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IDENTIFICATION OF ANTI HYPERLIPIDEMIC ACTIVITY OF CERIUM OXIDE NANO PARTICLES IN RAT MODEL
Cerium oxide is an oxide of the rare earth metal which is widely used for several disorders. However, there are no complete toxicity studies done on it. The purpose of present study is to evaluate acute and Anti-hyper lipidemic activity of cerium oxide nano particles on Wistar albino rats. In this study, Cerium oxide was administered to six rats in different groups in different concentrations (100...
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EVIDENCE FOR COMPLEX FORMATION OF IBUPROFEN WITH GO-GHRITA
Present investigation provides evidence for complex formation of Ibuprofen (Ib) with Go-Ghrita (GG). Ibuprofen binary mixture in (1:0.5), (1:1), (1:2), (1:3) w/w proportions were prepared by adding to molten Go-Ghrita kept over a water bath at 65-70oC with continuous stirring. Organoleptic and Physico-chemical properties of GG (procured from Magan Sangrahalaya, Wardha) were as per the specificat...
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ANTIBACTERIAL ACTIVITIES OF TRIGONELLA FOENUM-GRAECUM AND ZINGIBER OFFICINALE
An in vitro study was conducted for screening antibacterial activities of seeds of Trigonella foenum-graecum (fenugreek)and rhizomes of Zingiber officinale (ginger), in their different forms viz. aqueous extracts, essential oils and powders against some common food borne pathogens. Bacterial strains involved in the study were Bacillus cereus (MTCC 430), Enterococcus feacalis (MTCC 439), Escheric...
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POSSIBLE RETRIEVAL OF ORGANOCHLORINE INDUCED RENAL TOXICITY IN FISH BY AQUEOUS ROOT EXTRACT OF WITHANIA SOMNIFERA: IN VIVO STUDY
The present study was aimed to assess the reno-protective impact of aqueous extract of root of Withania somnifera (WSR) commonly known as Ashwagandha against organochlorine induced renal toxicity in fish Clarias batrachus (Linn.).Fishes were exposed to 4ppb concentration of commercial brand Endocel, an organochlorine pesticide for one week and two week to prepare the toxic model. These toxic group...
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DESIGNING NATURAL AGONISTS FOR THYROID HORMONE RECEPTOR ALFA-1
Hypothyroidism is a common disorder of endocrine system in which the thyroid gland does not produce enough thyroid hormone. The most common cause of hypothyroidism is inflammation of the thyroid gland, which damages the gland’s cells. It can affect growth, cellular processes and many other body functions. As more damage accumulates, the risk of Hypothyroidism increases. In order to make an impac...
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EFFECT OF CEREBELLAR FASTIGIAL NUCLEUS LESION ON IMMUNITY IN WISTAR ALBINO RATS
The aim of the present study was to investigate the role of cerebellum in immunomodulation as cerebellum was thought traditionally to play an important role in voluntary motor activities. Rats weighing about 200-220 gm were subjected to bilateral electrolytic lesion of fastigial nucleus and following immune parameters were assessed- leucocyte migration inhibition test, foot pad thickness, antibody...
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THE EFFECT OF DI-BUTYL PHTHALATES (DBP) AND DI (2-ETHYLHEXYL) PHTHALATES (DEHP) ON FEMALE RATS FERTILITY
Phthalate esters are industrial chemicals widely used in cosmetics, plastics bottles and medical devices, and the risk of exposure to phthalates is on the increase. In recent years, many studies have been carried out on the possible health hazards of phthalates, including the effect on reproduction. In this studyrats were injected twice weekly with Di-butyl Phthalates (DBP) or Di (2-Ethylhexyl) ...
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IMMUNOLOGICAL AND BIOCHEMICAL CHARACTERIZATION OF GLUTATHIONE-S-TRANSFERASE IN PARTHENIUM POLLINOSIS AND ITS CROSS-REACTIVITY WITH BIRCH POLLINOSIS FOR CLINICAL RELEVANCE
Pollinosis is one of the most common allergic diseases in Asia, Central and Northern Europe as well as in North America. Several proteins in parthenium pollen have already been characterized as allergens causing sensitization and the development of allergic symptoms in atopic individuals. Glutathione-S-transferase are a phylogenetically widespread enzyme family mainly involved in cellular detoxifi...
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FORMULATION DEVELOPMENT AND EVALUATION OF CANDESARTAN BUCCAL TABLETS
Buccal tablets are prepared by direct compression method using different polymers like carbopol, hydroxypropyl methylcellulose and sodium alginate. Nine formulations were prepared while (F1) to (F3) were prepared by taking individual concentrations whereas all the remaining formulations were prepared by taking combinations of polymers. Aim of study is to develop and optimize mucoadhesive buccal ta...
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Anti-inflammatory activity of Methanolic Extract of Aerial parts of Momordica Cymbalaria Hook F
The aim of the present study is to evaluate the effect of methanol extract of aerial part of Momordica Cymbalaria Hook F on acute inflammation and it justifies the traditional use of this plant in the treatment of various types of pains and inflammation was evaluated in Albino rat. The aerial part of Momordica Cymbalaria Hook F extracted with methanol at an oral dose of 100 and 200 mg/kg body weig...
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