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ANTI-DEPRESSANT POTENTIAL OF MUSIC THERAPY
Depression should be recognized as a clinical syndrome that is characterised by a cluster of emotional, behavioural, and cognitive features. The prevalence of depression is consistently high worldwide, and is associated with considerable morbidity. Music is one of the oldest and most basic socio-cognitive domains of the human species. Music Therapy is growing as a profession globally, both in quan...
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1660
SOLUBILITY AND DISSOLUTION ENHANCEMENT OF POORLY AQUEOUS SOLUBLE DRUG GEFITINIB BY SELF EMULSIFYING DRUG DELIVERY SYSTEM
The present research work was aimed at the enhancement of solubility and dissolution rate of Gefitinib by Self Emulsifying Drug Delivery Systems (SEDDS). Gefitinib is a BCS class II drug with poor aqueous solubility (oral bioavailability 60%). The saturated solubility of Gefitinib in different oils, surfactants and co-surfactants were determined. The excipients were screened and selected showing m...
4085
1982
CLINICAL EVALUATION OF A NEW FORMULATION OF 99mTc-TRODAT-1 FOR SPECT IMAGING IN PARKINSON PATIENTS AND VOLUNTEER SUBJECTS
This study was conducted to evaluate the clinical usefulness of new developed kit of 99mTc-TRODAT-1 to differentiate PD(Parkinson disease) from volunteer subjects. The 925-1111MBq (25-30 mCi) 99mTc-TRODAT-1 samples were reconstituted by boiling water bath method. Fourteen subjects (women = 6, men = 8, age range 24 - 72, mean = 54.4) have been participated in this approach. The control group includ...
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1601
IN VITRO EVALUATION OF ANTIOXIDANT AND ANTIMICROBIAL ACTIVITY OF SERIES OF NEW PYRAZOLE DERIVATIVES; A STUDY ON THE STRUCTURE-ACTIVITY RELATIONSHIP
In present study, a series of new synthesized condensed pyrazole derivatives 1a-f have evaluated in vitro for their antioxidant activity, reducing power ability, antibacterial activity against Gram-positive and Gram-negative organisms and antifungal activity against different organisms. Minimum inhibitory concentration against the bacterial and fungal strains was determined. The study provides the...
4083
1970
THE INVESTIGATION ON TOTAL PHENOLIC CONTENT AND IN VITRO ANTIOXIDANT POTENTIAL OF DIFFERENT PLANT PARTS OF NYCTANTHES ARBOR-TRISTIS (NIGHT JASMINE)
Nyctanthes arbor-tristis (Paarijaat) is one of the important plants used in traditional medicines, mainly known for the medicinal properties of its flower and leaf. In this study, the four plant parts of Nyctanthes arbor-tristis were extracted sequentially with four solvents of decreasing polarity and investigated for antioxidant potential. The highest phenolic content was observed with flower, fo...
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1510
STUDY OF EFFECT OF METFORMIN ON LIPID PROFILE IN TYPE 2 DIABETES MELLITUS IN A TERTIARY CARE TEACHING HOSPITAL
Type 2 diabetes mellitus poses an important health care problem because of its associated two to threefold increased risk of cardiovascular disease and its high prevalence and incidence worldwide. Dyslipidemia is an independent risk factor for severe morbidity and mortality in terms of cardiovascular risk in type-2 DM patients. Studies have shown an association between metformin and lipid profile ...
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1385
SYNTHESIS AND EVALUATION OF SOME ALDEHYDE DERIVATIVES OF 1, 4 DI-HYDRO PYRIDINE AND THEIR BIOLOGICAL EVALUVATION
Synthesis of some aldehyde derivatives of 1, 4 di- hydro pyridine has been done. The entire synthesized compounds were characterized by UV, IR and 1HNMR spectroscopy. The anticonvulsant and antimicrobial activity were also evaluated. The present investigation deals with the synthesized compounds possessing good anticonvulsant, analgesic and antimicrobial activity. Synthesized compounds like PNH, P...
4082
1791
CHARACTERIZATION AND PHYSICAL STABILITY EVALUATION OF SNAKEHEAD FISH (OPHIOCEPHALUS STRIATUS) POWDER NANOEMULSION
Snakehead fish powder containing albumin has macromolecule size which is difficult to penetrate into membrane cell. So, It was formulated into nanoemulsion utilizing the best comparison of surfactant, co-surfactant and oil. Nanoemulsion of snakehead fish powder was characterized by particle size analyzer. The snakehead fish were extracted by atomizer (-40 °C, 1atm) to gain powder which was formul...
4082
1743
SCREENING OF BIOACTIVE COMPOUNDS FROM LEAF OF CENCHRUS CILIARIS L. FROM THAR REGION OF RAJASTHAN, INDIA
Cenchrus ciliaris L. (Poaceae) commonly known as “Dhaman grass”, is a common famine food used during drought and scarcity of food in Rajasthan. The present investigation was carried out to determine the phytochemical composition of leaf of C. ciliaris using gas chromatography - mass spectrometry technique. The mass spectrum of the compounds found in the extract was matched with the national in...
4082
1934
A LIQUID CHROMATOGRAPHY METHOD FOR THE DETERMINATION OF CURCUMIN IN PGPR INOCULATED CURCUMA LONGA. L PLANT
A rapid and simple HPLC method has been developed for the quantification of curcumin in PGPR inoculated curcuma longa plant. Treatment of PGPR such as Pseudomonas fluorescens and Bacillus megaterium improved the content of curcumin in rhizomes sample. The PGPR treated rhizomes were higher in curcumin content than the PGPR untreated plant rhizomes sample. Analysis was performed using a C18 column (...
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