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FORMULATION AND EVALUATION OF DICLOFENAC SODIUM MICROEMULSION SUBCUTANEOUS DRUG DELIVERY SYSTEM
The objective of this current work is to develop the formulation and evaluation of a subcutaneous drug delivery system based on diclofenac sodium microemulsion. A different formulation has been formulated using a modifying amount of gelling agent and a penetration enhancer. Pseudo ternary phase diagrams were constructed for different microemulsion formulations composed of the formulations FEG1, FE...
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FORMULATION AND IN-VITRO EVALUATION OF MUCOADHESION AND FLOATING MICROSPHERES OF ETODOLAC USING IONIC GELATION METHOD
The purpose of this study is to formulation and evaluation of floating and mucoadhesion microspheres of etodolac using ionic gelation method. The floating and mucoadhesion microspheres were studied for micromeritic properties were found to be within limits. The percentage yield of floating microsphere formulation F1 to F6 and mucoadhesive microspheres M1 to M3 were in the range of 77.14 ± 0.64 to...
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ANTI-ULCER ACTIVITY OF PSIDIUM GUAJAVA ON PYLORUS LIGATION INDUCED GASTRIC ULCER IN ALBINO RATS
The present study deals with the phytochemical analysis and evaluation of antibacterial activity of hydroalcohol, acetone, and hexane extracts of the leaves of Psidium guajava. The antimicrobial activity was measured by the agar well diffusion method. Gastric volume, pH, total and free acidity and the ulcerative index was also measured in hydroalcoholic extract of Psidium guajava on gastric ulcer ...
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HYDROGEL BASED COLON TARGETED DELIVERY OF RABEPRAZOLE SODIUM
The aim of this research was to develop controlled and sustained release formulation of hydrogel beads containing rabeprazole sodium, and to study the effects of Eudragit S100 coating on the release of rabeprazole sodium. The main objective was to develop a colon targeted drug delivery system to minimize - drug release in the upper gastro intestinal (GI) tract as well as to minimize GI adverse eff...
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QUANTITATIVE SIMULTANEOUS ESTIMATION OF ASPIRIN AND OMEPRAZOLE BY RP-HPLC METHOD IMPLEMENTING AQbD APPROACH IN PHARMACEUTICAL DOSAGE FORM
A simple, accurate, rapid and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous determination of Aspirin (ASP) and Omeprazole (OMP). By using box benchen design method have been developed and optimized. Effective chromatographic separation achieved using C18 column (250 × 4.6 mm, 5 µm) as a stationary phase and mobile phase consisted of ...
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ORAL SUPPLEMENTATION WITH RUTIN, A FLAVONOL GLYCOSIDE, INHIBITS ETHANOL INDUCED HEPATIC LIPID ACCUMULATION IN EXPERIMENTAL RATS
Our aim was to determine the effect of rutin, a flavonol glycoside on ethanol induced hepatic lipid accumulation in experimental rats. Male albino Wistar rats were randomized into four groups. Groups 1 and 2 received isocaloric glucose. Hepatic injury was induced in groups 3 and 4 by administering 20% ethanol via intragastric intubation for 60days. In addition, groups 2 and 4 were given rutin (100...
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BACTERICIDAL SCREENING AND ESTIMATION OF FREE RADICAL SCAVENGING ACTIVITY OF FRUTICOSE LICHEN CLADONIA SCABRIUSCULA DELISE (NYL.) FROM GOPESHWAR, UTTARAKHAND, INDIA
Lichens came as a consortium of two distinct and dissimilar components- the mycobiont and the phycobionts, which were defined as a composite organism. Lichen vegetation in India is dominated by more than 2500 species. Lichen secondary metabolites specially the phenolics, depsides and depsidones are unique in their origin and are found nowhere else. Much attention has been paid on the biological ro...
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IN-SILICO ANALYSIS OF SNPs FROM cAMP-GEFII GENE ASSOCIATED WITH POLYCYSTIC OVARIAN SYNDROME
Polycystic ovary syndrome (PCOS) is one of the most common disorders that occur in women at any age due to the endocrine hormone imbalance. The cause for this disorder is still not identified, but on recent research provided that disorder may be caused by some genetic variation. Predicting and understanding the effects of genetic variation that occurred in the gene are becoming more important for ...
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1425
ANTIFUNGAL ACTIVITY OF AMPHOTERICIN-B ETHOSOMAL GEL AGAINST CANDIDA ALBICANS: A COMPARATIVE STUDY
Amphotericin B is among the gold standard antifungal agents used for the treatment of the wide range of fungal infections. Work aimed to formulate the amphotericin B (AmB) ethosomal gel (EF), evaluate its antifungal activity against fungal isolates of human origin and compare its antifungal activity with marketed liposomal gel (MLG). AmB ethosomal gel (EF) was formulated and characterized for thei...
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A NOVEL METHOD FOR ESTIMATION OF DIPEPTIDYL PEPTIDASE-4 INHIBITOR IN BULK AND PHARMACEUTICAL DOSAGE FORMS BY VISIBLE SPECTROPHOTOMETRY
A new, simple and low cost spectrophotometric method for the determination of teneligliptin, a new DPP IV inhibitor drug in bulk and pharmaceutical dosage form using sodium nitroprusside was developed. The absorbance maximum (λmax) of the resulted colored product was at 445 nm. As different solvents were tried methanol was found to be the most suitable solvent. The Beer’s law has been obeyed i...
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