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DESIGN, OPTIMIZATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLET OF VALSARTAN
The main aim of this work was to formulate and study mucoadhesive buccal tablets of valsartan using various suitable bioadhesive polymers such as CP 934 and Xanthan gum. Nine formulations of valsartan were prepared by the direct compression method. The prepared tablets were characterized by swelling studies, % matrix erosion, surface pH, bioadhesive properties, in-vitro drug dissolution and in-vit...
1824
895
IMMUNOHISTOCHEMICAL EXPRESSION OF MMP9 IN DIFFERENT GRADES OF ORAL SQUAMOUS CELL CARCINOMA: OUR EXPERIENCE AT TERTIARY CARE CENTRE
Introduction: Oral carcinoma is amongst the leading malignancies worldwide, with squamous cell carcinoma (SCC) as the most common type accounting for over 90% of cases. In OSCC, MMPs, (MMP9) which belongs to gelatinase group, promote tumor progression by new blood vessel formation, disturbing tissue morphology which allows tumor growth breaks the basement membrane and enables metastasis and it's o...
1823
661
SYNTHESIS AND IN-VITRO ANTIPROLIFERATIVE ACTIVITY OF SUBSTITUTED-2, 3-DIMETHYL-N-(3-(4-PHENYL PIPERAZIN-1-YL) PROPYL)-6, 7-DIHYDRO-5H-BENZO [7] ANNULENE-8-CARBOXYLIC ACIDS
Benzosuberones and phenylpiperazinyl moieties are important heterocyclic compounds which constitute many biological activities which include anti bacterial, anti fungal, anti inflammatory, antioxidant, antitubercular and anti cancer activities. A novel series of 2,3-dimethyl-N-(3-(4-phenyl piperazin-1-yl)propyl)-6,7-dihydro-5H-benzo[7] annulene-8-carboxylic acids (5a-e) have been synthesized in go...
1822
782
NEUROPROTECTIVE EFFECT OF MORUS NIGRA L. (MULBERRY) FRUIT EXTRACT ON ACRYLAMIDE – INDUCED DANIO RERIO (ZEBRAFISH)
In the current scenario, high concentrations of acrylamide (ACR), a water-soluble vinyl monomer, which is used industrially and also found in thermally processed carbohydrate-rich foods, poses serious health risks to humans. Oxidative stress is an important mediator of central and peripheral neurotoxicity, which is one of the most recognized toxicological effects of high concentration acrylamide e...
1821
891
PHYTOCHEMICAL STUDY OF INDONESIAN CURCUMA ROTUNDA RHIZOME AND ITS ANTIOXIDANT ACTIVITY TOWARDS 1,1-DIPHENYL-2-PICRYLHYDRAZYL (DPPH)
Curcuma rotunda, locally known as temu kunci, has been reported containing flavonoids in its rhizome that exhibit antioxidant activity. This study aimed to isolate secondary metabolites from the polar fraction of acetone extract from C. rotunda rhizome and to determine their antioxidant activities. The secondary metabolites were isolated using various chromatography methods yielded two fractions. ...
1820
957
DESIGN, SYNTHESIS, DOCKING STUDIES AND BIOLOGICAL EVALUATION OF NOVEL HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES AS HISTONE DEACETYLASE ENZYME INHIBITORS
A new series of hydroxamic (5a-5j) and carboxylic acid analogs (4a-4j) based on the 1, 3, 4-thiadiazole scaffold was designed and synthesized to explore its potential as new antitumor agents. The chemical structures of the compounds were confirmed based on TLC, IR, 1H NMR, and 13C NMR analysis. Molecular docking studies showed that the target compounds correctly dock into the binding pocket of his...
1820
673
FORMULATION AND IN-VITRO CHARACTERIZATION OF 5-FLUOROURACIL AND FLAVONOID DUAL LIPID DRUG CONJUGATES LOADED SELF NANOMULSIFYING DRUG DELIVERY SYSTEM FOR CANCER TARGETING
Objective: The Failure in chemotherapy is mainly because of the resistance of the chemotherapeutic drugs towards the neoplastic cells. The main reason behind this study was to develop a novel combination of 5-Fluorouracil (5-FU) lipid curcumin conjugates for the treatment of cancer. Methods: In this study, the lipid group stearic acid and oleic acid was conjugated with the parent drug moiety 5-Flu...
1819
731
THE EVALUATION OF VITAMIN C SUPPLEMENTATION ON NUTRITIONAL STATUS OF PATIENTS WITH ACUTE MYELOID LEUKEMIA UNDERGOING CHEMOTHERAPY
Background: Leukemia is the seventh common cancer in Iran, and AML is considered as the most common type. Malnutrition is common among patients with cancer. Vitamin C deficiency has a high prevalence among patients with cancer, which may influence a patient's survival chance. This study was aimed to evaluate the effect of vitamin C supplementation on nutritional status and serum albumin in patient...
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701
ATTENUATION OF QUORUM SENSING ASSOCIATED VIRULENCE FACTORS AND BIOFILM FORMATION IN PSEUDOMONAS AERUGINOSA PAO1 BY PHOMA MULTI-ROSTRATA PUTY3, A SAPROPHYTIC FUNGUS, ISOLATED FROM CARICA PAPAYA
Pseudomonas aeruginosa is one of the most emerging multidrug-resistant opportunistic pathogens, which poses a threat to immunocompromised patients. Treatment of P. aeruginosa in the affected patients has become difficult because of its ability to develop resistant strains against most of the conventional therapeutic antibiotics. Quorum sensing plays a crucial role in the virulence nature of P. aer...
1818
722
RECENT FRONTIERS IN SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM: A REVIEW
Oral route has always been the preferred route of drug administration in many diseases. This route is limited to those drugs molecules that are permeable across the gastric mucosa and are sparingly soluble. Solubility is an important parameter to achieve the desired concentration of drug in systemic circulation for therapeutic response. As a consequence of modern drug discovery techniques, there h...
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