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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL COUMARIN ANALOGUES
The desired target Compounds (4a-e), (5a-e) and (6a-e) were prepared in two steps. Reaction of 3-acetyl-6-bromo-2H-chromen-2-one (1) with 3-(Aryl)-1-phenyl-1H-pyrazole-4-carbaldehydes (2a-e) in presence of aqueous KOH solution and the reaction mixture stirred for 2 hours and then filtered, furnished the desired 6-bromo-3-((E)-3-(3-(Aryl)-1-phenyl- 1H-pyrazole-4-yl) acryloyl)- 2H-chromen-2- ones ...
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EXTRACTIVE SPECTROPHOTOMETRY METHOD FOR ESTIMATION OF ROSIGLITAZONE IN PHARMACEUTICAL FORMULATIONS USING BROMOTHYMOL BLUE
An accurate and precise method was developed for Rosiglitazone Maleate in the visible range of electromagnetic spectrum sing Bromothymol Blue (BTB) in alkaline medium resulting in a blue chromogen showing its absorption maxima at 615 nm. Sandell’s sensitivity to the proposed method was found to be 1.5 × 10-4 µg/ml. The extracted complexes obey Beer–Lambert’s law in the concentration range ...
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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW4-(SUBSTITUTED\ARYL)-((1, 3–DIPHENYL-1H-PYRAZOLE-4-YL) METHYLENEAMINO)-1, 5-DIMETHYL-2-PHENYLPYRAZOLILDIN-3-ONE DERIVATIVES
Schiff Base derivatives are important class of compounds. They possess different types of Biological activities like antibacterial, antiviral, anti HIV, antifungal etc. Schiff base derivatives are prepared by the condensation of aldehyde and amine and these compounds are characterized by chemical and instrumental methods. Their important biological properties have been investigated....
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PHYTOCHEMICAL SCREENING AND EVALUATION OF PHARMACOLOGICAL ACTIVITIES OF BUCHANANIA LANZAN SPRENG LEAVES
The aim of this research was to perform phytochemical screening and evaluation of the pharmacological activities of Buchanania lanzan Spreng. leaves. Preliminary phytochemical screening revealed the presence of phytoconstituents like steroids, tannins, saponins, carbohydrates, alkaloids, and flavonoids. Three leaf extracts were prepared by using solvents e.g. chloroform, ethyl acetate, and ethanol...
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FORMULATION AND EVALUATION OF DICLOFENAC SODIUM MICROEMULSION SUBCUTANEOUS DRUG DELIVERY SYSTEM
The objective of this current work is to develop the formulation and evaluation of a subcutaneous drug delivery system based on diclofenac sodium microemulsion. A different formulation has been formulated using a modifying amount of gelling agent and a penetration enhancer. Pseudo ternary phase diagrams were constructed for different microemulsion formulations composed of the formulations FEG1, FE...
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EVALUATION OF SAFETY PROFILE OF ANTI HYPERTENSIVE DRUGS WITH THE EFFECT OF PATIENT COUNSELING
Objective: To establish does response relationship to the hypertensive patients and ensure safety profile of drugs through counseling of patients. Method: Patients who have suffered by secondary hypertension with blood pressure range of above 145-170/100-110 mmHg are selected and divided in two groups. First group of patients to administer for Nifedipine 5mg and furosemide 40mg administered for...
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A PRELIMINARY STUDY ON TOTAL PHENOLIC CONTENT AND ANTIOXIDANT ACTIVITIES OF CALYCOPTERIS FLORIBUNDA ROOT EXTRACTS
We evaluated the total phenolic acid content and antioxidant activity of methanolic and aqueous extracts of Calycopteris floribunda roots. Antioxidant activity of the extracts was determined using Reducing Power Assay and Total Antioxidant Capacity (TAC) assays. Preliminary phytochemical analysis of the extracts revealed the presence of various phytochemicals. The total phenolic content of the ext...
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EFFECTS OF NON-CALORIC ARTIFICIAL SWEETENERS (NAS) ON GLYCAEMIC STATUS IN MALE SWISS ALBINO MICE
Objective: The objective of the study was to estimate the effects of Non-caloric Artificial Sweeteners (NAS) on glycaemic status in male Swiss albino mice. Methods: 36 male Swiss albino mice were selected and divided into six groups of 6 animals each. Group 1 served as control and received a normal pellet diet with drinking water. Groups 2, 3, 4, 5 and 6 received normal pellet diet and drinking wa...
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COMPARISON OF 3%, 5% AND 8% CONCENTRATIONS OF SEVOFLURANE FOR INDUCTION AND INTUBATION IN ADULTS WITHOUT USING NEUROMUSCULAR BLOCKING AGENTS
Introduction: Tracheal intubation is commonly facilitated by the use of muscle relaxants. Sevoflurane fulfills the criteria for successful rapid & smooth inhalational induction when muscle relaxants are contra-indicated. Aim: To compare the success rate of intubation characteristics, hemodynamic changes, the effectiveness of the trapezius squeezing test for an adequate condition for intubation...
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QUANTITATIVE SIMULTANEOUS ESTIMATION OF ASPIRIN AND OMEPRAZOLE BY RP-HPLC METHOD IMPLEMENTING AQbD APPROACH IN PHARMACEUTICAL DOSAGE FORM
A simple, accurate, rapid and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous determination of Aspirin (ASP) and Omeprazole (OMP). By using box benchen design method have been developed and optimized. Effective chromatographic separation achieved using C18 column (250 × 4.6 mm, 5 µm) as a stationary phase and mobile phase consisted of ...
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