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CADMIUM MONITORING AMONG SOME PLANT AND VEGETABLE SPECIES IN SINGRAULI REGION OF MADHYA PRADESH
Thermal power plants produce enormous quantity of pollutants such as fly ash as a by - product of combustion of coal or any pulverized fuel at higher temperature. Industrial effluents contain several heavy metals including cadmium distrusted the metabolic process of living organism due to easily dispersion and mobilization in environment. The eatables and applicable potential plants and vegetables...
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GABA-AT INHIBITORY ACTIVITY OF BENZOTHIAZOLE – GABA ANALOGS: IN-SILICO APPROACH FOR ANTIEPILEPTIC PROFILE
Estimation of binding affinity of receptor – ligand complex in docking study of small molecules plays an Important role in structure based drug development process. The γ-amino-butyric acid amino-transferase (GABA-AT) exhibits a catalytic role in regulating γ-amino -butyric acid (GABA) level in brain and responsible for many physiological and pathological changes. Here, in – silico study o...
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DIETARY HYPERCHOLESTEROLEMIA INDUCES OXIDATIVE STRESS CHALLENGING SPERMATOGENESIS IN RAT MODEL: A LINK TO POSSIBLE INFERTILITY
Background: Hypercholesterolemia is rapidly becoming a worldwide epidemic that affects children and adults. Some attempt had made to generalize a relationship between hypercholesterolemia and infertility, but until now it remains scanty. Thus, the aim of the present study was initiated. Methods: Male Wistar rats were divided into four groups of six each (n=6). The first group was control and secon...
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SYNERGISTIC EFFECT OF (S)-CIS-VERBENOL WITH THE ANTIBIOTICS AMOXICILLIN AND GENTAMICIN AGAINST SENSITIVE AND RESISTANT STAPHYLOCOCCUS AUREUS STRAINS
The synergistic activity among the monoterpene (S)-cis-Verbenol and the antibiotics Amoxicillin and Gentamicin were evaluated against a sensitive and a resistant strain of Staphylococcus aureus, is the last one also resistant to methicillin (MRSA). The combinations were evaluated by the checkerboard method. The combinations of both antibiotics with the terpene showed synergic effects for the MRSA ...
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IONTOPHORESIS OF FLUVASTATIN SODIUM: STUDY OF VARIOUS FACTOR AND IN-VITRO PERMEATION
Fluvastatin sodium (FVS) is the first fully synthetic 3-hydroxy-3-methylglutaryl coenzyme (HMG-CoA) reductase inhibitors used for the treatment of hypercholesterolemia. It shows extensive first pass metabolism with short plasma half-life (3 hrs). The iontophoresis approach was used to determine the permeability of drug through isolated rat skin. In-vitro permeation of drug was determined by using ...
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ANALGESIC AND ANTIDIARRHOEAL ACTIVITIES OF LAWSONIA INERMIS
The leaf of the plant Lawsonia inermis was examined for analgesic and anti-diarrhoeal properties. From the study of analgesic activity it was found that ethanol extract at a dose of 500 mg/kg exhibited no significant (p<0.3) inhibition of writhing reflex (28.45 % inhibition) while the inhibition of standard drug diclofenac sodium showed 82.7 % inhibition at a dose of 25 mg/kg body weight. The f...
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EFFECT OF COMBINED MIXTURE OF FOUR MINOR MILLETS ON BLOOD GLUCOSE, SERUM LIPIDS AND OXIDATIVE STRESS IN OVARIECTOMISED WISTAR ALBINO RATS AN ANIMAL MODEL FOR MENOPAUSAL COMPLICATIONS
Diabetes mellitus, coronary artery disease and oxidative stress are some of the important complications encountered by women during menopause due to decrease in estrogen levels. Food intake has a strong impact on menopausal women and a well balanced diet is important for good health and to combat some of the complications of menopause to certain extent. Minor millets has much health benefits and h...
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DEVELOPMENT AND VALIDATION FOR HIGH-PERFORMANCE MASS SPECTROMETRY METHOD FOR DETERMINATION OF BALOXAVIR MARBOXIL IN BIOLOGICAL MATRICES
The validated protein precipitation method was applied for the estimation of Baloxavir marboxil in human plasma with Oseltamivir as an internal standard (ISTD) by using HPLC-ESI-MS/MS. The chromatographic separation was achieved with 0.1% formic acid in combination with methanol (25:75 v/v) using the C18 column Ascentis Express (50 mm × 4.6 mm, 2.7 µm). The total analysis time was 3 min and the ...
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A NOVEL SUSTAINED RELEASE ROBUST MATRIX PELLETS OF GLIPIZIDE
Multiparticulate drug delivery system are mainly oral dosage forms consisting of a multiplicity of small discrete units, each exhibiting some amount desired characteristics such as pellets.The purpose of present study was to prepare sustained release robust matrix pellets of Glipizide. The study revealed successful application of factorial design, optimization of extrusion spheronization process, ...
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DEVELOPMENT AND VALIDATION OF RP-HPLC AND SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF ATORVASTATIN AND AMLODIPINE IN PHARMACEUTICAL DOSAGE FORMS
A simple, rapid, precise, accurate, sensitive and time consuming reverse phase high performance liquid chromatography (RP-HPLC) and spectrophotometric method for simultaneous estimation of atorvastatin and amlodipine in pharmaceutical dosage forms have been developed and validated. Drug was resolved on a C18 column (Phenomenex phenyl hexyl column, 250mm* 4.6mm i.d, 5um). Utilizing mobile phase of ...
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