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CHARACTERIZATION AND CYTOTOXICITY EVALUATION OF SUPERPARAMAGNETIC NANOPARTICLES BIOSYNTHESIZED BY FUSARIUM OXYSPORUM SK
Superparamagnetic iron oxide nanoparticles have been used for various industrial and clinical applications. In the present study, biosynthesis of superparamagnetic Fe3O4 nanoparticles was carried out using a fungal isolate. The fungal isolate was identified as Fusarium oxysporum SK through 18S ribosomal DNA sequence analysis. The synthesized magnetic nanoparticles were subjected to Transmission El...
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EVALUATION OF ANTI- INFLAMMATORY ACTIVITY OF CAPPARIS GRANDIFLORA WALL. EX HOOK. F. & THOMSON IN RODENTS
Capparis grandiflora was used to treat diarrhoea and other infective disorders in folklore. The present study aims at evaluating the action of chloroform soluble fraction, ethanol soluble fraction and ether soluble fraction of the leaves of Capparis grandiflora against inflammatory diseases. The anti-inflammatory effects were investigated by employing acute inflammatory model i.e.; carrageenan-ind...
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SIMULTANEOUS ESTIMATION OF HYDROCHLORTHIAZIDE AND CANDESARTAN CILEXTIL IN BULK AND PHARMACEUTICAL DOSAGE FORMS BY RP-HPLC PDA METHOD
Hydrochlorothiazide and Candesartan cilextil are used in combination for the treatment of hypertension. The aim of the present investigation was to develop and validate a simple, efficient, economical RP-HPLC method for the simultaneous estimation of Hydrochlorothiazide and Candesartan cilextilin bulk and dosage forms. Chromatographic analysis was performed on Phenomenex C18RP column (250 x 4.6mm;...
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STUDY OF EFFECT OF METFORMIN ON LIPID PROFILE IN TYPE 2 DIABETES MELLITUS IN A TERTIARY CARE TEACHING HOSPITAL
Type 2 diabetes mellitus poses an important health care problem because of its associated two to threefold increased risk of cardiovascular disease and its high prevalence and incidence worldwide. Dyslipidemia is an independent risk factor for severe morbidity and mortality in terms of cardiovascular risk in type-2 DM patients. Studies have shown an association between metformin and lipid profile ...
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A NOVEL RP- HPLC METHOD FOR THE QUANTIFICATION OF CABOZANTINIB IN ACTIVE PHARMACEUTICAL INGREDIENTS AND PHARMACEUTICAL DOSAGE FORMS
A simple, specific, accurate reversed-phase high performance liquid chromatographic method was developed for the quantification of Cabozantinib. Although extensive studies on Cabozantinib have been developed for determining Cabozantinib in human place and urine by LC-MS, studies on the pharmaceutically active ingredient and formulation are scarce. The effective separation was achieved through BDS ...
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NITRIC OXIDE: A NOVEL THERAPEUTIC TARGET
Nitric oxide (NO), the most potent natural vasorelaxant, has close relation to cardiovascular physiology, inspite of its complex chemistry; it is a signal-transducing radical. Aspects of NO biology critical to gastrointestinal health and, consequently, nutritional status are increasingly being recognized. Cross-talk between NO and micronutrients within and outside the gastrointestinal system affec...
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SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 2-(2-(BENZO [D] OXAZOL-2-YL) PHENYLAMINO)-N-(SUBSTITUTED PHENYL) ACETAMIDES
In the present work six new benzoxazole derivatives were synthesized adopting the suitably selected scheme. The synthetic methodology included the synthesis of 2-(2-aminophenyl) benzoxazole (D1) by the reaction of anthranilic acid with 2-aminophenol in poly phosphoric acid. Substituted chloroacetanilides (A1-A6) were synthesized by the reaction of substituted anilines with chloroacetyl chloride. F...
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IMMUNOLOGICAL AND BIOCHEMICAL CHARACTERIZATION OF GLUTATHIONE-S-TRANSFERASE IN PARTHENIUM POLLINOSIS AND ITS CROSS-REACTIVITY WITH BIRCH POLLINOSIS FOR CLINICAL RELEVANCE
Pollinosis is one of the most common allergic diseases in Asia, Central and Northern Europe as well as in North America. Several proteins in parthenium pollen have already been characterized as allergens causing sensitization and the development of allergic symptoms in atopic individuals. Glutathione-S-transferase are a phylogenetically widespread enzyme family mainly involved in cellular detoxifi...
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THE INVESTIGATION ON TOTAL PHENOLIC CONTENT AND IN VITRO ANTIOXIDANT POTENTIAL OF DIFFERENT PLANT PARTS OF NYCTANTHES ARBOR-TRISTIS (NIGHT JASMINE)
Nyctanthes arbor-tristis (Paarijaat) is one of the important plants used in traditional medicines, mainly known for the medicinal properties of its flower and leaf. In this study, the four plant parts of Nyctanthes arbor-tristis were extracted sequentially with four solvents of decreasing polarity and investigated for antioxidant potential. The highest phenolic content was observed with flower, fo...
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IN VIVO ANTI-INFLAMMATORY ACTIVITY OF ETHYL ACETATE EXTRACT DERIVED FROM MARINE STREPTOMYCES CARPATICUS
Anti-inflammatory activity of the SC-EA extract of the marine Streptomyces carpaticus was studied in Wistar rats using acute and chronic inflammatory models like carrageenan induced paw edema and cotton pellet induced granuloma models respectively. The acute toxicity of SC-EA extract was tested on adult Wistar rats. The maximum dose of SC-EA extract at 2000mg/kg does not show any sign of visual ch...
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