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EVALUATION OF CARDIOPROTECTIVE EFFECTS OF CAMELLIA SINENSIS ON ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION
Background: Black tea is rich in polyphenols which are antioxidants. The most abundant polyphenolic compounds are flavonols and catechins. Black tea antioxidants showed protective actions against chronic diseases like cardiovascular diseases due to their antioxidant action. Objective: The present study was conducted to evaluate the cardioprotective effects of Camellia sinensis on isoproterenol ...
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ASSESSMENT AND QUALITY BASIL (OCIMUM BASILICUM) GENETIC VARIABILITY AND VIRAL DISEASE IN LAKHIMPUR, UTTAR PRADESH, INDIA
The study aims at assessing Basil’s genetic phenotypic variability and viral disease incidence in India for sustainable pathological interventions. Basil (Ocimum basilicum) is important for its medicinal and nutritive value. It is highly adaptable as a potential crop in the tropics and could therefore enhance the food security of India nations. Germplasm seed evaluation and characterization was ...
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FORMULATION, CHARACTERIZATION AND DETERMINATION OF ANTI-ALZHEIMERIC ACTIVITY OF TACRINE LOADED POLY (LACTIDE-CO-GLYCOLIDE) NANOPARTICLES
The objective of this study was to formulate and characterize Tacrine loaded poly (lactide-co-glycolide) (PLGA) nanoparticles used for the treatment of alzheimer’s disease and were prepared by modified nano precipitation method. Pharmacodynamics studies of the nanoparticles were evaluated for brain targeting and memory improvement in scopolamine-induced amnesic mice using Morris water maze test ...
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CHEMICAL EXAMINATION OF A NEW ALLELOCHEMICAL FROM STEMS OF GLOSSOCARDIA BOSVALLIA DC.
Glossocardia bosvallia DC.1-3 belongs to family Composite which is commonly known as “Patthar-suva or seri” in Hindi. It is found almost throughout in India and Deccan Peninsula. It is a small annual herb, 10-20 cm tall. The tribal inhabitants of western Maharashtra use a decoction of the plant as febrifuge. It has a bitter taste and fennel like odor. Besides serving as a medicinal plant Pi...
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EVALUATION OF BRONCHIAL SMOOTH MUSCLE RELAXANT ACTIVITY OF FLUPIRTINE IN EXPERIMENTALLY INDUCED ASTHMA IN GUINEA PIGS
Objectives: The study aimed at evaluating the broncho-relaxant effect of the test drug Flupirtine in experimentally induced Asthma in Guinea pigs & compares its efficacy with the Standard. Materials and Methods: Guinea pigs of both sexes weighing around 350-400 gm were randomly divided into 3 groups of 6 animals each. Groups were categorised into Control, Standard and test groups. Animals serv...
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BIOAVAILABILITY AND BIOEQUIVALENCE OF BIOSIMILARS
Biosimilars are the most promising medicines for treating complex diseases. The first biosimilar was approved in India in 2000, and since then, there is no looking back. CDSCO in collaboration with DBT has developed new guidelines in 2012, which were revised in 2016 for pre and post-marketing approval of biosimilars in India. India is one of the leading manufacturers of biosimilars catering to dom...
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ANTIBACTERIAL ACTIVITY OF THE CRUDE EXTRACTS OF B. SUBTILIS FROM SML
The rise of antibiotic-resistant pathogens leads to the development of new antibiotics and drugs. Natural products capture the attention of the researchers for such drug discovery. Apart from medicinal plants, many microorganisms also play a great role in the discovery of antibiotics. In this context, bacteria from Sea surface microlayer (SML) are also investigated nowadays. The secondary metaboli...
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BRINE SHRIM LETHALITY BIOASSAY OF METHANOLIC CRUDE EXTRACTS OF TERMINALIA ARJUNA
The aim of this work is to determine the cytotoxic activities of Terminalia arjuna (Family: Combretaceae) by brine shrimp lethality bioassay. The leaves of Terminalia arjuna were extracted with methanol and the methanolic extract was fractionated into three fractions by using organic solvents like n-hexane, ethyl acetate and chloroform. The n-hexane, ethyl acetate and chloroform soluble fractions ...
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LESS TOXIC NANOPARTICLES OF PLATINUM BASED ANTI-CANCER DRUG
Objectives: The objective of this research was dose reduction and toxicity reduction. Dose reduction: various anti-cancer drugs are very costly, and their high dose increases cost. If bioavailability is enhanced, the dose shall be reduced thereby; the cost will also decrease. Dose reduction will also reduce toxicity, and the preparation will become more tolerable. Method: In this study, the nanopa...
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ROLE OF ACUTE PHASE PROTEINS STATUS IN CHRONIC ALCOHOLIC LIVER DISEASES
Back ground: Alcoholic cirrhosis is a condition of irreversible liver disease due to the chronic inflammatory and toxic effects of ethanol on the liver. Acute alcoholic hepatitis occurs in habitual drinkers, often a period of increased alcohol intake. Although, the clinical features may mimic acute viral hepatitis. Progression of liver fibrosis to cirrhosis is dangerous as well as potentially life...
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