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MECHANISM OF DRUG INDUCED RENAL FAILURE: A REVIEW
Acute renal failure (ARF) is characterized by a rapid, potentially reversible decline in renal function, including a rapid fall in glomerular filtration rate (GFR) and retention of nitrogenous waste products over a period of hours or days. The mortality rate of patients with ARF has remained 25–70% despite the use of various pharmacologic agents. Due to the multiple causes of renal failure, many...
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SYNTHESIS OF NEFOPAM ANALOGUES AND CHARACTERISATION
Modified Benzoxazocine moiety of Nefopam with N-Protected-ethanolamine, fluorobenzene benzylbromide, 2,3-dimethyl-benzene, naphthalene, fluro-naphthalene. In these modification Friedel Craft alkylation plays vital role with using grignard reagent and aluminum chloride with the starting phthalic anhydride to form acid compound and was converted to amide compound with using of thionyl chloride, N-Pr...
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GC–MS ANALYSIS OF ANTIOXIDANT COMPOUNDS PRESENT IN DIFFERENT EXTRACTS OF AN ENDEMIC PLANT DILLENIA SCABRELLA (DILLENIACEAE) LEAVES AND BARKS
The study aimed to investigate and characterize the antioxidant compounds from the leaves and barks of Dillenia scabrella (Dilleniaceae) (D. scabrella), an indigenous plant in the Northeast. The air-dried leaves and barks were powdered and subjected to selective sequential extraction using solvents of increasing polarity through percolation, namely, methanol, ethyl acetate + ethanol and water to o...
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IDENTIFICATION AND QUANTIFICATION OF OLEANOLIC ACID FROM CYCLEA PELTATA BY HIGH-PERFORMANCE THIN LAYER CHROMATOGRAPHY (HPTLC) METHOD
Objective: To identify and quantify oleanolic acid from the roots of cyclea peltata by HPTLC method. Methods: The Plant cyclea peltata is a perennial herb from Menispermacae family. The powdered roots of plant cyclea peltata were extracted with methanol. Methanolic extract prepared separated with n-butanol, chloroform, and ethyl acetate as total saponin, total alkaloid and phenolic compound fracti...
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PHYTOCHEMICAL INVESTIGATION AND SCREENING FOR INFLAMMATORY BOWEL DISEASE ACTIVITY OF ETHANOLIC EXTRACT OF TECTONA GRANDIS LINN. BARK
Inflammatory bowel disease (IBD) is a multifactorial process that causes ulcerative colitis and Crohn’s disease due to unknown mechanisms associated with release of proinflammatory mediators. Aim of the present study is to evaluate inhibitory activity by bark extract Tectona grandis Linn. (TGE) against experimental induced IBD. Two different models were used to induce IBD viz., Indomethacin-indu...
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IN-VITRO ANTIOXIDANT POTENTIAL OF SELECTED NUTRACEUTICALS
The current study involves evaluation of antioxidant potential of selected nutraceuticals like barley grass juice (Hordeum vulgare L.), ethanolic extracts of cashew apple (Anacardium occidentale L.) and sea lettuce (Ulva reticulata F.) in in-vitro experimental model using goat liver slices at different concentrations (100, 200, 400, 800 and 1600 mg/kg, p.o). The oxidative stress was induced using ...
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NEWER VACCINE INTRODUCTION (PNEUMOCOCCAL CONJUGATE VACCINE) FROM THE STATE’S OWN RESOURCES IN HARYANA, INDIA: AN EXAMPLE OF ADVOCACY TO POLICY AND ACCELERATED PUBLIC HEALTH ACTION
Introduction: Global pneumonia mortality (50%) caused by pneumococcus is responsible for invasive pneumococcal disease. Pneumococcal Conjugate Vaccine (PCV) has been introduced by the Government of India in a phased manner in selected states, but Haryana was not included. Objective: To draw key lessons learned from the process of newer vaccine introduction (PCV) in Haryana from the state’s resou...
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IMPACT OF PETROCHEMICAL EFFLUENT ON HEMATOLOGICAL PARAMETERS IN THE FRESHWATER FISH, LABEO ROHITA
The present investigation was carried out the effect of petrochemical effluent on hematological parameters in freshwater fish, Labeo rohita using the standard method. The petrochemical effluent has the potential to cause developmental effects in fish. Blood offers important profile to study the toxicological impact on animal tissues. Hematology is used as an index of fish health status under diffe...
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MEDICINAL SIGNIFICANCE OF BENZIMIDAZOLE ANALOGUES: A REVIEW
Benzimidazoles are well known biologically active N-containing heterocycles, widely used as drugs such as antifungal, antibacterial, antiparasitic, and antihelmintic. In addition, N1 and C2-substituted benzimidazoles and their derivatives have been found to be potent biologically active compounds as well. Further, N1-substituted benzimidazoles have exhibited anti-microbial, antihelmintic activitie...
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FORMULATION, EVALUATION AND RADIOGRAPHIC STUDY OF STOMACH SPECIFIC FLOATING TABLETS CONTAINING VENLAFAXINE HYDROCHLORIDE FOR TREATMENT OF DEPRESSION
Depression is a chronic, recurring, and potentially life-threatening illness. The present work is to formulate floating tablets of Venlafaxine hydrochloride as this drug is used to treat depression. GIT absorption of Venlafaxine hydrochloride is poor due to low aqueous solubility. Thus, an attempt was made to enhance it gastric residence time that will improve its dissolution profile. The floating...
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