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DEVELOPMENT AND EVALUATION OF A DIRECTLY COMPRESSIBLE CO-PROCESSED MULTIFUNCTION SUSTAINED RELEASE AGENT FOR ISOSORBIDE MONONITRATE SUSTAINED RELEASE TABLETS
Directly compressible co-processed sustained release multifunction agent [DCCSRA] comprising povidone and glyceryl behenate in the ratio of 1:1, 1:2 and 1:3 were prepared and evaluated for formulation of sustained release tablets of isosorbide mononitrate. The DCCSRA exhibited good flow and compressibility. The DCCSRA, prepared by hot melting method and co-precipitation method served as a retardan...
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EVALUATION OF MOI GUM IN THE FORMULATION OF CONTROLLED RELEASE MATRIX TABLETS USING LOSARTAN POTASSIUM
Matrix tablets were developed using moi gum for investigating its suitability for the controlled release using losartan potassium as a model drug. Tablets were prepared by direct compression method. Lactose and dibasic calcium phosphate (DCP) were used as channelling agents. In-vitro studies were performed in 0.1N hydrochloric acid for the first two hours and pH 6.8 phosphate buffer for the next t...
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EFFECT OF NIMODIPINE ON NOCICEPTIVE PAIN AND ITS INTERACTION WITH OPIOID ANALGESICS IN RATS
Objective: To explore the effect of nimodipine on nociception and on opioid-induced antinociception in rats by using the tail-flick method. Method: Sixty albino rats were used for the study. The tail-flick method was used to induce nociception in rats. Analgesic effect of nimodipine was evaluated by using three graded doses (200 mcg/kg, 400 mcg/kg, and 800 mcg/kg). To study the effect of nimodipin...
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SPIRULINA PLATENSIS AT TENUATES STRESS-INDUCED PHYSICAL AND BIOCHEMICAL CHANGES IN RATS
The aim of present study on Spirulina platensis (Spirulina) was to evaluate the anti-stress activity. The anti-stress activity was assessed by tail suspension method andcold immobilization induced change of biochemical parameters. Acute toxicity (LD50) of Spirulina platensis values was also studied. Duration of immobilization time and cold immobilization induced alteration of biochemical parameter...
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ACECLOFENAC ENCAPSULATED ETHANOLIC NANO-VESICLES FOR EFFECTIVE TREATMENT OF OSTEOARTHRITIS
In the present study, ethanolic nanovesicles of Aceclofenac developed for the site specific delivery to joints for effective treatment of osteoarthritis. Ethanolic nano-vesicles were prepared by solvent dispersion method. Vesicles were characterized for vesicular size, surface morphology, size and size distribution, zeta potential, entrapment efficiency. Formulations were also evaluated for drug-v...
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TARGETED DELIVERY OF CATALASE TO MACROPHAGES BY USING SURFACE MODIFICATION OF BIODEGRADABLE NANOPARTICLE
Reactive oxygen species (ROS) produced by activated macrophages play a major role in causing liver disorders. Small antioxidants and scavengers are protective only at very high concentrations and they poorly detoxify toxic ROS. Catalase (CAT) is an antioxidant enzyme that scavenges ROS and has great potential for treating liver disorders. In the present research work, gelatin nanoparticles bearing...
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THE IN-VITRO ANTI-DENATURATION EFFECTS INDUCED BY SUBSTITUTED OXY/THIOXY PYRIMIDINE DERIVATIVES IN BOVINE SERUM ALBUMIN IS PROPOSED AS A SCREENING ASSAY FOR THE DETECTION OF ANTI-INFLAMMATORY COMPOUNDS WITHOUT THE USE OF ANIMALS
A series of novel 2-{[6-(2-substituted Phenyl)-2-oxo-1, 2-dihydropyrimidin -4-yl]oxy} benzoic acid (2a-b)/ 2-{[6-(2-substituted Phenyl)-2 thioxo-1, 2-dihydropyrimidin-4-yl]oxy} benzoic acid (2c-d) were synthesized and tested for their in-vitro protein denaturation activity. Compound 2d was found to be promising and was more potent than the Acetylsalicylic acid (NSAID) in the inhibition of Bovine s...
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ACETYLCHOLINESTERASE INHIBITORY ACTIVITY OF DOREMA AMMONIACUM GUM EXTRACTS AND MOLECULAR DOCKING STUDIES
Ammoniacum gum is traditionally used as an expectorant, stimulant, antispasmodic, catarrh, asthma, chronic bronchitis, and enlargement of liver and spleen in Medicine. The Soxhlet extraction of the oleo gum resin of D. ammoniacum was carried out with organic solvents including hexane, dichloromethane, chloroform, ethyl acetate, and methanol. The screening of the anti-alzheimer activity of the extr...
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BIOCHEMICAL CHARACTERIZATION OF PROTEASE FROM ZINGIBER OFFICINALE RHIZOME BY USING NEURAL NETWORKING APPROACH
Biochemical characterization of enzyme is the most fundamental aspects of enzymology from industrial point, as it is desirable to choose an enzyme which will have the fastest reaction rate per unit amount of enzyme which indicates the maximum effect for the minimum amount of added catalyst. In this study, Protease enzyme was extracted from Z. officinale and purified by using various down streaming...
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STUDY OF THE ANTI-TUMOR ACTIVITY OF SYNTHETIC PYRIDO [2,3-d]PYRIMIDINES, PYRIMIDINES AND CORRESPONDING CHALCONE DERIVATIVES
Chalcones (3a-m) was prepared by condensing 4-aminoacetophenone (1) with various aromatic aldehydes (2a-m) according to Claisen-Schmidt condensation. These 4-aminochalcones on cyclization with guanidine hydrochloride under basic alcoholic conditions gave 2,4,6-trisubstituted pyrimidines 4a-m with quantitative yields. Novel 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidines 6a-g were synthesized vi...
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