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DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR DETERMINATION OF PHENOBARBITONE AS BULK DRUG AND IN PHARMACEUTICAL FORMULATION
A sensitive, selective, precise and stability indicating high performance thin layer chromatographic method of analysis of Phenobarbitone both as a bulk drug and in formulations was developed and validated in pharmaceutical dosage form. The method employed TLC aluminium plates precoated with silica gel 60F-254 as the stationary phase. The solvent system consisted of dichloromethane: ethyl acetate:...
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OPTIMIZATION, EVALUATION AND STABILITY STUDY OF NUTRACEUTICAL POWDER FORMULATIONS DEVELOPED FROM EDIBLE SEED AND LEAFY- VEGETABLE SOURCES
Nutraceutical term is a combination of terms nutrient and pharmaceutical. There is a wide scope in applying pharmaceutical formulation parameters to nutraceuticals. Amongst the variety of nutraceuticals available, powder form of nutraceuticals are most popular. The nutraceutical powder mixtures can contain many ingredients, of which the nutrient source contents are generally present in more than 5...
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ANALYSIS OF MOLECULAR INTERACTION IN TRAMADOL DRUG WITH ALCOHOLS UNDER ULTRASONIC TECHNIQUE AT TEMPERATURE T= 278.15 K
The prime aim of this research paper is to find out the various kinds of intermolecular interactions in the alcoholic tramadol below the room temperature. Study of molecular interaction in the mixture of alcohols namely ethanol,1-propanol,1-butanol with tramadol drug at T = 278.15 K have been examined under the ultrasonic technique at 2MHz. Ultrasonic data of drug solutions has been evaluated at v...
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PRELIMINARY PHYTOCHEMICAL STUDIES ON FRUITS OF TERMINALIA SPECIES (COMBRETACEAE), USED BY THE LOCAL TRIBALS OF ANDHRA PRADESH
The present paper deals with preliminary phyto-chemical screening of Terminalia species (Combretaceae), used by the local tribal communities for different human and veterinary ailments. The personal interviews conducted with local herbal practitioners and review of literature yielded 5 species of Terminalia as an effective remedy for diabetes, dysentery, diarrhoea, asthma, rheumatic pains etc. The...
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SYNTHESIS, CHARACTERIZATION, PHARMACOLOGICAL EVALUATION AND MOLECULAR DOCKING STUDIES OF NOVEL BENZOXAZINE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION
An attempt has been made to synthesize Benzoxazines and conduct Molecular docking studies of the same using Cyclooxygenase-1. All the synthesized compounds are then tested for anti-inflammatory activity by using fresh egg-white induced Paw edema method. The synthesis of novel Benzoxazine derivatives has been achieved by the reaction of Salicylaldehyde with Para Amino Benzoic Acid (PABA), which aff...
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PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF AQUEOUS EXTRACT OF THE AERIAL PARTS OF VIBURNUM PUNCTATUM BUCH. – HAM. Ex. D. DON
The genus Viburnum punctatum Linn. Under the family Caprifoliaceae (formerly) and Adoxaceae (currently) consists of about 200 species throughout the world. Many of these species have been recognized for their medicinal properties from very early times of this century. The aerial parts of Viburnum punctatum was collected from Nilgiri hills, Tamilnadu, India and was authenticated by Dr. A. B. Rema...
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VALIDATION FOR QUANTITATIVE DETERMINATION OF AZTREONAM IN SIMULATED LUNG FLUID BY UV SPECTROSCOPY METHOD
Aztreonam, a synthetic beta-lactam antibiotic is widely used for the treatment of infections in lungs, meninges, bladder, etc. Its potential use in the treatment of pneumonia and cystic fibrosis has been established. Recently FDA has approved Cayston® for inhalation therapy of Aztreonam in lungs infection. Many studies have been reported on the quantitative determination of Aztreonam by UV spectr...
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THE INVESTIGATION ON TOTAL PHENOLIC CONTENT AND IN VITRO ANTIOXIDANT POTENTIAL OF DIFFERENT PLANT PARTS OF NYCTANTHES ARBOR-TRISTIS (NIGHT JASMINE)
Nyctanthes arbor-tristis (Paarijaat) is one of the important plants used in traditional medicines, mainly known for the medicinal properties of its flower and leaf. In this study, the four plant parts of Nyctanthes arbor-tristis were extracted sequentially with four solvents of decreasing polarity and investigated for antioxidant potential. The highest phenolic content was observed with flower, fo...
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EVALUATION OF RATIONALITY IN PRESCRIBING FOR CARDIOVASCULAR DISORDERS IN INTENSIVE CARDIAC CARE UNIT: A PROSPECTIVE OBSERVATIONAL STUDY
Objective: To evaluate the prescribing pattern in patients admitted to intensive cardiac care unit, to evaluate direct cost of the treatment in patients admitted in intensive cardiac care unit, to evaluate the rationality of drugs prescribed and to prepare and submit therapeutic guideline for management of ACS. Method: This prospective observational study was carried out in ICCU for a period of te...
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DEVELOPMENT AND VALIDATION OF AN RP-HPLC METHOD FOR QUANTITATIVE ESTIMATION OF ILOPERIDONE IN RAT PLASMA
A simple and fast isocratic reverse phase- high performance liquid chromatography (RP-HPLC) method was developed for estimation of iloperidone from rat plasma employing a photo diode array (PDA) detector. The plasma samples were prepared by protein precipitation using acetonitrile as extracting solvent. The chromatographic separation was performed on a BDS Hypersil Phenyl column (250 mm × 4.6 ...
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