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LESS TOXIC NANOPARTICLES OF PLATINUM BASED ANTI-CANCER DRUG
Objectives: The objective of this research was dose reduction and toxicity reduction. Dose reduction: various anti-cancer drugs are very costly, and their high dose increases cost. If bioavailability is enhanced, the dose shall be reduced thereby; the cost will also decrease. Dose reduction will also reduce toxicity, and the preparation will become more tolerable. Method: In this study, the nanopa...
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BIOAVAILABILITY AND BIOEQUIVALENCE OF BIOSIMILARS
Biosimilars are the most promising medicines for treating complex diseases. The first biosimilar was approved in India in 2000, and since then, there is no looking back. CDSCO in collaboration with DBT has developed new guidelines in 2012, which were revised in 2016 for pre and post-marketing approval of biosimilars in India. India is one of the leading manufacturers of biosimilars catering to dom...
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A REVIEW OF DIFFERENT DISSOLUTION METHODS
Dissolution is an authorized test used by Pharmacopoeias for assessing drug arrival of solid and semisolid measurement structures. The primary utilization of dissolution testing incorporates the biopharmaceutical portrayal of medication items as a device to guarantee reliable item quality and to predict in-vivo drug bioavailability. Dissolution testing was initially grown for solid orals; later on...
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DESIGN AND DEVELOPMENT OF IONTOPHORETIC DRUG DELIVERY SYSTEM OF L-TYROSINE
This study was aimed to design and develop iontophoretic drug delivery of L-Tyrosine in the treatment of phenylketonuria. The In-house iontophoretic drug delivery device was designed and validation was performed respect to Current intensity, Voltage, and Power Resistance. The study was also focused various parameters such as effect of different drug concentrations (2.5mg/5ml, 5mg/5ml, 10mg/5ml, 15...
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PRELIMINARY PHYTOCHEMICAL SCREENING AND GC MS ANALYSIS OF CHLOROFORM EXTRACT OF KANDELIA CANDEL (L.) DRUCE
The aim of the present study is to screen the phytochemicals present in the leaf extract of Kandelia candel and further analysis of the bioactive components present in it by Gas chromatography - Mass spectrometry (GC-MS) analysis. Carbohydrates, proteins, amino acids, Saponins, flavonoids, terpenoids, glycosides, tannins, alkaloids, and phenols were present in the sample. The percentage yield of p...
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TREATING DIABETES AND RHEUMATOID ARTHRITIS USING PERSONALIZED MEDICATION
As in the cases of non-communicable but chronic and autoimmune disorders like diabetes, cancer, anemia and rheumatoid arthritis are growing threat to humans. They depend on the genetic information and the genome sequence of the patients and other factors like environmental factors. In most of the cases, the pattern of the disease, i.e. pathogenesis is different for every individual, though phenoty...
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APPLICATION OF STEM CELL THERAPEUTIC AGENTS TO CONTROL CRITICAL DISEASE
Stem cell research has been hailed for the potential to revolutionize the future of medicine with the ability to regenerate damaged and diseased organs. On the other hand, stem cell research has been highly controversial due to the ethical issues concerned with the culture and use of stem cells derived from human embryos. This article presents an overview of what stem cells are, what roles they pl...
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THE SYNERGESTIC EFFECTS OF EDTA / ANTIBACTERIAL COMBINATIONS IN KLEBSIELLA PNEUMONAE INDUCED PNEUMONIA RAT MODEL
The study was conducted to evaluate the synergistic effect of EDTA with antibacterial (Ceftriaxone + Sulbactum) as a combinational therapy against antioxidant enzyme activity, lipid peroxidation level, some hematological and biochemical parameters in Klebsiella pneumoniae induced nosocomial pneumonia followed by histopathology of lungs tissue in experimental exposed Sprague Dayle (S.D) rats. Total...
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PHYTOCHEMICAL SCREENING ON THE AERIAL PART OF THE LUFFA ECHINATA LINN.
The present work deals with development and standardization of phytochemical screening for quantification of ethanolic extract of aerial part of the Luffa echinata Linn. The scientific parameter is necessary to identify the exact plant material and to find its quality and purity. The present study deals with various, physical evaluation and preliminary phytochemical screening of various successive...
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STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF DOXYCYCLINE MONOHYDRATE AND ORNIDAZOLE IN BULK AND PHARMACEUTICAL DOSAGE FORM
A simple, rapid, precise, cost effective, stability indicating RP-HPLC method has been developed and validated for the simultaneous estimation of Doxycycline monohydrate (DOXM) and Ornidazole (ORN) in Bulk and pharmaceutical dosage form. The chromatographic separation was achieved on Hypersil BDS C18 column (250mm ×4.6mm, 5μm) using a mobile phase consisting of Buffer : Acetonitrile (55:45 v/v...
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