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IN VITRO COMPARATIVE STUDY OF MEMBRANE STABILIZATION CAPACITY OF DIFFERENT EXTRACTS OF BLEPHARIS MADERASPATENSIS (L.) HEYNE EX ROTH. AND BLEPHARIS MOLLUGINIFOLIA PERS. GROWN IN THE REGION OF MYSORE, KARNATAKA
Blepharis is a genus belonging to family Acanthaceae. It is an Afro-asiatic genus comprising 129 species which occur in arid and semi-arid habitats. They are used for the treatment of a number of ailments. Anti-inflammatory activity was performed based on the folk lore information. The present study is aimed at the evaluation ofanti-inflammatory property of the petroleum ether, ethyl acetate and e...
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STUDY OF ELECTRODE KINETICS AND THERMODYNAMIC PARAMETERS OF TINIDAZOLE POLAROGRAPHYCALLY
The electrochemical reduction of anti- parasitic drug “Tinidazole” has been carried out in aqueous solution in the pH range 2.3 to 11.3 by Direct current (DC) polarography. Tinidazole exhibits one or two reduction peaks depending on pH. In basic medium one reduction peak was observed. Along with different pH, studies of drug have been carried out with different concentrations of drug and at di...
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SOME CONNECTIVITY INDICES AND ZAGREB INDEX OF HONEYCOMB GRAPHS
In this paper, we investigate several topological indices in honeycomb graphs: Randić connectivity index, sum-connectivity index, atom-bond connectivity index, geometric-arithmetic index, First and Second Zagreb indices and Zagreb polynomials. Formulas for computing the above topological descriptors in honeycomb graphs are given....
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THE ROLE OF AQUEOUS EXTRACT OF CITRUS SINENSIS PEEL IN CADMIUM MEDIATED HEPATOTOXICITY
Predisposing exposures to cadmium have been implicated in hepatotoxicity, hence the search for therapeutic interventions. Thirty Wistar rats were randomly grouped into six (1-6) with 5 rats each. Group 1 received only 5mg/kg body weight (b.wt) of Cadmium Chloride (CdCl2) intra-peritoneally. Group 2 received feed and water ad libitum. Groups 3 and 4 received CdCl2 followed by low and high dose (10m...
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TARGETING INFLAMMATORY PROTEINS USING IMMUNOMODULATOR FOR REGULATION OF HEPATOCELLULAR CARCINOMA MICROENVIRONMENT
Inflammation plays fundamental role in hepatocellular carcinoma (HCC) initiation, progression and metastasis. The over expression of pro-inflammatory factors like Tumor necrosis factor-α (TNF-α), selectin, (IL)-6, nuclear factor-κB, TGF-β can alter the hepatic microvasculature. Natural products such as polyphenols, alkaloids, flavonoids, and flavonols have the ability to interface microenviron...
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HIGH – PERFORMANCE LIQUID CHROMATOGRAPHY METHOD VALIDATION AND DEVELOPMENT STRATEGY FOR RIFABUTIN
A simple, economical, accurate and precise high performance liquid chromatographic method was developed and validated for the determination of rifabutin. A Shimadzu LC-2010C HT version 3.01 system using a C-18 column with dimensions of 250 × 4.6 mm and silica particle size of 5 μm. Isocratic elution was employed with methanol, acetonitrile and water (75:25 v/v) were used. The flow rate was 1 ml/...
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GC–MS ANALYSIS OF ANTIOXIDANT COMPOUNDS PRESENT IN DIFFERENT EXTRACTS OF AN ENDEMIC PLANT DILLENIA SCABRELLA (DILLENIACEAE) LEAVES AND BARKS
The study aimed to investigate and characterize the antioxidant compounds from the leaves and barks of Dillenia scabrella (Dilleniaceae) (D. scabrella), an indigenous plant in the Northeast. The air-dried leaves and barks were powdered and subjected to selective sequential extraction using solvents of increasing polarity through percolation, namely, methanol, ethyl acetate + ethanol and water to o...
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pH RESPONSIVE CASEIN MICROPARTICLES AS A CARRIER FOR METHOTREXATE
Casein microparticles cross linked with glutaraldehyde were prepared by steric stabilization process and the controlled release of drug from the particles were evaluated in-vitro. Casein is a natural biopolymer present abundantly in milk is utilized because of its biocompatibility through oral route. Methotrexate loaded Casein microparticles of size 0.5 to 5 µm were prepared. The release of metho...
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SCHWANNOMA PRESENTING AS A GYNAECOLOGICAL MASS WITH PREGNANCY- A CASE REPORT
Schwannomas are usually benign tumors that result from the proliferation of the perineural cells. Since these tumors are very rare, misdiagnosis is common. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous patt...
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AN IN SILICO APPROACH TO IDENTIFY NEW ANTI-HIV INTEGRASE INHIBITOR LIKE LEADS BY DOCKING STUDIES
The Human immunodeficiency virus(HIV)type-1 integrase is one of the most important target of highly active anti retrovirus therapy (HAART), due toits role to incorporate genetic information into the host DNA, so its prevention to its proper function results in very fine therapeutic effect for the treatment of all acquired immune deficiency syndrome(AIDS), extensive research work on integrase inhib...
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