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IN-SILICO DESIGN, SYNTHESIS AND IN-VITRO ANTI-TUBERCULAR AND ANTI-MICROBIAL SCREENING OF NOVEL BENZIMIDAZOLE DERIVATIVES
The present work aims to design, synthesize some novel benzimidazole derivatives and to perform in-vitro evaluation of their antitubercular and antimicrobial activity. In-silico modelling of benzimidazole derivatives was carried out using various softwares such as, ACD Labs Chemsketch, Molinspiration, PASS (Prediction of activity spectra for substances) and Schrodinger Glide XP (Grid based ligan...
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ANTIEPILEPTIC DRUGS: PRESCRIPTION PATTERN, HEMATOBIOCHEMICAL CHANGES AND ADVERSE EFFECTS: A RETROSPECTIVE STUDY IN EASTERN PROVINCE OF SAUDI-ARABIA
Objectives: To retrospectively determine the prescription pattern of antiepileptic drugs (AEDs), hematobiochemical changes, and associated adverse effects. Methodology: A retrospective observational study was conducted at the Department of Neurology, King Fahad Hospital of the University, Khobar, KSA. Data Collection was through Electronic Health Record. A designed validated form to record demogra...
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ISOLATION AND IDENTIFICATION OF STREPTOCOCCUS MUTANS FROM PATIENTS WITH DENTAL CARIES: EVALUATING THE ANTI-BACTERIAL EFFICACY OF THE AZADIRACHTA INDICA EXTRACTS FOR THE TREATMENT OF PERIODONTITIS
Periodontitis is a common infection occurring among a wide range of population globally. Streptococcus mutans is found to be the predominant pathogen responsible for dental caries. The present study concentrates on isolation and identification of the predominant pathogen from patients suffering from dental caries. The isolates were grown on various selective and differential media. Biochemical tes...
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GREEN NANOTECHNOLOGY AND NANOPARTICLES: AN ECO-FRIENDLY APPROACH
The field of nanotechnology is one of the notable active analysis areas in modern material science. Recent advances in Nanoscience and nanotechnology have led to the development of nanoparticles, which ultimately decrease potential health and environment hazards. Interest in developing environmentally friendly procedures for the synthesis of metallic nanoparticles has been increased. The purpose...
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A SHORT PERIOD STUDY ON VELLORE ENRICHED SOILS – A SOURCE FOR POTENTIAL MICROBIAL ENZYMES WHICH DEGRADES THE WASTE GENERATED FROM VARIOUS INDUSTRIES AND BYPRODUCTS CAN BE USED IN PHARMACEUTICALS
Waste is anything, which is not used by any owner, producer and processor, even though it has always been a part of the earth’s ecosystem. Enriched Soil is a good source for the isolation of power full and potential microorganisms which produces specific enzymes which target the waste and in turn produces pharmacologically viable products; Microbes hold this prominent position because of their d...
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RP-HPLC METHOD QUANTITATIVE ESTIMATION OF TAPENTADOL HYDROCHLORIDE AND ITS TABLETS
The objective was to develop and validate an easy, economical, fast, reliable, reproducible, precise and accurate reversed-phase high-performance liquid chromatography (RP-HPLC) method for the estimation of tapentadol hydrochloride (TAP, a mu opioid-receptor agonist, and noradrenaline reuptake inhibitor) in the bulk and pharmaceutical dosage form. The chromatographic separation was achieved by u...
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NOVEL THERAPEUTIC OPTIONS FOR FAMILIAL HYPERCHOLESTEROLEMIA
Background: Familial Hypercholesterolemia (FH) is an autosomal dominant disorder caused by mutation in the LDL receptor gene and characterized by raised LDL-C, tendon xanthomata and premature atherosclerosis. Existing therapies for FH such as statins and LDL apheresis do not offer adequate lipid control in most patients, which has led to the search for more definite alternatives. Two new drugs hav...
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EFFECT OF SOLANUM CHRYSOTRICHUM SCHLDL. ON CELL PROLIFERATION IN VITRO
The effect of four extracts of Solanum chrysotrichum on the proliferation of bacteria, yeasts, mouse spleen cells and human transformed cells was determined. Dry leaves grounded were consecutively macerated 24 h with hexane, chloroform, methanol and water. Dilutions of 1, 10 and 100 µg/mL / DMSO were used for the assays with normal mouse spleen cells, DU-145 and MCF-7 cells. The cellular prolifer...
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MOLECULAR DOCKING STUDIES OF INDENOISOQUINOLINE DERIVATIVES WITH DNA-TOPOISOMERASE I COMPLEX
The aim of the present study is to find the effectiveness of two series of indenoisoquinolines compounds against cancer. Topoisomerase I (Top 1) an essential enzyme that participates in the processes associated with separation of DNA strands and manages the super helical tensions through the transient breakage of one strand of duplex DNA, monitored by the unwinding of supercoiled DNA. The Top 1-DN...
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SYNTHESIS, CHARACTERIZATION, CYTOTOXIC AND ANTIOXIDANT STUDIES OF MIXED LIGAND SCHIFF BASE COMPLEXES DERIVED FROM P- NITROANILINE AND 2, 4-DINITROANILINE
Four isatin mixed ligand complexes of the type ML1L2, where M =Co(II), Ni(II), Cu(II) and Zn(II) (LI = Schiff base formed by the condensation of isatin and p-nitroaniline and L2= Schiff base formed by the condensation of isatin and 2,4-dinitroaniline) are synthesized. Mixed ligand complexes are different from routine metal complexes that they have a minimum of two special kinds of ligands linked...
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