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THE IN-VIVO EFFECTS OF PARTIALLY PURIFIED SUB-FRACTION (TAF2) OF THE CRUDE METHANOLIC EXTRACT OF EURYCOMA LONGIFOLIA ROOTS ON THE HAEMATOLOGICAL, BIOCHEMICAL AND HISTOLOGY PARAMETERS
Eurycoma longifolia (E. longifolia) Jack has been widely used in traditional medicine for its antimalarial, aphrodisiac, anti-diabetic, antimicrobial, anti-pyretic and anticancer activities. As yet, no study has been done on biosafety of partially purified sub-fraction (TAF2) of the crude methanolic extract of E. longifolia roots. This study aims to evaluate, in vivo, the effects of TAF2 on the ha...
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SYNTHESIS AND SPECTROSCOPIC CHARACTERISATION OF Cr(III) COMPLEXES DERIVED FROM 2-BENZOYLPYRIDINE AND 2-BENZOYLTHIOPHENE WITH THIOSEMICARBAZONE AND SEMICARBAZONE
The complexes of chromium(III) are synthesised with thiosemicarbazone (L1&L3) and semicarbazone (L2) derived from 2-benzoylpyridine and 2-benzoylthiophene having general composition [CrL2X2]X (Where L=L1&L3(L1&L3= thiosemicarbazone ligand and L2= semicarbazone ligand) and X= NO3- and OAc-) have been synthesised. The complexes and ligand under study are characterised by elemental analys...
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SYNTHESIS, SPECTRAL CHARACTERIZATION AND DNA BINDING PROPERTIES OF LANTHANIDE (III) COMPLEXES WITH 2-FORMYLPYRIDINE NICOTINOYLHYDRAZONE
The lanthanide (III) complexes of general formula of [Ln(FPNH)2(NO3)](NO3)2.nH2O (where, Ln = La, Ce, Pr, Nd, Sm; FPNH = 2-formylpyridine nicotinoylhydrazone, n = 0, 2 and 5 for La/Ce/Pr, Sm and Nd complexes, respectively) were synthesized under mild reaction conditions with excellent yields. The complexes were characterized based on elemental analysis, molar conductivity, and infrared spectroscop...
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DYSLIPIDEMIC AND PROTECTIVE EFFECTS OF ASPIRIN AND CLOPIDOGREL IN OBESE RATS
Introduction: Antiplatelets play a crucial role in improving many metabolic disorders and complications, including dyslipidemia, atherosclerosis, diabetes mellitus and cardiovascular diseases. The most common and effective antiplatelets used widely are aspirin and clopidogrel. The aim of this study is to evaluate the dyslipidemic and protective effects of aspirin and clopidogrel in obese rats. Mat...
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ANTIMICROBIAL ACTIVITY OF SOME ETHNOMEDICINAL PLANTS USED IN KASHMIR, INDIA
Antimicrobial activity of 11 ethnomedicinal plant extracts was evaluated against five bacterial strains (Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Proteus vulgaris) and one fungal strain (Candida albicans). Plants were collected from different regions of Kashmir Valley and the ethnomedicinal data were gathered from traditional healers and elders of the stu...
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GC-MS ANALYSIS AND IDENTIFICATION OF PHYTOCONSTITUENTS FROM HEXANE EXTRACTS OF ADHATODA VASICA NEES AND ADHATODA BEDDOMEI CB CLARKE LEAVES
The medicinal plants, Adhatoda vasica, and Adhatoda beddomei are commonly used in the treatment of several illnesses and respiratory disorders viz., cold, severe cough, chronic bronchitis, asthma and tuberculosis. The present study aimed to identify the phytochemical constituents and quantification of bioactive contents of hexane extracts of these plants, followed by metabolic fingerprinting, whic...
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MATHEMATICALLY DESIGNED BIOPROCESS FOR RELEASE OF VALUE ADDED PRODUCTS WITH PHARMACEUTICAL APPLICATIONS FROM WASTES GENERATED FROM SPICES INDUSTRIES
A mathematical model optimizing bio-physico-chemical pre-treatment of steam exploded Piper nigrum, and Syzygium aromaticum lignocellulosic biomass waste was developed. The model was developed using, RSM, involving central composite face-centered design (CCD) with six parameters, three levels and 40 runs, at 95% confidence level. Six parameters optimized were quantity of each enzyme (a) Cellulase (...
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MANAGEMENT OF GREEN PHARMACEUTICALS
Green Pharmacy represents a holistic approach to healthcare that emphasizes the importance of controlling the environmental contamination caused by pharmaceuticals. Also, Green Pharmacy prevents environmental contamination due to the API (active pharmaceutical ingredient) present in the medicines. Contamination of the environment by Active pharmaceutical ingredients can occur through various pathw...
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SPECTROPHOTOMETRIC DETERMINATION OF Co(II) AS A COMPLEX WITH 1, 2 – PROPANEDIONE, 1- PHENYL – 1 – ( 2 – HYDROXYL – 5 – BROMO – BENZILIDINEAZINE)-2-OXIME [PDPHBBAO]
The reagent was synthesized and characterization was carried out by FTIR, NMR, elemental analysis as well as Mass spectrometry. This reagent was then applied for the development of the analytical method for the extractive spectrophotometric determination of Cobalt (II). Cobalt metal forms yellow coloured complex, which can be extracted in chloroform at pH 9.0 having absorption maxima at 430 nm. Be...
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ROLE OF EMBLICA OFFICINALIS IN MITIGATING THE SULPHUR DIOXIDE INDUCED TOXICITY IN RATTUS NORVEGICUS (BERKENHOUT)
SO2 is considered as one of the most poisonous and irritant gas because it alters the physiology, biochemistry and behaviour of the living individuals. In the present investigation the effect of oral administration of Emblica officinalis on serum electrolyte in SO2 exposed albino rats. The thirty albino rats were grouped in three sets - control set (1) were kept in control conditions, while, rats ...
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