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ANTIMICROBIAL AND ANTIPLASMODIAL ACTIVITY DISPLAYED BY ACTINOMYCETES ISOLATED FROM SOILS FROM KAVANGO AND HARDAP REGIONS IN NAMIBIA
Plasmodium falciparum and multidrug resistant bacteria such as Mycobacterium avium, Staphylococcus aureus and Escherichia coli are among the top causes of morbidity and mortality especially in developing countries. These pathogens are responsible for the reported antibiotic resistance incidents globally. Due to the increase in antibiotic resistance worldwide, there is an urgent need for new bioact...
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N-[MORPHOLINO (4-NITROPHENYL) METHYL] NICOTINAMIDE AND ITS METAL COMPLEXES: SYNTHESIS AND EXPLORATION OF THEIR BIOACTIVITY
Synthetic organic compounds, containing relatively higher number of nitrogen attracting interest in the current medical research due to their utility in chemotherapy. The development of new medicines with more number of nitrogen atoms in their structural framework is an important challenging task for medicinal chemists. The lipophilicity of Mannich bases and their metal complexes enables them to b...
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AN UPDATED REVIEW ON THE THERAPEUTIC POTENTIAL OF PRUNUS ARMENIACA
Excessive drug therapy, environmental pollutants, hepatic cancer and alcoholic intoxicants are the main causes of liver disorders. The hepatic disorders/toxicity can occur by several mechanisms like cytochrome P450 activation, lipid peroxidation, induction of nitric acid synthase, mitochondrial dysfunction, activation of pro-inflammatory mediators and bile acid-indu...
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ADRENAL MYELOLIPOMA ASSOCIATED WITH CHOLELITHIASIS- A CASE REPORT
Adrenal myelolipomas are rare benign endocrinologically inactive tumor composed of mature adipose tissue and hematopoietic cells in varying proportions. Most lesions are small, unilateral and asymptomatic, discovered incidentally at autopsy or on imaging studies performed for other reasons. Its characteristic appearance on sonography and computed tomography enables preoperative diagnosis with a hi...
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SYNTHESIS, EVALUATION AND POLYMORPHISM STUDIES OF NEW BENZIMIDAZOLE DERIVATIVES AS POTENT ANTIBACTERIAL AGENTS
Ten, 2-substituted benzimidazole derivatives were prepared and assessed against two Gram-positive bacteria (Streptococcus mutans, Staphylococcus aureus) and two Gram-negative bacteria (Psuedomonas aeruginosa, Escherichia coli). The derivatives were obtained by the condensation of 2-((1H-benzo[d] imidazol-2-yl) thio) acetohydrazide(4) with different substituted aromatic aldehydes and their structur...
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SOLID DOSAGE FORM DEVELOPMENT OF DABIGATRAN ETEXILATE MESYLATE WITH INCREASED SOLUBILITY AND DISSOLUTION USING COCRYSTALLIZATION
Dabigatran Etexilate Mesylate (DEM), an anticoagulant used to treat and prevent blood clots and to inhibit the occurrence of stroke in people with cardiac arrhythmia. The purpose of this study was to obtain DEM co-crystals by screening eight different conformers and prepare the co-crystals by evaporation technique. Molecular docking was used to identify suitable coformer. Tartaric acid DEM co-crys...
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QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP STUDIES OF SULFADIAZINE- SALICYLALDEHYDE SCHIFF BASE AS AN ANTI-MYCOBACTERIAL AGENTS
Quantitative structure activity relationship is among the most widely used computational technology for analogue-based drug design. A molecular modelling approach using sulfadiazine- salicylaldehyde Schiff base analogue as anti-mycobacterial activity from recently reported literature were taken and was designed using MOE 2009.10. Sulfanilamide sulfa drugs have been shown to inhibit dihydropteroate...
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INDOLE 1,2,3,4-TETRAHYDROPYRIMIDINONE: SYNTHESIS, CHARACTERIZATION AND IT’S BIOLOGICAL APPLICATIONS
The present research work involves the use of exclusively and commercially available indole-3-carbaldehyde as a starting material to synthesize novel pyrimidine analogues. The synthesis of series of indole and pyrimidine containing N-substituted-4-(1H-indol-3-yl)-6-methyl-2-oxo-1, 2, 3, 4-tetrahydro-pyrimidine-5-carbohydrazide U(1-10) has been done by using principle of Biginelli condensation reac...
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DEVELOPMENT AND VALIDATION OF STABILITY INDICATING METHOD FOR THE SIMULTANEOUS ESTIMATION OF ELBASVIR AND GRAZOPREVIRIN PHARMA-CEUTICAL DOSAGE FORMS BY RP-HPLC
The present study aimed to develop and validate stability indicating method for the simultaneous determination of Elbasvir and Grazoprevir in its pharmaceutical dosage form using RP-HPLC. Chromatographic separation was done with Discovery C18 (250 mm × 4.6 mm, 5 µ) column using 0.1% ortho-phosphoric acid (OPA) and acetonitrile in the ratio 50:50% v/v as mobile phase on isocratic mode. The column...
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FOLATE ANCHORED CONJUGATES OF POLY (AMIDOAMINE) (PAMAM) DENDRIMER FOR CONTROLLED SITE SPECIFIC DELIVERY OF PIROXICAM IN ARTHRITIC RATS
The purpose of the present study was to synthesize and evaluate the potential of folate-G.4.0-PAMAM dendrimer conjugates as acceptable vehicle for site specific delivery of piroxicam (PXM) to inflammatory regions and to determine its targeting efficiency in carreganan induced arthritic rats. PXM was selected as a model acidic anti inflammatory drug. Folic acid was linked to the surface amino gro...
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