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A COMPREHENSIVE REVIEW ON VIRAL ZOONOSIS: EMPHASIZING ON PATHOGENESIS, DIAGNOSIS, TREATMENT, PREVENTION STRATEGIES AND FUTURE PERSPECTIVES
Zoonoses are human diseases caused by animal pathogens or animal diseases that are transmissible to humans. They are caused by all types of pathogenic agents, including bacteria, parasites, fungi, viruses, and prions. Zoonotic diseases can be transmitted to humans by infected saliva, aerosols, contaminated urine or feces, and direct contact with the animal or pathogenic microbes. Furthermore, tran...
2041
1504
MOLECULAR DOCKING AND IN-SILICO ADME STUDIES OF NOVEL DERIVATIVE OF ERLOTINIB IN GLIOMA
Glioblastoma (GBM), with restricted therapy alternatives, is a catastrophic primary brain tumor. The receptor of the epidermal growth factor receptor (EGFR) in glioblastomas is recurrently enhanced, over articulated, or mutated, but up to 20 percent of GBM patients find it to be responded to kinase inhibition of EGFR. Several inhibitors of EGFR tyrosine kinase (TKI) failed clinically, due in part ...
2037
818
INFLAMMATION: A POTENTIAL SCENARIO ON NOVEL TARGETS AND TARGETED DRUG THERAPY
Inflammation is the vascular event shown by the body against the external material by activating different cells and releasing various chemical mediators to prevent noxious effects. Many drugs like steroidal and non-steroidal drugs are available till the date to treat inflammation but have a number of side effects and centralized on to counteract the COX and LOX pathways. This perspective will use...
2036
803
STUDYING THE EFFECT OF DISPERSED DRUG CRYSTAL IN THE ORGANIC PHASE ON THE ENCAPSULATION BY SOLVENT EVAPORATION TECHNIQUE; (1) EFFECT OF DRUG LOADING EXTENT ON THE PRODUCT SIZE ANALYSIS, MORPHOLOGY AND DRUG CONTENT
Eudragit RS100 microcapsules containing Aspirin as a model drug was prepared using solvent evaporation technique. The drug was dispersed in the organic phase and poured into the aqueous phase with stirring until microcapsules formation. The product was collected by filtration and air dried. The particle size analysis of the products was done and normal distribution curve showed for the same size r...
2033
922
FORMULATION AND EVALUATION OF NANOSUSPENSION OF ROSUVASTATIN FOR SOLUBILITY ENHANCEMENT BY QUALITY BY DESIGN APPROACH
Rosuvastatin is an antihyperlipidemic agent belonging to BCS class II Drugs with low aqueous solubility and high permeability. Objective: To formulate Rosuvastatin nanosuspension by Emulsification solvent diffusion technique by QbD approach and its evaluation. A 2² factorial design was employed to study the effect of independent variables [SLS (X1) and amount of PVP K -30(X2)] and dependent varia...
2032
926
THE RELATIONSHIP BETWEEN NUTRITIONAL STATUS AND NUTRIENT INTAKE WITH ANEMIA INCIDENCE IN ADOLESCENT GIRLS IN KUPANG INDONESIA
The study aimed to determine the relationship between nutritional status and nutrient intake and the incidence of anemia in adolescent girls in Kupang. It was an observational research with a cross-sectional design. The study was conducted at Kupang State Agricultural Polytechnic (KSAP) from December 2017 to January 2018. The research subjects were adolescent girls aged 16-19 years; withdrawal met...
2030
848
PRELIMINARY PHYTOCHEMICAL INVESTIGATIONS AND ANTIEPILEPTIC ACTIVITY OF TREMA ORIENTALIS (LINN.) EXTRACTS
Objective: The antiepileptic potential of the petroleum ether (PETO) and methanolic extracts (METO) of the whole plant (roots, leaves, stem, and bark) of Trema orientalis (family: Ulmaceae) was evaluated using different experimental models of epilepsy in rats and mice. Materials and Methods: The anti-epileptic activity of the PETO and METO was evaluated using Picrotoxin, Isoniazid, and NMDA induce...
2028
920
COMPARATIVE STUDY OF PHARMACOGNOSTIC PARAMETERS, ANTIOXIDANT AND ANTICHOLINESTERASE POTENTIAL OF BRASSICA NAPUS AND BRASSICA OLERACEA VAR. ACEPHALA
Introduction: Green leafy vegetables are known for their anti-alzheimer potential. There are many leafy vegetables, however, that have not been examined scientifically for this activity. The present study was designed to evaluate antioxidant and antiacetylcholinesterase activities of two Brassica species namely B. napus and B. oleracea var. acephala, along with the comparison of their pharmacognos...
2027
958
DESIGN AND DEVELOPMENT OF DANTROLENE SPHERICAL AGGLOMERATES FOR IMPROVEMENT IN BIOAVAILABILITY
The purpose of this research was to obtain directly compressible agglomerates of Dantrolene using spherical agglomerates. Spherical agglomeration technique enables simultaneous crystallization and agglomeration. Sodium hydroxide acted as a good solvent, aqueous solution of PEG 6000 in hydrochloric acid served as bad solvent and isopropyl acetate was used as bridging liquid. The optimization of for...
2026
993
COSTUS IGNUS: INSULIN PLANT AND IT’S PREPARATIONS AS REMEDIAL APPROACH FOR DIABETES MELLITUS
Costus igneus, commonly known as insulin plant, has been traditionally reported for its anti-diabetic, anti-oxidant, anti-inflammatory, anti-proliferative, anti-urolithiasis, hypolipidemic, neuroprotective and anti-microbial activity. This review is all about anatomical and morphological investigations of Costus igneus, including its medicinal use. Secondary metabolites of this plant such as b-sit...
2026
1043