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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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14.

DEVELOPMENT AND EVALUATION OF A DIRECTLY COMPRESSIBLE CO-PROCESSED MULTIFUNCTION SUSTAINED RELEASE AGENT FOR ISOSORBIDE MONONITRATE SUSTAINED RELEASE TABLETS

Directly compressible co-processed sustained release multifunction agent [DCCSRA] comprising povidone and glyceryl behenate in the ratio of 1:1, 1:2 and 1:3 were prepared and evaluated for formulation of sustained release tablets of isosorbide mononitrate. The DCCSRA exhibited good flow and compressibility. The DCCSRA, prepared by hot melting method and co-precipitation method served as a retardan...

J. Ayyappan*, P. Umapathi and Darlin Quine

Department of Research and Development, Micro Labs Ltd, 67/68-A, Third Phase, Peenya Industrial Area, Bangalore, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).103-13

103-113

3579

1611

12.

EVALUATION OF MOI GUM IN THE FORMULATION OF CONTROLLED RELEASE MATRIX TABLETS USING LOSARTAN POTASSIUM

Matrix tablets were developed using moi gum for investigating its suitability for the controlled release using losartan potassium as a model drug. Tablets were prepared by direct compression method. Lactose and dibasic calcium phosphate (DCP) were used as channelling agents. In-vitro studies were performed in 0.1N hydrochloric acid for the first two hours and pH 6.8 phosphate buffer for the next t...

P. Eswaramma * and K. V. R. Murthy

Department of Pharmaceutics, Vagdevi College of Pharmacy, Gurazala, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(1).121-29

121-129

3579

1490

26.

EFFECT OF NIMODIPINE ON NOCICEPTIVE PAIN AND ITS INTERACTION WITH OPIOID ANALGESICS IN RATS

Objective: To explore the effect of nimodipine on nociception and on opioid-induced antinociception in rats by using the tail-flick method. Method: Sixty albino rats were used for the study. The tail-flick method was used to induce nociception in rats. Analgesic effect of nimodipine was evaluated by using three graded doses (200 mcg/kg, 400 mcg/kg, and 800 mcg/kg). To study the effect of nimodipin...

M. G. Bhole *, A. S. Borkar, R. T. Badwaik and N. A. Ingole

Department of Pharmacology NKP Salve Institute of Medical Sciences, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.5(9).3763-67

3763-3767

3578

1478

38.

SPIRULINA PLATENSIS AT TENUATES STRESS-INDUCED PHYSICAL AND BIOCHEMICAL CHANGES IN RATS

The aim of present study on Spirulina platensis (Spirulina) was to evaluate the anti-stress activity. The anti-stress activity was assessed by tail suspension method andcold immobilization induced change of biochemical parameters. Acute toxicity (LD50) of Spirulina platensis values was also studied. Duration of immobilization time and cold immobilization induced alteration of biochemical parameter...

S. Neekhra*, R. Verma and R. R. Chandra

College of Pharmacy, SR Group of Institutions, Jhansi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(1).292-97

292-297

3578

1416

26.

ACECLOFENAC ENCAPSULATED ETHANOLIC NANO-VESICLES FOR EFFECTIVE TREATMENT OF OSTEOARTHRITIS

In the present study, ethanolic nanovesicles of Aceclofenac developed for the site specific delivery to joints for effective treatment of osteoarthritis. Ethanolic nano-vesicles were prepared by solvent dispersion method. Vesicles were characterized for vesicular size, surface morphology, size and size distribution, zeta potential, entrapment efficiency. Formulations were also evaluated for drug-v...

Arvinder Kaur*, Sunil K. Jain and Ravi S. Pandey

Pharmaceutics Research Laboratory, SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur- 495 009, Chhattisgarh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2562-67

2562-2567

3577

1575

19.

TARGETED DELIVERY OF CATALASE TO MACROPHAGES BY USING SURFACE MODIFICATION OF BIODEGRADABLE NANOPARTICLE

Reactive oxygen species (ROS) produced by activated macrophages play a major role in causing liver disorders. Small antioxidants and scavengers are protective only at very high concentrations and they poorly detoxify toxic ROS. Catalase (CAT) is an antioxidant enzyme that scavenges ROS and has great potential for treating liver disorders. In the present research work, gelatin nanoparticles bearing...

Ajay Saraf *, Amit Dasani and Ashok Soni

Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(6).2221-29

2221-2229

3575

1556

48.

THE IN-VITRO ANTI-DENATURATION EFFECTS INDUCED BY SUBSTITUTED OXY/THIOXY PYRIMIDINE DERIVATIVES IN BOVINE SERUM ALBUMIN IS PROPOSED AS A SCREENING ASSAY FOR THE DETECTION OF ANTI-INFLAMMATORY COMPOUNDS WITHOUT THE USE OF ANIMALS

A series of novel 2-{[6-(2-substituted Phenyl)-2-oxo-1, 2-dihydropyrimidin -4-yl]oxy} benzoic acid (2a-b)/ 2-{[6-(2-substituted Phenyl)-2 thioxo-1, 2-dihydropyrimidin-4-yl]oxy} benzoic acid (2c-d) were synthesized and tested for their in-vitro protein denaturation activity. Compound 2d was found to be promising and was more potent than the Acetylsalicylic acid (NSAID) in the inhibition of Bovine s...

M. Banerjee * and S. K. Sahu

Institute of Pharmacy & Technology, Salipur, Cuttack, Orissa, India.

DOI: 10.13040/IJPSR.0975-8232.11(4).1885-88

1885-1888

3572

1635

16.

ACETYLCHOLINESTERASE INHIBITORY ACTIVITY OF DOREMA AMMONIACUM GUM EXTRACTS AND MOLECULAR DOCKING STUDIES

Ammoniacum gum is traditionally used as an expectorant, stimulant, antispasmodic, catarrh, asthma, chronic bronchitis, and enlargement of liver and spleen in Medicine. The Soxhlet extraction of the oleo gum resin of D. ammoniacum was carried out with organic solvents including hexane, dichloromethane, chloroform, ethyl acetate, and methanol. The screening of the anti-alzheimer activity of the extr...

M. Mazaheritehrani *, R. Hosseinzadeh, M. Mohadjerani, M. Tajbakhsh and S. N. Ebrahimi

Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.

DOI: 10.13040/IJPSR.0975-8232.11(2).637-44

637-644

3568

1671

40.

BIOCHEMICAL CHARACTERIZATION OF PROTEASE FROM ZINGIBER OFFICINALE RHIZOME BY USING NEURAL NETWORKING APPROACH

Biochemical characterization of enzyme is the most fundamental aspects of enzymology from industrial point, as it is desirable to choose an enzyme which will have the fastest reaction rate per unit amount of enzyme which indicates the maximum effect for the minimum amount of added catalyst. In this study, Protease enzyme was extracted from Z. officinale and purified by using various down streaming...

N. Jabalia*, Kanagarethinam, P. C. Mishra and N. Chaudhary

Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(12).5276-81

5276-5281

3567

1544

25.

STUDY OF THE ANTI-TUMOR ACTIVITY OF SYNTHETIC PYRIDO [2,3-d]PYRIMIDINES, PYRIMIDINES AND CORRESPONDING CHALCONE DERIVATIVES

Chalcones (3a-m) was prepared by condensing 4-aminoacetophenone (1) with various aromatic aldehydes (2a-m) according to Claisen-Schmidt condensation. These 4-aminochalcones on cyclization with guanidine hydrochloride under basic alcoholic conditions gave 2,4,6-trisubstituted pyrimidines 4a-m with quantitative yields. Novel 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidines 6a-g were synthesized vi...

S. R. Atla *, R. Sistla and R. P. Yejella

Department of Pharmaceutical Analysis and QA, Shri Vishnu College of Pharmacy, Bhimavaram, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3804-14

3804-3814

3566

1887