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SYNTHESIS OF MANNICH BASES OF NORFLOXACIN: CONVENTIONAL AND MICROWAVE ASSISTED SYNTHESIS
Quinolones are the organic compounds that act against the DNA-gyrase enzyme, a type II topoisomerase. Norfloxacin is one such quinolone which is characterized by a piperazinemoiety at C-7 position. This moiety plays a significant role in determining the antibacterial spectrum and potency and serves as a site amenable to significant modification. N-Mannich bases have proved to be potential prodrug ...
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ANTIDIABETIC EFFECT OF METHANOLIC EXTRACT OF WHOLE PLANT OF LINDERNIA CILIATA (COLSM.) PENNELL. ON STREPTOZOTOCIN INDUCED DIABETIC RATS
During the past few years many phytochemicals responsible for anti-diabetic effects have been isolated from the plants. Several phyto-constituents such as alkaloids, glycosides, flavonoids, saponins, dietary fibers, polysaccharides, glycolipids, peptidoglycans, amino acids and others obtained from various plant sources that have been reported as potent hypoglycemic agents. In the present study, th...
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DOCKING, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL QUINOLINE CONTAINING SCHIFF BASES FOR ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITIES
Quinolines bears a very good synthon so that a variety of novel heterocyclic with good pharmaceutical profile can be designed. There are various biological activities for quinolones such as antibacterial, antimalarial and various drugs possessing quinolone as nucleus are ciprofloxacin (Cipro), lomefloxacin (Maxaquin), norfloxacin (Noroxin), ofloxacin (Floxin), moxifloxacin (Avelox) and levofloxaci...
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FORMULATION AND EVALUATION OF CONTROLLED POROSITY OSMOTIC TABLET OF VERAPAMIL HYDROCHLORIDE
Verapamil hydrochloride is a water-soluble drug, so it is suitable to develop controlled porosity osmotic pump. As Verapamil HCl is a short-acting drug, so developed formulation provides the advantages of controlled release formulations. The developed formulation provides advantages of less steps of manufacturing procedure, no need for laser drilling, and economical, all of which made the proced...
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PHYTOCHEMICAL SCREENING AND EVALUATION OF ANALGESIC AND THROMBOLYTIC ACTIVITY OF THE CRUDE METHANOLIC EXTRACT OF CALAMUS ROTANG L. LEAVES (ARECACEAE)
Medicinal plants abound with many phytochemicals that are effective in representing lots of pharmacological activities. The current study aimed at investigating the phytochemical and pharmaco-logical activity of crude methanol extract of Calamus rotang L. (CRME) leaves. The analgesic activity and thrombolytic activity were examined by the acetic acid-induced writhing method, while the clot lysis e...
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FORMULATION OF EMULSIONS FROM PLANT ESSENTIAL OILS AGAINST MICROBIAL BIOFILMS
A biofilms are sessile aggregate mode of growth in some bacteria, fungi, protozoa, and algae which makes the microorganism tolerant to adverse environmental conditions biofilm-forming microorganism may possibly create conditions including native valve endocarditis, osteomyelitis, dental caries, middle ear infections, medical device-related infections, ocular implant infections and chronic lung inf...
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CHARACTERIZATION AND EVALUATION OF NIZATIDINE FLOATING MICROSPHERES BASED DRUG DELIVERY SYSTEM FOR ANTI-ULCER ACTIVITY
Objective: The purpose of the present study to develop gastro-retentive drug delivery formulation for enhancing GRT, including the physiological and formulation variables affecting gastric retention. It is a widely employed approach to retain the dosage form in the stomach for an extended period and release the drug slowly that can address many challenges like poor bioavailability. Methods: Floati...
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STEADY SHEAR AND DYNAMIC SHEAR RHEOLOGICAL PROPERTIES OF CARBOXY-METHYL LOCUST BEAN GUM INFLUENCING EROSION OF THE POLYSACCHARIDE COAT OF COMPRESSION COATED TABLETS
Rheological properties of carboxymethyl locust bean gum (CMLBG) solutions having different concentrations and solution pH were evaluated through steady shear and oscillatory measurements and were used to describe the erosion propensity of CMLBG coat of compression coated placebo tablets. CMLBG solutions, irrespective of concentration and solution pH, exhibited predominant viscous character as the ...
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ESTIMATION OF PERINDOPRIL ARGININE, INDAPAMIDE AND AMLODIPINE IN BULK AND FIXED DOSE COMBINATION USING STABILITY INDICATING REVERSE PHASE HIGH-PRESSURE LIQUID CHROMATOGRAPHY
A simple, accurate, and precise stability-indicating reverse phase high pressure liquid chromatographic method was developed and validated for the estimation of Perindopril arginine, Indapamide, and Amlodipine in the bulk and pharmaceutical dosage form. Chromatographic separation was carried out on ZORBAX RX C8 (250 mm × 4.6 mm, 5 µm) as a stationary phase with a mobile phase of gradient system ...
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SYNTHESIS, CHARACTERIZATION, CYTOTOXIC AND ANTIOXIDANT STUDIES OF MIXED LIGAND SCHIFF BASE COMPLEXES DERIVED FROM P- NITROANILINE AND 2, 4-DINITROANILINE
Four isatin mixed ligand complexes of the type ML1L2, where M =Co(II), Ni(II), Cu(II) and Zn(II) (LI = Schiff base formed by the condensation of isatin and p-nitroaniline and L2= Schiff base formed by the condensation of isatin and 2,4-dinitroaniline) are synthesized. Mixed ligand complexes are different from routine metal complexes that they have a minimum of two special kinds of ligands linked...
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