on sciatic nerve through electrophysiological and histopathological studies. We found that treatment of animals with vincristine results in significant decrease in sciatic nerve conducti...
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1486
ANALYTICAL CHARACTERIZATION OF A CONTROLLED RELEASE POLYMERIC SUSPENSION
Aims: Qualitative analysis of a mucoadhesive polymeric (Carbopol940) suspension of Norfloxacin was carried out with the aim of developing an oral controlled release gastro-retentive dosage form. Methods: The characterization of ultrasonicated formulation was performed by Fourier Transform Infrared Spectroscopy (FTIR), Raman Spectroscopy, X-ray powder diffraction (XRD) and Scanning electron micr...
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1386
SYNTHESIS, CHARACTERIZATION AND IN-VITRO ANTICANCER EVALUATION OF NOVEL BENZO[D]IMIDAZOLE DERIVATIVES
The novel benzimidazole derivatives were synthesized by 2-acetyl benzimidazole consent to react with various substituted aromatic aldehyde (2a–e) to obtain preferred intermediate chalcones (3a–j), these intermediates are undergo the cyclocondensation with guanidine hydrochloride and phenyl hydrazine yielded benzimidazole derivatives (4a–j and 5a–j respectively). The synthesized compounds w...
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1852
THE INVESTIGATION ON TOTAL PHENOLIC CONTENT AND IN VITRO ANTIOXIDANT POTENTIAL OF DIFFERENT PLANT PARTS OF NYCTANTHES ARBOR-TRISTIS (NIGHT JASMINE)
Nyctanthes arbor-tristis (Paarijaat) is one of the important plants used in traditional medicines, mainly known for the medicinal properties of its flower and leaf. In this study, the four plant parts of Nyctanthes arbor-tristis were extracted sequentially with four solvents of decreasing polarity and investigated for antioxidant potential. The highest phenolic content was observed with flower, fo...
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