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ANALYSIS OF CUTANEOUS ADVERSE DRUG REACTIONS PRESENTING TO THE DERMATOLOGY DEPARTMENT OF A TERTIARY CARE TEACHING HOSPITAL: A PROSPECTIVE, OBSERVATIONAL STUDY
Background: Cutaneous adverse drug reactions (CADRs), having a wide range in terms of its spectrum, are an important cause of morbidity and mortality. They comprise 2-3% of all ADRs. This study was conducted to analyze various parameters of CADRs at our setup. Methodology: This prospective, observational study was carried out for 1 year at our setup after ethical approval. Those diagnosed as CADRs...
2050
788
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING ASSAY METHOD FOR DETERMINATION OF LOXAPINE SUCCINATE IN CAPSULE DOSAGE FORM
To develop and validate simple, selective, specific, sensitive and accurate stability indicating assay method by RP-HPLC for determination of Loxapine succinate in the capsule dosage form. Several trials are taken by changing mobile phase composition, and ratio and finally the drug was eluted on a C18 Purospher star (250 mm × 4.6 mm, 5 µm) column using mobile phase consisting of water: Methanol:...
2045
769
STUDY OF THERAPEUTIC OUTCOME AND MONITORING OF ADVERSE DRUG REACTIONS (ADRS) IN PATIENTS COMING TO OUTDOOR PATIENT DEPARTMENT (OPD) OF DERMATOLOGY, VENEREOLOGY AND LEPROSY IN TERTIARY CARE HOSPITAL OF NORTHERN INDIA
Introduction: Cutaneous adverse drug reactions (CADRs) associated with significant morbidity and mortality are probably the most frequent of all manifestations of drug sensitivity. Material and Methods: It was a prospective observational study where newly diagnosed patients with ADRs reporting to OPD of Dermatology, K.G.M.U, Lucknow and satisfying inclusion criteria were enrolled. The various stud...
2045
904
HPLC STANDARDIZATION OF ETHYL ACETATE EXTRACT OF FAGOPYRUM ESCULENTUM MOENCH. SEEDS AND IN-VITRO ENZYME INHIBITORY ACTIVITIES
Fagopyrum esculentum Moench. is a versatile herb as beyond its nutritional properties it also have various health benefits like anti-diabetic, anti-inflammation, anticancer, antibacterial, anti hypertensive etc. Most of these activities can be attributed to the presence of certain bioactive components categorised as polyphenols, present in its various parts. Present work describes a method for sim...
2044
877
QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP STUDIES OF SULFADIAZINE- SALICYLALDEHYDE SCHIFF BASE AS AN ANTI-MYCOBACTERIAL AGENTS
Quantitative structure activity relationship is among the most widely used computational technology for analogue-based drug design. A molecular modelling approach using sulfadiazine- salicylaldehyde Schiff base analogue as anti-mycobacterial activity from recently reported literature were taken and was designed using MOE 2009.10. Sulfanilamide sulfa drugs have been shown to inhibit dihydropteroate...
2044
899
BIOSYNTHESIS OF SILVER NANOPARTICLES USING EXTRACTS OF TWO SPECIES OF PORTULACA AND THEIR ANTIBACTERIAL ACTIVITY
Portulaca oleraceae commonly known as Purslane and Portulaca quadrifida commonly known as chicken weed are consumed in salads, pickles, and soup in Asia, Africa, and Mediterranean region. In the traditional systems of medicine in Asia and Africa, they have been attributed to several pharmacological properties. Phytochemical investigations point to the presence of various beneficial constituents in...
2041
826
ANTIOXIDANT POTENTIAL FRACTIONATION FROM METHANOL EXTRACT OF AERIAL PARTS OF RUELLIA PROSTRATA POIR (ACANTHACEAE)
Aerial parts of Ruellia prostrata were subjected to extraction and further fractionation to obtain antioxidant rich fraction. Different concentrations of methanolic extract and its n-butanolic fraction were subjected to antioxidant assay by DPPH method, Nitric oxide scavenging activity and reducing power assay. The fractions showed dose dependent free radical scavenging property in all the models....
2039
546
IN-VIVO APPRAISAL OF PHARMACOLOGICAL ACTIVITY OF BACOPA MONNIERI AND ITS HPLC ANALYSIS FOR BACOSIDE A
Bacopa monnieri is a herb, known to possesses various pharmacological and medicinal properties. Aim: The objective of the study was to analyse the activity of Bacopa monnieri as an antipyretic, analgesic and anti-ulcerogenic agent. Methods: Indomethacin was used as the standard of comparison for this study. Animals were arbitrarily separated into three groups of six animals in each group. The firs...
2039
719
PURIFICATION AND CHARACTERIZATION OF ANTI-HYPERGLYCEMIC BIOACTIVE MOLECULE FROM COSTUS PICTUS D. DON
Costus pictus D. Don., commonly known as the ‘Insulin plant’ is being used as a natural remedy to treat diabetes mellitus. The present study is focused to identify the chemical constituent responsible for the anti-diabetic activity of Costus pictus. The methanol extract was prepared from the fresh leaves of Costus pictus and washed with water to remove excess oxalic acid content present to get...
2038
860
PHYTOCHEMICAL SCREENING AND EVALUATION OF PHARMACOLOGICAL ACTIVITIES OF BUCHANANIA LANZAN SPRENG LEAVES
The aim of this research was to perform phytochemical screening and evaluation of the pharmacological activities of Buchanania lanzan Spreng. leaves. Preliminary phytochemical screening revealed the presence of phytoconstituents like steroids, tannins, saponins, carbohydrates, alkaloids, and flavonoids. Three leaf extracts were prepared by using solvents e.g. chloroform, ethyl acetate, and ethanol...
2037
899