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ANTIFUNGAL ACTIVITY OF AMPHOTERICIN-B ETHOSOMAL GEL AGAINST CANDIDA ALBICANS: A COMPARATIVE STUDY
Amphotericin B is among the gold standard antifungal agents used for the treatment of the wide range of fungal infections. Work aimed to formulate the amphotericin B (AmB) ethosomal gel (EF), evaluate its antifungal activity against fungal isolates of human origin and compare its antifungal activity with marketed liposomal gel (MLG). AmB ethosomal gel (EF) was formulated and characterized for thei...
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SYNTHESIS OF MANNICH BASES OF NORFLOXACIN: CONVENTIONAL AND MICROWAVE ASSISTED SYNTHESIS
Quinolones are the organic compounds that act against the DNA-gyrase enzyme, a type II topoisomerase. Norfloxacin is one such quinolone which is characterized by a piperazinemoiety at C-7 position. This moiety plays a significant role in determining the antibacterial spectrum and potency and serves as a site amenable to significant modification. N-Mannich bases have proved to be potential prodrug ...
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OUTCOMES OF COMMUNITY PHARMACIST’ CARDIOVASCULAR RISK INTERVENTION AMONG HIGH RISK RURAL DWELLERS
Community pharmacists are well placed to contribute to reduction of premature deaths from cardiovascular disease by implementing risk assessment and reduction strategies. The objective of this study was to assess outcomes of pharmacist's cardiovascular risk reduction intervention among high risk persons dwelling in a rural community. Cardiovascular risk reduction intervention was carried out among...
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EFFECT OF COMBINED EXPOSURE OF DICHLORVOS AND MONOCROTOPHOS ON NEUROTRANSMITTERS AND ACETYLCHOLINESTERASE IN RAT
Organophosphate pesticides are associated with neurotoxicity. Organophosphates are cholinesterase-inhibiting chemicals used predominately as pesticides. These have played a very important role in sustainable production of food, animal feed and as protection against disease vectors. They are also used as chemical warfare agents (nerve agents). The effects of dichlorvos and monocrotophos on brain ne...
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MACORVIS – A NEW OPPORTUNITY FOR ADDITION TO THE TREATMENT OF CARDIOVASCULAR DISEASES
Standartizated plants extracts are new opportunity in addition with standard therapy. Hawthorn extract, Tribulus terrestris extract and magnesium gluconate are forming well balanced nutritional supplement that could benefits people with cardiovascular diseases and diabetes. All three substances are well known in the common herbal medicine in our country and abroad. Their mechanisms’ of actions i...
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CARDIO-PROTECTIVE EFFECT OF ALCOHOLIC EXTRACT OF CYPERUS ROTUNDUS RHIZOME ON ISOPROTERENOL-INDUCED MYOCARDIAL NECROSIS IN RATS
The study was designed to scientifically evaluate the effect of alchoholic extract of Cyperus rotundus rhizomes, a traditional medicinal herb, on isoproterenol-induce myocardial necrosis in rats model. The albino wistar rats were divided into five different groups with six animal in each group. Group I serves as a control group, group II were given isoproterenol (85 mg/kg s.c) for 2 days while Gro...
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ORAL SUPPLEMENTATION WITH RUTIN, A FLAVONOL GLYCOSIDE, INHIBITS ETHANOL INDUCED HEPATIC LIPID ACCUMULATION IN EXPERIMENTAL RATS
Our aim was to determine the effect of rutin, a flavonol glycoside on ethanol induced hepatic lipid accumulation in experimental rats. Male albino Wistar rats were randomized into four groups. Groups 1 and 2 received isocaloric glucose. Hepatic injury was induced in groups 3 and 4 by administering 20% ethanol via intragastric intubation for 60days. In addition, groups 2 and 4 were given rutin (100...
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IN-VIVO ANTIFUNGAL ACTIVITY OF THE AERIAL PART OF ANVILLEA RADIATA BY USING A NEW METHOD OF STORAGE BY COATING GRAIN
The aim of the present study is to evaluate the antifungal effect of Anvillea radiata and to test the storage efficiency of soft wheat by coating. Phytochemical screening conducted on the Anvillea radiata extracts revealed the presence of the elements has known medical and physiological activities. Our results show a correlation between the plant part, extract concentrations and mold species. In g...
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IN-VITRO ANTIOXIDANT POTENTIAL OF SELECTED NUTRACEUTICALS
The current study involves evaluation of antioxidant potential of selected nutraceuticals like barley grass juice (Hordeum vulgare L.), ethanolic extracts of cashew apple (Anacardium occidentale L.) and sea lettuce (Ulva reticulata F.) in in-vitro experimental model using goat liver slices at different concentrations (100, 200, 400, 800 and 1600 mg/kg, p.o). The oxidative stress was induced using ...
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NANOPHYTOSOMES AN IMPERATIVE TECHNOLOGY FOR ENHANCING THE BIOAVAILABILITY OF BIOACTIVE CONSTITUENTS
Herbal medicine has been widely accepted as a promising approach for the treatment of various diseases with lower cost and minimized toxicity. Bioactive constituents isolated from the herbal source are equipped with synthetic drugs. The potency of any herbal medication is contingent on the delivery of the effectual level of the therapeutically active constituent. The integration of a novel drug de...
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