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EVALUATION OF NUTRITIONAL AND PHYSICO-CHEMICAL CHARACTERISTICS OF DIETARY FIBRE ENRICHED WITH CARROT POMACE PASTA
ABSTRACT: Fibre rich pasta were prepared by substituting refined wheat flour with carrot pomace powder (CPP) at 5%, 15%, and 25% and evaluated for its physical properties, chemical composition, textural properties and sensory characteristics. The fat content of the pasta showed no pronounced variation. The hardness of the pasta increased with increase in the level of incorporation of CPP in the fl...
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NOVEL METHODS FOR THE VISIBLE SPECTROPHOTOMETRIC DETERMINATION OF PIPAZETHATE HCl AND CHLORPHENOXAMINE HCl IN PURE AND TABLET DOSAGE FORMS
Three rapid, simple, precise and sensitive visible spectrophotometric methods (A-C) have been developed for the determination of pipazethate hydrochloride (PZ-HCl) and Chlorphenoxamine hydrochloride (CPA-HCl) in pure and Tablet Dosage Forms. Both methods (A-C) involves the formation of intense yellow ion-association complex between drug(s) and either of picric acid (PA) or phenol red (PR) or chlor...
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CLINICAL EVALUATION OF A NEW FORMULATION OF 99mTc-TRODAT-1 FOR SPECT IMAGING IN PARKINSON PATIENTS AND VOLUNTEER SUBJECTS
This study was conducted to evaluate the clinical usefulness of new developed kit of 99mTc-TRODAT-1 to differentiate PD(Parkinson disease) from volunteer subjects. The 925-1111MBq (25-30 mCi) 99mTc-TRODAT-1 samples were reconstituted by boiling water bath method. Fourteen subjects (women = 6, men = 8, age range 24 - 72, mean = 54.4) have been participated in this approach. The control group includ...
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DESIGN AND EVALUATION OF ORO – FLASH RELEASE FILMS OF AMLODIPINE BESYLATE
This work aimed to formulate amlodipine besylate Oro flash release films by solvent casting method. Various film forming polymers like Hydroxy propyl methyl cellulose (HPMC) E5, HPMC E15, sodium carboxymethyl cellulose, sodium alginate, xanthan gum were used and out of which HPMCE5 was found to be satisfactory. Propylene glycol was used as plasticizer at a range of 13-32%w/w of the film and 31%w/w...
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ISRADIPINE ENHANCES THE ANTICONVULSANT ACTIVITY OF CARBAMAZEPINE AGAINST MES AND PTZ INDUCED CONVULSIONS IN RATS
The aim of this study was to investigate the possible anticonvulsant effect of a Dihydropyridine calcium antagonist, Isradipine, which easily crosses the blood–brain barrier displaying high affinity and specificity for the brain L-type voltage-sensitive calcium channel, on maximal electroshock seizures and PTZ induced seizures. The seizures were induced in rats by maximum electroshock method and...
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QUANTITATIVE DETERMINATION OF PIPERACILLIN BY IODOMETRIC METHOD USING POTASSIUM PEROXOMONOSULFATE
Kinetics and stoichiometry S-oxidation reaction of sodium piperacillin by means of potassium hydrogen peroxomonosulfate in aqueous solutions using iodometric titration were studied. Zopercin® – powder in vials for piperacillin injection solution in the combined form with tazobactam (piperacillin 4.0 g and tazobactam 0.5 g) was used for analysis. A new iodometric method for quantitative determin...
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DENDRIMERS FOR DRUG SOLUBILITY ENHANCEMENT– A REVIEW
Sufficient fluid solvency has been one in everything about required properties while choosing drug particles and completely uncommon bio-actives for advancement. Here and there dissolvability of a medication decides its pharmaceutical and remedial execution. Most of these days organized medicine IOTAS miss the mark or are rejected for the length of the main times of drug disclosure and improvement...
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SOLUBILITY AND DISSOLUTION ENHANCEMENT OF POORLY AQUEOUS SOLUBLE DRUG GEFITINIB BY SELF EMULSIFYING DRUG DELIVERY SYSTEM
The present research work was aimed at the enhancement of solubility and dissolution rate of Gefitinib by Self Emulsifying Drug Delivery Systems (SEDDS). Gefitinib is a BCS class II drug with poor aqueous solubility (oral bioavailability 60%). The saturated solubility of Gefitinib in different oils, surfactants and co-surfactants were determined. The excipients were screened and selected showing m...
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VARIOUS SCORES USED FOR PROGRESSION OF LIVER DISEASE
Multiple causes of liver diseases that will affect the health related quality of life and are dispersed globally. It is difficult to diagnose the different stages of liver disease. Scores like Child Pugh Score(CPS), Model For End Stage Liver Disease(MELD), Monoethylglycinexylidine(MEGX), Von willibrand factor (vWF) etc are used to detect the progression of liver disease like hepatitis, cirrhosis, ...
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DEVELOPMENT AND CHARACTERIZATION OF BILAYER TABLET CONTAINING TRAMADOL AND PREGABALIN AS A GASTRIC BUOYANT DRUG DELIVERY SYSTEM FOR COMBINATION PHARMACOTHERAPY OF NEUROPATHIC PAIN
Experiments were performed to design, develop and characterize bilayer buoyant tablets with Tramadol (TH), immediate release layer and Pregabalin (PGB), sustained release layer. Super disintegrants like crosscarmellose sodium and sodium starch glycolate, for IR layer where as Hydroxypropyl methylcellulose (HPMC-K4M, HPMC-K100M) and sodium carboxymethyl cellulose, as sustaining polymers for SR laye...
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