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SOME CONNECTIVITY INDICES AND ZAGREB INDEX OF HONEYCOMB GRAPHS
In this paper, we investigate several topological indices in honeycomb graphs: Randić connectivity index, sum-connectivity index, atom-bond connectivity index, geometric-arithmetic index, First and Second Zagreb indices and Zagreb polynomials. Formulas for computing the above topological descriptors in honeycomb graphs are given....
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IN-VITRO EVALUATION OF ANTIASTHMATIC ACTIVITY OF FICUS RACEMOSA L. (MORACEAE)
Asthma is a disease of the human respiratory system. The different extract of bark was obtained by successive extraction with petroleum ether, butanol, ethyl acetate and alcohol by Soxhlet. These extracts were evaluated for antiasthmatic activity by using in-vitro model, i.e., spasmolytic activity in isolated guinea pig lung strip using histamine for induction of bronchoconstriction in guinea pigs...
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HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC DETERMINATION OF COLCHICINE IN PHARMACEUTICAL PREPARATIONS AND BIOLOGICAL FLUIDS
A simple and rapid high performance thin layer chromatographic (HPTLC) method was developed for the assay of colchicine in bulk drug, pharmaceutical preparations and biological fluids. The method has a linear range of 4 - 35 μg/ml. The limits of detection and quantification were 1 and 4 μg/ml respectively. The results obtained by the proposed method were compared statistically by means...
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DEVELOPMENT OF OSMOTICALLY CONTROLLED DRUG DELIVERY SYSTEM OF METFORMIN HYDROCHLORIDE
The aim of the present study was to formulate an osmotically controlled drug delivery system (O-CDDS) of Metformin hydrochloride to reduce the frequency of multiple dosing in non-insulin dependent diabetes mellitus-II which is a lifelong disease. Metformin hydrochloride a BCS Class-III drug having a poor biological half-life of 6 h. O-CDDS of Metformin hydrochloride is a recent approach for the ze...
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QSAR STUDIES ON POLYCHLORINATED AROMATIC COMPOUNDS USING TOPOLOGICAL DESCRIPTORS
Polychlorinated dibenzo-p-dioxins(PCDDs) and Polychlorinated dibenzofurans(PCDFs) represent a large group of industrial and byproduct compound is resistance to chemical and biological degradation and highly toxic.A series of 18 PCDD and PCDF compounds is subjected to QSTR studies by using differnt molecular descripters. The dependent variable used in this study represents log(EC50) values (EC50-...
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CONCEPTS OF ANTI-HIV THERAPY & ITS APPLICATIONS IN RESOURCE POOR SETTINGS
HIV since its invention has become global burden. In last two decades of the HIV prevalence many anti-retroviral drugs have been developed. Poor countries like India have started central government funded programmes to tackle the menace of the HIV. These programmes have been started because many people cannot afford costly ART drugs. In this review article, we have discussed current ART regimens a...
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STUDY OF ELECTRODE KINETICS AND THERMODYNAMIC PARAMETERS OF TINIDAZOLE POLAROGRAPHYCALLY
The electrochemical reduction of anti- parasitic drug “Tinidazole” has been carried out in aqueous solution in the pH range 2.3 to 11.3 by Direct current (DC) polarography. Tinidazole exhibits one or two reduction peaks depending on pH. In basic medium one reduction peak was observed. Along with different pH, studies of drug have been carried out with different concentrations of drug and at di...
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AN IN SILICO APPROACH TO IDENTIFY NEW ANTI-HIV INTEGRASE INHIBITOR LIKE LEADS BY DOCKING STUDIES
The Human immunodeficiency virus(HIV)type-1 integrase is one of the most important target of highly active anti retrovirus therapy (HAART), due toits role to incorporate genetic information into the host DNA, so its prevention to its proper function results in very fine therapeutic effect for the treatment of all acquired immune deficiency syndrome(AIDS), extensive research work on integrase inhib...
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COMPARATIVE STUDY ON FILTER EFFICIENCY OF DIFFERENT BRANDS OF CIGARETTES BY MICROSCOPIC AND SPECTROSCOPIC TECHNIQUES
Internationally there has been research on large scale for determination of efficiency of cigarette filters but in India it still remains a topic of discussion. Being the second largest consumers of tobacco and tobacco products and one of the largest and fastest growing consumers of cigarettes, such studies need to be undertaken at a greater level to assess the risk and hazards of cigarette smokin...
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IMPACT OF CELL SENESCENCE ON AGE – RELATED NEURODEGENERATIVE DISORDERS: THE MECHANISM TO THERAPY- A REVIEW
Aging is a natural phenomenon; it is a well-known fact that everyone is aging as time passes. A major contributor to this process is cell senescence. Cell senescence can be a result of the exposure to stress such as oxidative stress, epigenomic damage or DNA damage, or it can be due to telomere shortening is also known as end replication problem. It was first observed by Hayflick. Senescent cells ...
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