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STUDY OF THE ANTI-TUMOR ACTIVITY OF SYNTHETIC PYRIDO [2,3-d]PYRIMIDINES, PYRIMIDINES AND CORRESPONDING CHALCONE DERIVATIVES
Chalcones (3a-m) was prepared by condensing 4-aminoacetophenone (1) with various aromatic aldehydes (2a-m) according to Claisen-Schmidt condensation. These 4-aminochalcones on cyclization with guanidine hydrochloride under basic alcoholic conditions gave 2,4,6-trisubstituted pyrimidines 4a-m with quantitative yields. Novel 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidines 6a-g were synthesized vi...
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1906
ANTIHYPERGLYCEMIC AND ANTIOXIDATIVE EFFECT OF HYDRO-METHANOLIC EXTRACT OF LEAF OF ABROMA AUGUSTA IN STREPTOZOTOCIN INDUCED DIABETIC MALE ALBINO RAT
The present study was conducted to investigate protective effect of hydro-methanolic (2:3) extract of leaf of Abroma augusta in streptozotocin induced diabetic male albino rat. For this purpose animals were divided into three treatment groups (n = 6): control group, STZ induced diabetic group (STZ 4 mg / 0.1 ml citrate buffer/ 100 g body weight), hydro-methanolic extract of leaf of Abroma augusta ...
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1612
EFFECTS OF PORPHYRA VIETNAMENSIS EXTRACT ON TNBS-INDUCED COLITIS IN RATS
Objective: This study aimed to investigate the intestinal anti-inflammatory activity of a methanolic extract of Porphyra vietnamensis in the TNBS model of intestinal inflammation in rats. Methods: The study included (i) Identification and quantification of Porphyra-334 in P. vietnamensis, (ii) investigation of the effect of methanolic extract on DNA cleavage induced by H2O2 UV-photolysis, (iii) 50...
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1491
ROLE OF LIQUID MEMBRANE HYPOTHESIS IN THE MECHANISM OF ACTION OF ERTAPENEM
The role of liquid membrane hypothesis has been studied in the mechanism of action of Ertapenem. In the present study transport of selected permeants (glucose, p-amino benzoic acid and ions like magnesium, ammonium, phosphate, calcium, sodium, potassium and chloride) through liquid membrane generated by Ertapenem in series with supporting membrane has been studied. The results indicate that the li...
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1586
THE EFFECT ON CELL VIABILITY AND REDUCTION OF CORTISOL ACTIVITY BY AQUEOUS EXTRACTS OF GREEN COFFEE BEAN
A recent surge of lifestyle disorders such as obesity, Type II Diabetes Mellitus and cardiovascular diseases, has led to a search of dietary changes that could be adopted into the daily lifestyle to prevent these lifestyle disorders. A nutraceutical is an upcoming option that has garnered a lot of attention and has warranted a lot of research. Green coffee beans are unroasted coffee beans which ha...
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1408
ASSESSMENT OF QUALITY OF LIFE IN DIALYSIS AND NON-DIALYSIS CHRONIC KIDNEY DISEASE PATIENTS
Quality of life is an essential measure that proves the effectiveness of health care, health level, and well-being. Kidney diseases are one of the major health problems that affect Quality of life. This study aimed to assess the quality of life in dialysis (CRF-D) and non-dialysis (CRF-ND) chronic renal failure (CRF) patients using Kidney Disease Quality of Life-short form (KDQOL-SFTM) and identif...
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1511
IN-VITRO ANTIBACTERIAL EFFECT OF MUPIROCIN IN COMBINATION WITH THREE ESSENTIAL OILS AGAINST STAPHYLOCOCCUS AUREUS
Mupirocin is a topical antibiotic which is very effective against staphylococci, streptococci and Methicillin-Resistant Staphylococcus aureus (MRSA) infection. Because of its high effectiveness against MRSA infection, it is frequently used in clinical practice for decolonization of MRSA. Due to the increased use of mupirocin, increased resistance rates have been reported. Essential oil is a natura...
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1393
DRUG UTILIZATION STUDY OF ANTIHYPERTENSIVE TREATMENT BEING PRESCRIBED IN PATIENTS COMING TO MEDICINE OPD OF A TERTIARY CARE HOSPITAL IN NORTHERN INDIA
Introduction: Hypertension, is a global public health issue. It is a significant contributor to rising morbidity and mortality because of its associations with cardiovascular, renal and cerebrovascular complications. Given the prevalence and impact of the disease on health care a drug utilization study becomes essential to determine the current drug utilization pattern. Materials and Methods: 127 ...
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FORMULATION AND EVALUATION OF FLOATING MICROSPHERES OF BACLOFEN
The present study was aimed to formulate and evaluate floating microspheres of Baclofen. The research work's objective was to retain Baclofen in the stomach for a prolonged period of time, which has absorption window in the upper gastrointestinal tract. The microspheres were prepared by solvent evaporation technique. A 32 full factorial was applied to investigate the combined effect of the two ind...
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1916
EVOLVING KNOWLEDGE IN FRAMING OF TERATOGENIC ACTIVITY TOWARDS RISK PERCEPTION
Birth defects induced by maternal exposure to exogenous agents during pregnancy are preventable if the agents themselves can be identified and avoided. This might be the causative effect in mechanical fetal diseases and retarded in the development of embryo and fetus. Often, the safety of a drug in the mother’s fetuses and nursing infants cannot be determined until it has been widely used. This ...
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