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INFLUENCE OF VERAPAMIL ON PHARMACOKINETICS OF PIOGLITAZONE IN NORMAL AND DIABETIC RATS
The study was undertaken to find out the pharmacokinetic drug interaction of verapamil on pioglitazone in normal and alloxan induced diabetic rats following single and multiple dose treatment. Human oral therapeutic doses of pioglitazone and verapamil were extrapolated to rats based on their body surface area. The serum pioglitazone concentrations were estimated by a sensitive reverse phase – hi...
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BRINE SHRIM LETHALITY BIOASSAY OF METHANOLIC CRUDE EXTRACTS OF TERMINALIA ARJUNA
The aim of this work is to determine the cytotoxic activities of Terminalia arjuna (Family: Combretaceae) by brine shrimp lethality bioassay. The leaves of Terminalia arjuna were extracted with methanol and the methanolic extract was fractionated into three fractions by using organic solvents like n-hexane, ethyl acetate and chloroform. The n-hexane, ethyl acetate and chloroform soluble fractions ...
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TO INVESTIGATE THE EFFECT OF GINGER (ZINGIBER OFFICINALE ROSCOE) ON PENDULAR INTESTINE MOTILITY OF RAT
To investigate the effects of ginger-juice (Zingiber Officinale Roscoe) on rat’s intestinependular motility. Methods: Albino rats were sacrificed to isolate intestine. Concentration of ginger is expressed in term of mg/ml of ginger rhizome. It is based on preparation of ginger-juice as detailed in material and methods section. 150 ml of filtrate used in the isolated experiment represented 500 gm...
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ASSESSMENT OF PHYSICO-CHEMICAL STATUS OF GROUND WATER SAMPLES OF PARBHANI DISTRICT (M.S., INDIA)
Ground water is the most preferred water source in recent day. Once believed to be safe from pollution as it is available many strata below the surface, is now provided to be prone to pollution by many researchers across the world. The contamination of ground water may be due to improper disposal of domestic and industrial west water. A study was carried out to assess the ground water quality of P...
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ASSESSMENT OF KNOWLEDGE, ATTITUDE AND PRACTICE OF PRESCRIBING FIXED DOSE COMBINATIONS AMONG POSTGRADUATE MEDICAL STUDENTS – A CROSS SECTIONAL SURVEY
Objective: To evaluate the knowledge, attitude and practice, regarding Fixed Dose Combinations (FDCs) among Postgraduate medical students of Bangalore Medical College and Research Institute, Bengaluru. Materials and methods: The questionnaire based study was conducted among 150 Postgraduate medical students of BMCRI, Bengaluru. The data obtained was analyzed using descriptive statistics. Results: ...
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QSAR STUDY TO PREDICT ANTI-AMOEBIC ACTIVITIES OF PYRAZOLINE AND DIOXAZOLE DERIVATIVES WITH THE HELP OF PM5-BASED DESCRIPTORS
In quest of better anti-amoebic agents, quantitative structure-activity relationship (QSAR) studies were performed on a series of pyrazoline & dioxazoles derivatives with the help of PM5 calculations and geometry optimizations using CAChe software. Multiple Linear Regression (MLR) analysis was performed to derive QSAR models using the descriptors, molecular weight (MW), conformation minimum en...
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TREATING DIABETES AND RHEUMATOID ARTHRITIS USING PERSONALIZED MEDICATION
As in the cases of non-communicable but chronic and autoimmune disorders like diabetes, cancer, anemia and rheumatoid arthritis are growing threat to humans. They depend on the genetic information and the genome sequence of the patients and other factors like environmental factors. In most of the cases, the pattern of the disease, i.e. pathogenesis is different for every individual, though phenoty...
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SAFETY AND ADVERSE EVENTS OF PROPHYLACTIC HPV VACCINES AMONG HEALTHY WOMEN: A SYSTEMATIC REVIEW & META ANALYSIS
Cervical cancer (CaCx) is the third most common female cancer worldwide with an estimated 5, 27, 624 new cases and 2, 65, 653 deaths in 2014. We conducted a systematic review and meta- analysis to assess safety of prophylactic HPV vaccines compared against placebo. Four unique trials were included out of 607 publications. The total patient data evaluated was 1427(852 in vaccinated arm; 575 in the ...
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COMPARATIVE ANALYSIS OF MOLECULAR INTERACTIONS BETWEEN DRUGS OF AQUEOUS PROPYLENE GLYCOL WITH CERTAIN ALCOHOLS AT 308.15K: AN INSIGHT FROM DENSITY AND VISCOSITY STUDIES
Density, ρ and viscosity, η of drug of aqueous solution of propylene glycol (PG) (3 m and 7 m) with tert-butanol/2-propanol have been measured over the entire composition range of alkanols at 308.15 K. From this experimental data, excess molar volume, , deviation in viscosity, Δη, and excess Gibbs free energy of activation of viscous flow, ΔG*E have been determined. Positive values of Δη, ...
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ANALYSIS OF LIVER FUNCTION TESTS AND RENAL FUNCTION TESTS IN MAJOR DEPRESSIVE PATIENTS ON IMIPRAMINE, SERTRALINE AND ESCITALOPRAM THERAPY: AN OBSERVATIONAL STUDY IN A TERTIARY CARE HOSPITAL, AJMER, RAJASTHAN
Depression is the major cause of disability Worldwide. Antidepressant medications remain a mainstay of treatment for major depressive disorder. Our aim in this study was to analyze the LFT & RFT in patients of major depressive disorder taking imipramine, sertraline and escitalopram. A total of 810 such patients meeting the inclusion and exclusion criteria were randomly divided into three group...
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