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TOXICITY STUDIES OF A SAPONIN ISOLATED FROM THE FRUITS OF MOMORDICA DIOICA IN RATS
The objective of this study was to evaluate the toxicity of a saponin isolated from the fruits of the Momordica dioica as per OECD guidelines. Saponin was isolated from the methanolic extract of the fruits of M. dioica, and acute, sub-acute, sub-chronic and chronic toxicity was evaluated. The study of the acute toxicity of saponin M. dioica (SMD) at a single dose of 5000 mg/kg/b.w. by oral route i...
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ANTIHYPERGLYCEMIC, ANTIOXIDANT AND ANTIDYSLIPIDEMIC PROPERTIES OF HEMIDESMUS INDICUS ROOT EXTRACT STUDIED IN ALLOXAN-INDUCED EXPERIMENTAL DIABETES IN RATS
Diabetes mellitus is a chronic metabolic disorder associated with hyperglycemia, oxidative stress and dyslipidemia. Hemidesmus indicus is employed as an indigenous medicine for a variety of ailments from earlier days. The present study was aimed to evaluate the role of Hemidesmus indicus in alloxan-induced experimental diabetic rats. The effect of oral administration of Hemidesmus indicus root ext...
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EVALUATION OF MURRAYA EXTRACTS FOR CONTROLLING FUNGI GROWTH ON ZAPOTA THROUGH ESTIMATION STUDIES
Medicinal plants are various plants which are used in herbalism having medicinal properties. Few plants or their phytochemical constituents have been proven to have medicinal effects by rigorous science or have been approved by regulatory agencies. Shade dried leaves of Murraya koenigii was extracted using successive solvent extraction method using ethanol, chloroform and aqueous. Qualitative ph...
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INVESTIGATION ON THE IMPACT OF CORE AND BARRIER LAYER COMPOSITION ON THE DRUG RELEASE FROM A TRIPLE LAYER TABLET
In this study, Monolayer matrix (MLM) tablet and triple layer matrix (TLM) tablet formulation of metoprolol succinate were fabricated by using Hydroxypropyl-methylcellulose and Polymethacrylates (Eudragit) as the matrix forming agent in both the tablet core layer and barrier layers. The prepared tablets were analyzed for their drug content and in-vitro drug release studies. In-vitro evaluation a...
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X-RAY DIFFRACTION STUDY OF A PANCHAVAKTRA RAS
Analytical monitoring of Pharmaceutical products is necessary to ensure its safety and efficacy throughout all phases of the drug. A systematic approach should be adapted to the presentation and evaluation of stable information, which should include, as necessary, physical, chemical, biological and microbiological test characteristics. Indian System of Medicine (ISM) frequently uses metal/mineral ...
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IN VITRO ANTIOXIDANT, TOTAL PHENOLIC CONTENT AND BRINE SHRIMP LETHALITY STUDIES OF SYNEDRELLA NODIFLORA
The antioxidant activity of methanol extract of whole plant of Synedrella nodiflora as well as its petroleum ether, carbon tetrachloride, dichloro-methane and aqueous soluble partitionates were evaluated by DPPH of (1, 1-diphenyl-2-picrylhydrazyl) and phosphomolybdenum total antioxidant assay and compared with standard antioxidants butylated hydroxytoluene (BHT) and ascorbic acid (ASA). The to...
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ANTIDIABETIC EFFECT OF ETHANOLIC SEED EXTRACT OF DECALEPIS HAMILTONII WIGHT AND ARN ON OXIDATIVE STRESS AND ENZYMIC ACTIVITIES IN ALLOXAN INDUCED DIABETIC RATS
Decalepis hamiltonii Wight and Arn. is an indigenous medicinal plant, which has a folk reputation in Western and southern India as hypoglycemic agent. The present investigation was carried out to evaluate the antidiabetic effect of ethanolic seed extract of Decalepis hamiltonii in alloxan induced diabetic Albino rats. Blood glucose levels and body weights of control and diabetic rats were monitore...
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ROSMARINIC ACID ENHANCES CISPLATIN CYTOTOXICITY IN HEPG2 CELL LINE AND ATTENUATES ITS NEPHROTOXICITY IN MICE
The present study aimed to investigate the anticancer effect of rosmarinic acid (RA), both alone and in combination with cisplatin (cis). Also, the potential nephroprotective effects of RA against cis-induced nephrotoxicity in mice and the possible mechanisms underlying this protection were explored. Treatment of HepG2 cells with RA produced a significant decline in cellular proliferation. RA indu...
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IN – VIVO CONFIRMATION OF A 49.6 KDA PROTEIN PILI OF HELICOBACTER PYLORI TO PREVENT DESTRUCTION OF GASTRIC CELLS AGAINST LIVE HOMOLOGOUS BACTERIA IN MICE
Peptic ulcers is one of the major gastrointestinal disorder in human being that generally associated with the infection of Helicobacter pylori, a gram-negative microaerophilic bacterium in stomach. It is also linked to the development of the stomach cancer. The aim of this study was to investigate the in vivo properties of the sub-unit pili proteins with molecular weight of about 49,6 kDa in m...
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ANTIMICROBIAL ACTIVITY OF ETHANOL AND AQUEOUS EXTRACTS OF PARINARI CURATELLIFOLIA (STEM) ON DENTAL CARIES CAUSING MICROBES
Antimicrobial activity of ethanol and aqueous extracts of Parinari curatellifolia (stem) were tested against five dental carries causing bacteria and three fungi strains by agar diffusion method. The crude extracts showed a broad spectrum of antibacterial activity inhibiting the five strains of bacteria and the three fungi. The extracts were most effective against Aspergilusflavus, followed by Str...
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