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ADRENAL MYELOLIPOMA ASSOCIATED WITH CHOLELITHIASIS- A CASE REPORT
Adrenal myelolipomas are rare benign endocrinologically inactive tumor composed of mature adipose tissue and hematopoietic cells in varying proportions. Most lesions are small, unilateral and asymptomatic, discovered incidentally at autopsy or on imaging studies performed for other reasons. Its characteristic appearance on sonography and computed tomography enables preoperative diagnosis with a hi...
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QMS VERSUS HPLC-UV FOR LAMOTRIGINE PLASMA MONITORING
Lamotrigine (LTG), a synthetic anticonvulsant, may lead to therapy failure or toxicity risks due to the wide inter and intra individual pharmacokinetic variations. Those wide variations in LTG require its therapeutic drug monitoring (TDM). Our study aims to compare the QMS method with the HPLC-UV which is considered as a reference method for TDM of LTG. The study was conducted in the Clinical Phar...
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A PROSPECTIVE STUDY TO COMPARE HYPO-FRACTIONATED RADIOTHERAPY VERSUS CONVENTIONAL RADIOTHERAPY IN CARCINOMA BREAST
Background: The standard management of operable LABC is by initial modified radical mastectomy. Because of the high risk of metastasis, systemic therapy is involved as an additional integral part of treatment. The postmastectomy radiation is given to reduce the high risk (20-40%) of loco-regional relapse following adjuvant systemic therapy. The loco-regional control ranges from 85% to 90% for 10 y...
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DEVELOPMENT AND VALIDATION OF A NEW RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF ANTIRETROVIRAL DRUGS: COBICISTAT AND ELVITEGRAVIR
A simple, precise, rapid and accurate reverse phase HPLC method was developed for the simultaneous estimation of cobicistat and elvitegravir in the pharmaceutical dosage form. A column of ODS (250mm 4.6mm; i.d and 5µ particle size) was used along with the mobile phase comprising of 0.02M dipotassium hydrogen orthophosphate buffer (pH adjusted to 3.3) and methanol in the ratio of 80:20 (v/v). The...
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IN-VIVO CHARACTERIZATION OF TRANSDERMAL PATCHES OF ALISKIREN HEMIFUMARATE FOR TREATMENT OF HYPERTENSION
The low bioavailability of drugs in the oral drug delivery system is the main concern and the development of a delivery system with a controlled release profile. This research aims in the dose reduction of aliskiren hemifumarate, evaluate the release efficacy of the drug from the patches by using various permeation enhancers. FTIR studies established the drug and polymer compatibility. The transde...
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SOLID DOSAGE FORM DEVELOPMENT OF DABIGATRAN ETEXILATE MESYLATE WITH INCREASED SOLUBILITY AND DISSOLUTION USING COCRYSTALLIZATION
Dabigatran Etexilate Mesylate (DEM), an anticoagulant used to treat and prevent blood clots and to inhibit the occurrence of stroke in people with cardiac arrhythmia. The purpose of this study was to obtain DEM co-crystals by screening eight different conformers and prepare the co-crystals by evaporation technique. Molecular docking was used to identify suitable coformer. Tartaric acid DEM co-crys...
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EVALUATION OF ACUTE AND SUBACUTE TOXICITY OF ALCOHOLIC EXTRACT OF THE ROOTS OF TRAGIA CANNABINA IN RATS
The toxicity profile of alcoholic extract of roots ofTragia cannabina Family: Euphorbiaceae was studied in wistar rats. The multiple oral administration of extract at single dose of 100, 500, 1000, 2000 and 3000 mg/kg body weight for 24 hrs. did not produce sign of toxicity, behavioral appearance, change on a gross appearance. The sun-acute toxicity was determined by administration of graded dosag...
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MICROWAVE ASSISTED SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NEWLY SYNTHESIZED 1, 3, 4-THIADIAZOLE DERIVATIVE OF GUAR GUM
A new derivative of Guar gum, incorporated with 1, 3, 4-thiadiazole nucleus was synthesized by using a new green and efficient synthetic approach. Guar gum is a biodegradable polymer having numerous applications in various industries. Thiadiazole compounds are well known in the therapeutic world due to their pharmacological importance. The newly synthesized derivative was characterized by IR, H1 N...
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ANTIOXIDANT EFFICIENCY OF VARIOUS EXTRACTS OF SEED COAT AND COTYLEDON OF CAJANUS CAJAN (L.) MILLSP.
Cajanus cajan L. (Pigeonpea) is an important pulse crop of India. The aim of this study was to determine and compare the antioxidant activity and bioactive compounds of seed coat and cotyledon of C. cajan. The antioxidant properties of pet ether, chloroform, ethanol and aqueous extracts of the seed coat and cotyledon of C. cajan were examined by a ferric thiocynate (FTC) assay, DPPH radical scaven...
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CHARACTERIZATION OF LIGNINOLYTIC ENZYMES AND DECOLOURIZATION OF SELECTED TEXTILE DYES FROM THE BLUSHING BRACKET MUSHROOM, DAEDALEOPSIS CONFRAGOSA
The effect of a wide range of culture conditions on the production of laccase (Lac), Lignin peroxidase (Lip) and Manganese peroxidases (MnP) by Daedaleopsis confragosa was studied. A ligninolytic enzyme-producing bracket mushroom, Daedaleopsis confragosa was isolated from tree trunk from Karwar coastal region, Karnataka, India and subjected to production and dye decolorization study. Ligninolytic ...
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