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A VALIDATED STABILITY INDICATING RP-UPLC METHOD FOR DETERMINATION OF ERYTHROMYCIN ESTOLATE IN PHARMACEUTICAL FORMULATION
A novel, sensitive and selective stability-representing RP-UPLC method was developed and validated for the quantitative determination of Erythromycin estolate in Erythromycin 250 mg capsules. The chromatographic separation was achieved on BEH C18; 50 × 2.1 mm; 1.7 µm column by using mobile phase containing a mixture of 0.002M di-potassium hydrogen phosphate and acetonitrile 53:47 v/v at a flow r...
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EUPHORBIA HIRTA LINN. – AN INVASIVE PLANT: A REVIEW OF ITS TRADITIONAL USES, PHYTOCHEMISTRY AND PHARMACOLOGICAL PROPERTIES
Euphorbia hirta Linn. (Euphorbiaceae), commonly known as ‘Dudhy’ is an annual medicinal herb of Kumaun Himalaya Uttarakhand. It is an invasive plant used in conventional medicine to treat various diseases such as gastrointestinal disorders, respiratory system disorders, and asthma. The present review is designed with the aim to compile updated information on E. hirta including its medicinal us...
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ANTIBACTERIAL ACTIVITIES AND BRINE SHRIMP LETHALITY BIOASSAY OF THE CHLOROFORM EXTRACT OF STEM BARK OF CRATAEVA NURVALA BUCH HAM
Antibacterial and cytotoxic activities of the chloroform extract of the stem bark of Crataeva nurvala (Bengali name- Borun; Family- Capparidaceae) were studied. Antibacterial activity was determined against two Gram positive (Bacillus cereus, Bacillus megaterium,) and four Gram negative (Escherichia coli, Shigella dysenteriae, Shigella sonnei, Shigella boydii) human pathogenic bacteria by disc d...
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TOLERANCE STUDY OF “SPIRULINE PLUS” AND EVOLUTION OF BIOLOGICAL PARAMETERS IN PEOPLE LIVING WITH HIV-1 FOR TWELVE MONTHS
Spirulina is an algae used in our country for people living with HIV (PLHIV) and it is known especially for its therapeutic immunostimulatory effects. Spirulina capsules produced locally enriched in zinc and selenium called "spiruline plus" were formulated and given to PLHIV. The objectives of this randomized placebo controlled trial were to assess the tolerance by reporting side effects and t...
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FORMULATION AND EVALUATION OF MATRIX MICROSPHERES FOR SIMULTANEOUS DELIVERY OF CANDESARTAN CILEXETIL AND CAPTOPRIL FOR TREATMENT OF NEPHRITIC SYNDROME
The objective of the present study was to prepare and evaluate matrix microspheres system for simultaneous and sustained release of candesartan cilexetil and captopril for the management of nephritic syndrome, Ethyl cellulose was used as a retardant polymer and IR study showed better compatibility of it with both the drugs, the matrix microspheres were prepared by emulsion solvent evaporation me...
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ISOLATION AND CHARACTERIZATION OF L-ASPARAGINASE EXTRACELLULAR ENZYME PRODUCING BACTERIA FROM INDUSTRIAL SOIL SAMPLES
Industrial soil contains a variety of L-Asparaginase producing microorganisms such as bacteria and fungi. Microorganisms can produce different types of enzymes which are frequently used in different types of industries for different purpose. In the present study, we focused on isolation of L-Asparaginase enzyme producing bacteria from industrial soil samples collected from different regions of Gwa...
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OPTIMIZATION OF TETRABENAZINE TABLET FORMULATION TO MEET THE REQUIRED DISSOLUTION PROFILE AND CONTENT UNIFORMITY
An approach to determine the relationship between independent process variables and their two level four factor partial factorial design was adopted, composite of experiment design was applied to optimize a tablet formulation of Tetrabenazine (TBZ) Tablets 25mg containing high percentage of Lactose Anhydrous, Sodium starch Glycolate, Magnesium Stearate and Starch / Lactose Ratio. The particle size...
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CURCUMIN CONSUMPTION AND COGNITIVE FUNCTION IN ELDERLY
Cognitive impairment in elderly is a growing public health concern, and is mainly caused by dementia of various etiologies. Hence, it is important to explore possible measures to mitigate the risk of dementia. Curcumin, active ingredient of turmeric (Curcuma longa) is used in curry and has shown protective effect on cognition. This study aims to explore the association between curcumin consumption...
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A CRITICAL ANALYSIS OF ELECTROPORATION IN MEDICAL TECHNOLOGY
When a high amplitude nanosecond electric field applied to a biological cell it disrupts the equilibrium of the phospholipid bilayer resulting in the permeability of the cell membrane to increase. This results in movement of extracellular material into the cell which otherwise cannot move inside the cell. This phenomenon is known as electroporation. In the initial years of research people concentr...
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SALVIA HISPANICA (CHIA) SEEDS – A REVIEW ON PHARMACOLOGICAL BENEFITS, NUTRACEUTICAL PROPERTIES, EXTRACTION METHOD AND APPLICATIONS
The plant Salvia hispanica belongs to the family Lamiaceae, a highly valued medicinally important seed, commonly known as chia seeds. About 75% of the fats in chia seeds consist of omega-3 alpha-linolenic acid (ALA), while about 20% consist of omega-6 fatty acid. Omega-3s play an important role in sharpening memory and improving mood. Chia seeds also contain polyunsaturated fatty acids, dietary fi...
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